Excited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n] rdcu.be/fdqbr
Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity
Nature - Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity
rdcu.be
April 15, 2026 at 3:50 PM
Excited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n] rdcu.be/fdqbr
new out in Nature www.nature.com/articles/s41...
Polyclonal origins of human premalignant colorectal lesions - Nature
Nature - Polyclonal origins of human premalignant colorectal lesions
www.nature.com
November 26, 2025 at 5:27 PM
new out in Nature www.nature.com/articles/s41...
The polyclonal CD8+ T cell response is a composite of unbiased and biased clonotypes with varying capacity to incorporate environmental cues in their cell fate decisions @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
February 27, 2025 at 5:39 PM
The polyclonal CD8+ T cell response is a composite of unbiased and biased clonotypes with varying capacity to incorporate environmental cues in their cell fate decisions @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
so, Ineal is one of the Sickly, a caste engineered to be antibody farms. you inoculate them with a disease, their "lattice" (a network of lymph vessels near the skin) fills with fluid, and eventually vesicles full of polyclonal antibodies emerge, ready for harvest.
At a guess: Ineal is a member of one of the technical castes and Aja's job is a combination of doctor, bodyguard and jailer?
June 5, 2025 at 5:47 AM
so, Ineal is one of the Sickly, a caste engineered to be antibody farms. you inoculate them with a disease, their "lattice" (a network of lymph vessels near the skin) fills with fluid, and eventually vesicles full of polyclonal antibodies emerge, ready for harvest.
A whole new world… Inigo Martincorena presents paradigm shifting work showing a key role for somatic evolution in autoimmune disease. Long-term, polyclonal, multistage evolution #MITS2026
April 14, 2026 at 4:25 PM
A whole new world… Inigo Martincorena presents paradigm shifting work showing a key role for somatic evolution in autoimmune disease. Long-term, polyclonal, multistage evolution #MITS2026
Polyclonal epitope mapping reveals anti–immune complex antibodies that target idiotopes on antibodies bound to HIV Env @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Anti–immune complex antibodies are elicited during repeated immunization with HIV Env immunogens
Polyclonal epitope mapping reveals anti–immune complex antibodies that target idiotopes on antibodies bound to HIV Env.
www.science.org
January 17, 2025 at 9:52 PM
Polyclonal epitope mapping reveals anti–immune complex antibodies that target idiotopes on antibodies bound to HIV Env @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
And finally Adam Mulkern (Oxford): "Antibiotics reshape the antagonism landscape of polyclonal Pseudomonas aeruginosa infections" #meehubs26 #meehubs2026
August 5, 2026 at 3:01 PM
And finally Adam Mulkern (Oxford): "Antibiotics reshape the antagonism landscape of polyclonal Pseudomonas aeruginosa infections" #meehubs26 #meehubs2026
Very happy that @nvmp.bsky.social and @francescoterenzi.bsky.social work on the Evolution of Polyclonal Competition in Aging Hematopoiesis is published in the September issue of Cancer Discovery @aacrjournals.bsky.social
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
The Evolution of Polyclonal Competition in Aging Hematopoiesis
An evolutionary model of clonal hematopoiesis (CH) describes the genetic changes of HSCs through life, predicts the ubiquity of polyclonal competition, and identifies multistage CH progression with va...
aacrjournals.org
September 7, 2026 at 1:49 PM
Very happy that @nvmp.bsky.social and @francescoterenzi.bsky.social work on the Evolution of Polyclonal Competition in Aging Hematopoiesis is published in the September issue of Cancer Discovery @aacrjournals.bsky.social
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
It's #WorldRabiesDay | Health care professionals are invited to consult our Pocket Guide for Immunizers: Pooled Polyclonal Immunoglobulin Products | immunize.ca/sites/default/f...
September 28, 2026 at 1:40 PM
It's #WorldRabiesDay | Health care professionals are invited to consult our Pocket Guide for Immunizers: Pooled Polyclonal Immunoglobulin Products | immunize.ca/sites/default/f...
'Our results support the hypothesis that somatic mutations in autoimmune lymphocytes may allow them to escape tolerance constraints through a polyclonal cascade of somatic evolution, providing new insights into the molecular basis of autoimmune disease.'
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity - Nature
Nature - Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity
www.nature.com
April 15, 2026 at 12:17 PM
'Our results support the hypothesis that somatic mutations in autoimmune lymphocytes may allow them to escape tolerance constraints through a polyclonal cascade of somatic evolution, providing new insights into the molecular basis of autoimmune disease.'
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ALSO: the repository now contains 1 example from Abcam's catalog! Curiously, this image features the same "background pattern A" as hundreds of Thermo Fisher images, suggesting that it was sourced from the same third-party lab.
www.abcam.com/en-us/produc...
www.abcam.com/en-us/produc...
Anti-HC-II antibody (ab196758) | Abcam
Rabbit Polyclonal HC-II antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human SERPIND1.
www.abcam.com
June 5, 2026 at 5:27 PM
ALSO: the repository now contains 1 example from Abcam's catalog! Curiously, this image features the same "background pattern A" as hundreds of Thermo Fisher images, suggesting that it was sourced from the same third-party lab.
www.abcam.com/en-us/produc...
www.abcam.com/en-us/produc...
