#RedoxBiol
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haoyin.bsky.social
Lung #Pericyte #Ferroptosis #Sepsis

A pro-ferroptotic axis
#YAP ACSL4 ⏫PUFA esterification ⏫Phospholipids for #LipidPeroxidation

1⃣Fer-1
2⃣Pericyte Acsl4 KO
3⃣NG2/CD13-targeting LNP to deliver ad-shACSL4
⏬🫁 pericyte loss
⏫Survival
in CLP septic🐭

#RedoxBiol 2024
www.sciencedirect.com/science/arti...
December 13, 2024 at 1:22 PM
haoyin.bsky.social
#EndothelialCell #MerTK #Efferocytosis #Atherosclerosis

EC MerTK KO🐭+ AAV8-PCSK9 + #HighFatDiet 2-mo
👉⏫lesion burden
👉⏫NADPH oxidase
👉⏫inflamm cytokines

Aortic Arch lesion #Proteomics➡️
⏫TGFβ HIF1α Wnt3a IL2
⏬LARP1 NAMPT TEAD1

Zufeng Ding lab #RedoxBiol 2025
www.sciencedirect.com/science/arti...
November 28, 2025 at 12:24 PM
realbiomassspec.bsky.social
Rapid quantitation of NAD+/NADH and NADPH/NADP+ with mass spectrometry by using calibration constants #RedoxBiol www.sciencedirect.com/science/arti...
Rapid quantitation of NAD+/NADH and NADPH/NADP+ with mass spectrometry by using calibration constants
NAD+/NADH and NADPH/NADP+ are important indicators of cellular redox status, but they cannot be reliably calculated from the relative intensities of m…
www.sciencedirect.com
December 14, 2025 at 6:47 PM
realbiomassspec.bsky.social
Multi-tissue metabolomics reveal mtDNA- and diet-specific metabolite profiles in a mouse model of cardiometabolic disease #RedoxBiol #MassSpec www.sciencedirect.com/science/arti...
Multi-tissue metabolomics reveal mtDNA- and diet-specific metabolite profiles in a mouse model of cardiometabolic disease
Excess consumption of sugar- and fat-rich foods has heightened the prevalence of cardiometabolic disease, which remains a driver of cardiovascular dis…
www.sciencedirect.com
February 22, 2025 at 8:38 AM
realbiomassspec.bsky.social
Quantitative analysis of the proteome and protein oxidative modifications in primary human coronary artery endothelial cells and associated extracellular matrix #RedoxBiol #MassSpec www.sciencedirect.com/science/arti...
Quantitative analysis of the proteome and protein oxidative modifications in primary human coronary artery endothelial cells and associated extracellular matrix
Vascular endothelial cells (ECs) play a key role in physiology by controlling arterial contraction and relaxation, and molecular transport. EC dysfunc…
www.sciencedirect.com
February 16, 2025 at 9:19 AM
realbiomassspec.bsky.social
Quantitative mapping of methionine sensitivity to oxidation in the copper-bound PcuC chaperone #RedoxBiol #MassSpec www.sciencedirect.com/science/arti...
Quantitative mapping of methionine sensitivity to oxidation in the copper-bound PcuC chaperone
Copper is typically coordinated by histidine, cysteine, or methionine in proteins, and these residues are particularly sensitive to oxidation. However…
www.sciencedirect.com
January 25, 2026 at 1:25 PM
realbiomassspec.bsky.social
Mapping the oxidative stress metabolome in neurology by gas chromatography–mass spectrometry: a systematic review on signature-driven diagnosis and disease monitoring #RedoxBiol www.sciencedirect.com/science/arti...
Mapping the oxidative stress metabolome in neurology by gas chromatography–mass spectrometry: a systematic review on signature-driven diagnosis and disease monitoring
Oxidative stress is a pivotal factor in the pathogenesis of neurological conditions; however, its clinical assessment is constrained by the ephemeral …
www.sciencedirect.com
November 20, 2025 at 7:34 PM
realbiomassspec.bsky.social
Ether lipids and sphingolipids drive sex-specific human aging dynamics #RedoxBiol #MassSpec www.sciencedirect.com/science/arti...
Ether lipids and sphingolipids drive sex-specific human aging dynamics
Aging is a dynamic process characterized by complex molecular changes, including shifts in lipid metabolism. To systematically define lipidome dynamic…
www.sciencedirect.com
July 26, 2025 at 4:36 AM
realbiomassspec.bsky.social
A high-resolution N-glycoproteome landscape of aging mouse ovary #RedoxBiol #MassSpec www.sciencedirect.com/science/arti...
A high-resolution N-glycoproteome landscape of aging mouse ovary
Ovarian aging typically precedes the decline of other organ systems, yet its molecular mechanisms remain poorly understood. Glycosylation as one of th…
www.sciencedirect.com
March 13, 2025 at 11:37 AM
realbiomassspec.bsky.social
Dehydroascorbic acid quantification in human plasma: Simultaneous direct measurement of the ascorbic acid/dehydroascorbic acid couple by UPLC/MS-MS #RedoxBiol www.sciencedirect.com/science/arti...
Dehydroascorbic acid quantification in human plasma: Simultaneous direct measurement of the ascorbic acid/dehydroascorbic acid couple by UPLC/MS-MS
Ascorbic acid (AA, vitamin C) and dehydroascorbic acid (DHA) constitute a biological couple. No technique can accurately, independently, and simultane…
www.sciencedirect.com
November 27, 2024 at 7:18 PM