Our work in collaboration with the Hadden Lab on the REV7 inhibitor and mitotic sensitization of colorectal cancer cells is now available on bioRxiv: www.biorxiv.org/content/10.6...
Targeting REV7 exposes a mitotic vulnerability in colorectal cancer cells
Therapeutic resistance remains a barrier to durable treatment of colorectal cancer (CRC), highlighting the need to identify vulnerabilities in resistant tumor cells. REV7 (MAD2L2) is a multifunctional...
www.biorxiv.org
September 30, 2026 at 10:45 PM
Our work in collaboration with the Hadden Lab on the REV7 inhibitor and mitotic sensitization of colorectal cancer cells is now available on bioRxiv: www.biorxiv.org/content/10.6...
Alright, it's finally happening!
You can now order an OpenCTD rev7 Kit and build your own oceanographic instruments, directly from Oceanography for Everyone! A phenomenal STEM project and introduction to marine and environmental science.
oceanographyforeveryone.bigcartel.com/product/open...
You can now order an OpenCTD rev7 Kit and build your own oceanographic instruments, directly from Oceanography for Everyone! A phenomenal STEM project and introduction to marine and environmental science.
oceanographyforeveryone.bigcartel.com/product/open...
OpenCTD rev7 Kit
This kit contains all of the components and most of the consumables you will need to build you own CTD. Not included are the weights needed to...
oceanographyforeveryone.bigcartel.com
February 25, 2025 at 5:15 PM
Alright, it's finally happening!
You can now order an OpenCTD rev7 Kit and build your own oceanographic instruments, directly from Oceanography for Everyone! A phenomenal STEM project and introduction to marine and environmental science.
oceanographyforeveryone.bigcartel.com/product/open...
You can now order an OpenCTD rev7 Kit and build your own oceanographic instruments, directly from Oceanography for Everyone! A phenomenal STEM project and introduction to marine and environmental science.
oceanographyforeveryone.bigcartel.com/product/open...
REV7 functions with REV3 as a checkpoint protein delaying mitotic entry until DNA replication is completed
REV7 functions with REV3 as a checkpoint protein delaying mitotic entry until DNA replication is completed
How cells ensure that they enter mitosis after completing replication of their genome is not fully resolved. Sobkowiak et al. describe a checkpoint involving REV7. This checkpoint has mechanistic similarities to the spindle anaphase checkpoint mediated by…
dlvr.it
March 19, 2025 at 12:36 PM
REV7 functions with REV3 as a checkpoint protein delaying mitotic entry until DNA replication is completed
A study by @nimratchatterjee.bsky.social et al. suggests that the combination of a multifunctional protein, REV7(MAD2L2)-targeted inhibition with mitotic disruption warrants further investigation as a therapeutic strategy for colorectal cancer (CRC) and possibly other cancer types.
Targeting REV7 exposes a mitotic vulnerability in colorectal cancer cells
Therapeutic resistance remains a barrier to durable treatment of colorectal cancer (CRC), highlighting the need to identify vulnerabilities in resistant tumor cells. REV7 (MAD2L2) is a multifunctional...
www.biorxiv.org
October 2, 2026 at 9:52 AM
A study by @nimratchatterjee.bsky.social et al. suggests that the combination of a multifunctional protein, REV7(MAD2L2)-targeted inhibition with mitotic disruption warrants further investigation as a therapeutic strategy for colorectal cancer (CRC) and possibly other cancer types.
Mixing and cutting #GlitchHop on my #Rev7 🤍
October 21, 2024 at 6:41 PM
Mixing and cutting #GlitchHop on my #Rev7 🤍
Targeting REV7 exposes a mitotic vulnerability in colorectal cancer cells https://www.biorxiv.org/content/10.64898/2026.09.29.755408v1
September 30, 2026 at 4:47 PM
Targeting REV7 exposes a mitotic vulnerability in colorectal cancer cells https://www.biorxiv.org/content/10.64898/2026.09.29.755408v1
btw I did fix this in the next rev7 batch being made right now, but it's not gonna be a separate product or anything. People will just start getting these as the other ones run out.
November 24, 2025 at 9:53 PM
btw I did fix this in the next rev7 batch being made right now, but it's not gonna be a separate product or anything. People will just start getting these as the other ones run out.
