Day 241 of 365 — Titin
The largest protein in your body is a spring. ~34,000 amino acids stretching halfway across a unit of muscle, popping open one domain at a time.
🔬 PDB: 1TIT
#ProteinOfTheDay #Biochemistry
The largest protein in your body is a spring. ~34,000 amino acids stretching halfway across a unit of muscle, popping open one domain at a time.
🔬 PDB: 1TIT
#ProteinOfTheDay #Biochemistry
November 5, 2026 at 12:06 AM
Day 241 of 365 — Titin
The largest protein in your body is a spring. ~34,000 amino acids stretching halfway across a unit of muscle, popping open one domain at a time.
🔬 PDB: 1TIT
#ProteinOfTheDay #Biochemistry
The largest protein in your body is a spring. ~34,000 amino acids stretching halfway across a unit of muscle, popping open one domain at a time.
🔬 PDB: 1TIT
#ProteinOfTheDay #Biochemistry
Day 240 of 365 — Aquaporin
Passes ~3 billion water molecules a second, per pore — and blocks protons, by breaking the chain they hop along.
🔬 PDB: 1J4N
#ProteinOfTheDay #Biochemistry
Passes ~3 billion water molecules a second, per pore — and blocks protons, by breaking the chain they hop along.
🔬 PDB: 1J4N
#ProteinOfTheDay #Biochemistry
November 3, 2026 at 12:07 AM
Day 240 of 365 — Aquaporin
Passes ~3 billion water molecules a second, per pore — and blocks protons, by breaking the chain they hop along.
🔬 PDB: 1J4N
#ProteinOfTheDay #Biochemistry
Passes ~3 billion water molecules a second, per pore — and blocks protons, by breaking the chain they hop along.
🔬 PDB: 1J4N
#ProteinOfTheDay #Biochemistry
Day 239 of 365 — Nitrogenase
78% of the air is nitrogen and almost none of it is any use to you. This enzyme cracks the triple bond at room temperature.
🔬 PDB: 1M1N
#ProteinOfTheDay #Biochemistry
78% of the air is nitrogen and almost none of it is any use to you. This enzyme cracks the triple bond at room temperature.
🔬 PDB: 1M1N
#ProteinOfTheDay #Biochemistry
October 31, 2026 at 11:01 PM
Day 239 of 365 — Nitrogenase
78% of the air is nitrogen and almost none of it is any use to you. This enzyme cracks the triple bond at room temperature.
🔬 PDB: 1M1N
#ProteinOfTheDay #Biochemistry
78% of the air is nitrogen and almost none of it is any use to you. This enzyme cracks the triple bond at room temperature.
🔬 PDB: 1M1N
#ProteinOfTheDay #Biochemistry
Protein of the Day — MHC Class I
Your cell's billboard. It displays bits of internal proteins, so immune cells can spot what's foreign.
🔬 PDB: 1HLA
🧬 STEAMulater.com/proteins
#ProteinOfTheDay #MHCClassI
Your cell's billboard. It displays bits of internal proteins, so immune cells can spot what's foreign.
🔬 PDB: 1HLA
🧬 STEAMulater.com/proteins
#ProteinOfTheDay #MHCClassI
October 29, 2026 at 2:22 PM
Protein of the Day — MHC Class I
Your cell's billboard. It displays bits of internal proteins, so immune cells can spot what's foreign.
🔬 PDB: 1HLA
🧬 STEAMulater.com/proteins
#ProteinOfTheDay #MHCClassI
Your cell's billboard. It displays bits of internal proteins, so immune cells can spot what's foreign.
🔬 PDB: 1HLA
🧬 STEAMulater.com/proteins
#ProteinOfTheDay #MHCClassI
Why did the herpes enzyme get hired? It knew how to activate the right candidate. 😄
Herpes Thymidine Kinase switches things on only where the virus is.
Which protein is next Oct 29? #ProteinOfTheDay #HerpesThymidineKinase
Herpes Thymidine Kinase switches things on only where the virus is.
Which protein is next Oct 29? #ProteinOfTheDay #HerpesThymidineKinase
October 29, 2026 at 12:03 AM
Why did the herpes enzyme get hired? It knew how to activate the right candidate. 😄
Herpes Thymidine Kinase switches things on only where the virus is.
