Glucose-induced pseudohypoxia and advanced glycosylation end products explain peritoneal damage in long-term peritoneal dialysis (2024) doi.org/10.1177/0896...
October 1, 2026 at 1:07 PM
Glucose-induced pseudohypoxia and advanced glycosylation end products explain peritoneal damage in long-term peritoneal dialysis (2024) doi.org/10.1177/0896...
Why do some HEK293 cells crank out more viral vectors than others? 🧬
We used multi-omics + metabolic modeling to find out. Turns out, pseudohypoxia is a big deal.
Check out our new paper led by the fantastic #LeopoldZehetner & @diana-sz.bsky.social 🔗 doi.org/10.1016/j.ym...
🧵👇
We used multi-omics + metabolic modeling to find out. Turns out, pseudohypoxia is a big deal.
Check out our new paper led by the fantastic #LeopoldZehetner & @diana-sz.bsky.social 🔗 doi.org/10.1016/j.ym...
🧵👇
April 17, 2025 at 8:30 PM
Why do some HEK293 cells crank out more viral vectors than others? 🧬
We used multi-omics + metabolic modeling to find out. Turns out, pseudohypoxia is a big deal.
Check out our new paper led by the fantastic #LeopoldZehetner & @diana-sz.bsky.social 🔗 doi.org/10.1016/j.ym...
🧵👇
We used multi-omics + metabolic modeling to find out. Turns out, pseudohypoxia is a big deal.
Check out our new paper led by the fantastic #LeopoldZehetner & @diana-sz.bsky.social 🔗 doi.org/10.1016/j.ym...
🧵👇
🚀 New paper out in @mol-biomed.bsky.social (@springernature.com)!
🔬 We show that miR-210-3p links pseudohypoxia to mitotic dysregulation, revealing context-dependent roles in tumor aggressiveness and its potential as a therapeutic target.
link.springer.com/article/10.1..., @iuopa.bsky.social, #ISPA
🔬 We show that miR-210-3p links pseudohypoxia to mitotic dysregulation, revealing context-dependent roles in tumor aggressiveness and its potential as a therapeutic target.
link.springer.com/article/10.1..., @iuopa.bsky.social, #ISPA
August 10, 2026 at 7:36 AM
🚀 New paper out in @mol-biomed.bsky.social (@springernature.com)!
🔬 We show that miR-210-3p links pseudohypoxia to mitotic dysregulation, revealing context-dependent roles in tumor aggressiveness and its potential as a therapeutic target.
link.springer.com/article/10.1..., @iuopa.bsky.social, #ISPA
🔬 We show that miR-210-3p links pseudohypoxia to mitotic dysregulation, revealing context-dependent roles in tumor aggressiveness and its potential as a therapeutic target.
link.springer.com/article/10.1..., @iuopa.bsky.social, #ISPA
RRIDs were included in this None paper. Thanks for making your methods matter! #reproducibility #ReproducibleResearch #RRID
Pseudohypoxia-Stabilized HIF2α Transcriptionally Inhibits MNRR1, a Druggable Target in MELAS
doi.org
July 31, 2025 at 7:01 AM
RRIDs were included in this None paper. Thanks for making your methods matter! #reproducibility #ReproducibleResearch #RRID
Weekend read! Staphylococcus promotes metastasis
· Staphylococcus enriched in metastatic lung tumor lesions
· S. nepalensis & S. capitis-secreted lactate promotes metastasis via MCT1 & pseudohypoxia signaling
· MCT1 inhibition abolishes metastasis
www.cell.com/cell-host-mi...
· Staphylococcus enriched in metastatic lung tumor lesions
· S. nepalensis & S. capitis-secreted lactate promotes metastasis via MCT1 & pseudohypoxia signaling
· MCT1 inhibition abolishes metastasis
www.cell.com/cell-host-mi...
Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma
Yu et al. demonstrate that Staphylococcus is selectively enriched in metastatic lung
tumor lesions. Staphylococcus nepalensis and S. capitis secrete lactate to promote
the metastatic potential of tumo...
www.cell.com
April 3, 2026 at 7:53 PM
Weekend read! Staphylococcus promotes metastasis
· Staphylococcus enriched in metastatic lung tumor lesions
· S. nepalensis & S. capitis-secreted lactate promotes metastasis via MCT1 & pseudohypoxia signaling
· MCT1 inhibition abolishes metastasis
www.cell.com/cell-host-mi...
