#PureTarget
What happens after genome editing? Using PacBio PureTarget sequencing (>1000× coverage), we resolved CRISPR-Cas9 on-target and off-target outcomes at high resolution. In zebrafish, this revealed widespread mosaicism and edits transmitted to the offspring 🧬 🧪 link.springer.com/article/10.1...
Accurate characterization of CRISPR-Cas9 genome editing outcomes and mosaicism with near-perfect long reads - Genome Medicine
Background Genetic mosaicism is a well-recognized consequence of CRISPR–Cas9 genome editing, yet its characterization remains challenging, especially when it involves low-frequency structural variants...
link.springer.com
September 16, 2026 at 6:55 AM
What can you learn from a clinical lab's PureTarget implementation?

Discover how the team at CHU Nîmes in France implemented #PacBio PureTarget and transitioned to routine clinical use in just ~3 months to expand repeat expansion testing.

Read the story: bit.ly/4fMGHWI
August 7, 2026 at 3:43 PM
Which targeted sequencing approach is right for you?

In this short video, Samantha walks through three key PacBio HiFi approaches: amplicon, hybrid capture, and PureTarget.

Watch to find the best fit to simplify your strategy: bit.ly/4ffnKMe

#PacBio #HiFiSequencing #Genomics
July 16, 2026 at 3:32 PM
🧬 What I like about PureTarget™ is its end-to-end approach from targeted HiFi sequencing to dedicated analysis tools.
It supports analysis of repeat expansions, homologous genes, structural variants, and copy number changes in a single workflow.
Check out the overview below 😊
Streamlined sequencing deserves streamlined analysis.

The #PureTarget workflow brings complex variant types together into a single pipeline, combining PacBio tools to support comprehensive targeted data analysis.

📘 Download the Pre-Clinical Playbook: bit.ly/437tTEM
June 23, 2026 at 10:36 AM
Streamlined sequencing deserves streamlined analysis.

The #PureTarget workflow brings complex variant types together into a single pipeline, combining PacBio tools to support comprehensive targeted data analysis.

📘 Download the Pre-Clinical Playbook: bit.ly/437tTEM
June 18, 2026 at 4:50 PM
Happy to present poster P23.040.D at #ESHG2026 today! 😃

Exploring how #PureTarget and #PacBio HiFi sequencing enable flexible targeting of challenging genomic regions, from repeat expansions to difficult inherited disease genes.
June 14, 2026 at 9:25 AM
Excited to be heading to #ESHG2026 😃

If you're attending, feel free to stop by the #PacBio booth (420) and say hello. I'd be happy to chat about #PureTarget, HiFi sequencing, and targeted sequencing applications.

If you're not attending ESHG, you can still catch this webinar on demand below.
Repeat expansions and other complex genomic regions continue to challenge traditional sequencing workflows.

🎥 Hear how Dr. Maximilian Thelen is using PureTarget™ HiFi sequencing for repeat expansion analysis and custom panel development.

Watch the recording: bit.ly/3S1axP5

#PureTarget
June 12, 2026 at 11:34 AM
Repeat expansions and other complex genomic regions continue to challenge traditional sequencing workflows.

🎥 Hear how Dr. Maximilian Thelen is using PureTarget™ HiFi sequencing for repeat expansion analysis and custom panel development.

Watch the recording: bit.ly/3S1axP5

#PureTarget
June 9, 2026 at 4:05 PM
One of my favorite things about PureTarget: simplify complex workflows 😃 Nice short video on carrier screening 🧬
Replace legacy assays with one streamlined carrier screening workflow.

In this short video, see how PureTarget HiFi sequencing consolidates PCR and Southern blot into a single workflow for challenging genes like FMR1 and SMN.

Download our Pre-Clinical Playbook: bit.ly/437tTEM

#PureTarget
June 3, 2026 at 10:01 AM
Replace legacy assays with one streamlined carrier screening workflow.

In this short video, see how PureTarget HiFi sequencing consolidates PCR and Southern blot into a single workflow for challenging genes like FMR1 and SMN.

Download our Pre-Clinical Playbook: bit.ly/437tTEM

#PureTarget
June 2, 2026 at 8:27 PM
Last call to register for our gene editing webinar!

Short reads and PCR bias can hide critical editing outcomes. Join us to see how amplification free #PacBio HiFi sequencing and PureTarget provide a complete view of #CRISPR edits.

Register here: bit.ly/4mbDW4i
April 26, 2026 at 7:04 PM
Join #PacBio at #ACMGMtg26 to see how HiFi sequencing is redefining genetic testing. We are featuring two posters presentations:

• P165: CFTR profiling using PureTarget panels (Billy Rowell)
• P636: DNA extraction from low-mass samples (Deborah Moine)

Full program here: bit.ly/3OBZmee
March 10, 2026 at 1:30 PM
Repeat expansions and complex regions still challenge PCR and short reads.

See how labs use PureTarget with PCR-free HiFi sequencing of native DNA to build scalable custom panels and improve confidence across difficult loci.

