Congrats Milica @alessandrick.bsky.social & everyone @gekaragoz.bsky.social lab. Glad we could contribute to this awesome story on #UFMylation & #RQC crosstalk @embojournal.org link.springer.com/article/10.1...
The coordinated action of UFMylation and the RQC pathways clears arrested polypeptides at the ER - The EMBO Journal
Clearance of arrested nascent polypeptides resulting from ribosomal stalling is essential for proteostasis. Stalled endoplasmic reticulum (ER)-bound ribosomes are marked by ubiquitin-fold modifier 1 (...
link.springer.com
March 25, 2026 at 12:51 PM
Congrats Milica @alessandrick.bsky.social & everyone @gekaragoz.bsky.social lab. Glad we could contribute to this awesome story on #UFMylation & #RQC crosstalk @embojournal.org link.springer.com/article/10.1...
This cast-metal sculpture at Cold Spring Harbor Laboratory is called "Waltz of the Polypeptides".
Commissioned by Human Genome Sciences Inc. & designed by artist Mara G. Haseltine, it depicts a protein being born from a 'polyribosome', where multiple ribosomes bind to the same messenger RNA.
Commissioned by Human Genome Sciences Inc. & designed by artist Mara G. Haseltine, it depicts a protein being born from a 'polyribosome', where multiple ribosomes bind to the same messenger RNA.
July 9, 2025 at 2:49 PM
This cast-metal sculpture at Cold Spring Harbor Laboratory is called "Waltz of the Polypeptides".
Commissioned by Human Genome Sciences Inc. & designed by artist Mara G. Haseltine, it depicts a protein being born from a 'polyribosome', where multiple ribosomes bind to the same messenger RNA.
Commissioned by Human Genome Sciences Inc. & designed by artist Mara G. Haseltine, it depicts a protein being born from a 'polyribosome', where multiple ribosomes bind to the same messenger RNA.
POSSIBLE NEW IDIOMS:
a real piazza of greasy focaccia
polypeptides are liiiiiiiiiiiiiiinking
can’t kiss Scottish & expect a Welsh hug
…soap needs more lye
bang, bang, but you still ain’t a radiator
Polonius behind the curtain & Ophelia with no shampoo
snuggling up to the lollipop heads
a real piazza of greasy focaccia
polypeptides are liiiiiiiiiiiiiiinking
can’t kiss Scottish & expect a Welsh hug
…soap needs more lye
bang, bang, but you still ain’t a radiator
Polonius behind the curtain & Ophelia with no shampoo
snuggling up to the lollipop heads
April 30, 2026 at 3:34 PM
POSSIBLE NEW IDIOMS:
a real piazza of greasy focaccia
polypeptides are liiiiiiiiiiiiiiinking
can’t kiss Scottish & expect a Welsh hug
…soap needs more lye
bang, bang, but you still ain’t a radiator
Polonius behind the curtain & Ophelia with no shampoo
snuggling up to the lollipop heads
a real piazza of greasy focaccia
polypeptides are liiiiiiiiiiiiiiinking
can’t kiss Scottish & expect a Welsh hug
…soap needs more lye
bang, bang, but you still ain’t a radiator
Polonius behind the curtain & Ophelia with no shampoo
snuggling up to the lollipop heads
What are the roles of UFMylation during ribosome-associated quality control?
@gekaragoz.bsky.social @plantophagy.bsky.social and colleagues find it to cooperate with RQC factors in promoting clearance of arrested nascent polypeptides at the ER
link.springer.com/article/10.1...
@gekaragoz.bsky.social @plantophagy.bsky.social and colleagues find it to cooperate with RQC factors in promoting clearance of arrested nascent polypeptides at the ER
link.springer.com/article/10.1...
The coordinated action of UFMylation and the RQC pathways clears arrested polypeptides at the ER - The EMBO Journal
Clearance of arrested nascent polypeptides resulting from ribosomal stalling is essential for proteostasis. Stalled endoplasmic reticulum (ER)-bound ribosomes are marked by ubiquitin-fold modifier 1 (...
link.springer.com
March 26, 2026 at 2:00 PM
What are the roles of UFMylation during ribosome-associated quality control?