· Staphylococcus enriched in metastatic lung tumor lesions
· S. nepalensis & S. capitis-secreted lactate promotes metastasis via MCT1 & pseudohypoxia signaling
· MCT1 inhibition abolishes metastasis
www.cell.com/cell-host-mi...
#Pseudohypoxia and family history are key predictors of severe outcomes in hereditary #pheochromocytoma and #paraganglioma syndromes by Reut Halperin et al
EJE Volume 194, Issue 3, March 2026
👉 https://doi.org/10.1093/ejendo/lvag042
ESE members free via 👉 my.ese-hormones.org
EJE Volume 194, Issue 3, March 2026
👉 https://doi.org/10.1093/ejendo/lvag042
ESE members free via 👉 my.ese-hormones.org
September 18, 2026 at 2:02 PM
#Pseudohypoxia and family history are key predictors of severe outcomes in hereditary #pheochromocytoma and #paraganglioma syndromes by Reut Halperin et al
EJE Volume 194, Issue 3, March 2026
👉 https://doi.org/10.1093/ejendo/lvag042
ESE members free via 👉 my.ese-hormones.org
EJE Volume 194, Issue 3, March 2026
👉 https://doi.org/10.1093/ejendo/lvag042
ESE members free via 👉 my.ese-hormones.org
Weekend read:Tumor-resident Staph promotes metastasis
Staphylococcus enriched in metastatic lung tumor lesions. S. nepalensis & S. capitis secreted lactate promotes metastasis via MCT1-mediated pseudohypoxia signaling. MCT1 inhibition abolishes metastasis
www.cell.com/cell-host-mi...
Staphylococcus enriched in metastatic lung tumor lesions. S. nepalensis & S. capitis secreted lactate promotes metastasis via MCT1-mediated pseudohypoxia signaling. MCT1 inhibition abolishes metastasis
www.cell.com/cell-host-mi...
Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma
Yu et al. demonstrate that Staphylococcus is selectively enriched in metastatic lung
tumor lesions. Staphylococcus nepalensis and S. capitis secrete lactate to promote
the metastatic potential of tumo...
www.cell.com
March 6, 2026 at 9:51 PM
Weekend read:Tumor-resident Staph promotes metastasis
Staphylococcus enriched in metastatic lung tumor lesions. S. nepalensis & S. capitis secreted lactate promotes metastasis via MCT1-mediated pseudohypoxia signaling. MCT1 inhibition abolishes metastasis
www.cell.com/cell-host-mi...
Staphylococcus enriched in metastatic lung tumor lesions. S. nepalensis & S. capitis secreted lactate promotes metastasis via MCT1-mediated pseudohypoxia signaling. MCT1 inhibition abolishes metastasis
www.cell.com/cell-host-mi...
Staphylococcus promotes metastasis:
· Staphylococcus enriched in metastatic lung tumor lesions
· S. nepalensis & S. capitisl-secreted lactate promotes metastatic potential via MCT1-mediated pseudohypoxia signaling
· MCT1 inhibition abolishes metastasis
www.cell.com/cell-host-mi...
· Staphylococcus enriched in metastatic lung tumor lesions
· S. nepalensis & S. capitisl-secreted lactate promotes metastatic potential via MCT1-mediated pseudohypoxia signaling
· MCT1 inhibition abolishes metastasis
www.cell.com/cell-host-mi...
Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma
Yu et al. demonstrate that Staphylococcus is selectively enriched in metastatic lung
tumor lesions. Staphylococcus nepalensis and S. capitis secrete lactate to promote
the metastatic potential of tumo...
www.cell.com
July 14, 2025 at 5:03 PM
Staphylococcus promotes metastasis:
· Staphylococcus enriched in metastatic lung tumor lesions
· S. nepalensis & S. capitisl-secreted lactate promotes metastatic potential via MCT1-mediated pseudohypoxia signaling
· MCT1 inhibition abolishes metastasis
www.cell.com/cell-host-mi...
