Photocatalytic free radical geminal carboamination of α-diazo esters toward chromone-derived α-amino acids
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
December 5, 2025 at 2:11 PM
Photocatalytic free radical geminal carboamination of α-diazo esters toward chromone-derived α-amino acids
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
Photocatalytic free radical geminal carboamination of α-diazo esters toward chromone-derived α-amino acids
Photocatalytic free radical geminal carboamination of α-diazo esters toward chromone-derived α-amino acids
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
December 5, 2025 at 2:43 PM
Photocatalytic free radical geminal carboamination of α-diazo esters toward chromone-derived α-amino acids
Photocatalytic free radical geminal carboamination of α-diazo esters toward chromone-derived α-amino acids
Photocatalytic free radical geminal carboamination of α-diazo esters toward chromone-derived α-amino acids
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
December 5, 2025 at 2:44 PM
Photocatalytic free radical geminal carboamination of α-diazo esters toward chromone-derived α-amino acids
Check out research by You-Cai Xiao, Fen-Er Chen & co. from Sichuan University in our latest issue describing the total synthesis of γ-tocopherol via asymmetric 1,4-conjugate addition of alkyl Grignard reagents to 2-methyl chromone #orgchem #natprod
Read in full here🔽
Read in full here🔽
Total synthesis of γ-tocopherol via asymmetric 1,4-conjugate addition of alkyl Grignard reagents to 2-methyl chromone
CuI/(S,R)-rev-Josiphos-catalyzed asymmetric 1,4-conjugate addition of alkyl Grignard reagents to 2-methyl-substituted chromone derivatives by Lewis acid activation is reported, enabling the…
pubs.rsc.org
May 31, 2026 at 8:48 AM
Our democratically elected #paperofthemonth is the synthesis of astonishingly complex cage compounds in a single-step by triple-dearomative photocycloaddition (Sivaguru and
Porco). #chemsky
doi.org/10.1021/jacs...
Porco). #chemsky
doi.org/10.1021/jacs...
Triple-Dearomative Photocycloaddition: A Strategy to Construct Caged Molecular Frameworks
An unprecedented caged 2H-benzo-dioxo-pentacycloundecane framework was serendipitously obtained in a single transformation via triple-dearomative photocycloaddition of chromone esters with furans. Thi...
doi.org
June 11, 2024 at 2:12 PM
Our democratically elected #paperofthemonth is the synthesis of astonishingly complex cage compounds in a single-step by triple-dearomative photocycloaddition (Sivaguru and
Porco). #chemsky
doi.org/10.1021/jacs...
Porco). #chemsky
doi.org/10.1021/jacs...
Very excited to see another molecule discovered by @LoesgenLab being synthesized! Congrats to the Blakemore lab- thanks for the collaboration! Stay tuned for some awesome activity! Congrats to Oh-Seok Kwon! @Whitney_Lab @UFChemistry pubs.acs.org/doi/full/10....
Total Synthesis of Chalaniline A: An Aminofulvene Fused Chromone from Vorinostat-Treated Fungus Chalara sp. 6661
Chalaniline A, an aminofulveno[1,2-b]chromone derivative previously isolated from a vorinostat-treated ascomycete Chalara sp., was prepared in nine steps from orcinol (3,5-dihydroxytoluene). In a key ...
pubs.acs.org
September 28, 2024 at 3:03 PM
Very excited to see another molecule discovered by @LoesgenLab being synthesized! Congrats to the Blakemore lab- thanks for the collaboration! Stay tuned for some awesome activity! Congrats to Oh-Seok Kwon! @Whitney_Lab @UFChemistry pubs.acs.org/doi/full/10....
Artigo é incrível para results pré-clínicos. Mostrou uma molécula promissora contra células de mama cancerígenas, com redução de tamanho e peso de tumores em camundongos.
It shows a promising molecule against breast cancer cells, with reduced tumor size and weight in mice.
doi.org/10.1002/ddr....
It shows a promising molecule against breast cancer cells, with reduced tumor size and weight in mice.
doi.org/10.1002/ddr....