@gekaragoz.bsky.social @plantophagy.bsky.social and colleagues find it to cooperate with RQC factors in promoting clearance of arrested nascent polypeptides at the ER
link.springer.com/article/10.1...
@gekaragoz.bsky.social @plantophagy.bsky.social and colleagues find it to cooperate with RQC factors in promoting clearance of arrested nascent polypeptides at the ER
link.springer.com/article/10.1...
❄️ Antifreeze from fish blood
A lab-made version of a fish blood protein stops ice crystals from forming, protecting foods and medicines from freeze damage. Cheap, safe, and biodegradable.
🔗 advanced.onlinelibrary.wiley.com/doi/10.1002/...
#SciComm 🧪 #MaterialsScience #Biotech
A lab-made version of a fish blood protein stops ice crystals from forming, protecting foods and medicines from freeze damage. Cheap, safe, and biodegradable.
🔗 advanced.onlinelibrary.wiley.com/doi/10.1002/...
#SciComm 🧪 #MaterialsScience #Biotech
An Ultrapotent, Ultraeconomical, Antifreeze Polypeptide
Simple and inexpensive polypeptides composed of random copolymers of alanine and glutamic acid are effective antifreezes for applications in foods and biomedicine. The polypeptides, inspired by natur...
advanced.onlinelibrary.wiley.com
October 10, 2025 at 8:20 AM
❄️ Antifreeze from fish blood
A lab-made version of a fish blood protein stops ice crystals from forming, protecting foods and medicines from freeze damage. Cheap, safe, and biodegradable.
🔗 advanced.onlinelibrary.wiley.com/doi/10.1002/...
#SciComm 🧪 #MaterialsScience #Biotech
A lab-made version of a fish blood protein stops ice crystals from forming, protecting foods and medicines from freeze damage. Cheap, safe, and biodegradable.
🔗 advanced.onlinelibrary.wiley.com/doi/10.1002/...
#SciComm 🧪 #MaterialsScience #Biotech
About our coop with Mibelle on #vegan #collagen:
Moss Produces Human Collagen for Skincare
Unlike bacteria or yeast, #moss can produce large polypeptides of human collagen along with the post-translational modifications that make it stable and bioactive.
www.the-scientist.com/moss-produce...
Moss Produces Human Collagen for Skincare
Unlike bacteria or yeast, #moss can produce large polypeptides of human collagen along with the post-translational modifications that make it stable and bioactive.
www.the-scientist.com/moss-produce...
Moss Produces Human Collagen for Skincare | The Scientist
Unlike bacteria or yeast, moss can produce large polypeptides of human collagen along with the post-translational modifications that make it stable and bioactive.
www.the-scientist.com
March 31, 2026 at 8:42 AM
About our coop with Mibelle on #vegan #collagen:
Moss Produces Human Collagen for Skincare
Unlike bacteria or yeast, #moss can produce large polypeptides of human collagen along with the post-translational modifications that make it stable and bioactive.
www.the-scientist.com/moss-produce...
Moss Produces Human Collagen for Skincare
Unlike bacteria or yeast, #moss can produce large polypeptides of human collagen along with the post-translational modifications that make it stable and bioactive.
www.the-scientist.com/moss-produce...
Moss Produces Human Collagen for Skincare
Unlike bacteria or yeast, #moss can produce large polypeptides of human #collagen along with the post-translational modifications that make it stable and bioactive. And it's #vegan.
www.the-scientist.com/moss-produce...
Unlike bacteria or yeast, #moss can produce large polypeptides of human #collagen along with the post-translational modifications that make it stable and bioactive. And it's #vegan.
www.the-scientist.com/moss-produce...
Moss Produces Human Collagen for Skincare | The Scientist
Unlike bacteria or yeast, moss can produce large polypeptides of human collagen along with the post-translational modifications that make it stable and bioactive.
www.the-scientist.com
April 29, 2026 at 11:21 AM
Moss Produces Human Collagen for Skincare
Unlike bacteria or yeast, #moss can produce large polypeptides of human #collagen along with the post-translational modifications that make it stable and bioactive. And it's #vegan.
www.the-scientist.com/moss-produce...
