RCTs aka fisher price my first causality.
October 29, 2026 at 12:23 AM
RCTs aka fisher price my first causality.
I do this for RCTs! Hypothetical treatment is three diff exam study guides. 😆
November 3, 2026 at 5:16 PM
I do this for RCTs! Hypothetical treatment is three diff exam study guides. 😆
Wanna see RCTs....
October 31, 2026 at 8:17 PM
Wanna see RCTs....
He should be the placebo on all RCTs. Maybe his peptides will save him
November 4, 2026 at 2:03 AM
He should be the placebo on all RCTs. Maybe his peptides will save him
Was bleibt da jetzt über?
Ja, wir brauchen RCT, um aus off-label on-label zu machen - alleine wegen der Verordnung.
Gleichzeitig gibt es, auch für simple Kliniker wie mich erkennbare, Probleme bei der Gestaltung mancher RCTs.
Ja, wir brauchen RCT, um aus off-label on-label zu machen - alleine wegen der Verordnung.
Gleichzeitig gibt es, auch für simple Kliniker wie mich erkennbare, Probleme bei der Gestaltung mancher RCTs.
October 30, 2026 at 1:23 PM
Was bleibt da jetzt über?
Ja, wir brauchen RCT, um aus off-label on-label zu machen - alleine wegen der Verordnung.
Gleichzeitig gibt es, auch für simple Kliniker wie mich erkennbare, Probleme bei der Gestaltung mancher RCTs.
Ja, wir brauchen RCT, um aus off-label on-label zu machen - alleine wegen der Verordnung.
Gleichzeitig gibt es, auch für simple Kliniker wie mich erkennbare, Probleme bei der Gestaltung mancher RCTs.
Ha! Though to be pedantic, you need:
1) large N
2) a very rich set of covariates
3) at least some RCTs to show that your observational version is informative
So Keith got it 1/3 right!
1) large N
2) a very rich set of covariates
3) at least some RCTs to show that your observational version is informative
So Keith got it 1/3 right!
November 2, 2026 at 6:25 PM
Ha! Though to be pedantic, you need:
1) large N
2) a very rich set of covariates
3) at least some RCTs to show that your observational version is informative
So Keith got it 1/3 right!
1) large N
2) a very rich set of covariates
3) at least some RCTs to show that your observational version is informative
So Keith got it 1/3 right!
🎥 New video time 🎥
A short look at some of the model railways on show at this weekends Cardiff Model Railway Exhibition
youtu.be/XlYscSbPiS4
A short look at some of the model railways on show at this weekends Cardiff Model Railway Exhibition
youtu.be/XlYscSbPiS4
Sidetracked Cardiff Model Railway Exhibition 2026
Not a modeller myself, but while on duty at the RCTS stall in Sophia Gardens, I made sure to take in the Cardiff Model Railway Show layouts!
youtu.be
November 2, 2026 at 7:38 PM
🎥 New video time 🎥
A short look at some of the model railways on show at this weekends Cardiff Model Railway Exhibition
youtu.be/XlYscSbPiS4
A short look at some of the model railways on show at this weekends Cardiff Model Railway Exhibition
youtu.be/XlYscSbPiS4
I've run cluster-randomized trials using stepped-wedge and similar designs. Ethics is somewhat complex but not that difficult. Certainly there are no insurmountable barriers to running RCTs on even complex interventions, and we should strive to do more of them.
November 3, 2026 at 11:39 PM
I've run cluster-randomized trials using stepped-wedge and similar designs. Ethics is somewhat complex but not that difficult. Certainly there are no insurmountable barriers to running RCTs on even complex interventions, and we should strive to do more of them.
A separate question would be a mask mandate *in a particular context* (eg doctors waiting room) reducing risk of people getting infected *in that location*. Could imagine RCTs, but not sure how you'd measure the effect (unless people aren't getting infected anywhere else)
November 3, 2026 at 11:25 PM
A separate question would be a mask mandate *in a particular context* (eg doctors waiting room) reducing risk of people getting infected *in that location*. Could imagine RCTs, but not sure how you'd measure the effect (unless people aren't getting infected anywhere else)
It's the perfect demonstration of how vacuous the MAHA movement is: they keep saying they won't take vaccines "until there are more placebo-controlled trials" & yet they're out there peddling entirely untested peptides that have zero safety or efficacy data from rigorous RCTs. Make it make sense!
The Venn diagram of the people who refuse COVID19 vaccines and the people who will buy untested, unapproved injectible peptides from a compounding pharmacy is a perfect circle.