· Staphylococcus enriched in metastatic lung tumor lesions
· S. nepalensis & S. capitisl-secreted lactate promotes metastatic potential via MCT1-mediated pseudohypoxia signaling
· MCT1 inhibition abolishes metastasis
www.cell.com/cell-host-mi...
New study (n=75 LUAD patients +in vitro/in vivo models) shows lactate-producing Staphylococcus in lung tumors can promote metastasis, with S. nepalensis & S. capitis driving tumor spread by activating MCT1–pseudohypoxia–NDRG1 signaling in tumor cells in mice.
🔗 www.sciencedirect.com/science/arti...
🔗 www.sciencedirect.com/science/arti...
Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma
The role of the lung microbiota in cancer remains unclear. Here, we reveal that Staphylococcus is selectively enriched in metastatic tumor lesions and…
www.sciencedirect.com
July 16, 2025 at 11:56 AM
New study (n=75 LUAD patients +in vitro/in vivo models) shows lactate-producing Staphylococcus in lung tumors can promote metastasis, with S. nepalensis & S. capitis driving tumor spread by activating MCT1–pseudohypoxia–NDRG1 signaling in tumor cells in mice.
🔗 www.sciencedirect.com/science/arti...
🔗 www.sciencedirect.com/science/arti...
Mitochondrial genome instability disrupts brown adipose tissue through pseudohypoxia-iron-NAD⁺ axis https://www.biorxiv.org/content/10.64898/2026.08.28.747463v1
August 31, 2026 at 5:15 PM
Mitochondrial genome instability disrupts brown adipose tissue through pseudohypoxia-iron-NAD⁺ axis https://www.biorxiv.org/content/10.64898/2026.08.28.747463v1
Mitochondrial genome instability disrupts brown adipose tissue through pseudohypoxia-iron-NAD⁺ axis https://www.biorxiv.org/content/10.64898/2026.08.28.747463v1
August 31, 2026 at 5:15 PM
Mitochondrial genome instability disrupts brown adipose tissue through pseudohypoxia-iron-NAD⁺ axis https://www.biorxiv.org/content/10.64898/2026.08.28.747463v1
So we built condition-specific genome-scale metabolic models and integrated lipidomics, exometabolomics, and transcriptomics
What stood out?
HIF-1α was active in the low-producer—driving that pseudohypoxia
So we tried inhibiting HIF-1α and ...
capsid yield jumped 2.5x 🎉
But... there’s a catch.
What stood out?
HIF-1α was active in the low-producer—driving that pseudohypoxia
So we tried inhibiting HIF-1α and ...
capsid yield jumped 2.5x 🎉
But... there’s a catch.
April 17, 2025 at 8:30 PM
So we built condition-specific genome-scale metabolic models and integrated lipidomics, exometabolomics, and transcriptomics
What stood out?
HIF-1α was active in the low-producer—driving that pseudohypoxia
So we tried inhibiting HIF-1α and ...
capsid yield jumped 2.5x 🎉
But... there’s a catch.
What stood out?
HIF-1α was active in the low-producer—driving that pseudohypoxia
So we tried inhibiting HIF-1α and ...
capsid yield jumped 2.5x 🎉
But... there’s a catch.
A Breakthrough in Immunology: Reviving Sleepy Cellular Powers with Iron-Mobilizing Chelators#Japan#Okayama#Okayama_University#pseudohypoxia#iron_chelator
A Breakthrough in Immunology: Reviving Sleepy Cellular Powers with Iron-Mobilizing Chelators
Okayama University reveals a transformative method to induce pseudohypoxia, enhancing immune and repair responses, potentially revolutionizing cancer therapy.
third-news.com
March 29, 2026 at 2:08 PM
A Breakthrough in Immunology: Reviving Sleepy Cellular Powers with Iron-Mobilizing Chelators#Japan#Okayama#Okayama_University#pseudohypoxia#iron_chelator
📢 New publication in Cells explores how pseudohypoxia in MELAS suppresses MNRR1 through HIF2α—uncovering a promising druggable pathway for mitochondrial disease.