If anyone has been keen to build their own OpenCTD, we have 5 Rev7 kits back in stock and ready to ship.
oceanographyforeveryone.bigcartel.com
oceanographyforeveryone.bigcartel.com
Oceanography For Everyone
Supply Depot for the OpenCTD and Oceanography for Everyone. Here you can find custom PCBS, stickers, OpenCTD kits, and other OpenCTD accessories.
oceanographyforeveryone.bigcartel.com
September 23, 2025 at 3:37 PM
If anyone has been keen to build their own OpenCTD, we have 5 Rev7 kits back in stock and ready to ship.
oceanographyforeveryone.bigcartel.com
oceanographyforeveryone.bigcartel.com
#Sorghum develops aerial roots and (like maize) produces abundant carb-rich mucilage after rain. @rev7.bsky.social @jeanmichelane.bsky.social &co show that diazotrophic #bacteria in the aerial roots can fix nitrogen, reducing need for synthetic fertilizers 🧪 @plosbiology.org plos.io/3EYPZjK
March 4, 2025 at 2:21 PM
#Sorghum develops aerial roots and (like maize) produces abundant carb-rich mucilage after rain. @rev7.bsky.social @jeanmichelane.bsky.social &co show that diazotrophic #bacteria in the aerial roots can fix nitrogen, reducing need for synthetic fertilizers 🧪 @plosbiology.org plos.io/3EYPZjK
I have 2 OpenCTD Rev7 Kits left! I am working on getting out the final designs for Rev8, so I don't plan to restock the Rev7s.
If you've wanted to build an OpenCTD and have been waiting to jump in, this is your last chance for a while!
oceanographyforeveryone.bigcartel.com/product/open...
If you've wanted to build an OpenCTD and have been waiting to jump in, this is your last chance for a while!
oceanographyforeveryone.bigcartel.com/product/open...
OpenCTD rev7 Kit
This kit contains all of the components and most of the consumables you will need to build you own CTD. Not included are the weights needed to...
oceanographyforeveryone.bigcartel.com
January 13, 2026 at 4:35 PM
I have 2 OpenCTD Rev7 Kits left! I am working on getting out the final designs for Rev8, so I don't plan to restock the Rev7s.
If you've wanted to build an OpenCTD and have been waiting to jump in, this is your last chance for a while!
oceanographyforeveryone.bigcartel.com/product/open...
If you've wanted to build an OpenCTD and have been waiting to jump in, this is your last chance for a while!
oceanographyforeveryone.bigcartel.com/product/open...
Targeting REV7 exposes a mitotic vulnerability in colorectal cancer cells https://www.biorxiv.org/content/10.64898/2026.09.29.755408v1
September 30, 2026 at 4:47 PM
Targeting REV7 exposes a mitotic vulnerability in colorectal cancer cells https://www.biorxiv.org/content/10.64898/2026.09.29.755408v1
#Sorghum develops aerial roots and (like maize) produces abundant carb-rich mucilage after rain. @rev7.bsky.social @jeanmichelane.bsky.social &co show that diazotrophic #bacteria in the aerial roots can fix nitrogen, reducing need for synthetic fertilizers 🧪 @plosbiology.org plos.io/3EYPZjK
March 5, 2025 at 9:08 AM
#Sorghum develops aerial roots and (like maize) produces abundant carb-rich mucilage after rain. @rev7.bsky.social @jeanmichelane.bsky.social &co show that diazotrophic #bacteria in the aerial roots can fix nitrogen, reducing need for synthetic fertilizers 🧪 @plosbiology.org plos.io/3EYPZjK
Whew! I am finalizing the materials list for the new Rev8 OpenCTD, which is a massive improvement in both data quality and build complexity over the Rev7 version.
Final material cost if you want to build your own CTD: $463.57
oceanographyforeveryone.com
Final material cost if you want to build your own CTD: $463.57
oceanographyforeveryone.com
June 15, 2026 at 2:36 PM
Whew! I am finalizing the materials list for the new Rev8 OpenCTD, which is a massive improvement in both data quality and build complexity over the Rev7 version.
Final material cost if you want to build your own CTD: $463.57
oceanographyforeveryone.com
Final material cost if you want to build your own CTD: $463.57
oceanographyforeveryone.com
There is no #Bluesky algorithm.
You curate your own feeds.
Here are 2 "independent journalist" feeds to get you going while I work on my #trustedsources #starterpack.
bsky.app/profile/rev7...
and bsky.app/profile/bsch...
And sign up for my #TruthBomb zoom!
www.mobilize.us/civicsundays...
You curate your own feeds.
Here are 2 "independent journalist" feeds to get you going while I work on my #trustedsources #starterpack.
bsky.app/profile/rev7...
and bsky.app/profile/bsch...
And sign up for my #TruthBomb zoom!
www.mobilize.us/civicsundays...
CIVIC SUNDAYS -TRUTH BOMB BRIEFING WITH JOHANNA SIEGMANN · Civic Sundays
Civic Sundays LA is having a Truth Bomb Briefing, led by Johanna Siegmann, previewing a new way of communicating that meets the moment. This is a virtual event and will be held over Zoom on Wednesday...
www.mobilize.us
January 26, 2025 at 1:38 AM
There is no #Bluesky algorithm.
You curate your own feeds.