October 29, 2026 at 4:58 PM
It's the perfect demonstration of how vacuous the MAHA movement is: they keep saying they won't take vaccines "until there are more placebo-controlled trials" & yet they're out there peddling entirely untested peptides that have zero safety or efficacy data from rigorous RCTs. Make it make sense!
There we disagree. I think Ioannidis is eliding two separate issues - whether mandates reduce the spread of infection and whether masks themselves "work" - but certainly RCTs can - and were! - used to measure mask mandate effects.
November 3, 2026 at 11:20 PM
There we disagree. I think Ioannidis is eliding two separate issues - whether mandates reduce the spread of infection and whether masks themselves "work" - but certainly RCTs can - and were! - used to measure mask mandate effects.
Ultra-low-dose #naloxone (50–100 ng) with local anesthetics may prolong analgesia & reduce opioid use in nerve blocks/IVRA (7 RCTs, n=564). Promising but limited evidence; more trials needed. #Anesthesia #PainManagement onlinelibrary.wiley.com/doi/10.1002/...
November 1, 2026 at 11:04 AM
Ultra-low-dose #naloxone (50–100 ng) with local anesthetics may prolong analgesia & reduce opioid use in nerve blocks/IVRA (7 RCTs, n=564). Promising but limited evidence; more trials needed. #Anesthesia #PainManagement onlinelibrary.wiley.com/doi/10.1002/...
All those randomized trials he wants repeated though! For the things that already have RCTs
October 29, 2026 at 12:33 AM
All those randomized trials he wants repeated though! For the things that already have RCTs
Psyllium reduces LDL by 13 mg/dL through bile acid sequestration, supported by meta-analysis of 28 RCTs.
https://news.gmj.ge/briefs/13-mg-dl-the-evidence-based-impact-of-psyllium-on-ldl-cholesterol/
https://news.gmj.ge/briefs/13-mg-dl-the-evidence-based-impact-of-psyllium-on-ldl-cholesterol/
13 mg/dL: The Evidence-Based Impact of Psyllium on LDL Cholesterol
Psyllium reduces LDL by 13 mg/dL through bile acid sequestration, supported by meta-analysis of 28 RCTs.
news.gmj.ge
October 31, 2026 at 5:27 AM
Psyllium reduces LDL by 13 mg/dL through bile acid sequestration, supported by meta-analysis of 28 RCTs.
https://news.gmj.ge/briefs/13-mg-dl-the-evidence-based-impact-of-psyllium-on-ldl-cholesterol/
https://news.gmj.ge/briefs/13-mg-dl-the-evidence-based-impact-of-psyllium-on-ldl-cholesterol/
I guess we’re not waiting for gold standard, double-blind RCTs
October 31, 2026 at 4:14 PM
I guess we’re not waiting for gold standard, double-blind RCTs
Bioprinted scaffolds for leg ulcers: 8 clinical studies, 139 patients, faster healing in both RCTs. https://doi.org/10.3389/fbioe.2026.1912135
November 3, 2026 at 5:01 PM
Bioprinted scaffolds for leg ulcers: 8 clinical studies, 139 patients, faster healing in both RCTs. https://doi.org/10.3389/fbioe.2026.1912135
The RCTs I saw were always "giving out masks" or "asking people to wear masks (as part of a scientific study with no legal mandate)" - do you have a link to an example of an RCT for a legal mandate? (Curious about how - could they fine people for non compliance? And what was the messaging?)
November 3, 2026 at 11:23 PM
The RCTs I saw were always "giving out masks" or "asking people to wear masks (as part of a scientific study with no legal mandate)" - do you have a link to an example of an RCT for a legal mandate? (Curious about how - could they fine people for non compliance? And what was the messaging?)
The SHR-5 extract used in multiple RCTs lowered cortisol awakening response and burnout scores after 28 days of daily use (Olsson et al. 2009).
November 3, 2026 at 6:01 PM
The SHR-5 extract used in multiple RCTs lowered cortisol awakening response and burnout scores after 28 days of daily use (Olsson et al. 2009).
RCTs ongoing to see if they prevent and treat heart failure, which are very likely to make them the “fifth pillar” of guideline directed medical therapy.
October 30, 2026 at 4:53 AM
RCTs ongoing to see if they prevent and treat heart failure, which are very likely to make them the “fifth pillar” of guideline directed medical therapy.