Which protein is next Oct 29? #ProteinOfTheDay #HerpesThymidineKinase
Herpes Thymidine Kinase switches things on only where the virus is.
Which protein is next Oct 29? #ProteinOfTheDay #HerpesThymidineKinase
#proteinoftheday IGF2R:p, insulin like growth factor 2 receptor (Homo sapiens) Large subunit; CTMs: ∅; PTMs: 49×K+acetyl; 4×K+succinyl; 21×K+GGyl; 1×K+SUMOyl; 67×S, 18×T, 1×Y+phosphoryl; 15×N+glycosyl; SAVS: L252V (13%), R1619G (10%); mature form: (41-2491 […]
[Original post on mastodon.social]
[Original post on mastodon.social]
October 24, 2024 at 11:58 PM
#proteinoftheday IGF2R:p, insulin like growth factor 2 receptor (Homo sapiens) Large subunit; CTMs: ∅; PTMs: 49×K+acetyl; 4×K+succinyl; 21×K+GGyl; 1×K+SUMOyl; 67×S, 18×T, 1×Y+phosphoryl; 15×N+glycosyl; SAVS: L252V (13%), R1619G (10%); mature form: (41-2491 […]
[Original post on mastodon.social]
[Original post on mastodon.social]
#proteinoftheday INSR:p, insulin receptor (Homo sapiens) Large subunit; CTMs: ∅; PTMs: 0×K+acetyl; 0×K+succinyl; 4×K+GGyl; 0×K+SUMOyl; 5×S, 2×T, 9×Y+phosphoryl; 7×N+glycosyl; SAVS: ∅; mature form: (28-1570, 21 exons) [15,479×, 109 kTa]. θ(max) = 45. aka […]
[Original post on mastodon.social]
[Original post on mastodon.social]
October 23, 2024 at 12:06 AM
#proteinoftheday INSR:p, insulin receptor (Homo sapiens) Large subunit; CTMs: ∅; PTMs: 0×K+acetyl; 0×K+succinyl; 4×K+GGyl; 0×K+SUMOyl; 5×S, 2×T, 9×Y+phosphoryl; 7×N+glycosyl; SAVS: ∅; mature form: (28-1570, 21 exons) [15,479×, 109 kTa]. θ(max) = 45. aka […]
[Original post on mastodon.social]
[Original post on mastodon.social]
#proteinoftheday TFRC:p, transferrin receptor 1 (Homo sapiens) Midsized subunit; CTMs: M1, M2+acetyl; PTMs: 31×K+acetyl; 6×K+succinyl; 33×K+GGyl; 0×K+SUMOyl; 34×S, 23×T, 18×Y+phosphoryl; 1×S, 1×T, 3×N+glycosyl; SAVS: G142S (45%), G420S (1%); mature form: (1 […]
[Original post on mastodon.social]
[Original post on mastodon.social]
October 18, 2024 at 12:40 AM
#proteinoftheday TFRC:p, transferrin receptor 1 (Homo sapiens) Midsized subunit; CTMs: M1, M2+acetyl; PTMs: 31×K+acetyl; 6×K+succinyl; 33×K+GGyl; 0×K+SUMOyl; 34×S, 23×T, 18×Y+phosphoryl; 1×S, 1×T, 3×N+glycosyl; SAVS: G142S (45%), G420S (1%); mature form: (1 […]
[Original post on mastodon.social]
[Original post on mastodon.social]
#proteinoftheday IGFBP4:p, insulin like growth factor binding protein 4 (Homo sapiens) Small subunit; CTMs: ∅; PTMs: 0×K+acetyl; 0×K+succinyl; 0×K+GGyl; 0×K+SUMOyl; 0×S, 0×T, 0×Y+phosphoryl; 0×N+glycosyl; SAVS: ∅; mature form: (22-258, 4 exons) [8,656×, 50 […]
[Original post on mastodon.social]