Unlike bacteria or yeast, #moss can produce large polypeptides of human #collagen along with the post-translational modifications that make it stable and bioactive. And it's #vegan.
www.the-scientist.com/moss-produce...
Nice article about our biotech work.
Moss Produces Human Collagen for Skincare
Unlike bacteria or yeast, moss can produce large polypeptides of human collagen along with the post-translational modifications that make it stable and bioactive.
www.the-scientist.com/moss-produce...
Moss Produces Human Collagen for Skincare
Unlike bacteria or yeast, moss can produce large polypeptides of human collagen along with the post-translational modifications that make it stable and bioactive.
www.the-scientist.com/moss-produce...
Moss Produces Human Collagen for Skincare | The Scientist
Unlike bacteria or yeast, moss can produce large polypeptides of human collagen along with the post-translational modifications that make it stable and bioactive.
www.the-scientist.com
June 23, 2026 at 11:26 AM
Nice article about our biotech work.
Moss Produces Human Collagen for Skincare
Unlike bacteria or yeast, moss can produce large polypeptides of human collagen along with the post-translational modifications that make it stable and bioactive.
www.the-scientist.com/moss-produce...
Moss Produces Human Collagen for Skincare
Unlike bacteria or yeast, moss can produce large polypeptides of human collagen along with the post-translational modifications that make it stable and bioactive.
www.the-scientist.com/moss-produce...
Structural studies by Ahmad Jomaa and colleagues @jomaalab.bsky.social show how NAC on translating #ribosomes couples protein synthesis to N-myristoylation of nascent polypeptides by NMT2
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
September 3, 2025 at 11:31 AM
Structural studies by Ahmad Jomaa and colleagues @jomaalab.bsky.social show how NAC on translating #ribosomes couples protein synthesis to N-myristoylation of nascent polypeptides by NMT2
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
May 9, 2025 at 12:13 AM
Fantastic teamwork by Milica Mihailovic & Aleksandra Anisimova from the Karagöz lab @gekaragoz.bsky.social @maxperutzlabs.ac.at together with the @plantophagy.bsky.social lab — Another great collaboration 🙌 within our SFB program, published in @embojournal.org
🔗 link.springer.com/article/10.1...
🔗 link.springer.com/article/10.1...
April 8, 2026 at 11:36 PM
Fantastic teamwork by Milica Mihailovic & Aleksandra Anisimova from the Karagöz lab @gekaragoz.bsky.social @maxperutzlabs.ac.at together with the @plantophagy.bsky.social lab — Another great collaboration 🙌 within our SFB program, published in @embojournal.org
🔗 link.springer.com/article/10.1...
🔗 link.springer.com/article/10.1...
#NewResearch
Two polypeptides synthesised by common bacterial strains in human gut microbiota lower body fat and blood glucose, and increasing bone density to improve metabolism in rodents.
#MicroSky 🦠
www.nature.com/articles/s41...
Two polypeptides synthesised by common bacterial strains in human gut microbiota lower body fat and blood glucose, and increasing bone density to improve metabolism in rodents.
#MicroSky 🦠
www.nature.com/articles/s41...
Polypeptides synthesized by common bacteria in the human gut improve rodent metabolism - Nature Microbiology
Two polypeptides synthesized by common bacterial strains in human gut microbiota lower body fat and blood glucose and increase bone density, improving the metabolism of rodents.
www.nature.com
August 1, 2025 at 2:07 PM
#NewResearch
Two polypeptides synthesised by common bacterial strains in human gut microbiota lower body fat and blood glucose, and increasing bone density to improve metabolism in rodents.
#MicroSky 🦠
www.nature.com/articles/s41...
Two polypeptides synthesised by common bacterial strains in human gut microbiota lower body fat and blood glucose, and increasing bone density to improve metabolism in rodents.
#MicroSky 🦠
www.nature.com/articles/s41...