Microfluidics combined with electron microscopy for rapid and high-throughput mapping of antibody–viral glycoprotein complexes
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Microfluidics combined with electron microscopy for rapid and high-throughput mapping of antibody–viral glycoprotein complexes - Nature Biomedical Engineering
A microfluidics- and electron-microscopy-based method enables the characterization of polyclonal antibody responses to infection and vaccination.
www.nature.com
July 13, 2025 at 4:02 PM
Microfluidics combined with electron microscopy for rapid and high-throughput mapping of antibody–viral glycoprotein complexes
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Simultaneous polyclonal antibody sequencing and epitope mapping by cryoEM and mass spec: how far can we go? Check out the final version of our paper in eLife:
elifesciences.org/articles/101...
elifesciences.org/articles/101...
April 29, 2025 at 9:18 AM
Simultaneous polyclonal antibody sequencing and epitope mapping by cryoEM and mass spec: how far can we go? Check out the final version of our paper in eLife:
elifesciences.org/articles/101...
elifesciences.org/articles/101...
Thank you @natrevcancer.nature.com for the invitation to talk about this really cool study by Lu and collaborators! www.nature.com/articles/s41...
Thank you as well to my coauthor @pbasurto.bsky.social 😄
Thank you as well to my coauthor @pbasurto.bsky.social 😄
November 21, 2025 at 5:29 PM
Thank you @natrevcancer.nature.com for the invitation to talk about this really cool study by Lu and collaborators! www.nature.com/articles/s41...
Thank you as well to my coauthor @pbasurto.bsky.social 😄
Thank you as well to my coauthor @pbasurto.bsky.social 😄
New Parrish-Hafenstein collab work just dropped. Polyclonal antibody response to parvovirus vaccination in dogs 🐕, resolved by CryoEM.
ViroSky ☣️
ImmunoSky
www.nature.com/articles/s42...
ViroSky ☣️
ImmunoSky
www.nature.com/articles/s42...
Cryo EM structures map a post vaccination polyclonal antibody response to canine parvovirus - Commun...
The polyclonal response from the serum of dogs infected with canine parvovirus is identified using cryo EM and a computational method to map the harvested Fab onto an icosahedral capsid.
www.nature.com
September 25, 2023 at 2:34 AM
New Parrish-Hafenstein collab work just dropped. Polyclonal antibody response to parvovirus vaccination in dogs 🐕, resolved by CryoEM.
ViroSky ☣️
ImmunoSky
www.nature.com/articles/s42...
ViroSky ☣️
ImmunoSky
www.nature.com/articles/s42...
In new study led by @bdadonaite.bsky.social, we measure how spike mutations affect function & antigenicity of spike of KP.3.1.1 strain of SARS-CoV-2.
Sheds light on how key neutralizing epitopes are changing & importance of RBD up/down motion.
www.biorxiv.org/content/10.1...
Sheds light on how key neutralizing epitopes are changing & importance of RBD up/down motion.
www.biorxiv.org/content/10.1...
Spike mutations that affect the function and antigenicity of recent KP.3.1.1-like SARS-CoV-2 variants
SARS-CoV-2 is under strong evolutionary selection to acquire mutations in its spike protein that reduce neutralization by human polyclonal antibodies. Here we use pseudovirus-based deep mutational sca...
www.biorxiv.org
August 20, 2025 at 5:22 AM
In new study led by @bdadonaite.bsky.social, we measure how spike mutations affect function & antigenicity of spike of KP.3.1.1 strain of SARS-CoV-2.
Sheds light on how key neutralizing epitopes are changing & importance of RBD up/down motion.
www.biorxiv.org/content/10.1...
Sheds light on how key neutralizing epitopes are changing & importance of RBD up/down motion.
www.biorxiv.org/content/10.1...
Good to hear :) The polyclonal antibody alone would have made me avoid a western.
October 3, 2025 at 11:21 AM
Good to hear :) The polyclonal antibody alone would have made me avoid a western.
The final published version of this study is now available in Journal of Virology at journals.asm.org/doi/10.1128/...
Spike mutations that affect the function and antigenicity of recent KP.3.1.1-like SARS-CoV-2 variants | Journal of Virology
This study measures how mutations to the spike of a SARS-CoV-2 variant that circulated
in early 2025 affect its function and recognition by both the polyclonal antibodies
produced by the human immune ...
journals.asm.org
October 14, 2025 at 4:22 PM
The final published version of this study is now available in Journal of Virology at journals.asm.org/doi/10.1128/...
In study led by @csimonich.bsky.social & Teagan McMahon, we quantify antigenic evolution of RSV F
Important because:
1️⃣ RSV top cause of infant hospitalization in USA
2️⃣ New antibodies & vax can prevent hospitalizations
3️⃣ Will virus evolution erode their efficacy?
www.biorxiv.org/content/10.1...