[Original post on mastodon.social]
October 8, 2024 at 11:37 PM
#proteinoftheday IGFBP4:p, insulin like growth factor binding protein 4 (Homo sapiens) Small subunit; CTMs: ∅; PTMs: 0×K+acetyl; 0×K+succinyl; 0×K+GGyl; 0×K+SUMOyl; 0×S, 0×T, 0×Y+phosphoryl; 0×N+glycosyl; SAVS: ∅; mature form: (22-258, 4 exons) [8,656×, 50 […]
[Original post on mastodon.social]
[Original post on mastodon.social]
#proteinoftheday IGFALS:p, insulin like growth factor binding protein acid labile subunit (Homo sapiens) Midsized subunit; CTMs: ∅; PTMs: 2×K+acetyl; 1×K+succinyl; 0×K+GGyl; 0×K+SUMOyl; 0×S, 0×T, 0×Y+phosphoryl; 1×N+glycosyl; SAVS: H164P (13%), T283I (11%) […]
[Original post on mastodon.social]
[Original post on mastodon.social]
October 7, 2024 at 11:57 PM
#proteinoftheday IGFALS:p, insulin like growth factor binding protein acid labile subunit (Homo sapiens) Midsized subunit; CTMs: ∅; PTMs: 2×K+acetyl; 1×K+succinyl; 0×K+GGyl; 0×K+SUMOyl; 0×S, 0×T, 0×Y+phosphoryl; 1×N+glycosyl; SAVS: H164P (13%), T283I (11%) […]
[Original post on mastodon.social]
[Original post on mastodon.social]
#proteinoftheday IGFBP3:p, insulin like growth factor binding protein 3 (Homo sapiens) Small subunit; CTMs: ∅; PTMs: 1×K+acetyl; 0×K+succinyl; 0×K+GGyl; 0×K+SUMOyl; 12×S, 2×T, 0×Y+phosphoryl; 4×S, 1×N+glycosyl; SAVS: H164P (13%), T283I (11%); mature form […]
[Original post on mastodon.social]
[Original post on mastodon.social]
October 6, 2024 at 11:42 PM
#proteinoftheday IGFBP3:p, insulin like growth factor binding protein 3 (Homo sapiens) Small subunit; CTMs: ∅; PTMs: 1×K+acetyl; 0×K+succinyl; 0×K+GGyl; 0×K+SUMOyl; 12×S, 2×T, 0×Y+phosphoryl; 4×S, 1×N+glycosyl; SAVS: H164P (13%), T283I (11%); mature form […]
[Original post on mastodon.social]
[Original post on mastodon.social]
#proteinoftheday IGFBP2:p, insulin like growth factor binding protein 2 (Homo sapiens) Small subunit; CTMs: ∅; PTMs: 0×K+acetyl; 0×K+succinyl; 1×K+GGyl; 0×K+SUMOyl; 2×S, 0×T, 0×Y+phosphoryl; SAVS: ∅; mature form: (37,38,40,41-325, 4 exons) [15,257×, 102 […]
[Original post on mastodon.social]
[Original post on mastodon.social]
October 6, 2024 at 12:00 AM
#proteinoftheday IGFBP2:p, insulin like growth factor binding protein 2 (Homo sapiens) Small subunit; CTMs: ∅; PTMs: 0×K+acetyl; 0×K+succinyl; 1×K+GGyl; 0×K+SUMOyl; 2×S, 0×T, 0×Y+phosphoryl; SAVS: ∅; mature form: (37,38,40,41-325, 4 exons) [15,257×, 102 […]
[Original post on mastodon.social]
[Original post on mastodon.social]