Here are 2 "independent journalist" feeds to get you going while I work on my #trustedsources #starterpack.
bsky.app/profile/rev7...
and bsky.app/profile/bsch...
And sign up for my #TruthBomb zoom!
www.mobilize.us/civicsundays...
You curate your own feeds.
Here are 2 "independent journalist" feeds to get you going while I work on my #trustedsources #starterpack.
bsky.app/profile/rev7...
and bsky.app/profile/bsch...
And sign up for my #TruthBomb zoom!
www.mobilize.us/civicsundays...
#Sorghum develops aerial roots and (like maize) produces abundant carb-rich mucilage after rain. @rev7.bsky.social @jeanmichelane.bsky.social &co show that diazotrophic #bacteria in the aerial roots can fix nitrogen, reducing need for synthetic fertilizers 🧪 @plosbiology.org plos.io/3EYPZjK
March 4, 2025 at 5:35 PM
#Sorghum develops aerial roots and (like maize) produces abundant carb-rich mucilage after rain. @rev7.bsky.social @jeanmichelane.bsky.social &co show that diazotrophic #bacteria in the aerial roots can fix nitrogen, reducing need for synthetic fertilizers 🧪 @plosbiology.org plos.io/3EYPZjK
艦これ覚書_ブルネイ周回編成アップデート_7-1.主ソ爆.rev7_20260528
増設電探できる艦が多くなったり時雨が出てきてから大分ブルネイ周回は楽になりましたが、ぶっきー改三護の実装と時雨改三が4スロになってからもっと周回しやすくなった。編成のように旗艦に睦月改二のような装甲低い艦を置いてもほぼ撤退なし。バケツも0.05以下になりほぼバケツは使わなくなった。ぶっきーは主3より主2電1の方が強い。キラ付けに旗艦レベリングにおすすめです
#艦これ
増設電探できる艦が多くなったり時雨が出てきてから大分ブルネイ周回は楽になりましたが、ぶっきー改三護の実装と時雨改三が4スロになってからもっと周回しやすくなった。編成のように旗艦に睦月改二のような装甲低い艦を置いてもほぼ撤退なし。バケツも0.05以下になりほぼバケツは使わなくなった。ぶっきーは主3より主2電1の方が強い。キラ付けに旗艦レベリングにおすすめです
#艦これ
May 28, 2026 at 12:03 PM
艦これ覚書_ブルネイ周回編成アップデート_7-1.主ソ爆.rev7_20260528
増設電探できる艦が多くなったり時雨が出てきてから大分ブルネイ周回は楽になりましたが、ぶっきー改三護の実装と時雨改三が4スロになってからもっと周回しやすくなった。編成のように旗艦に睦月改二のような装甲低い艦を置いてもほぼ撤退なし。バケツも0.05以下になりほぼバケツは使わなくなった。ぶっきーは主3より主2電1の方が強い。キラ付けに旗艦レベリングにおすすめです
#艦これ
増設電探できる艦が多くなったり時雨が出てきてから大分ブルネイ周回は楽になりましたが、ぶっきー改三護の実装と時雨改三が4スロになってからもっと周回しやすくなった。編成のように旗艦に睦月改二のような装甲低い艦を置いてもほぼ撤退なし。バケツも0.05以下になりほぼバケツは使わなくなった。ぶっきーは主3より主2電1の方が強い。キラ付けに旗艦レベリングにおすすめです
#艦これ
![screenshot of a floating terminal window displaying fastfetch output:
winter@drifter
--------------
OS: Arch Linux x86_64
Host: Reef (rev7)
Kernel: Linux 6.18.45-1-lts
Uptime: 25 mins
Packages: 1 (appimage), 6 (flatpak), 962 (pacman)
Shell: fish 4.8.1
Display (AUO145C): 1366x768 in 12", 60 Hz [Built-in]
DE: sway;wlroots
WM: Sway 1.12 (Wayland)
Cursor: Adwaita
Terminal: foot 1.27.0
Terminal Font: Maple Mono NF CN (10pt)
CPU: Intel(R) Celeron(R) N3350 (2) @ 2.40 GHz
GPU: Intel HD Graphics 500 @ 0.65 GHz [Integrated]
Memory: 2.06 GiB / 3.70 GiB (56%)
Swap: 561.94 MiB / 7.70 GiB (7%)
Disk (/): 10.78 GiB / 24.12 GiB (45%) - btrfs
Local IP (wlan0): 192.168.1.228/24
Battery (AP16K5J): 55% (5 hours, 4 mins remaining) [Discharging]
Locale: en_US.UTF-8](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:7exy3k53z33dvghn6edyayxt/bafkreiaaqmgkibhltllo5psridlrmi545xsgorckek37hjoufkzitig4wy)
i gotta give full credit to @lizardking.mpr.tf for bein the one to say hey girl put a tail on the next iteration but now capability rev7 has a tail and man it turns out the key to making lego mechs balance is to get nonhuman w it. i see why god put these things on like 99% of nature
August 2, 2026 at 4:35 AM
i gotta give full credit to @lizardking.mpr.tf for bein the one to say hey girl put a tail on the next iteration but now capability rev7 has a tail and man it turns out the key to making lego mechs balance is to get nonhuman w it. i see why god put these things on like 99% of nature
Excited to share our recent publication in collaboration with the Hadden lab, where we characterized potent REV7 inhibitors. One of them holds great promise! Kudos to Vihit and Colin for getting the many assays completed !!