🧬 WSU EACPHS faculty co-authored this breakthrough work.
🔗 doi.org/10.3390/cell...
#Mitochondria #MELAS #RareDiseases #WayneState #MNRR1
🧬 WSU EACPHS faculty co-authored this breakthrough work.
🔗 doi.org/10.3390/cell...
#Mitochondria #MELAS #RareDiseases #WayneState #MNRR1
doi.org
August 29, 2025 at 8:08 PM
📢 New publication in Cells explores how pseudohypoxia in MELAS suppresses MNRR1 through HIF2α—uncovering a promising druggable pathway for mitochondrial disease.
🧬 WSU EACPHS faculty co-authored this breakthrough work.
🔗 doi.org/10.3390/cell...
#Mitochondria #MELAS #RareDiseases #WayneState #MNRR1
🧬 WSU EACPHS faculty co-authored this breakthrough work.
🔗 doi.org/10.3390/cell...
#Mitochondria #MELAS #RareDiseases #WayneState #MNRR1
Pseudohypoxia-stabilized HIF2α transcriptionally inhibits MNRR1, a druggable target in MELAS https://www.biorxiv.org/content/10.1101/2024.10.07.617011v1
Pseudohypoxia-stabilized HIF2α transcriptionally inhibits MNRR1, a druggable target in MELAS https://www.biorxiv.org/content/10.1101/2024.10.07.617011v1
The observation that amounts of the mitochondrial regulator MNRR1 (CHCHD2, AAG10, PARK22) are reduce
www.biorxiv.org
October 9, 2024 at 7:19 AM
Pseudohypoxia-stabilized HIF2α transcriptionally inhibits MNRR1, a druggable target in MELAS https://www.biorxiv.org/content/10.1101/2024.10.07.617011v1
More mad thoughts: In naked mole rats, a tuber-based diet and protected subterranean life may interact with hypoxic signalling. In humans, increased starch consumption and better shelter/safety occurred without chronic hypoxia, but phytochemicals may have provided mild pseudohypoxia-like signals.
May 9, 2026 at 12:30 AM
More mad thoughts: In naked mole rats, a tuber-based diet and protected subterranean life may interact with hypoxic signalling. In humans, increased starch consumption and better shelter/safety occurred without chronic hypoxia, but phytochemicals may have provided mild pseudohypoxia-like signals.
Oocytes develop in hypoxia with active HIF signaling, which is linked to hyaluronan pathways. More actual hypoxia probably isn’t helpful, but plant defence metabolites can affect HIF and cause pseudohypoxia. Could that increase HAS2 expression and protective HMW-HA and set it like that?
March 17, 2026 at 1:15 AM
Oocytes develop in hypoxia with active HIF signaling, which is linked to hyaluronan pathways. More actual hypoxia probably isn’t helpful, but plant defence metabolites can affect HIF and cause pseudohypoxia. Could that increase HAS2 expression and protective HMW-HA and set it like that?
Could our neoteny be historically linked to diet?
Some plant defence metabolites can induce pseudohypoxia, while others affect hypoxia-related signalling pathways.
Some plant defence metabolites can induce pseudohypoxia, while others affect hypoxia-related signalling pathways.
February 16, 2026 at 11:13 PM
Could our neoteny be historically linked to diet?
Some plant defence metabolites can induce pseudohypoxia, while others affect hypoxia-related signalling pathways.
Some plant defence metabolites can induce pseudohypoxia, while others affect hypoxia-related signalling pathways.
This doesn’t require infection.
Physiological states that raise HA turnover include:
• elevated insulin
• elevated estrogen
• hypoxia / pseudohypoxia (e.g. preeclampsia)
All increase the chance of HA fragmentation.
Physiological states that raise HA turnover include:
• elevated insulin
• elevated estrogen
• hypoxia / pseudohypoxia (e.g. preeclampsia)
All increase the chance of HA fragmentation.
February 1, 2026 at 3:04 AM
This doesn’t require infection.
Physiological states that raise HA turnover include:
• elevated insulin
• elevated estrogen
• hypoxia / pseudohypoxia (e.g. preeclampsia)
All increase the chance of HA fragmentation.
