What was published On November 6, 2026 , the journal Nature published a preclinical study on a single-dose treatment to reduce LDL cholesterol and triglycerides.
CRISPR Editing of ANGPTL3: A Single Dose Reduces Lipids for Up to 3 Years in Primates - Sinaptica
What was published
On November 6, 2026, the journal Nature published a preclinical study on a single-dose treatment to reduce LDL cholesterol and triglycerides.
sinapti.ca
November 9, 2026 at 1:09 AM
What was published On November 6, 2026 , the journal Nature published a preclinical study on a single-dose treatment to reduce LDL cholesterol and triglycerides.
The main goal during early preclinical development is to determine if the product is safe for initial use in humans. INDs may be used for patients with serious diseases when there are no other satisfactory treatment options available.
November 6, 2026 at 5:06 PM
The main goal during early preclinical development is to determine if the product is safe for initial use in humans. INDs may be used for patients with serious diseases when there are no other satisfactory treatment options available.
Linguistic features from constrained spontaneous speech as potential markers of preclinical Alzheimer's disease https://pubmed.ncbi.nlm.nih.gov/42987558/
November 6, 2026 at 7:50 AM
Linguistic features from constrained spontaneous speech as potential markers of preclinical Alzheimer's disease https://pubmed.ncbi.nlm.nih.gov/42987558/
It's getting impressive how unimpressive the NAD precursor clinical trial literature is. The whole preclinical ratioanle literature is built on a methodologically shaky house of cards as is so not totally surprising, but we're 10yrs into a wellne$$ification of NR/NMN with little clinical excitement
A phase 3 trial does not support #NicotinamideRiboside for early #ParkinsonDisease treatment. The findings are clinically relevant given the widespread use of this supplement and ongoing related trials.
📌 Learn more: ja.ma/4Afh4Xp
#Nicotinamide #ParkinsonDisease #VitaminB3 #supplements
📌 Learn more: ja.ma/4Afh4Xp
#Nicotinamide #ParkinsonDisease #VitaminB3 #supplements
November 6, 2026 at 2:21 PM
It's getting impressive how unimpressive the NAD precursor clinical trial literature is. The whole preclinical ratioanle literature is built on a methodologically shaky house of cards as is so not totally surprising, but we're 10yrs into a wellne$$ification of NR/NMN with little clinical excitement
Effects of environmental enrichment and social isolation in preclinical rodent models: role of the endocannabinoid system
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
www.sciencedirect.com
November 4, 2026 at 6:30 PM
Effects of environmental enrichment and social isolation in preclinical rodent models: role of the endocannabinoid system
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
NIR-II Fluorescence Surgical Navigation for Gastric Cancer: Systematic Preclinical Validation Toward Clinical Application
DOI: https://doi.org/10.1002/agt2.70398
DOI: https://doi.org/10.1002/agt2.70398
November 6, 2026 at 6:18 AM
NIR-II Fluorescence Surgical Navigation for Gastric Cancer: Systematic Preclinical Validation Toward Clinical Application
DOI: https://doi.org/10.1002/agt2.70398
DOI: https://doi.org/10.1002/agt2.70398
@thermofishersci.bsky.social's resource, RRID:AB_464893, was just reported to be used in the paper. Thanks for making your methods matter! #OpenScience #methodsmatter #accelerateopenscience
Integrative transcriptomic analysis and preclinical validation identify lansoprazole as a therapeutic candidate for preeclampsia
Read the full paper: Integrative transcriptomic analysis and preclinical validation identify lansoprazole as a therapeutic candidate for preeclampsia
doi.org
November 6, 2026 at 8:01 AM
@thermofishersci.bsky.social's resource, RRID:AB_464893, was just reported to be used in the paper. Thanks for making your methods matter! #OpenScience #methodsmatter #accelerateopenscience
Two additional candidate vaccines will be entering the Tumaini clinical trial after promising preliminary early clinical and preclinical data.This is wonderful news.
www.who.int/news/item/04...
www.who.int/news/item/04...