Important because:
1️⃣ RSV top cause of infant hospitalization in USA
2️⃣ New antibodies & vax can prevent hospitalizations
3️⃣ Will virus evolution erode their efficacy?
www.biorxiv.org/content/10.1...
RSV F evolution escapes some monoclonal antibodies but does not strongly erode neutralization by human polyclonal sera
Vaccines and monoclonal antibodies targeting the respiratory syncytial virus (RSV) fusion protein (F) have recently begun to be widely used to protect infants and high-risk adults. Some other viral pr...
www.biorxiv.org
March 12, 2025 at 10:31 PM
In study led by @csimonich.bsky.social & Teagan McMahon, we quantify antigenic evolution of RSV F
Important because:
1️⃣ RSV top cause of infant hospitalization in USA
2️⃣ New antibodies & vax can prevent hospitalizations
3️⃣ Will virus evolution erode their efficacy?
www.biorxiv.org/content/10.1...
Important because:
1️⃣ RSV top cause of infant hospitalization in USA
2️⃣ New antibodies & vax can prevent hospitalizations
3️⃣ Will virus evolution erode their efficacy?
www.biorxiv.org/content/10.1...
In patients with heparin-induced thrombocytopenia, pathogenic antibodies were found to be monoclonal, which challenges previous views of HIT as a polyclonal disorder and suggests new avenues for diagnosis and treatment. Full study results: nej.md/4pkaYAq
#MedSky #CardioSky
#MedSky #CardioSky
September 3, 2025 at 10:00 PM
In patients with heparin-induced thrombocytopenia, pathogenic antibodies were found to be monoclonal, which challenges previous views of HIT as a polyclonal disorder and suggests new avenues for diagnosis and treatment. Full study results: nej.md/4pkaYAq
#MedSky #CardioSky
#MedSky #CardioSky
Scientists in China found that Omicron variants JN.1, KP.2, and KP.3 escape immunity from vaccines and monoclonal antibodies.
Their mutations weaken protection, highlighting the urgent need for updated vaccines and treatments.
www.sciencedirect.com/science/arti...
Their mutations weaken protection, highlighting the urgent need for updated vaccines and treatments.
www.sciencedirect.com/science/arti...
Immune evasion of Omicron variants JN.1, KP.2, and KP.3 to the polyclonal and monoclonal antibodies from COVID-19 convalescents and vaccine recipients
The Omicron BA.2.86 subvariants, JN.1, KP.2, and KP.3, have become predominant globally, raising concerns about their immune evasion from vaccines and…
www.sciencedirect.com
February 2, 2025 at 5:32 PM
Scientists in China found that Omicron variants JN.1, KP.2, and KP.3 escape immunity from vaccines and monoclonal antibodies.
Their mutations weaken protection, highlighting the urgent need for updated vaccines and treatments.
www.sciencedirect.com/science/arti...
Their mutations weaken protection, highlighting the urgent need for updated vaccines and treatments.
www.sciencedirect.com/science/arti...
Now online in Cancer Discovery @aacrjournals.bsky.social: The Evolution of Polyclonal Competition in Aging Hematopoiesis - by @nvmp.bsky.social, Francesco Terenzi, and @benjaminwerner.bsky.social doi.org/10.1158/2159... @qmbci.bsky.social
May 14, 2026 at 2:17 PM
Now online in Cancer Discovery @aacrjournals.bsky.social: The Evolution of Polyclonal Competition in Aging Hematopoiesis - by @nvmp.bsky.social, Francesco Terenzi, and @benjaminwerner.bsky.social doi.org/10.1158/2159... @qmbci.bsky.social
2) Lipkin explained that in the 1990s, his team looked at whether Bornavirus might be the cause of ME/CFS. They found no evidence of that, but they did see immune activation (nonspecific polyclonal B-cell activation) in a majority of patients.
September 12, 2025 at 11:42 AM
2) Lipkin explained that in the 1990s, his team looked at whether Bornavirus might be the cause of ME/CFS. They found no evidence of that, but they did see immune activation (nonspecific polyclonal B-cell activation) in a majority of patients.
However, an infection can induce bystander autoreactive T and B cell polyclonal activation, believed to result in non-pathogenic and pathogenic autoimmune responses.
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⬇️
January 17, 2025 at 7:37 PM
However, an infection can induce bystander autoreactive T and B cell polyclonal activation, believed to result in non-pathogenic and pathogenic autoimmune responses.
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We had an amazing γδ T Cell Conference with @yeganeh-almasi.bsky.social, @marileel.bsky.social & the incredible #gdTcells community, @forum-gd.bsky.social. Yeganeh & Marilee presented their work on KIR-enriched polyclonal γδ T cells in cancer immunotherapy. See you all in Wrocław in two years!
May 24, 2025 at 3:32 PM
We had an amazing γδ T Cell Conference with @yeganeh-almasi.bsky.social, @marileel.bsky.social & the incredible #gdTcells community, @forum-gd.bsky.social. Yeganeh & Marilee presented their work on KIR-enriched polyclonal γδ T cells in cancer immunotherapy. See you all in Wrocław in two years!