Physiological states that raise HA turnover include:
• elevated insulin
• elevated estrogen
• hypoxia / pseudohypoxia (e.g. preeclampsia)
All increase the chance of HA fragmentation.
🧬 scHiCAR maps RNA, chromatin accessibility & 3D genome in the same cell at scale
🩺 KRAS inhibitors can intercept pancreatic cancer before it starts
⚡ CSCs steal neutrophil mitochondria → pseudohypoxia → metastasis
🩺 KRAS inhibitors can intercept pancreatic cancer before it starts
⚡ CSCs steal neutrophil mitochondria → pseudohypoxia → metastasis
March 22, 2026 at 7:00 PM
🧬 scHiCAR maps RNA, chromatin accessibility & 3D genome in the same cell at scale
🩺 KRAS inhibitors can intercept pancreatic cancer before it starts
⚡ CSCs steal neutrophil mitochondria → pseudohypoxia → metastasis
🩺 KRAS inhibitors can intercept pancreatic cancer before it starts
⚡ CSCs steal neutrophil mitochondria → pseudohypoxia → metastasis
Mitochondria-mediated induction of #pseudohypoxia drives #HIF1α stabilization and #melanoma #metastasis, while its inhibition effectively blocks HIF1 signaling, offering a novel therapeutic strategy for treating metastatic cancers. #medsky
Latest in #STTT #OpenAccess: buff.ly/gw0U4h5
Latest in #STTT #OpenAccess: buff.ly/gw0U4h5
August 7, 2025 at 1:04 PM
Mitochondria-mediated induction of #pseudohypoxia drives #HIF1α stabilization and #melanoma #metastasis, while its inhibition effectively blocks HIF1 signaling, offering a novel therapeutic strategy for treating metastatic cancers. #medsky
Latest in #STTT #OpenAccess: buff.ly/gw0U4h5
Latest in #STTT #OpenAccess: buff.ly/gw0U4h5
Pseudohypoxia-stabilized HIF2α transcriptionally inhibits MNRR1, a druggable target in MELAS https://www.biorxiv.org/content/10.1101/2024.10.07.617011v1
Pseudohypoxia-stabilized HIF2α transcriptionally inhibits MNRR1, a druggable target in MELAS https://www.biorxiv.org/content/10.1101/2024.10.07.617011v1
The observation that amounts of the mitochondrial regulator MNRR1 (CHCHD2, AAG10, PARK22) are reduce
www.biorxiv.org
October 9, 2024 at 7:19 AM
Pseudohypoxia-stabilized HIF2α transcriptionally inhibits MNRR1, a druggable target in MELAS https://www.biorxiv.org/content/10.1101/2024.10.07.617011v1
Decline in UF in PD.
⬆️NADH/NAD1=pseudohypoxia⏭️proangiogenic/fibrotic pathway
⬆️GLUT1 exp ⏭️⬆️uptake of glucose by myofibroblasts⏭️loss of conc gradient⏭️UFF
https://jasn.asnjournals.org/content/32/10/2408 #homedialysis
⬆️NADH/NAD1=pseudohypoxia⏭️proangiogenic/fibrotic pathway
⬆️GLUT1 exp ⏭️⬆️uptake of glucose by myofibroblasts⏭️loss of conc gradient⏭️UFF
https://jasn.asnjournals.org/content/32/10/2408 #homedialysis
December 12, 2024 at 10:18 AM
Decline in UF in PD.
⬆️NADH/NAD1=pseudohypoxia⏭️proangiogenic/fibrotic pathway
⬆️GLUT1 exp ⏭️⬆️uptake of glucose by myofibroblasts⏭️loss of conc gradient⏭️UFF
https://jasn.asnjournals.org/content/32/10/2408 #homedialysis
⬆️NADH/NAD1=pseudohypoxia⏭️proangiogenic/fibrotic pathway
⬆️GLUT1 exp ⏭️⬆️uptake of glucose by myofibroblasts⏭️loss of conc gradient⏭️UFF
https://jasn.asnjournals.org/content/32/10/2408 #homedialysis