Two new candidate vaccines to join Ebola trial as treatment research advances
Expert groups convened by the World Health Organization (WHO) have recommended adding two new Ebola vaccine candidates to the ongoing Tumaini clinical trial in the Democratic Republic of the Congo (DR...
www.who.int
November 4, 2026 at 5:32 PM
Two additional candidate vaccines will be entering the Tumaini clinical trial after promising preliminary early clinical and preclinical data.This is wonderful news.
www.who.int/news/item/04...
www.who.int/news/item/04...
researchers report an 18f-labeled pcna-directed pet tracer derived from aoh1996 for imaging glioblastoma in preclinical models. a potentially valuable approach for noninvasive interrogation of tumor biology.
doi.org/10.1021/acs....
doi.org/10.1021/acs....
Design, Synthesis, and Preclinical Evaluation of [18F]FPON, a First-In-Class PET Tracer Targeting Proliferating Cell Nuclear Antigen for Glioblastoma Imaging
Abstract. Proliferating cell nuclear antigen (PCNA) is a central regulator of glioma stem cell maintenance and therapy resistance, yet no noninvasive metho
doi.org
November 8, 2026 at 1:26 PM
researchers report an 18f-labeled pcna-directed pet tracer derived from aoh1996 for imaging glioblastoma in preclinical models. a potentially valuable approach for noninvasive interrogation of tumor biology.
doi.org/10.1021/acs....
doi.org/10.1021/acs....
$IMRX #Biotech #SITC2026 — Immuneering disclosed preclinical atebimetinib plus anti-PD-1 data. Preclinical combinations are research inputs, not clinical benefit.
https://www.merlintrader.com/immuneering-corporation-stock-hub/
https://www.merlintrader.com/immuneering-corporation-stock-hub/
November 6, 2026 at 8:57 PM
$IMRX #Biotech #SITC2026 — Immuneering disclosed preclinical atebimetinib plus anti-PD-1 data. Preclinical combinations are research inputs, not clinical benefit.
https://www.merlintrader.com/immuneering-corporation-stock-hub/
https://www.merlintrader.com/immuneering-corporation-stock-hub/
Our CircaVent Team is using a high-throughput drug screening platform that combines predictive algorithms, preclinical models, and human brain organoids to efficiently identify and test drugs that could treat the underlying causes of bipolar disorder.
CircaVent: A Drug Discovery Platform for Mental Health Conditions
CircaVent is a novel drug discovery platform that combines predictive algorithms, high-throughput preclinical models, and human organoids to identify and test drugs that could treat mental health conditions like bipolar disorder.
wyss.harvard.edu
November 8, 2026 at 4:06 PM
Our CircaVent Team is using a high-throughput drug screening platform that combines predictive algorithms, preclinical models, and human brain organoids to efficiently identify and test drugs that could treat the underlying causes of bipolar disorder.
Can obesity drugs protect the brain? 🧠
In our new review in Science, we look at what we know, and what we don't, about GLP-1-based drugs like semaglutide and tirzepatide and cognition.
Short answer: promising, but we are not there yet 🧵
🧪 #neuroskyence #glp1 #obesitydrugs
In our new review in Science, we look at what we know, and what we don't, about GLP-1-based drugs like semaglutide and tirzepatide and cognition.
Short answer: promising, but we are not there yet 🧵
🧪 #neuroskyence #glp1 #obesitydrugs
Obesity pharmacotherapies and cognition
Pharmacotherapies for obesity and type 2 diabetes are increasingly being evaluated for their effects on cognition and brain health. Evidence from preclinical models, observational cohorts, and clinica...
www.science.org
November 6, 2026 at 8:16 AM
Can obesity drugs protect the brain? 🧠
In our new review in Science, we look at what we know, and what we don't, about GLP-1-based drugs like semaglutide and tirzepatide and cognition.
Short answer: promising, but we are not there yet 🧵
🧪 #neuroskyence #glp1 #obesitydrugs
In our new review in Science, we look at what we know, and what we don't, about GLP-1-based drugs like semaglutide and tirzepatide and cognition.