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
Docking‐Based Virtual Screening Identifies a Small‐Molecule Inhibitor of the Translesion Synthesis REV7/REV3 Protein–Protein Interaction
Computational screening identified a small-molecule scaffold that inhibits REV7 protein–protein interactions. Initial structure–activity relationships were performed and compounds capable of synergiz...
chemistry-europe.onlinelibrary.wiley.com
August 21, 2026 at 12:10 PM
Excited to share our recent publication in collaboration with the Hadden lab, where we characterized potent REV7 inhibitors. One of them holds great promise! Kudos to Vihit and Colin for getting the many assays completed !!
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
This week I received a Deimos DAQ Rev7 from @deimoscontrols.bsky.social
It acquires precision measurement, here from two thermocouples, and can use these to control outputs, here a GPIO pin.
All controllable from #Rust (or python).
Thanks @ponderingpothos.bsky.social for all your help!
It acquires precision measurement, here from two thermocouples, and can use these to control outputs, here a GPIO pin.
All controllable from #Rust (or python).
Thanks @ponderingpothos.bsky.social for all your help!
August 28, 2026 at 9:51 AM
This week I received a Deimos DAQ Rev7 from @deimoscontrols.bsky.social
It acquires precision measurement, here from two thermocouples, and can use these to control outputs, here a GPIO pin.
All controllable from #Rust (or python).
Thanks @ponderingpothos.bsky.social for all your help!
It acquires precision measurement, here from two thermocouples, and can use these to control outputs, here a GPIO pin.
All controllable from #Rust (or python).
Thanks @ponderingpothos.bsky.social for all your help!
Got to try this out tonight. While I like the rev7 more, I did have fun using this for a while.
June 23, 2026 at 1:52 AM
Got to try this out tonight. While I like the rev7 more, I did have fun using this for a while.
New in the OpenCTD Store: Custom parts pack, including custom carrier board, all 3D-printed components, and some stickers.
oceanographyforeveryone.bigcartel.com/product/open...
oceanographyforeveryone.bigcartel.com/product/open...
OpenCTD Custom Parts Pack
All the custom parts needed to build the OpenCTD, including: 1. Rev7 Custom Carrier Board 2. 3D-printed OpenCTD Chassis (top) 3. 3D-printed OpenCTD...
oceanographyforeveryone.bigcartel.com
March 17, 2025 at 5:27 PM
New in the OpenCTD Store: Custom parts pack, including custom carrier board, all 3D-printed components, and some stickers.
oceanographyforeveryone.bigcartel.com/product/open...
oceanographyforeveryone.bigcartel.com/product/open...
E3-4堀編成.rev7
Wasp2隻目掘れてないけど、堀編成ここからもう変えることはないだろうと思うので晒す。ルートは2→F→A2→G→H→M→Y1→U→Y2→Y→Zの空襲1戦追加の準最短ルート編成。基地は劣勢2部隊をボスへ派遣。40周ほどしてるけど、9割S取れているからつけばほぼ勝てる。道中の空襲はアトランタと初月入れて対空CI発動100%にしてます。空母は艦戦2いれるより艦爆2入れた方がボス前もボスもいい。第二は夜戦CI艦4隻いればボスを残すことはほぼなし。米空母は中破でも動ける黒トガを採用。Iowaは連撃させるよりタッチ仕様にした方がいい。支援なしなし
#艦これ #艦これ26夏イベ
Wasp2隻目掘れてないけど、堀編成ここからもう変えることはないだろうと思うので晒す。ルートは2→F→A2→G→H→M→Y1→U→Y2→Y→Zの空襲1戦追加の準最短ルート編成。基地は劣勢2部隊をボスへ派遣。40周ほどしてるけど、9割S取れているからつけばほぼ勝てる。道中の空襲はアトランタと初月入れて対空CI発動100%にしてます。空母は艦戦2いれるより艦爆2入れた方がボス前もボスもいい。第二は夜戦CI艦4隻いればボスを残すことはほぼなし。米空母は中破でも動ける黒トガを採用。Iowaは連撃させるよりタッチ仕様にした方がいい。支援なしなし
#艦これ #艦これ26夏イベ
July 31, 2026 at 12:23 PM
