#ProteinProcessing
Mutations in the presenilin-1 gene cause gamma-secretase to stall during protein processing, leading to stable enzyme-substrate complexes. This disruption, rather than amyloid beta buildup, may drive… #AlzheimersDisease #Neurodegeneration #ProteinProcessing #GammaSecretase #Presenilin1
Stalled protein processing may underlie Alzheimer’s disease
Mutations in the presenilin-1 gene cause gamma-secretase to stall during protein processing, leading to stable enzyme-substrate complexes. This disruption, rather than amyloid beta buildup, may drive neurodegeneration in Alzheimer’s disease.
www.psypost.org
February 10, 2025 at 5:24 PM
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September 2, 2026 at 3:43 AM