Short answer: promising, but we are not there yet 🧵
🧪 #neuroskyence #glp1 #obesitydrugs
“collected the genetic sequence data of all the bird flu viruses logged by surveillance programs around the world, which take virus samples from wildlife, livestock, and humans infected with bird flu. They built an AI tool to integrate the huge amount of genetic data”
Bird Flu Vaccine Developed Using AI Outperforms Current Stockpiled Vaccines in Preclinical Tests
In preclinical studies, the DVX-panH5Nx vaccine outperformed existing vaccines stockpiled by governments.
www.genengnews.com
November 6, 2026 at 4:06 PM
“collected the genetic sequence data of all the bird flu viruses logged by surveillance programs around the world, which take virus samples from wildlife, livestock, and humans infected with bird flu. They built an AI tool to integrate the huge amount of genetic data”
Obesity pharmacotherapies and cognition | Science www.science.org/doi/10.1126/... 🧪
Obesity pharmacotherapies and cognition
Pharmacotherapies for obesity and type 2 diabetes are increasingly being evaluated for their effects on cognition and brain health. Evidence from preclinical models, observational cohorts, and clinica...
www.science.org
November 6, 2026 at 10:04 PM
Obesity pharmacotherapies and cognition | Science www.science.org/doi/10.1126/... 🧪
Boehringer returns to Sino Biopharma in $7.4B deal for preclinical TCEs, ADCs | #biotech #pharma #biotechsky
Boehringer returns to Sino Biopharma in $7.4B deal for preclinical TCEs, ADCs
Boehringer Ingelheim has
www.fiercebiotech.com
November 6, 2026 at 6:30 PM
Boehringer returns to Sino Biopharma in $7.4B deal for preclinical TCEs, ADCs | #biotech #pharma #biotechsky
CARB-X-supported companies benefit from access to NIAID’s Preclinical Services, which address key scientific questions and help inform next steps toward clinical development. #CARBXComprehensiveSupport
November 4, 2026 at 2:00 PM
CARB-X-supported companies benefit from access to NIAID’s Preclinical Services, which address key scientific questions and help inform next steps toward clinical development. #CARBXComprehensiveSupport
$BCTX #Preclinical #Biotech — BriaCell and BriaPro present positive preclinical immunotherapy data across four posters at SITC 2026.
https://justcharts.merlintrader.com/?utm_source=bluesky&utm_medium=social&utm_campaign=jc20261107&utm_content=BCTX#BCTX
Visit Justcharts for bull/bear scenarios.
https://justcharts.merlintrader.com/?utm_source=bluesky&utm_medium=social&utm_campaign=jc20261107&utm_content=BCTX#BCTX
Visit Justcharts for bull/bear scenarios.
November 7, 2026 at 6:09 AM
$BCTX #Preclinical #Biotech — BriaCell and BriaPro present positive preclinical immunotherapy data across four posters at SITC 2026.
https://justcharts.merlintrader.com/?utm_source=bluesky&utm_medium=social&utm_campaign=jc20261107&utm_content=BCTX#BCTX
Visit Justcharts for bull/bear scenarios.
https://justcharts.merlintrader.com/?utm_source=bluesky&utm_medium=social&utm_campaign=jc20261107&utm_content=BCTX#BCTX
Visit Justcharts for bull/bear scenarios.
This study examines why many #Alzheimersdisease interventions fail in clinical trials despite promising epidemiological associations and preclinical evidence . The study analyze failed programs across infectious, inflammatory, metabolic, lipid, iron, dietary, hormonal, and amyloid domains .
November 6, 2026 at 12:59 PM
This study examines why many #Alzheimersdisease interventions fail in clinical trials despite promising epidemiological associations and preclinical evidence . The study analyze failed programs across infectious, inflammatory, metabolic, lipid, iron, dietary, hormonal, and amyloid domains .
Tenure Track Assistant Professor Position Now Open at UCI!!
Neurobiol & Behav is hiring a preclinical addiction neuroscientist, broadly conceived.
Addiction, comorbidities, social factors desirable.
HARD $, Beautiful SoCal, collaborative env't.
Hard to beat!!
recruit.ap.uci.edu/JPF10400
Neurobiol & Behav is hiring a preclinical addiction neuroscientist, broadly conceived.
