Communications Chemistry, Published online: 14 November 2025; doi:10.1038/s42004-025-01735-4Optically pure phosphonates are crucial in pharmaceuticals, yet the development of chiral H-phosphonates has been stagnant for decades. Here, the authors report an H-phosphonate derived from camphor-derived 2,3-diols (CAMDOL), that enables efficient stereoselective Pudovik reactions and yields diverse bioactive molecules, with significant implications for asymmetric synthesis.

Flow chemistry has shown significant versatility over the last two decades, offering advantages in efficiency, scalability, and sustainability. In this study, the continuous stirred tank reactor (CSTR...

A transition-metal-free deoxygenative functionalization of trifluoromethyl ketones via a Pudovik addition/phospha-Brook rearrangement sequence followed by benzylic substitution has been developed.…