When @jonathanhaidt.bsky.social said that phone bans had initially negative followed by positive effects people here said he was just trying to wriggle out of unfavorable RCTs.
But in fact that is exactly what we see in this large DiD study in QJE. academic.oup.com/qje/advance-...
But in fact that is exactly what we see in this large DiD study in QJE. academic.oup.com/qje/advance-...
November 1, 2026 at 1:07 AM
When @jonathanhaidt.bsky.social said that phone bans had initially negative followed by positive effects people here said he was just trying to wriggle out of unfavorable RCTs.
But in fact that is exactly what we see in this large DiD study in QJE. academic.oup.com/qje/advance-...
But in fact that is exactly what we see in this large DiD study in QJE. academic.oup.com/qje/advance-...
You're right, there were no RCTs on mandates precisely (the Danish healthcare worker study was sort of a mandate but not exactly). I do think such studies could have been run, but no one ever did. Perhaps a better way to put it is that mask promotion and free masks had a modest impact on spread.
November 3, 2026 at 11:25 PM
You're right, there were no RCTs on mandates precisely (the Danish healthcare worker study was sort of a mandate but not exactly). I do think such studies could have been run, but no one ever did. Perhaps a better way to put it is that mask promotion and free masks had a modest impact on spread.
Read the full evidence review of 10 RCTs before changing your protocol. https://humanupgradeai.com/rhodiola-rosea-timing/?utm_source=bluesky&utm_medium=social&utm_campaign=2026-10-30-001 #RhodiolaRoseaTiming #Adaptogens #ScienceBased Not medical advice.
November 3, 2026 at 6:01 PM
Read the full evidence review of 10 RCTs before changing your protocol. https://humanupgradeai.com/rhodiola-rosea-timing/?utm_source=bluesky&utm_medium=social&utm_campaign=2026-10-30-001 #RhodiolaRoseaTiming #Adaptogens #ScienceBased Not medical advice.
We are hiring pre-doctoral fellows for 2027-28 at the SCALE Lab at @yalesph.bsky.social.
Medicaid and SNAP research embedded with the CT Dept of Social Services. RCTs, admin data, policy work.
Past predocs coauthor with us and place well
Rolling review, July start. tobin.yale.edu/opportunitie...
Medicaid and SNAP research embedded with the CT Dept of Social Services. RCTs, admin data, policy work.
Past predocs coauthor with us and place well
Rolling review, July start. tobin.yale.edu/opportunitie...
Economics of the Safety Net
tobin.yale.edu
October 28, 2026 at 9:37 PM
We are hiring pre-doctoral fellows for 2027-28 at the SCALE Lab at @yalesph.bsky.social.
Medicaid and SNAP research embedded with the CT Dept of Social Services. RCTs, admin data, policy work.
Past predocs coauthor with us and place well
Rolling review, July start. tobin.yale.edu/opportunitie...
Medicaid and SNAP research embedded with the CT Dept of Social Services. RCTs, admin data, policy work.
Past predocs coauthor with us and place well
Rolling review, July start. tobin.yale.edu/opportunitie...
One word to consider when asking for RCTs - ethics
Asking HCWs to unmask during a pandemic is probably not the best idea ever suggested.
Asking HCWs to unmask during a pandemic is probably not the best idea ever suggested.
October 29, 2026 at 11:40 AM
One word to consider when asking for RCTs - ethics
Asking HCWs to unmask during a pandemic is probably not the best idea ever suggested.
Asking HCWs to unmask during a pandemic is probably not the best idea ever suggested.
💊 β-Blockers in Hemodialysis: Does Dialyzability Matter?
Nondialyzable β-blockers were associated with fewer cardiovascular events, particularly early after HD initiation.
Promising findings, but RCTs are still needed.
#Nephrology
🔗 doi.org/10.1681/ASN....
Nondialyzable β-blockers were associated with fewer cardiovascular events, particularly early after HD initiation.
Promising findings, but RCTs are still needed.
#Nephrology
🔗 doi.org/10.1681/ASN....
November 2, 2026 at 7:41 PM
💊 β-Blockers in Hemodialysis: Does Dialyzability Matter?
Nondialyzable β-blockers were associated with fewer cardiovascular events, particularly early after HD initiation.
Promising findings, but RCTs are still needed.
#Nephrology
🔗 doi.org/10.1681/ASN....
Nondialyzable β-blockers were associated with fewer cardiovascular events, particularly early after HD initiation.
Promising findings, but RCTs are still needed.
#Nephrology
🔗 doi.org/10.1681/ASN....