#proteinoftheday IGF2R:p, insulin like growth factor 2 receptor (Homo sapiens) Large subunit; CTMs: ∅; PTMs: 49×K+acetyl; 4×K+succinyl; 21×K+GGyl; 1×K+SUMOyl; 67×S, 18×T, 1×Y+phosphoryl, 15×N+glycosyl; SAVS: L252V (13%), R1619G (90%), N2020S (10%); mature […]
[Original post on mastodon.social]
[Original post on mastodon.social]
October 3, 2024 at 11:13 PM
#proteinoftheday IGF2R:p, insulin like growth factor 2 receptor (Homo sapiens) Large subunit; CTMs: ∅; PTMs: 49×K+acetyl; 4×K+succinyl; 21×K+GGyl; 1×K+SUMOyl; 67×S, 18×T, 1×Y+phosphoryl, 15×N+glycosyl; SAVS: L252V (13%), R1619G (90%), N2020S (10%); mature […]
[Original post on mastodon.social]
[Original post on mastodon.social]
#proteinoftheday IGFLR1:p, IGF like family receptor 1 (Homo sapiens) Small subunit; CTMs: ∅; PTMs: 0×K+acetyl; 0×K+succinyl; 5×K+GGyl; 0×K+SUMOyl; 2×S, 0×T, 0×Y+phosphoryl; SAVS: Q334H (1%); mature form: (23-355, 4 exons) [1,852×, 6.1 kTa]. θ(max) = 25. aka […]
[Original post on mastodon.social]
[Original post on mastodon.social]
October 1, 2024 at 11:56 PM
#proteinoftheday IGFLR1:p, IGF like family receptor 1 (Homo sapiens) Small subunit; CTMs: ∅; PTMs: 0×K+acetyl; 0×K+succinyl; 5×K+GGyl; 0×K+SUMOyl; 2×S, 0×T, 0×Y+phosphoryl; SAVS: Q334H (1%); mature form: (23-355, 4 exons) [1,852×, 6.1 kTa]. θ(max) = 25. aka […]
[Original post on mastodon.social]
[Original post on mastodon.social]
#proteinoftheday TBX3:p, T-box transcription factor 3 (Homo sapiens) Small subunit; CTMs: S2+acetyl; PTMs: 0×K+acetyl; 0×K+succinyl; 6×K+GGyl; 6×K+SUMOyl; 25×S, 2×T, 0×Y+phosphoryl; SAVS: ∅; mature form: (2-723, 7 exons) [4,766×, 13 kTa]. θ(max) = 32. aka […]
[Original post on mastodon.social]
[Original post on mastodon.social]
September 28, 2024 at 11:24 PM
#proteinoftheday TBX3:p, T-box transcription factor 3 (Homo sapiens) Small subunit; CTMs: S2+acetyl; PTMs: 0×K+acetyl; 0×K+succinyl; 6×K+GGyl; 6×K+SUMOyl; 25×S, 2×T, 0×Y+phosphoryl; SAVS: ∅; mature form: (2-723, 7 exons) [4,766×, 13 kTa]. θ(max) = 32. aka […]
[Original post on mastodon.social]
[Original post on mastodon.social]
#proteinoftheday TBX2:p, T-box transcription factor 2 (Homo sapiens) Small subunit; CTMs: ∅; PTMs: 0×K+acetyl; 0×K+succinyl; 3×K+GGyl; 1×K+SUMOyl; 22×S, 2×T, 0×Y+phosphoryl; SAVS: ∅; mature form: (2-712, 7 exons) [3,017×, 8.8 kTa]. θ(max) = 49. aka VETD. Top tissue: MCF-7 cells (2.9 kTa).
September 28, 2024 at 12:08 AM
#proteinoftheday TBX2:p, T-box transcription factor 2 (Homo sapiens) Small subunit; CTMs: ∅; PTMs: 0×K+acetyl; 0×K+succinyl; 3×K+GGyl; 1×K+SUMOyl; 22×S, 2×T, 0×Y+phosphoryl; SAVS: ∅; mature form: (2-712, 7 exons) [3,017×, 8.8 kTa]. θ(max) = 49. aka VETD. Top tissue: MCF-7 cells (2.9 kTa).
