ABSTRACTManogepix, the active moiety of the prodrug fosmanogepix, is a novel investigational agent in clinical trials that inhibits Gwt1, depleting glycosylphosphatidylinositol (GPI)-anchored mannoproteins critical for fungal cell wall integrity. It has potent broad-spectrum antifungal activity, including against fungi that are often resistant to clinically available antifungals (e.g., Fusarium species and Lomentospora prolificans). Our objective was to evaluate the in vitro activity of manogepix against different Aspergillus species, Coccidioides, and rare molds with reduced in vitro susceptibility or resistance to other antifungals. A total of 257 clinical isolates of Aspergillus, Coccidioides, Scopulariopsis/Microascus, Rasamsonia argillaceae species complex members, Purpureocillium lilacinum, Curvularia, Exophiala, and Exserohilum rostratum were used. Minimum effective concentrations (MECs) (manogepix and caspofungin) and minimum inhibitory concentrations (MICs) (amphotericin B, fluconazole, isavuconazole, itraconazole, posaconazole, and fluconazole) were determined by CLSI M38 broth dilution. Manogepix demonstrated potent in vitro activity against Aspergillus, Coccidioides, and several other molds (MEC range ≤ 0.002–0.015 mg/L; GM MEC range 0.003–0.007 mg/L). The activity of manogepix was also maintained against strains with reduced in vitro susceptibility to, or resistance to, other antifungals, including those with elevated MEC values to caspofungin, as well as isolates that were intrinsically resistant to other antifungals. Reduced or variable activity for manogepix was observed against Curvularia, Exophiala, and Exserohilum rostratum. Additional studies are warranted to determine if this potent in vitro activity translates into in vivo activity and enhanced clinical efficacy against infections caused by these fungal pathogens.

PDF | Background: Crop protection using mycopesticides has a crucial role in sustainable pest management programmes. Biocontrol agents, such as... | Find, read and cite all the research you need on Re...

Penicillium, Talaromyces, and Purpureocillium species (so called Penicillium-like) are increasingly recognised as opportunistic fungal pathogens capable of causing a wide range of infections, from superficial to invasive. Although ocular infections caused by these environmental fungi have been repor …

Three patients contracted fungal keratitis after undergoing laser eye surgery at a New York City clinic in December 2024, according to a report in Morbidity and Mortality Weekly Report. When the patients reported eye pain and vision loss after surgery, the clinic sent corneal specimens to a clinical laboratory that returned findings of fungal elements on microscopy. Cultures later revealed Purpureocillium lilacinum in two of the patient specimens. The laboratory then notified the New York City Health Department, according to the report. Michelle E. Chang, MD, and colleagues wrote that the first

Three patients contracted fungal keratitis after undergoing laser eye surgery at a New York City clinic in December 2024, according to a report in Morbidity and Mortality Weekly Report. When the patients reported eye pain and vision loss after surgery, the clinic sent corneal specimens to a clinical laboratory that returned findings of fungal elements on microscopy. Cultures later revealed Purpureocillium lilacinum in two of the patient specimens. The laboratory then notified the New York City Health Department, according to the report. Michelle E. Chang, MD, and colleagues wrote that the first

PDF | The effect of seed treatment and foliar application with two endophytic entomopathogenic fungi (EPF), Beauveria bassiana and Purpureocillium... | Find, read and cite all the research you need on...

Our planet is inhabited by an estimated 2.5 million species of fungi, of which fewer than 10% have been scientifically described. Some of the most understudied yet remarkable fungal species are those ...

Create an account or log in to Instagram - Share what you're into with the people who get you.

Three patients at New York City clinic developed fungal keratitis caused by a mold

This report describes the public health response to a Purpureocillium lilacinum keratitis outbreak in New York City associated with an ophthalmology clinic.