Save your spot: bit.ly/3MElTWS

#PacBio #PureTarget #HiFisequencing
February 16, 2026 at 9:25 PM
As long read sequencing scales to large biobanks, it’s clear that DNA repeat expansions are more dynamic and individualized than once thought. Long read approaches like PureTarget helps bring challenging regions into focus, turning discovery into deeper biological insights.

📎 go.nature.com/49rjTc9
January 8, 2026 at 8:25 PM
Attendees will see how their computational workflow leverages PacBio PureTarget long-read sequencing assay to resolve difficult genetic structural variations and improve the accuracy of Myriad’s Foresight® Carrier Screen.

#StructuralVariants #PacBio #MyriadGenetics
January 6, 2026 at 8:24 PM
Couldn’t make it live? 🎥 The replay is now available!

Watch Zach Freeman, DVM, PhD & Emily Madden, PhD discuss how Fiber-seq + PureTarget™ uncover hidden transgene alterations.
👉 https://app.livestorm.co/epicypher/combining-fiber-seq-and-puretarget

#Epigenetics #WebinarReplay
Combining PureTarget and Fiber-seq to Discover Hidden Alterations in Genome Engineered Models | EpiCypher
Developing transgenic animal models is essential for biomedical research — but confirming that a transgene is properly integrated and active can be challenging. Traditional methods often provide on...
app.livestorm.co
December 11, 2025 at 6:00 PM
🎥 The webinar recording is now live!

Catch up on insights from Zach Freeman, DVM, PhD and Emily Madden, PhD on how Fiber-seq + PureTarget™ reveal hidden integration and expression issues.
Replay here: https://app.livestorm.co/epicypher/combining-fiber-seq-and-puretarget

#Epigenetics #Chromatin
December 4, 2025 at 6:00 PM
It’s webinar day! 🎉

Join us at 3PM EST for a deep dive into Fiber-seq + PureTarget™ with Zach Freeman, DVM, PhD and Emily Madden, PhD.
Still time to register: https://app.livestorm.co/epicypher/combining-fiber-seq-and-puretarget

#Epigenetics #GenomeEngineering
December 3, 2025 at 3:00 PM
The wait is almost over ⏳

Our webinar on Fiber-seq + PureTarget™ goes live tomorrow! Zach Freeman, DVM, PhD and Emily Madden, PhD will share new insights + tips for transgene analysis.
Grab your spot: https://app.livestorm.co/epicypher/combining-fiber-seq-and-puretarget

#Epigenetics #CRISPR
December 2, 2025 at 4:00 PM
🚨 One-week countdown!

Don’t miss this free webinar on Fiber-seq + PureTarget™ for uncovering transgene integration and regulation issues.

📆 Dec 3 @ 3PM EST – sign up here: https://app.livestorm.co/epicypher/combining-fiber-seq-and-puretarget

#Epigenetics #CRISPR
November 26, 2025 at 6:00 PM
Subtle differences in repeat motifs can cause drastic diff in disease onset: using @pacbio.bsky.social PureTarget amp-free identifies non-canonical repeats and its ratio assoc. with disease onset for Spinocerebellar ataxia type 10 (SCA10)

www.neurology.org/doi/full/10....
Novel ATXN10 Repeat Motif Patterns in Peruvian Families Modify Disease Onset | Neurology Genetics
ObjectivesSpinocerebellar ataxia type 10 (SCA10) is an autosomal-dominant disorder caused by intronic expansions of pentanucleotide repeats in the ATXN10 gene. While various repeat motifs have been de...
www.neurology.org
November 24, 2025 at 8:54 PM
Your genome-edited models might be hiding more than you think. 🧬

Learn how Fiber-seq + PureTarget™ help uncover integration and expression issues in transgenic lines. Webinar Dec 3.
Register here: https://app.livestorm.co/epicypher/combining-fiber-seq-and-puretarget

#Epigenetics #GenomeEngineering
November 21, 2025 at 6:00 PM
Join our Live Webinar! Zach Freeman, DVM, PhD, will discuss using Fiber-seq with PacBio's PureTarget™ for transgene insights. Plus, Emily Madden, PhD, will provide practical tips for getting started with Fiber-seq.

Register Now: https://app.livestorm.co/epicypher/combining-fiber-seq-and-puretarget
November 18, 2025 at 7:01 PM
Excited to see our work featured! We evaluated PureTarget for verification of CRISPR-Cas9 genome editing outcomes, with great results. Read more in the publication spotlight by @pacbio.bsky.social and in our preprint: www.biorxiv.org/content/10.1...

www.pacb.com/blog/publica...
Publication spotlight:Capturing the full picture of genome editing with custom PureTarget panels - PacBio
Genetic mosaicism can occur within genome editing. Accurately characterize every edit within a model with PureTarget.
www.pacb.com
October 31, 2025 at 1:07 PM
Publication spotlight:Capturing the full picture of genome editing with custom PureTarget panels - PacBio url:https://www.pacb.com/blog/publication-spotlightcapturing-the-full-picture-of-genome-editing-with-custom-puretarget-panels/
October 30, 2025 at 2:45 PM