Latest endosomal publication with @brettcollins.bsky.social: Rebeka Butkovic's beautiful work identifying a new Commander assembly, the RAB32-LRMDA-Commander, and its role in melanosome biogenesis. Reveals molecular mechanism of human oculocutaneous albinism type 7. www.nature.com/articles/s41...
Identification of a RAB32-LRMDA-Commander membrane trafficking complex reveals the molecular mechanism of human oculocutaneous albinism type 7
Nature Communications - Membrane trafficking is essential for organelle biogenesis. Here, the authors discover an alternative assembly of the Commander trafficking complex and show its role in...
www.nature.com
October 2, 2025 at 10:30 AM
Latest endosomal publication with @brettcollins.bsky.social: Rebeka Butkovic's beautiful work identifying a new Commander assembly, the RAB32-LRMDA-Commander, and its role in melanosome biogenesis. Reveals molecular mechanism of human oculocutaneous albinism type 7. www.nature.com/articles/s41...
New PD genes session at #ParkinsonsGordonConference included #Rab32 #G6PD #PSMF1 & LRRK2/pRab12 in GVB formation
June 11, 2025 at 5:08 AM
New PD genes session at #ParkinsonsGordonConference included #Rab32 #G6PD #PSMF1 & LRRK2/pRab12 in GVB formation
www.biorxiv.org/content/10.6...
Rab32/Rab38-positive Lysosome-Related Organelle degrades lipid droplet in hepatocytes by microautophagy
Rab32/Rab38-positive Lysosome-Related Organelle degrades lipid droplet in hepatocytes by microautophagy
www.biorxiv.org
February 17, 2026 at 12:54 PM
www.biorxiv.org/content/10.6...
Rab32/Rab38-positive Lysosome-Related Organelle degrades lipid droplet in hepatocytes by microautophagy
Rab32/Rab38-positive Lysosome-Related Organelle degrades lipid droplet in hepatocytes by microautophagy
🧪 A study in The Lancet Neurology found a RAB32 gene mutation over 100 times more common in Parkinson's patients than in the general population.
Notably, 78% of those affected were women. 🩺 🧬🖥️
Notably, 78% of those affected were women. 🩺 🧬🖥️
ROPAD data support RAB32 gene mutation's link to Parkinson's
The link between a RAB32 gene mutation and Parkinson's disease was corroborated in a recent study analyzing global ROPAD study data.
parkinsonsnewstoday.com
September 30, 2024 at 5:36 PM
🧪 A study in The Lancet Neurology found a RAB32 gene mutation over 100 times more common in Parkinson's patients than in the general population.
Notably, 78% of those affected were women. 🩺 🧬🖥️
Notably, 78% of those affected were women. 🩺 🧬🖥️
Deep phenotyping of the RAB32 p.Ser71Arg variant in 11 cases of monogenic #Parkinsons "underscores the importance of carefully assessing non-motor symptoms in this newly described form of PD"
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
October 18, 2025 at 7:43 PM
Deep phenotyping of the RAB32 p.Ser71Arg variant in 11 cases of monogenic #Parkinsons "underscores the importance of carefully assessing non-motor symptoms in this newly described form of PD"
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
Identification of a RAB32-LRMDA-Commander membrane trafficking complex reveals the molecular mechanism of human oculocutaneous albinism type 7 https://www.biorxiv.org/content/10.1101/2025.02.04.636395v1
February 4, 2025 at 4:30 PM
Identification of a RAB32-LRMDA-Commander membrane trafficking complex reveals the molecular mechanism of human oculocutaneous albinism type 7 https://www.biorxiv.org/content/10.1101/2025.02.04.636395v1
Identification of a RAB32-LRMDA-Commander membrane trafficking complex reveals the molecular mechanism of human oculocutaneous albinism type 7 https://www.biorxiv.org/content/10.1101/2025.02.04.636395v1
February 4, 2025 at 4:30 PM
Identification of a RAB32-LRMDA-Commander membrane trafficking complex reveals the molecular mechanism of human oculocutaneous albinism type 7 https://www.biorxiv.org/content/10.1101/2025.02.04.636395v1
Identification of a RAB32-LRMDA-Commander membrane trafficking complex reveals the molecular mechanism of human oculocutaneous albinism type 7
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Identification of a RAB32-LRMDA-Commander membrane trafficking complex reveals the molecular mechanism of human oculocutaneous albinism type 7 - Nature Communications
Membrane trafficking is essential for organelle biogenesis. Here, the authors discover an alternative assembly of the Commander trafficking complex and show its role in melanosome biogenesis and in a subtype of albinism.
