Transposable elements as evolutionary substrates of proteindisorder in the human proteome https://www.biorxiv.org/content/10.64898/2026.06.12.731867v1
June 14, 2026 at 10:46 PM
Transposable elements as evolutionary substrates of proteindisorder in the human proteome https://www.biorxiv.org/content/10.64898/2026.06.12.731867v1
Transposable elements as evolutionary substrates of proteindisorder in the human proteome https://www.biorxiv.org/content/10.64898/2026.06.12.731867v1
June 14, 2026 at 10:46 PM
Transposable elements as evolutionary substrates of proteindisorder in the human proteome https://www.biorxiv.org/content/10.64898/2026.06.12.731867v1
#NatureReviews #DrugDiscovery #ProteinDisorder #ProteinEnsembles #TranscriptionFactors #BiomolecularCondensates #LLPS #imods #IDP #IDPs #HTS #HCS #Biophysics #StructuralBiology #Bioinformatics #ComputationalModeling #MolecularDynamics @viblifesciences.bsky.social @vubrussel.bsky.social
June 9, 2025 at 6:37 PM
🧬 How do SARS-CoV-2 mutations boost fitness?
With ISIDORe, Blackledge (IBS Grenoble) used high-field NMR to show that N protein mutations (e.g. Q229K, R203M) reshape structure & RNA binding.
Disorder = function.
#ISIDORe #SARSCoV2 #Nucleocapsid #NMR #ViralFitness #ProteinDisorder
With ISIDORe, Blackledge (IBS Grenoble) used high-field NMR to show that N protein mutations (e.g. Q229K, R203M) reshape structure & RNA binding.
Disorder = function.
#ISIDORe #SARSCoV2 #Nucleocapsid #NMR #ViralFitness #ProteinDisorder
June 10, 2025 at 10:59 AM
🧬 How do SARS-CoV-2 mutations boost fitness?
With ISIDORe, Blackledge (IBS Grenoble) used high-field NMR to show that N protein mutations (e.g. Q229K, R203M) reshape structure & RNA binding.
Disorder = function.
#ISIDORe #SARSCoV2 #Nucleocapsid #NMR #ViralFitness #ProteinDisorder
With ISIDORe, Blackledge (IBS Grenoble) used high-field NMR to show that N protein mutations (e.g. Q229K, R203M) reshape structure & RNA binding.
Disorder = function.
#ISIDORe #SARSCoV2 #Nucleocapsid #NMR #ViralFitness #ProteinDisorder