Exploring chromone‐2‐carboxamide derivatives for triple‐negative breast cancer targeting EGFR, FGFR3, and VEGF pathways: Design, synthesis, and preclinical insights
Chromone-based compounds have established cytotoxic, antiproliferative, antimetastatic, and antiangiogenic effects on various cancer cell types via modulating different molecular targets. Herein, 17 ....
doi.org
September 28, 2024 at 11:21 PM
Artigo é incrível para results pré-clínicos. Mostrou uma molécula promissora contra células de mama cancerígenas, com redução de tamanho e peso de tumores em camundongos.
It shows a promising molecule against breast cancer cells, with reduced tumor size and weight in mice.
doi.org/10.1002/ddr....
It shows a promising molecule against breast cancer cells, with reduced tumor size and weight in mice.
doi.org/10.1002/ddr....
www.organic-chemistry.org/abstracts/li...
Visible light induces an efficient and facile 3-alkyl chromone synthesis from easily accessible o-hydroxyaryl enaminones and α-diazo esters
Visible light induces an efficient and facile 3-alkyl chromone synthesis from easily accessible o-hydroxyaryl enaminones and α-diazo esters
November 24, 2024 at 4:19 PM
www.organic-chemistry.org/abstracts/li...
Visible light induces an efficient and facile 3-alkyl chromone synthesis from easily accessible o-hydroxyaryl enaminones and α-diazo esters
Visible light induces an efficient and facile 3-alkyl chromone synthesis from easily accessible o-hydroxyaryl enaminones and α-diazo esters
✨Herrera, Marqués-López & co-workers report the first asymmetric synthesis of #chromone derived compounds via the #Pudovik reaction, combining #organocatalysis, NMR analysis & computational studies to explore stereochemistry and molecular polarity🔬
👉 buff.ly/0Ec74T7
👉 buff.ly/0Ec74T7
July 1, 2026 at 7:01 AM
✨Herrera, Marqués-López & co-workers report the first asymmetric synthesis of #chromone derived compounds via the #Pudovik reaction, combining #organocatalysis, NMR analysis & computational studies to explore stereochemistry and molecular polarity🔬
👉 buff.ly/0Ec74T7
👉 buff.ly/0Ec74T7
The authors included RRIDs in their paper! Thanks for making your methods matter! #OpenScience #reproducibility #ReproducibleResearch
Novel Chromone–Hydrazone Conjugates: Synthesis, In Silico evaluation and Cytotoxic Assessment against Hormone Dependent Breast Cancer cell lines
doi.org
November 6, 2025 at 8:00 AM
The authors included RRIDs in their paper! Thanks for making your methods matter! #OpenScience #reproducibility #ReproducibleResearch
Safer and more effective therapies remain vital for improving #BreastCancer treatment.
This study identifies chromone-2-carboxamide derivatives with antiproliferative activity, with compound 5g showing strong potential. #EndometrialCancer
#OpenChemistry: doi.org/10.1515/chem...
#ResourceRecovery
This study identifies chromone-2-carboxamide derivatives with antiproliferative activity, with compound 5g showing strong potential. #EndometrialCancer
#OpenChemistry: doi.org/10.1515/chem...
#ResourceRecovery
August 5, 2026 at 5:15 AM
Safer and more effective therapies remain vital for improving #BreastCancer treatment.
This study identifies chromone-2-carboxamide derivatives with antiproliferative activity, with compound 5g showing strong potential. #EndometrialCancer
#OpenChemistry: doi.org/10.1515/chem...
#ResourceRecovery
This study identifies chromone-2-carboxamide derivatives with antiproliferative activity, with compound 5g showing strong potential. #EndometrialCancer
#OpenChemistry: doi.org/10.1515/chem...