www.nature.com
October 2, 2025 at 2:10 PM
Identification of a RAB32-LRMDA-Commander membrane trafficking complex reveals the molecular mechanism of human oculocutaneous albinism type 7
www.nature.com/articles/s41...
www.nature.com/articles/s41...
MDS Young Member Group highlight:
New study provides the first evidence for misfolded α-synuclein pathology in PARK-RAB32. https://loom.ly/nd5BtAU
New study provides the first evidence for misfolded α-synuclein pathology in PARK-RAB32. https://loom.ly/nd5BtAU
RAB32-linked Parkinson's disease: Deep phenotyping, MDSGene literature review, and application of SynNeurGe criteria
Study provides the first evidence for misfolded α-synuclein pathology in PARK-RAB32.
www.movementdisorders.org
April 18, 2026 at 1:02 PM
MDS Young Member Group highlight:
New study provides the first evidence for misfolded α-synuclein pathology in PARK-RAB32. https://loom.ly/nd5BtAU
New study provides the first evidence for misfolded α-synuclein pathology in PARK-RAB32. https://loom.ly/nd5BtAU
Peripheral inflammation mediates midbrain Lrrk2 kinase activity via Rab32 expression https://www.biorxiv.org/content/10.1101/2025.09.05.674552v1
September 7, 2025 at 6:30 AM
Peripheral inflammation mediates midbrain Lrrk2 kinase activity via Rab32 expression https://www.biorxiv.org/content/10.1101/2025.09.05.674552v1
Rab32/Rab38-positive Lysosome-Related Organelle degrades lipid droplet in hepatocytes by microautophagy https://www.biorxiv.org/content/10.64898/2026.02.13.705687v1
February 16, 2026 at 2:30 PM
Rab32/Rab38-positive Lysosome-Related Organelle degrades lipid droplet in hepatocytes by microautophagy https://www.biorxiv.org/content/10.64898/2026.02.13.705687v1
The Rab32-LRMDA-Retriever Complex is a Key Regulator of Intestinal Immune Homeostasis https://www.biorxiv.org/content/10.1101/2025.07.16.665158v1
July 21, 2025 at 3:17 PM
The Rab32-LRMDA-Retriever Complex is a Key Regulator of Intestinal Immune Homeostasis https://www.biorxiv.org/content/10.1101/2025.07.16.665158v1
Parkinson hastalığı için yeni keşfedilen RAB32 Ser71Arg adlı genetik mutasyon üç ailede Parkinsonizm ile ilişkilendirilmiş ve 9 ülkede 13 kişide daha bulunmuş. Daha önce hastalığın farklı formlarıyla ilişkilendirilen birkaç proteinle etkileşime giriyormuş.
theconversation.com/newly-discov...
theconversation.com/newly-discov...
April 11, 2024 at 8:05 AM
Parkinson hastalığı için yeni keşfedilen RAB32 Ser71Arg adlı genetik mutasyon üç ailede Parkinsonizm ile ilişkilendirilmiş ve 9 ülkede 13 kişide daha bulunmuş. Daha önce hastalığın farklı formlarıyla ilişkilendirilen birkaç proteinle etkileşime giriyormuş.
theconversation.com/newly-discov...
theconversation.com/newly-discov...
