Polyurea only bonds chemically to polyurea in a short "recoat window." Fresh polyurea has leftover reactive groups that covalently weld to the next coat, but only for a few hours. Rhino Pipeliner 5000 has a max recoat of ~4 hours. After that the surface goes inert. 2/
June 19, 2026 at 4:55 PM
Polyurea only bonds chemically to polyurea in a short "recoat window." Fresh polyurea has leftover reactive groups that covalently weld to the next coat, but only for a few hours. Rhino Pipeliner 5000 has a max recoat of ~4 hours. After that the surface goes inert. 2/
We've found a new gene linked to chronic pain in humans! The gene SLC45A4 encodes (the long-awaited) neuronal polyamine transporter, which is important for pain signalling in nerves. We hope this discovery might lead to new chronic pain treatments in the future!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature
The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.
www.nature.com
August 21, 2025 at 12:16 PM
We've found a new gene linked to chronic pain in humans! The gene SLC45A4 encodes (the long-awaited) neuronal polyamine transporter, which is important for pain signalling in nerves. We hope this discovery might lead to new chronic pain treatments in the future!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our paper on SLC45A4 is out now in @nature.com! The orphan SLC45A4 transporter is a polyamine transporter involved in chronic pain signalling!
SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature
The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.
www.nature.com
August 21, 2025 at 11:05 AM
Our paper on SLC45A4 is out now in @nature.com! The orphan SLC45A4 transporter is a polyamine transporter involved in chronic pain signalling!
Nature research paper: Reprogramming neuroblastoma by diet-enhanced polyamine depletion
go.nature.com/4nLY0to
go.nature.com/4nLY0to
Reprogramming neuroblastoma by diet-enhanced polyamine depletion - Nature
Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.
go.nature.com
September 29, 2025 at 4:16 PM
Nature research paper: Reprogramming neuroblastoma by diet-enhanced polyamine depletion
go.nature.com/4nLY0to
go.nature.com/4nLY0to
Polyamine-dependent metabolic shielding regulates alternative splicing
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Polyamine-dependent metabolic shielding regulates alternative splicing - Nature
Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing in cells.
www.nature.com
January 16, 2026 at 7:46 AM
Polyamine-dependent metabolic shielding regulates alternative splicing
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Spatial metabolomics links polyamine turnover and vascular lipid remodeling to barley spikelet fate https://www.biorxiv.org/content/10.64898/2026.09.23.753928v1
September 24, 2026 at 11:00 PM
Spatial metabolomics links polyamine turnover and vascular lipid remodeling to barley spikelet fate https://www.biorxiv.org/content/10.64898/2026.09.23.753928v1
Spatial metabolomics links polyamine turnover and vascular lipid remodeling to barley spikelet fate https://www.biorxiv.org/content/10.64898/2026.09.23.753928v1
September 24, 2026 at 11:00 PM
Spatial metabolomics links polyamine turnover and vascular lipid remodeling to barley spikelet fate https://www.biorxiv.org/content/10.64898/2026.09.23.753928v1
Nature research paper: Polyamine-dependent metabolic shielding regulates alternative splicing
go.nature.com/49kxV0m
go.nature.com/49kxV0m
Polyamine-dependent metabolic shielding regulates alternative splicing - Nature
Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing in cells.
go.nature.com
January 14, 2026 at 5:58 PM
Nature research paper: Polyamine-dependent metabolic shielding regulates alternative splicing
go.nature.com/49kxV0m
go.nature.com/49kxV0m
Nature research paper: SLC45A4 is a pain gene encoding a neuronal polyamine transporter
go.nature.com/471Kk8J
go.nature.com/471Kk8J
SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature
The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.
go.nature.com
August 22, 2025 at 8:23 AM
Nature research paper: SLC45A4 is a pain gene encoding a neuronal polyamine transporter
go.nature.com/471Kk8J
go.nature.com/471Kk8J
🚨 Excited to share our new paper is out in Nature!
🔗 Reprogramming neuroblastoma by diet-enhanced polyamine depletion
🔗 Reprogramming neuroblastoma by diet-enhanced polyamine depletion
Nature research paper: Reprogramming neuroblastoma by diet-enhanced polyamine depletion
go.nature.com/4nLY0to
go.nature.com/4nLY0to
Reprogramming neuroblastoma by diet-enhanced polyamine depletion - Nature
Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.
go.nature.com
September 29, 2025 at 9:45 PM
🚨 Excited to share our new paper is out in Nature!