Addiction, comorbidities, social factors desirable.
HARD $, Beautiful SoCal, collaborative env't.
Hard to beat!!
recruit.ap.uci.edu/JPF10400
Tenure-Track Assistant Professor in Neurobiology & Behavior
University of California, Irvine is hiring. Apply now!
recruit.ap.uci.edu
November 2, 2026 at 9:34 PM
Tenure Track Assistant Professor Position Now Open at UCI!!
Neurobiol & Behav is hiring a preclinical addiction neuroscientist, broadly conceived.
Addiction, comorbidities, social factors desirable.
HARD $, Beautiful SoCal, collaborative env't.
Hard to beat!!
recruit.ap.uci.edu/JPF10400
Neurobiol & Behav is hiring a preclinical addiction neuroscientist, broadly conceived.
Addiction, comorbidities, social factors desirable.
HARD $, Beautiful SoCal, collaborative env't.
Hard to beat!!
recruit.ap.uci.edu/JPF10400
Niche-reprogramming CAR T therapy improves skeletal muscle regeneration and function in preclinical murine models of Duchenne muscular dystrophy @cp-cellstemcell.bsky.social @yaruidiao.bsky.social
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
November 2, 2026 at 10:42 PM
Niche-reprogramming CAR T therapy improves skeletal muscle regeneration and function in preclinical murine models of Duchenne muscular dystrophy @cp-cellstemcell.bsky.social @yaruidiao.bsky.social
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
A little-known protein could be a major culprit in type 2 diabetes #Science #HealthandMedicine #MedicalTechnology #miro1 #type2diabetes #insulinresistance #diabetesresearch #musclehealth
A little-known protein could be a major culprit in type 2 diabetes
Scientists have discovered that a buildup of a protein called Miro1 may be a hidden driver of insulin resistance in Type 2 diabetes, with preclinical experiments showing that removing it restores the...
purescience.news
November 9, 2026 at 4:41 AM
A little-known protein could be a major culprit in type 2 diabetes #Science #HealthandMedicine #MedicalTechnology #miro1 #type2diabetes #insulinresistance #diabetesresearch #musclehealth
AbbVie disclosed a deal worth up to $757M with Beijing-based Brise for two preclinical migraine programs, a pact that dates back to 2024.
AbbVie discloses up to $757M deal with Beijing-based Brise for preclinical migraine meds
AbbVie licenses two preclinical migraine programs from China’s Brise Pharmaceuticals in a $757M deal that dates back to 2024.
endpoints.news
November 2, 2026 at 8:56 PM
AbbVie disclosed a deal worth up to $757M with Beijing-based Brise for two preclinical migraine programs, a pact that dates back to 2024.
Antengene Unveils Promising Preclinical Findings for AnTenGager-D2 at SITC 2026#China#Shanghai#Antengene#SITC_2026#AnTenGager-D2
Antengene Unveils Promising Preclinical Findings for AnTenGager-D2 at SITC 2026
Antengene Corporation Limited showcased new findings from its AnTenGager-D2 platform at SITC 2026, emphasizing advancements in T cell engager technology.
third-news.com
November 9, 2026 at 12:44 AM
Antengene Unveils Promising Preclinical Findings for AnTenGager-D2 at SITC 2026#China#Shanghai#Antengene#SITC_2026#AnTenGager-D2
CD38 is an interesting target. Now Cerevance researchers present preclinical data showing that CD38 inhibition (via their CD38 inhibitor CVN14)⬆️neuronal survival &⬇️α-synuclein in vitro, elevates brain NAD+, &⬇️motor deficits in a rat #Parkinsons model
www.frontiersin.org/journals/pha...
www.frontiersin.org/journals/pha...
November 8, 2026 at 1:21 PM
CD38 is an interesting target. Now Cerevance researchers present preclinical data showing that CD38 inhibition (via their CD38 inhibitor CVN14)⬆️neuronal survival &⬇️α-synuclein in vitro, elevates brain NAD+, &⬇️motor deficits in a rat #Parkinsons model
www.frontiersin.org/journals/pha...
www.frontiersin.org/journals/pha...