The Rab32-LRMDA-Retriever Complex is a Key Regulator of Intestinal Immune Homeostasis https://www.biorxiv.org/content/10.1101/2025.07.16.665158v1
July 21, 2025 at 3:17 PM
The Rab32-LRMDA-Retriever Complex is a Key Regulator of Intestinal Immune Homeostasis https://www.biorxiv.org/content/10.1101/2025.07.16.665158v1
Tenemos una nueva pista en la lucha contra el Parkinsin: la mutación RAB32 Ser71Arg
https://www.xataka.com/medicina-y-salud/tenemos-nueva-pista-lucha-parkinsin-mutacion-rab32-ser71arg
https://www.xataka.com/medicina-y-salud/tenemos-nueva-pista-lucha-parkinsin-mutacion-rab32-ser71arg
Tenemos una nueva pista en la lucha contra el Parkinsin: la mutación RAB32 Ser71Arg
Las enfermedades neurodegenerativas como el Parkinson y el Alzheimer suponen un doble reto para los expertos. Por una parte por su influencia creciente sobre...
www.xataka.com
April 17, 2024 at 3:10 PM
Tenemos una nueva pista en la lucha contra el Parkinsin: la mutación RAB32 Ser71Arg
https://www.xataka.com/medicina-y-salud/tenemos-nueva-pista-lucha-parkinsin-mutacion-rab32-ser71arg
https://www.xataka.com/medicina-y-salud/tenemos-nueva-pista-lucha-parkinsin-mutacion-rab32-ser71arg
@proteintech.bsky.social's resource, RRID:AB_2107436, was just reported to be used in the paper. Thanks for making your methods matter! #ReproducibleResearch #OpenResearch #STMpublishing
Targeting UGCG sensitizes AML cells to venetoclax through RAB32-mediated endoplasmic reticulum-mitochondria communication
Read the full paper: Targeting UGCG sensitizes AML cells to venetoclax through RAB32-mediated endoplasmic reticulum-mitochondria communication
doi.org
February 26, 2026 at 7:54 PM
@proteintech.bsky.social's resource, RRID:AB_2107436, was just reported to be used in the paper. Thanks for making your methods matter! #ReproducibleResearch #OpenResearch #STMpublishing
Targeting UGCG sensitizes AML cells to venetoclax through RAB32-mediated endoplasmic reticulum-mitochondria communication
Targeting UGCG sensitizes AML cells to venetoclax through RAB32-mediated endoplasmic reticulum-mitochondria communication
Sun et al. demonstrate that targeting UGCG in combination with venetoclax is an alternative combinatory strategy to treat AML and provide insights for ceramide-mediated cell death in anti-cancer therapies.
dlvr.it
March 13, 2026 at 12:35 PM
Targeting UGCG sensitizes AML cells to venetoclax through RAB32-mediated endoplasmic reticulum-mitochondria communication
The Rab32 small GTPase is required for efficient cross-priming of CD8+ T cellsagainst cell-associated antigens by XCR1+ type 1 DCs in vivo. https://www.biorxiv.org/content/10.1101/2025.05.03.652057v1
May 9, 2025 at 4:15 AM
The Rab32 small GTPase is required for efficient cross-priming of CD8+ T cellsagainst cell-associated antigens by XCR1+ type 1 DCs in vivo. https://www.biorxiv.org/content/10.1101/2025.05.03.652057v1
The Rab32 small GTPase is required for efficient cross-priming of CD8+ T cellsagainst cell-associated antigens by XCR1+ type 1 DCs in vivo. https://www.biorxiv.org/content/10.1101/2025.05.03.652057v1
May 9, 2025 at 4:15 AM
The Rab32 small GTPase is required for efficient cross-priming of CD8+ T cellsagainst cell-associated antigens by XCR1+ type 1 DCs in vivo. https://www.biorxiv.org/content/10.1101/2025.05.03.652057v1