🔗 Reprogramming neuroblastoma by diet-enhanced polyamine depletion
🔗 Reprogramming neuroblastoma by diet-enhanced polyamine depletion
Nope. Epoxy is resin + a polyamine. This is polyurea with something like an amine resin
Which is the right material for this job. But it takes real know-how to apply it
Which is the right material for this job. But it takes real know-how to apply it
June 18, 2026 at 9:24 PM
Nope. Epoxy is resin + a polyamine. This is polyurea with something like an amine resin
Which is the right material for this job. But it takes real know-how to apply it
Which is the right material for this job. But it takes real know-how to apply it
Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS
Ruggieri et al. developed a spatial transcriptomics dataset of skeletal muscle from
the SOD1G93A ALS mouse model. Their findings highlight polyamine metabolism’s role
in muscle fiber vulnerability, sh...
www.cell.com
February 11, 2025 at 7:30 PM
Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS
www.cell.com/cell-reports...
www.cell.com/cell-reports...
We did journal club on this paper from @nickburton.bsky.social lab and what a cool paper this is! It finds bacteria mutants that affect worm development that is caused by the accumulation of a polyamine and another screen finds the transporter in worms. www.nature.com/articles/s41...
A noncanonical polyamine from bacteria antagonizes host mitochondrial function - Nature Communications
Polyamines produced by gut bacteria have been proposed to contribute to inflammatory bowel diseases. Here, Nauta et al. show that bacteria can produce a noncanonical polyamine intermediate that functi...
www.nature.com
September 18, 2026 at 9:10 AM
We did journal club on this paper from @nickburton.bsky.social lab and what a cool paper this is! It finds bacteria mutants that affect worm development that is caused by the accumulation of a polyamine and another screen finds the transporter in worms. www.nature.com/articles/s41...
Version 1 of my student’s paper is out today after a successful PhD thesis defense! Congratulations to Dr. Esther Liu! #sciencesky
In @elife.bsky.social: G1 and G2 ApolipoproteinL1 modulate macrophage inflammation and lipid accumulation through the polyamine pathway doi.org/10.7554/eLif...
In @elife.bsky.social: G1 and G2 ApolipoproteinL1 modulate macrophage inflammation and lipid accumulation through the polyamine pathway doi.org/10.7554/eLif...
G1 and G2 ApolipoproteinL1 modulate macrophage inflammation and lipid accumulation through the polyamine pathway
doi.org
July 17, 2025 at 9:55 PM
Version 1 of my student’s paper is out today after a successful PhD thesis defense! Congratulations to Dr. Esther Liu! #sciencesky
In @elife.bsky.social: G1 and G2 ApolipoproteinL1 modulate macrophage inflammation and lipid accumulation through the polyamine pathway doi.org/10.7554/eLif...
In @elife.bsky.social: G1 and G2 ApolipoproteinL1 modulate macrophage inflammation and lipid accumulation through the polyamine pathway doi.org/10.7554/eLif...
Cancer cell-derived arginine fuels polyamine biosynthesis in tumor-associated macrophages to promote immune evasion @cp-cancercell.bsky.social
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
April 3, 2025 at 9:02 PM
Cancer cell-derived arginine fuels polyamine biosynthesis in tumor-associated macrophages to promote immune evasion @cp-cancercell.bsky.social
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
new out in Nature www.nature.com/articles/s41...
Reprogramming neuroblastoma by diet-enhanced polyamine depletion - Nature
Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.
www.nature.com
September 26, 2025 at 7:52 AM
new out in Nature www.nature.com/articles/s41...
🥂Congrats to Ori, Neri & co for their new Open Access study in our journal @natcellbio.nature.com showing that delayed #intestinal #regeneration results from protein homeostasis stress and can be improved by modulation of the #polyamine pathway dynamics.
bit.ly/3YhxZHC
bit.ly/3YhxZHC
Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis - Nature Cell Biology
Minetti, Omrani et al. report that delayed intestinal regeneration results from protein homeostasis stress and can be improved by modulation of the polyamine pathway dynamics.
bit.ly
December 7, 2025 at 10:32 AM
🥂Congrats to Ori, Neri & co for their new Open Access study in our journal @natcellbio.nature.com showing that delayed #intestinal #regeneration results from protein homeostasis stress and can be improved by modulation of the #polyamine pathway dynamics.
bit.ly/3YhxZHC
bit.ly/3YhxZHC
I'm extremely proud of my lab and this new (revised) preprint from my lab identifying an unexpected bacterial polyamine can directly be transported into animal cells where it inhibits deoxyhypusine synthase and causes mito stress - www.biorxiv.org/content/10.1...