Two polypeptides synthesized by common bacterial strains in human gut microbiota lower body fat and blood glucose and increase bone density, improving the metabolism of rodents, according to a paper in Nature Microbiology. go.nature.com/3IUZ2o0 🧪
August 4, 2025 at 1:29 PM
Two polypeptides synthesized by common bacterial strains in human gut microbiota lower body fat and blood glucose and increase bone density, improving the metabolism of rodents, according to a paper in Nature Microbiology. go.nature.com/3IUZ2o0 🧪
Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇
Oxidative stress sensing by the translation elongation machinery promotes production of detoxifying selenoproteins
Selenocysteine, incorporated into polypeptides at recoded termination codons, plays an essential role in redox biology. Using GPX1 and GPX4, selenoenzymes that mitigate oxidative stress, as reporters,...
www.biorxiv.org
October 14, 2025 at 10:28 PM
Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇
🦠 ENDOCRINOLOGY?
RORDEP1/2 secreted by gut commensal 𝘙𝘶𝘮𝘪𝘯𝘰𝘤𝘰𝘤𝘤𝘶𝘴 𝘵𝘰𝘳𝘲𝘶𝘦𝘴 mimic exercise hormone irisin → systemic effects on host metabolism
⭡ thermogenesis, insulin signaling, glycolysis
↓ gluconeogenesis, lipogenesis
These peptides may be candidate biologics for obesity and type 2 diabetes
RORDEP1/2 secreted by gut commensal 𝘙𝘶𝘮𝘪𝘯𝘰𝘤𝘰𝘤𝘤𝘶𝘴 𝘵𝘰𝘳𝘲𝘶𝘦𝘴 mimic exercise hormone irisin → systemic effects on host metabolism
⭡ thermogenesis, insulin signaling, glycolysis
↓ gluconeogenesis, lipogenesis
These peptides may be candidate biologics for obesity and type 2 diabetes
Polypeptides synthesized by common bacteria in the human gut improve rodent metabolism - Nature Microbiology
Two polypeptides synthesized by common bacterial strains in human gut microbiota lower body fat and blood glucose and increase bone density, improving the metabolism of rodents.
www.nature.com
August 1, 2025 at 5:28 PM
🦠 ENDOCRINOLOGY?
RORDEP1/2 secreted by gut commensal 𝘙𝘶𝘮𝘪𝘯𝘰𝘤𝘰𝘤𝘤𝘶𝘴 𝘵𝘰𝘳𝘲𝘶𝘦𝘴 mimic exercise hormone irisin → systemic effects on host metabolism
⭡ thermogenesis, insulin signaling, glycolysis
↓ gluconeogenesis, lipogenesis
These peptides may be candidate biologics for obesity and type 2 diabetes
RORDEP1/2 secreted by gut commensal 𝘙𝘶𝘮𝘪𝘯𝘰𝘤𝘰𝘤𝘤𝘶𝘴 𝘵𝘰𝘳𝘲𝘶𝘦𝘴 mimic exercise hormone irisin → systemic effects on host metabolism
⭡ thermogenesis, insulin signaling, glycolysis
↓ gluconeogenesis, lipogenesis
These peptides may be candidate biologics for obesity and type 2 diabetes
An intriguing investigation of really large prokaryotic ORFs. These ORFs tend to occur in predatory/epibiont lineages like the Omnitrophica - one up to 85,804 amino acids in length! Are these cleaved post translation? or maintained as huge polypeptides? So interesting!
November 23, 2023 at 3:11 AM
An intriguing investigation of really large prokaryotic ORFs. These ORFs tend to occur in predatory/epibiont lineages like the Omnitrophica - one up to 85,804 amino acids in length! Are these cleaved post translation? or maintained as huge polypeptides? So interesting!
