New preprint out today! [1/5] Can higher recombination rates help populations adapt more quickly to environmental change? We used forward-time simulations to find out. www.biorxiv.org/content/10.6...
Recombination accelerates adaptation across genetic architectures and demographic histories
According to classic population genetics theory, recombination shapes the efficacy of natural selection. However, whether variation in recombination rate itself translates into meaningful differences ...
www.biorxiv.org
September 24, 2026 at 7:08 PM
New preprint out today! [1/5] Can higher recombination rates help populations adapt more quickly to environmental change? We used forward-time simulations to find out. www.biorxiv.org/content/10.6...
Delighted to publish my new molecular animation:
DNA Break Repair by Homologous Recombination
youtu.be/Xe-83tBcxhs
DNA Break Repair by Homologous Recombination
youtu.be/Xe-83tBcxhs
DNA Break Repair by Homologous Recombination (2024) Drew Berry wehi.tv
YouTube video by WEHImovies
youtu.be
December 4, 2024 at 12:07 AM
Delighted to publish my new molecular animation:
DNA Break Repair by Homologous Recombination
youtu.be/Xe-83tBcxhs
DNA Break Repair by Homologous Recombination
youtu.be/Xe-83tBcxhs
Recombination helps evolution—but it can also cause mutations. New theory shows that even small increases in mutation near crossovers can oppose the evolution of higher recombination rates. By @sarperotto.bsky.social and Bret Payseur academic.oup.com/evlett/advan...
Elevated mutation near crossovers inhibits the evolution of recombination
Abstract. Recombination diversifies offspring genomes and helps ensure chromosome segregation during meiosis. Mutation rates are elevated near crossovers d
academic.oup.com
August 31, 2026 at 4:32 PM
Recombination helps evolution—but it can also cause mutations. New theory shows that even small increases in mutation near crossovers can oppose the evolution of higher recombination rates. By @sarperotto.bsky.social and Bret Payseur academic.oup.com/evlett/advan...
got my concluding slide on challenges with estimating ancestral recombination graphs ready for PEQG
June 7, 2026 at 6:25 PM
got my concluding slide on challenges with estimating ancestral recombination graphs ready for PEQG
This isn't even scientifically accurate. They are testing for SRY because even XX cis women can have it due to rare recombination of it from the Y to the X. These people don't even know the science.
July 31, 2025 at 1:53 PM
This isn't even scientifically accurate. They are testing for SRY because even XX cis women can have it due to rare recombination of it from the Y to the X. These people don't even know the science.
Recombination accelerates adaptation across genetic architectures and demographic histories https://www.biorxiv.org/content/10.64898/2026.09.23.753908v1
September 24, 2026 at 12:32 PM
Recombination accelerates adaptation across genetic architectures and demographic histories https://www.biorxiv.org/content/10.64898/2026.09.23.753908v1
New paper with Sarthak Mishra! Maybe it will bring you some joy given all this (waves arms around).
"Estimating recombination using only the allele frequency spectrum"
1/2
www.biorxiv.org/content/10.1...
"Estimating recombination using only the allele frequency spectrum"
1/2
www.biorxiv.org/content/10.1...
Estimating recombination using only the allele frequency spectrum
Standard methods for estimating the population recombination parameter, rho, are dependent on sampling individual genotypes and calculating various types of disequilibria. However, recent machine lear...
www.biorxiv.org
February 6, 2025 at 4:29 PM
New paper with Sarthak Mishra! Maybe it will bring you some joy given all this (waves arms around).
"Estimating recombination using only the allele frequency spectrum"
1/2
www.biorxiv.org/content/10.1...
"Estimating recombination using only the allele frequency spectrum"
1/2
www.biorxiv.org/content/10.1...
June 6, 2025 at 6:33 PM
My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social
DNA2 enables growth by restricting recombination-restarted replication - Nature
DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...
www.nature.com
September 3, 2025 at 3:59 PM
My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social
Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments
Homologous recombination (HR) deficiency upon Breast Cancer Gene 2 (BRCA2) loss arises from defects in the formation of RAD51 nucleoprotein filaments. We demonstrate that loss of the anti-recombinase ...
www.science.org
October 30, 2025 at 9:52 PM
Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Why do sex chromosomes stop recombining? New models show even weak sexual antagonism can strongly drive recombination suppression, with mating systems shaping the outcome. By @ewanflintham.bsky.social and @charlesmullon.bsky.social doi.org/10.1093/evle...