A noncanonical polyamine from bacteria antagonizes animal mitochondrial function
Canonical polyamines such as agmatine, putrescine, and spermidine are evolutionarily conserved metabolites found in nearly all forms of life ranging from bacteria to humans. Recently, interactions bet...
www.biorxiv.org
January 24, 2025 at 4:49 PM
I'm extremely proud of my lab and this new (revised) preprint from my lab identifying an unexpected bacterial polyamine can directly be transported into animal cells where it inhibits deoxyhypusine synthase and causes mito stress - www.biorxiv.org/content/10.1...
#bioGUNE_News | 🌍 Bilbao hosted the International Polyamine Conference for the first time, bringing together 90 participants from 18 countries
🔬 Organised by #CICbioGUNE Basque Research and Technology Alliance - BRTA with Universidad Deusto - Deustuko Unibertsitatea
🔗 https://ow.ly/eFfP50ZQU3h
🔬 Organised by #CICbioGUNE Basque Research and Technology Alliance - BRTA with Universidad Deusto - Deustuko Unibertsitatea
🔗 https://ow.ly/eFfP50ZQU3h
September 25, 2026 at 7:30 AM
#bioGUNE_News | 🌍 Bilbao hosted the International Polyamine Conference for the first time, bringing together 90 participants from 18 countries
🔬 Organised by #CICbioGUNE Basque Research and Technology Alliance - BRTA with Universidad Deusto - Deustuko Unibertsitatea
🔗 https://ow.ly/eFfP50ZQU3h
🔬 Organised by #CICbioGUNE Basque Research and Technology Alliance - BRTA with Universidad Deusto - Deustuko Unibertsitatea
🔗 https://ow.ly/eFfP50ZQU3h
How to keep warm in the chill! The microbiome of some arctic worms protects them from the freeze by making cryoprotective compounds including the polyamine spermidine. 🧪
Bacteria Help Worms Brave the Harsh Antarctic Cold
The microbiome of Antarctic worms helps them cope with extremely cold conditions, providing insights into the role of the microbiome in host health and adaptation.
www.the-scientist.com
January 23, 2025 at 7:38 PM
How to keep warm in the chill! The microbiome of some arctic worms protects them from the freeze by making cryoprotective compounds including the polyamine spermidine. 🧪
Transporters in pain! Exciting work from @middletonsj.bsky.social & Bennett lab @ox.ac.uk www.nature.com/articles/s41... #PainResearch
SLC45A4 is a pain gene encoding a neuronal polyamine transporter - Nature
The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.
www.nature.com
August 21, 2025 at 3:06 PM
Transporters in pain! Exciting work from @middletonsj.bsky.social & Bennett lab @ox.ac.uk www.nature.com/articles/s41... #PainResearch
Spatial Multiomics▶️ aberrant activation of Polyamine Metabolism in Oral Submucous Fibrosis-derived Oral Squamous Cell Carcinoma
#SpatialTranscriptomics Visium
#SpatialMetabolomics #MassSpecImaging
High polyamine➡️⏬OSCC survival
#AdvSci 2024
advanced.onlinelibrary.wiley.com/doi/10.1002/...
#SpatialTranscriptomics Visium
#SpatialMetabolomics #MassSpecImaging
High polyamine➡️⏬OSCC survival
#AdvSci 2024
advanced.onlinelibrary.wiley.com/doi/10.1002/...
January 20, 2026 at 10:29 PM
Spatial Multiomics▶️ aberrant activation of Polyamine Metabolism in Oral Submucous Fibrosis-derived Oral Squamous Cell Carcinoma
#SpatialTranscriptomics Visium
#SpatialMetabolomics #MassSpecImaging
High polyamine➡️⏬OSCC survival
#AdvSci 2024
advanced.onlinelibrary.wiley.com/doi/10.1002/...
#SpatialTranscriptomics Visium
#SpatialMetabolomics #MassSpecImaging
High polyamine➡️⏬OSCC survival
#AdvSci 2024
advanced.onlinelibrary.wiley.com/doi/10.1002/...