#proteinoftheday ABHD12:p, abhydrolase domain containing 12 (Homo sapiens) Small subunit; CTMs: M1+acetyl; PTMs: 0×K+acetyl; 0×K+succinyl; 9×K+GGyl; 0×K+SUMOyl; 0×S, 1×T, 1×Y+phosphoryl; SAVS: A349T (4%); mature form: (1-398, 13 exons) [21,752×, 89 kTa] […]
[Original post on mastodon.social]
[Original post on mastodon.social]
September 25, 2024 at 12:25 AM
#proteinoftheday ABHD12:p, abhydrolase domain containing 12 (Homo sapiens) Small subunit; CTMs: M1+acetyl; PTMs: 0×K+acetyl; 0×K+succinyl; 9×K+GGyl; 0×K+SUMOyl; 0×S, 1×T, 1×Y+phosphoryl; SAVS: A349T (4%); mature form: (1-398, 13 exons) [21,752×, 89 kTa] […]
[Original post on mastodon.social]
[Original post on mastodon.social]
#proteinoftheday ABHD8:p, abhydrolase domain containing 8 (Homo sapiens) Small subunit; CTMs: M1+acetyl; PTMs: 0×K+acetyl; 0×K+succinyl; 0×K+GGyl; 1×K+SUMOyl; 0×S, 0×T, 0×Y+phosphoryl; SAVS: G70R (9%); mature form: (1-439, 4 exons) [219×, 0.5 kTa]. θ(max) = […]
[Original post on mastodon.social]
[Original post on mastodon.social]
September 20, 2024 at 11:43 PM
#proteinoftheday ABHD8:p, abhydrolase domain containing 8 (Homo sapiens) Small subunit; CTMs: M1+acetyl; PTMs: 0×K+acetyl; 0×K+succinyl; 0×K+GGyl; 1×K+SUMOyl; 0×S, 0×T, 0×Y+phosphoryl; SAVS: G70R (9%); mature form: (1-439, 4 exons) [219×, 0.5 kTa]. θ(max) = […]
[Original post on mastodon.social]
[Original post on mastodon.social]
#proteinoftheday ABHD6:p, abhydrolase domain containing 6, acylglycerol lipase (Homo sapiens) Small subunit; CTMs: M1+acetyl; PTMs: 0×K+acetyl; 0×K+succinyl; 5×K+GGyl; 0×K+SUMOyl; 1×S, 0×T, 0×Y+phosphoryl; SAVS: ∅; mature form: (1-337, 8 exons) [6,450×, 20 […]
[Original post on mastodon.social]
[Original post on mastodon.social]
September 18, 2024 at 11:53 PM
#proteinoftheday ABHD6:p, abhydrolase domain containing 6, acylglycerol lipase (Homo sapiens) Small subunit; CTMs: M1+acetyl; PTMs: 0×K+acetyl; 0×K+succinyl; 5×K+GGyl; 0×K+SUMOyl; 1×S, 0×T, 0×Y+phosphoryl; SAVS: ∅; mature form: (1-337, 8 exons) [6,450×, 20 […]
[Original post on mastodon.social]
[Original post on mastodon.social]
#proteinoftheday ABHD4:p, abhydrolase domain containing 4, N-acyl phospholipase B (Homo sapiens) Small subunit; CTMs: A2+acetyl; PTMs: 0×K+acetyl; 0×K+succinyl; 3×K+GGyl; 0×K+SUMOyl; 0×S, 0×T, 0×Y+phosphoryl; SAVS: ∅; mature form: (2-342, 7 exons) [3,073× […]
[Original post on mastodon.social]
[Original post on mastodon.social]
September 16, 2024 at 11:52 PM
#proteinoftheday ABHD4:p, abhydrolase domain containing 4, N-acyl phospholipase B (Homo sapiens) Small subunit; CTMs: A2+acetyl; PTMs: 0×K+acetyl; 0×K+succinyl; 3×K+GGyl; 0×K+SUMOyl; 0×S, 0×T, 0×Y+phosphoryl; SAVS: ∅; mature form: (2-342, 7 exons) [3,073× […]
[Original post on mastodon.social]
[Original post on mastodon.social]
#proteinoftheday TRIM47:p, tripartite motif containing 47 (Homo sapiens) Midsized subunit; CTMs: M1+acetyl; PTMs: 1×K+acetyl; 0×K+succinyl; 10×K+GGyl; 1×K+SUMOyl; 15×S, 3×T, 0×Y+phosphoryl; SAVS: R187W (13%); mature form: (1-638, 6 exons) 18,779×, 68 kTa] […]
[Original post on mastodon.social]
[Original post on mastodon.social]
September 12, 2024 at 11:20 PM