#ResourceRecovery
RRIDs were included in this paper. We value the author's support of reproducibility. #methodsmatter #RRID #STMpublishing
Fluorinated Chromone
Derivatives: Synthesis, Theoretical
Study, and Evaluation of Their Biological Potential
Read the full paper: Fluorinated Chromone
Derivatives: Synthesis, Theoretical
Study, and Evaluation of Their Biological Potential
doi.org
August 2, 2026 at 7:01 AM
RRIDs were included in this paper. We value the author's support of reproducibility. #methodsmatter #RRID #STMpublishing
An Executive order that says that the gender expressed at the time of conception determines the sex. If you took any reproductive or even biology classes, you know that for the first month or so, we are a clump of all cells. XX cells, the Y chromone take a month to propagate throughout the fetus
January 23, 2025 at 6:21 PM
An Executive order that says that the gender expressed at the time of conception determines the sex. If you took any reproductive or even biology classes, you know that for the first month or so, we are a clump of all cells. XX cells, the Y chromone take a month to propagate throughout the fetus
plus with intersex people it varies and is different with the chromanone playing a part. i'm intersex but i don't know my chromone.
so i just now after research am having my mind play hop scotch jumping back and forth in a yoyo fashion..
i just found out orchiectomy can increase anger as well which has me concerned.
i want chopped nuts but i don't want an anger elevation increase..
i just found out orchiectomy can increase anger as well which has me concerned.
i want chopped nuts but i don't want an anger elevation increase..
October 8, 2025 at 9:15 PM
plus with intersex people it varies and is different with the chromanone playing a part. i'm intersex but i don't know my chromone.
Domagała et al.: Supramolecular architectures in the crystal structures of six chromone derivatives: Hirshfeld surface and energy framework analyses ##CrystalStructure##Chromone##HydrogenBond... ##IUCrhttps://journals.iucr.org/paper?S2053229625005674
Supramolecular architectures in the crystal structures of six chromone derivatives: Hirshfeld surface and energy framework analyses
The crystal structures of six new chromone derivatives have been determined and analysed using single-crystal X-ray diffraction. An analysis of the intermolecular hydrogen bonding was further supported by pairwise energy calculations and visualized using the energy framework approach.
journals.iucr.org
July 9, 2025 at 12:00 AM
Domagała et al.: Supramolecular architectures in the crystal structures of six chromone derivatives: Hirshfeld surface and energy framework analyses ##CrystalStructure##Chromone##HydrogenBond... ##IUCrhttps://journals.iucr.org/paper?S2053229625005674
A Chemical Investigation Approach of the Paraconiothyrium sp. FKR-0637 Fungal Strain Enables the Isolation of the New Chlorinated Chromone, (+)-Nohocumone
Authors: Haruki Azami, Yoshihiro Watanabe, Takahito Ouchi, Mika Watabe, Hiroki Kojima, Yui Hirano, ...
DOI: 10.26434/chemrxiv-2024-ks826
Authors: Haruki Azami, Yoshihiro Watanabe, Takahito Ouchi, Mika Watabe, Hiroki Kojima, Yui Hirano, ...
DOI: 10.26434/chemrxiv-2024-ks826
December 12, 2024 at 4:45 AM
A Chemical Investigation Approach of the Paraconiothyrium sp. FKR-0637 Fungal Strain Enables the Isolation of the New Chlorinated Chromone, (+)-Nohocumone
Authors: Haruki Azami, Yoshihiro Watanabe, Takahito Ouchi, Mika Watabe, Hiroki Kojima, Yui Hirano, ...
DOI: 10.26434/chemrxiv-2024-ks826
Authors: Haruki Azami, Yoshihiro Watanabe, Takahito Ouchi, Mika Watabe, Hiroki Kojima, Yui Hirano, ...
DOI: 10.26434/chemrxiv-2024-ks826
This Open Chemistry study presents the synthesis of chromone-2-carboxamide derivatives, featuring varied electron-donating & electron-withdrawing substituents, which exhibit a potent anti-#BreastCancer effect by interacting with #EstrogenReceptor-α.
#OpenAccess: doi.org/10.1515/chem...
#OpenAccess: doi.org/10.1515/chem...
November 21, 2025 at 12:30 PM
This Open Chemistry study presents the synthesis of chromone-2-carboxamide derivatives, featuring varied electron-donating & electron-withdrawing substituents, which exhibit a potent anti-#BreastCancer effect by interacting with #EstrogenReceptor-α.
#OpenAccess: doi.org/10.1515/chem...