If you're interested in learning more about the diversity of their potent neurotoxic cocktail & the highly distinct RF- and RL- amide peptides, there's a paper here:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 17, 2026 at 1:09 PM
If you're interested in learning more about the diversity of their potent neurotoxic cocktail & the highly distinct RF- and RL- amide peptides, there's a paper here:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A new publication from my lab a great work done with fantastic colleagues from #IGDR (Reynald Gillet’s team for all the cryoem work. pubmed.ncbi.nlm.nih.gov/40187343/
RQC2 is a major player in peptide release from stalled ribosomes - PubMed
Eukaryotic cells prevent the accumulation of potentially toxic aberrant polypeptides and maintain ribosome availability through surveillance and clearance mechanisms, including the evolutionarily cons...
pubmed.ncbi.nlm.nih.gov
April 6, 2025 at 7:41 PM
A new publication from my lab a great work done with fantastic colleagues from #IGDR (Reynald Gillet’s team for all the cryoem work. pubmed.ncbi.nlm.nih.gov/40187343/
i'm gonna be honest, idk what people mean when they say 'peptides'? like 'polypeptides,' the building blocks of proteins??
March 12, 2026 at 10:20 PM
i'm gonna be honest, idk what people mean when they say 'peptides'? like 'polypeptides,' the building blocks of proteins??
From here: wellcomecollection.org/works/eum3u8...
PhD Dissertation: <i>Polypeptides and Proteins: X-Ray Studies</i>
wellcomecollection.org
April 5, 2025 at 6:39 PM
From here: wellcomecollection.org/works/eum3u8...
MedSky🧪IDSky #SARSCoV2 infection can shut down host-cell synthesis of key polypeptides in 5 mitochondrial enzyme complexes. The infection prevents transcription of the genes that encode the polypeptides into mRNA.
@MicrobesInfect
www.wsws.org/en/articles/...
@MicrobesInfect
www.wsws.org/en/articles/...
Study finds that SARS-CoV-2 can shut down mitochondria, the cellular “power plants”
The study's authors conjecture that ongoing inhibition of the mitochondria after infection might also play a role in the symptoms of Long COVID, especially general fatigue and malaise.
www.wsws.org
November 27, 2023 at 11:00 AM
MedSky🧪IDSky #SARSCoV2 infection can shut down host-cell synthesis of key polypeptides in 5 mitochondrial enzyme complexes. The infection prevents transcription of the genes that encode the polypeptides into mRNA.
@MicrobesInfect
www.wsws.org/en/articles/...
@MicrobesInfect
www.wsws.org/en/articles/...
Here the authors propose that gut #microbiota derived peptides exhibit potential for prevention and treatment of human metabolic disorders www.nature.com/articles/s41...
Polypeptides synthesized by common bacteria in the human gut improve rodent metabolism - Nature Microbiology
Two polypeptides synthesized by common bacterial strains in human gut microbiota lower body fat and blood glucose and increase bone density, improving the metabolism of rodents.
www.nature.com
July 31, 2025 at 10:07 AM
Here the authors propose that gut #microbiota derived peptides exhibit potential for prevention and treatment of human metabolic disorders www.nature.com/articles/s41...
Our story about FASTKD5 is now published at @narjournal.bsky.social It was an amazing collaboration with @haukehillen.bsky.social and Toni Barrientos’ labs.
doi.org/10.1093/nar/...
FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites
doi.org/10.1093/nar/...
FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites
FASTKD5 processes mitochondrial pre-mRNAs at noncanonical cleavage sites
Abstract. The first post-transcriptional step in mammalian mitochondrial gene expression, required for the synthesis of the 13 polypeptides encoded in mito
doi.org
July 11, 2025 at 4:14 AM
Our story about FASTKD5 is now published at @narjournal.bsky.social It was an amazing collaboration with @haukehillen.bsky.social and Toni Barrientos’ labs.
doi.org/10.1093/nar/...
FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites
doi.org/10.1093/nar/...
FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites
A canonical chloroplast unfolded protein response triggered by misfolded polypeptides https://www.biorxiv.org/content/10.1101/2025.06.11.659047v1
June 16, 2025 at 8:01 PM
A canonical chloroplast unfolded protein response triggered by misfolded polypeptides https://www.biorxiv.org/content/10.1101/2025.06.11.659047v1