Sexual antagonism, mating systems, and recombination suppression on sex chromosomes
Abstract. The suppression of recombination between sex chromosomes is a widespread feature of genetic sex determination systems. Competing explanations for
doi.org
May 25, 2026 at 1:47 PM
Why do sex chromosomes stop recombining? New models show even weak sexual antagonism can strongly drive recombination suppression, with mating systems shaping the outcome. By @ewanflintham.bsky.social and @charlesmullon.bsky.social doi.org/10.1093/evle...
📣Our paper is out! 🤩 We found that local modification of H3K9me3 using CRISPR/dCas9 at hotspots changes crossover activity, bringing us closer to targeted recombination in plants.🌱
Huge thanks to @szymanskalejman.bsky.social, Wojtek, Ania, and Karolina!
www.science.org/doi/10.1126/...
Huge thanks to @szymanskalejman.bsky.social, Wojtek, Ania, and Karolina!
www.science.org/doi/10.1126/...
Modifying meiotic recombination by targeting chromatin regulators to crossover hotspots in Arabidopsis
Targeting chromatin modifiers to DNA hotspots reveals causal link between histone marks, transcription, and meiotic recombination.
www.science.org
March 13, 2026 at 8:47 PM
📣Our paper is out! 🤩 We found that local modification of H3K9me3 using CRISPR/dCas9 at hotspots changes crossover activity, bringing us closer to targeted recombination in plants.🌱
Huge thanks to @szymanskalejman.bsky.social, Wojtek, Ania, and Karolina!
www.science.org/doi/10.1126/...
Huge thanks to @szymanskalejman.bsky.social, Wojtek, Ania, and Karolina!
www.science.org/doi/10.1126/...
Nature research paper: An ancient recombination desert is a speciation supergene in placental mammals
go.nature.com/47UiBWa
go.nature.com/47UiBWa
An ancient recombination desert is a speciation supergene in placental mammals - Nature
Deep learning methods identified a large and evolutionarily conserved X-linked low recombination region in placental mammals that serves as both a barrier to gene flow in hybridizing lineages and an accurate phylogenomic marker.
go.nature.com
November 14, 2025 at 2:03 PM
Nature research paper: An ancient recombination desert is a speciation supergene in placental mammals
go.nature.com/47UiBWa
go.nature.com/47UiBWa
Genetics of recombination rate variation within and between species
Bret Payseur
academic.oup.com/jeb/advance-...
Bret Payseur
academic.oup.com/jeb/advance-...
Genetics of recombination rate variation within and between species
Abstract. Recombination diversifies the genomes of offspring, influences the evolutionary dynamics of populations, and ensures that chromosomes segregate p
academic.oup.com
January 31, 2025 at 5:03 PM
Genetics of recombination rate variation within and between species
Bret Payseur
academic.oup.com/jeb/advance-...
Bret Payseur
academic.oup.com/jeb/advance-...
The contribution of natural transformation for the acquisition of novel genes has been notoriously difficult to quantify because it relies on recombination (which is affected by other processes). Here's a first estimate : doi.org/10.1101/2025... (for the very busy: 1-6% of gene gains) #MicroSky
January 27, 2025 at 1:11 PM
The contribution of natural transformation for the acquisition of novel genes has been notoriously difficult to quantify because it relies on recombination (which is affected by other processes). Here's a first estimate : doi.org/10.1101/2025... (for the very busy: 1-6% of gene gains) #MicroSky
Transcription and recombination are two universal DNA-dependent processes, but how they are coordinated remains largely unknown. Here we characterized transcription-recombination priority rules in yeast. 🧵 www.embopress.org/doi/full/10....
August 27, 2025 at 12:00 PM
Transcription and recombination are two universal DNA-dependent processes, but how they are coordinated remains largely unknown. Here we characterized transcription-recombination priority rules in yeast. 🧵 www.embopress.org/doi/full/10....
1/Delighted to announce the newest paper from our lab, “Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage”, is out today in @naturecellbiology.bsky.social, www.nature.com/articles/s41....
Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage - Nature Cell Biology
Szmyd et al. show that DNA repair pathways impact whether cells with DNA lesions arrest in mitosis. The formation of homologous recombination-driven double Holliday junctions elicits mitotic cell deat...
www.nature.com
January 13, 2025 at 10:12 AM
1/Delighted to announce the newest paper from our lab, “Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage”, is out today in @naturecellbiology.bsky.social, www.nature.com/articles/s41....
We are excited to share our recent work on the surprising robustness of Ancestral Recombination Graph (ARG) inference tools to computational phasing errors, now available on BioRxiv: biorxiv.org/content/10.1....
This work is co-advised by @yundeng.bsky.social and Rasmus Nielsen.
1/7
This work is co-advised by @yundeng.bsky.social and Rasmus Nielsen.
1/7
Robustness of Ancestral Recombination Graph Inference Tools to Phasing Errors
Ancestral Recombination Graphs (ARGs) are fundamental population genetic structures that encode the genealogical history of a sample of haplotypes along the genome. They have recently received substan...
biorxiv.org
November 26, 2025 at 5:09 PM
We are excited to share our recent work on the surprising robustness of Ancestral Recombination Graph (ARG) inference tools to computational phasing errors, now available on BioRxiv: biorxiv.org/content/10.1....
This work is co-advised by @yundeng.bsky.social and Rasmus Nielsen.
1/7
This work is co-advised by @yundeng.bsky.social and Rasmus Nielsen.
1/7
Another Pathogenic Experiment (Recombination), I have to say cocoon = OP
youtu.be/aCW02X78uJM
#skytuber #youtuber
youtu.be/aCW02X78uJM
#skytuber #youtuber
I Survived the Recombination Experiment Using ONLY a Cocoon! | Pathogenic
YouTube video by TMOA
youtu.be
September 24, 2026 at 2:53 PM
Another Pathogenic Experiment (Recombination), I have to say cocoon = OP
youtu.be/aCW02X78uJM
#skytuber #youtuber
youtu.be/aCW02X78uJM
#skytuber #youtuber
Pregnancy loss is common in humans, and chromosomal abnormalities are the leading cause. Using genetic data from ~140,000 IVF embryos, we show that maternal variation in meiosis genes influences recombination and aneuploidy risk.
First authors: @saracarioscia.bsky.social & @aabiddanda.github.io
First authors: @saracarioscia.bsky.social & @aabiddanda.github.io
Common variation in meiosis genes shapes human recombination and aneuploidy - Nature
Analysis of data from pre-implantation genetic testing sheds light on the genetic basis of meiotic-origin aneuploidy, the leading cause of human pregnancy loss, identifying common genetic variants ass...
www.nature.com
January 21, 2026 at 9:14 PM
Pregnancy loss is common in humans, and chromosomal abnormalities are the leading cause. Using genetic data from ~140,000 IVF embryos, we show that maternal variation in meiosis genes influences recombination and aneuploidy risk.
First authors: @saracarioscia.bsky.social & @aabiddanda.github.io
First authors: @saracarioscia.bsky.social & @aabiddanda.github.io
Нарисовал набросоком рандомного нефора и вышло неплохо
Полноценки будут честно😭
#art #sketch #OC #nefor #recombination
Полноценки будут честно😭
#art #sketch #OC #nefor #recombination
February 13, 2025 at 3:27 AM
Нарисовал набросоком рандомного нефора и вышло неплохо
Полноценки будут честно😭
#art #sketch #OC #nefor #recombination
Полноценки будут честно😭
#art #sketch #OC #nefor #recombination
Recombination of genetic material between viral strains can result in new, highly transmissible influenza variants. Such viruses may emerge from hosts like pigs and infect new species with little to no immunity, raising the risk of outbreaks or pandemics.
December 25, 2024 at 5:56 PM
Recombination of genetic material between viral strains can result in new, highly transmissible influenza variants. Such viruses may emerge from hosts like pigs and infect new species with little to no immunity, raising the risk of outbreaks or pandemics.
the arknights episode titles "Partial Necrosis" and "Dissociative Recombination" are also the two kinds of embodiments of how modern Capital manifests
September 16, 2025 at 2:41 PM
the arknights episode titles "Partial Necrosis" and "Dissociative Recombination" are also the two kinds of embodiments of how modern Capital manifests
This Sheffield label as some strong releases you should check out.
Recombination, by Scape One
6 track album
buff.ly
January 22, 2025 at 8:00 PM
This Sheffield label as some strong releases you should check out.