#RNAscope
For #FluorescenceFriday - RNAscope marking subfields of the hippocampus in a section of postmortem human 🧠 tissue. Image credit to the Imaging Development team @lieberinstitute.bsky.social 🔬🧪👩‍🔬
December 5, 2025 at 2:01 PM
For #FluorescenceFriday - RNAscope for TRPC4 🟣 to identify lateral septum neurons in the human 🧠. Image credit to RA Madeline Abramson 🔬👩‍🔬🧪
February 7, 2025 at 5:28 PM
Great news! Successful RNAScope run on my first try😍🤩 #neuroskyence
November 26, 2024 at 7:52 PM
It's #FluorescenceFriday, so I wanna show off the gorgeous RNAscope images from our recently published paper on the mineralocorticoid receptor in area CA2 of the hippocampus 🤩🧠🌀 full paper here --> rdcu.be/evGGh
July 11, 2025 at 5:27 PM
Trying to calm my nerves this morning looking through pretty 🔬images. Fluorescence labeling with RNAscope of tissue section in human hippocampus 🧠
January 29, 2025 at 1:25 PM
Preliminary Valentine's data from my postdoc work with @ardemp.bskyverified.social - RNAscope of Piezo2 transcript (green) and a nociceptor marker (magenta) in a mouse dorsal root ganglion 💜
February 14, 2026 at 3:08 AM
For #FluorescenceFriday - tissue section through upper pons using RNAscope to visualize norepinephrine (NE) neurons in locus coeruleus (LC) of human 🧠. Image shows LC-NE marker genes (TH 🟣 and DBH 🟡), surrounded by white matter (MBP 🟢).

Image credit to Ishbel Del Rosario and Svitlana Bach 👩‍🔬🔬🧪🔵
January 17, 2025 at 1:42 PM
nothing like bringing a new technique to the lab, RNAScope Soxx9 (red) in P40 mouse tibia.
June 26, 2025 at 10:22 PM
Congrats to Kasey and the @daylab.bsky.social team! Honored for our teams to have contributed to the project, showing conservation of enrichment of RELN in DRD1-MSNs in nucleus accumbens of human 🧠. Including an image from RNAscope experiments in that project as my #FluorescenceFriday 🔬🧪👩‍🔬
March 28, 2025 at 3:21 PM
Fluorescence Friday - combined RNAscope for GHS-R and immunoreactivity for GFAP and NEUN in the dorsal vagal complex. We are RNAscope newbies and very proud of Katherine Pye for setting this up from scratch in the lab. Apologies for wonky orientation - just run out of steam on Friday!
February 7, 2025 at 5:39 PM
For #FluorescenceFriday - image from Research Associate Kelsey Montgomery in @kr-maynard.bsky.social lab @lieberinstitute.bsky.social - RNAscope at 3 levels of the habenula in human 🧠. 🟢 is MBP, 🟣 is GPR151 (lateral habenula), 🔴 is POU4F1 (general habenula), and 🟡 is TAC3 (medial habenula) 🔬🧪👩‍🔬
August 22, 2025 at 7:15 PM
A fun #FluorescenceFriday image from our recent publication looking at markers for cocaine-activated neurons (defined by induction of the immediate early gene Fos, probed here using RNAscope) in the rat brain.
www.science.org/doi/10.1126/...
April 18, 2025 at 2:45 PM
🚨 PI in the lab alert! 🚨 I’m doing RNAscope and making the whole lab anxious by looking through drawers and freezers. 😂
April 8, 2024 at 2:07 PM
Fresh off the🔬for #FluorescenceFriday from @ishbeldelrosario.bsky.social - pretty RNAscope as part of our continued exploration of spatially-organized populations of D1R-expressing island populations in nucleus accumbens of human 🧠. Excited to be bringing some key updates to the data resources soon!
July 17, 2026 at 6:20 PM
New Skeetorial time! 🦋
A new preprint led by Dr. #MinhooKim, where we present the characterization of #mouse models of #menopause using a combination of histology, endocrine measures, single-cell #transcriptomics, and #RNAscope validation! #GeroSky 🧪🖥️🧬 A 🧵 1/9
www.biorxiv.org/content/10.1...
June 16, 2025 at 11:21 AM
#FluorescenceFriday to mark my first foray into human neuroanatomy @lieberinstitute.bsky.social 🧠 RNAscope of marker genes for the ventral tegmental area (VTA) and nucleus accumbens (Ac) in the developing human brain
March 7, 2026 at 12:10 AM
For #FluorescenceFriday, activity-trapping experiments to better understand how amphetamine controls attention. RNAscope for glutamate neurons 🟢, inhibitory neurons 🔴 and our "ensemble" 🟣. Quotes for the loaded definition ;)

Image credit to JHU neuro student Suhaas Adiraju 🧠🔬🧪
January 30, 2026 at 3:00 PM
For #FluorescentFriday, some more D1-island RNAscope from @ishbeldelrosario.bsky.social. These cells are so weird in all the best ways. Excited to share this data with everyone soon 😎🏝️
July 24, 2026 at 4:28 PM
Baby's first RNAscope! (Its me, baby!)
Hi Everyone 👋 I'm here for the (neuro)science. Happy Fluorescence Friday from the Lucas Lab! We finally have RNAscope up and running to validate our snSEQ results from the lateral septum. Image courtesy postdoc Nina Baumgartner, who got this to work on the first trial 💪
November 2, 2023 at 2:37 AM
The new issue of #ScienceSignaling is out!

A study of fruit flies shows a common gut bacterium can enhance the rewarding properties of amphetamines, researchers uncover how proteins in extracellular vesicles can offer clues to HIV blockade, and more. https://scim.ag/45Up9V6
September 9, 2025 at 9:00 PM
bekannt sind, in den kritischen Übergang von einem lediglich lästigen COVID-19-Fall zu einem potenziell tödlichen Fall einbezogen. Interstitielle Makrophagen befinden sich tief in der Lunge und schützen dieses kostbare Organ normalerweise unter anderem dadurch, dass sie Viren,
April 12, 2024 at 9:28 AM
I will never tire of looking at these clusters of DRD1🔴/RXFP1🟡/OPRM1🟣 cells - here showing RNAscope in nucleus accumbens of human 🧠. Patterning of them is so neat!
April 23, 2025 at 7:00 PM
#FluorescenceFriday 🔬 Excited to share this RNAscope staining of TRPV1 and KCNS1 in human DRG, with DAPI marking nuclei. Human DRG are an incredible resource for understanding pain mechanisms—and we’re lucky to have access to this amazing ressource! 🧠✨ #PainResearch #Neuroscience
November 22, 2024 at 2:26 PM
For #FluorescenceFriday, some really pretty RNAscope labeling for neuropeptides localized to inhibitory neurons in the medial prefrontal cortex of the mouse 🧠. Image credit to PhD student Aaron Salisbury in the JHU Neuroscience Training Program 🔬🧪🤩
April 11, 2025 at 4:26 PM
👀 - me watching project channels on Slack on Fridays for #FluorescenceFriday contributions... literally fresh off the scope from JHU undergrad Mahima Sanghera, @ishbeldelrosario.bsky.social and @svitlanabach.bsky.social some dorsal raphe in human 🧠 labeling 5HT neurons - 🟣TPH2 and 🟡 SLC6A4
August 7, 2026 at 5:24 PM