#proteinoftheday TRIM47:p, tripartite motif containing 47 (Homo sapiens) Midsized subunit; CTMs: M1+acetyl; PTMs: 1×K+acetyl; 0×K+succinyl; 10×K+GGyl; 1×K+SUMOyl; 15×S, 3×T, 0×Y+phosphoryl; SAVS: R187W (13%); mature form: (1-638, 6 exons) 18,779×, 68 kTa] […]
[Original post on mastodon.social]
[Original post on mastodon.social]
#proteinoftheday TRIM46:p, tripartite motif containing 46 (Homo sapiens) Midsized subunit; CTMs: A2+acetyl; PTMs: 0×K+acetyl; 0×K+succinyl; 4×K+GGyl; 0×K+SUMOyl; 7×S, 3×T, 0×Y+phosphoryl; SAVS:∅; mature form: (2-759, 10 exons) 1,487×, 4.4 kTa]. θ(max) = 46 […]
[Original post on mastodon.social]
[Original post on mastodon.social]
September 12, 2024 at 12:20 AM
#proteinoftheday TRIM46:p, tripartite motif containing 46 (Homo sapiens) Midsized subunit; CTMs: A2+acetyl; PTMs: 0×K+acetyl; 0×K+succinyl; 4×K+GGyl; 0×K+SUMOyl; 7×S, 3×T, 0×Y+phosphoryl; SAVS:∅; mature form: (2-759, 10 exons) 1,487×, 4.4 kTa]. θ(max) = 46 […]
[Original post on mastodon.social]
[Original post on mastodon.social]
#proteinoftheday TRIM34:p, tripartite motif containing 34 (Homo sapiens) Midsized subunit; CTMs: A2+acetyl; PTMs: 0×K+acetyl; 0×K+succinyl; 6×K+GGyl; 3×K+SUMOyl; 1×S, 0×T, 0×Y+phosphoryl; SAVS:∅; mature form: (2-488, 7 exons) 1,343×, 2.4 kTa]. θ(max) = 41 […]
[Original post on mastodon.social]
[Original post on mastodon.social]
September 10, 2024 at 1:34 AM
#proteinoftheday TRIM34:p, tripartite motif containing 34 (Homo sapiens) Midsized subunit; CTMs: A2+acetyl; PTMs: 0×K+acetyl; 0×K+succinyl; 6×K+GGyl; 3×K+SUMOyl; 1×S, 0×T, 0×Y+phosphoryl; SAVS:∅; mature form: (2-488, 7 exons) 1,343×, 2.4 kTa]. θ(max) = 41 […]
[Original post on mastodon.social]
[Original post on mastodon.social]
#proteinoftheday TRIM29:p, tripartite motif containing 29 (Homo sapiens) Midsized subunit; CTMs: M1+acetyl; PTMs: 13×K+acetyl; 1×K+succinyl; 25×K+GGyl; 0×K+SUMOyl; 43×S, 15×T, 10×Y+phosphoryl; 16×R+deimidyl; SAVS: Y544C (3%); mature form: (1-588, 9 exons) 13 […]
[Original post on mastodon.social]
[Original post on mastodon.social]
September 7, 2024 at 11:50 PM
#proteinoftheday TRIM29:p, tripartite motif containing 29 (Homo sapiens) Midsized subunit; CTMs: M1+acetyl; PTMs: 13×K+acetyl; 1×K+succinyl; 25×K+GGyl; 0×K+SUMOyl; 43×S, 15×T, 10×Y+phosphoryl; 16×R+deimidyl; SAVS: Y544C (3%); mature form: (1-588, 9 exons) 13 […]
[Original post on mastodon.social]
[Original post on mastodon.social]
#proteinoftheday TRIM24:p, tripartite motif containing 24 (Homo sapiens) Large subunit; CTMs: M1+acetyl; PTMs: 3×K+acetyl; 0×K+succinyl; 6×K+GGyl; 18×K+SUMOyl; 54×S, 17×T, 2×Y+phosphoryl; SAVS: ∅; mature form: (1-1050, 19 exons) [23,095×, 118 kTa]. θ(max) = […]
[Original post on mastodon.social]
[Original post on mastodon.social]
September 5, 2024 at 11:41 PM
#proteinoftheday TRIM24:p, tripartite motif containing 24 (Homo sapiens) Large subunit; CTMs: M1+acetyl; PTMs: 3×K+acetyl; 0×K+succinyl; 6×K+GGyl; 18×K+SUMOyl; 54×S, 17×T, 2×Y+phosphoryl; SAVS: ∅; mature form: (1-1050, 19 exons) [23,095×, 118 kTa]. θ(max) = […]
[Original post on mastodon.social]
[Original post on mastodon.social]