#OpenAccess: doi.org/10.1515/chem...
📃Scientific paper: Chromone-embedded peptidomimetics and furopyrimidines as highly potent SARS-CoV-2 infection inhibitors: docking and MD simulation study
Ref.: BioMed Central, 2023
➡️ Continued on ES/IODE
Ref.: BioMed Central, 2023
➡️ Continued on ES/IODE
September 12, 2025 at 2:00 PM
📃Scientific paper: Chromone-embedded peptidomimetics and furopyrimidines as highly potent SARS-CoV-2 infection inhibitors: docking and MD simulation study
Ref.: BioMed Central, 2023
➡️ Continued on ES/IODE
Ref.: BioMed Central, 2023
➡️ Continued on ES/IODE
www.organic-chemistry.org/abstracts/li...
Visible light induces an efficient and facile 3-alkyl chromone synthesis from easily accessible o-hydroxyaryl enaminones and α-diazo esters
Visible light induces an efficient and facile 3-alkyl chromone synthesis from easily accessible o-hydroxyaryl enaminones and α-diazo esters
June 30, 2026 at 9:38 AM
www.organic-chemistry.org/abstracts/li...
Visible light induces an efficient and facile 3-alkyl chromone synthesis from easily accessible o-hydroxyaryl enaminones and α-diazo esters
Visible light induces an efficient and facile 3-alkyl chromone synthesis from easily accessible o-hydroxyaryl enaminones and α-diazo esters
www.organic-chemistry.org/abstracts/li...
A convenient copper-catalyzed decarboxylative direct cross-coupling of coumarin-/chromone-3-carboxylic acids with terminal alkynes
A convenient copper-catalyzed decarboxylative direct cross-coupling of coumarin-/chromone-3-carboxylic acids with terminal alkynes
June 29, 2026 at 2:43 PM
www.organic-chemistry.org/abstracts/li...
A convenient copper-catalyzed decarboxylative direct cross-coupling of coumarin-/chromone-3-carboxylic acids with terminal alkynes
A convenient copper-catalyzed decarboxylative direct cross-coupling of coumarin-/chromone-3-carboxylic acids with terminal alkynes
www.organic-chemistry.org/abstracts/li...
A facile one-pot transformation of 2-fluoroacetophenones provides chromone-2-carboxylates
A facile one-pot transformation of 2-fluoroacetophenones provides chromone-2-carboxylates
March 13, 2026 at 12:40 PM
www.organic-chemistry.org/abstracts/li...
A facile one-pot transformation of 2-fluoroacetophenones provides chromone-2-carboxylates
A facile one-pot transformation of 2-fluoroacetophenones provides chromone-2-carboxylates
www.organic-chemistry.org/abstracts/li...
A convenient copper-catalyzed decarboxylative direct cross-coupling of coumarin-/chromone-3-carboxylic acids with terminal alkynes
A convenient copper-catalyzed decarboxylative direct cross-coupling of coumarin-/chromone-3-carboxylic acids with terminal alkynes
November 24, 2024 at 4:17 PM
www.organic-chemistry.org/abstracts/li...
A convenient copper-catalyzed decarboxylative direct cross-coupling of coumarin-/chromone-3-carboxylic acids with terminal alkynes
A convenient copper-catalyzed decarboxylative direct cross-coupling of coumarin-/chromone-3-carboxylic acids with terminal alkynes
#CIBseminars
Biologically Active Xanthone and Chromone-type Compounds and their Aza-analogues
Artur Silva, Universidad de Aveiro, Portugal
📅April 11
⏰12pm
Biologically Active Xanthone and Chromone-type Compounds and their Aza-analogues
Artur Silva, Universidad de Aveiro, Portugal
📅April 11
⏰12pm
April 11, 2025 at 7:01 AM
#CIBseminars
Biologically Active Xanthone and Chromone-type Compounds and their Aza-analogues
Artur Silva, Universidad de Aveiro, Portugal
📅April 11
⏰12pm
Biologically Active Xanthone and Chromone-type Compounds and their Aza-analogues
Artur Silva, Universidad de Aveiro, Portugal
📅April 11
⏰12pm