Kingman,AZ (IGM) ASOS reports gust of 50 knots (57.5 mph) from SSW @ 2225Z -- KIGM 232236Z AUTO 20032G46KT 1SM -TSRA FEW004 BKN100 BKN120 28/16 A3002 RMK AO2 PK WND 19050/2225 VIS 1/4V5 RAB32 TSB08E24B28 P0000 T02830156
August 23, 2025 at 10:39 PM
Kingman,AZ (IGM) ASOS reports gust of 50 knots (57.5 mph) from SSW @ 2225Z -- KIGM 232236Z AUTO 20032G46KT 1SM -TSRA FEW004 BKN100 BKN120 28/16 A3002 RMK AO2 PK WND 19050/2225 VIS 1/4V5 RAB32 TSB08E24B28 P0000 T02830156
RRID:AB_2223815 was used by @proteintech.bsky.social in their International Immunopharmacology paper. RRIDs improve reproducibility in scientific research. #reproducibility #RRID #accelerateopenscience
Rab32 protects mitochondrial function by anchoring Fancd2 and mediates the protective effect of penehyclidine hydrochloride against myocardial ischemia-reperfusion injury
doi.org
May 25, 2025 at 7:00 AM
RRID:AB_2223815 was used by @proteintech.bsky.social in their International Immunopharmacology paper. RRIDs improve reproducibility in scientific research. #reproducibility #RRID #accelerateopenscience
According to SynNeurGe criteria, the latest MDSGene literature review found that the PARK-RAB32 form of PD can be classified as S+ (evidence of synucleinopathy), N+ (neurodegeneration supported by imaging data), and GP+ (presence of a genetic variant).
https://loom.ly/RWajhfA
https://loom.ly/RWajhfA
October 28, 2025 at 8:55 PM
According to SynNeurGe criteria, the latest MDSGene literature review found that the PARK-RAB32 form of PD can be classified as S+ (evidence of synucleinopathy), N+ (neurodegeneration supported by imaging data), and GP+ (presence of a genetic variant).
https://loom.ly/RWajhfA
https://loom.ly/RWajhfA
Philadelphia Intl,PA (PHL) ASOS reports gust of 54 knots (62.1 mph) from N @ 2138Z -- KPHL 252154Z 33009G17KT 7SM -TSRA SCT016 BKN048 BKN060CB BKN250 28/22 A2994 RMK AO2 PK WND 35054/2138 RAB32 TSB22 SLP139 FRQ LTGIC OHD TS OHD MOV SE P0034 T02830217 $
July 25, 2025 at 9:58 PM
Philadelphia Intl,PA (PHL) ASOS reports gust of 54 knots (62.1 mph) from N @ 2138Z -- KPHL 252154Z 33009G17KT 7SM -TSRA SCT016 BKN048 BKN060CB BKN250 28/22 A2994 RMK AO2 PK WND 35054/2138 RAB32 TSB22 SLP139 FRQ LTGIC OHD TS OHD MOV SE P0034 T02830217 $
Philadelphia Intl,PA (PHL) ASOS reports gust of 54 knots (62.1 mph) from WNW @ 2140Z -- KPHL 252140Z 29014G54KT 250V330 3/4SM +TSRA FEW022 SCT050CB BKN070 BKN250 27/23 A2995 RMK AO2 PK WND 35054/2138 RAB32 TSB22 PRESRR FRQ LTGIC OHD TS OHD MOV SE P0000 T02670228 RVRNO $
July 25, 2025 at 9:43 PM
Philadelphia Intl,PA (PHL) ASOS reports gust of 54 knots (62.1 mph) from WNW @ 2140Z -- KPHL 252140Z 29014G54KT 250V330 3/4SM +TSRA FEW022 SCT050CB BKN070 BKN250 27/23 A2995 RMK AO2 PK WND 35054/2138 RAB32 TSB22 PRESRR FRQ LTGIC OHD TS OHD MOV SE P0000 T02670228 RVRNO $
Rab32 regulates Golgi structure and cell migration through Protein Kinase A–mediated phosphorylation of Optineurin | PNAS www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
April 23, 2025 at 2:14 PM
Rab32 regulates Golgi structure and cell migration through Protein Kinase A–mediated phosphorylation of Optineurin | PNAS www.pnas.org/doi/10.1073/...