#ArterioVenousMalformation
Angiopoietin-2
In🐭AVM by induced #EndothelialCell BRAF V600E transgene➡️
Capillary #EndothelialCell Angpt2⏫
Pericyte coverage⏬ & gain α-SMA
Angpt2 Ab⏬AVM formation, vascular leakage, pericyte wrapping, EC junctions
#Angiogenesis 2024
link.springer.com/article/10.1...
Angiopoietin-2
In🐭AVM by induced #EndothelialCell BRAF V600E transgene➡️
Capillary #EndothelialCell Angpt2⏫
Pericyte coverage⏬ & gain α-SMA
Angpt2 Ab⏬AVM formation, vascular leakage, pericyte wrapping, EC junctions
#Angiogenesis 2024
link.springer.com/article/10.1...
February 5, 2025 at 8:18 PM
#ArterioVenousMalformation
Angiopoietin-2
In🐭AVM by induced #EndothelialCell BRAF V600E transgene➡️
Capillary #EndothelialCell Angpt2⏫
Pericyte coverage⏬ & gain α-SMA
Angpt2 Ab⏬AVM formation, vascular leakage, pericyte wrapping, EC junctions
#Angiogenesis 2024
link.springer.com/article/10.1...
Angiopoietin-2
In🐭AVM by induced #EndothelialCell BRAF V600E transgene➡️
Capillary #EndothelialCell Angpt2⏫
Pericyte coverage⏬ & gain α-SMA
Angpt2 Ab⏬AVM formation, vascular leakage, pericyte wrapping, EC junctions
#Angiogenesis 2024
link.springer.com/article/10.1...
hESC-derived #BloodVesselOrganoid with dual #EndothelialCell (PECAM1-mRuby3-secNluc) & #SmoothMuscleCell (ACTA2-EGFP) lineage reporters
For high-throughput screening
#Angiogenesis 2025
link.springer.com/article/10.1...
For high-throughput screening
#Angiogenesis 2025
link.springer.com/article/10.1...
January 28, 2025 at 1:00 PM
hESC-derived #BloodVesselOrganoid with dual #EndothelialCell (PECAM1-mRuby3-secNluc) & #SmoothMuscleCell (ACTA2-EGFP) lineage reporters
For high-throughput screening
#Angiogenesis 2025
link.springer.com/article/10.1...
For high-throughput screening
#Angiogenesis 2025
link.springer.com/article/10.1...
1st Preprint from Pickering lab!😆
#SciArt
Intussusceptive angiogenesis-on-a-chip: Evidence for transluminal vascular bridging by endothelial delamination
Real-time transluminal #EndothelialCell pillariogenesis
#IntussusceptiveAngiogenesis😎
bioRxiv 2024
www.biorxiv.org/content/10.1...
#SciArt
Intussusceptive angiogenesis-on-a-chip: Evidence for transluminal vascular bridging by endothelial delamination
Real-time transluminal #EndothelialCell pillariogenesis
#IntussusceptiveAngiogenesis😎
bioRxiv 2024
www.biorxiv.org/content/10.1...
December 22, 2024 at 2:46 PM
1st Preprint from Pickering lab!😆
#SciArt
Intussusceptive angiogenesis-on-a-chip: Evidence for transluminal vascular bridging by endothelial delamination
Real-time transluminal #EndothelialCell pillariogenesis
#IntussusceptiveAngiogenesis😎
bioRxiv 2024
www.biorxiv.org/content/10.1...
#SciArt
Intussusceptive angiogenesis-on-a-chip: Evidence for transluminal vascular bridging by endothelial delamination
Real-time transluminal #EndothelialCell pillariogenesis
#IntussusceptiveAngiogenesis😎
bioRxiv 2024
www.biorxiv.org/content/10.1...
"Plug"
Microglia (~20%) physically contract with #EndothelialCell & #Pericyte through gaps b/w adjacent #Astrocyte endfeet
A meticulous analysis of #MICrONS volumetric EM data
1 mm3 🐭visual cortex🤩
@gazz4science.bsky.social @sorengrubb.bsky.social #JCBFM 2024
journals.sagepub.com/doi/10.1177/...
Microglia (~20%) physically contract with #EndothelialCell & #Pericyte through gaps b/w adjacent #Astrocyte endfeet
A meticulous analysis of #MICrONS volumetric EM data
1 mm3 🐭visual cortex🤩
@gazz4science.bsky.social @sorengrubb.bsky.social #JCBFM 2024
journals.sagepub.com/doi/10.1177/...
July 29, 2025 at 6:56 PM
"Plug"
Microglia (~20%) physically contract with #EndothelialCell & #Pericyte through gaps b/w adjacent #Astrocyte endfeet
A meticulous analysis of #MICrONS volumetric EM data
1 mm3 🐭visual cortex🤩
@gazz4science.bsky.social @sorengrubb.bsky.social #JCBFM 2024
journals.sagepub.com/doi/10.1177/...
Microglia (~20%) physically contract with #EndothelialCell & #Pericyte through gaps b/w adjacent #Astrocyte endfeet
A meticulous analysis of #MICrONS volumetric EM data
1 mm3 🐭visual cortex🤩
@gazz4science.bsky.social @sorengrubb.bsky.social #JCBFM 2024
journals.sagepub.com/doi/10.1177/...
In🐭Skin wound healing, #LangerhansCell colocalizes with sprouting tip cells
Ablating CD207+ Langerhans cells impairs both #EndothelialCell- & Fibroblast-mediated repair
Angiogenic secretome of Langerhans cell🤓
@valeriejhorsley.bsky.social @cp-devcell.bsky.social 2022
www.cell.com/developmenta...
Ablating CD207+ Langerhans cells impairs both #EndothelialCell- & Fibroblast-mediated repair
Angiogenic secretome of Langerhans cell🤓
@valeriejhorsley.bsky.social @cp-devcell.bsky.social 2022
www.cell.com/developmenta...
June 18, 2025 at 11:50 AM
In🐭Skin wound healing, #LangerhansCell colocalizes with sprouting tip cells
Ablating CD207+ Langerhans cells impairs both #EndothelialCell- & Fibroblast-mediated repair
Angiogenic secretome of Langerhans cell🤓
@valeriejhorsley.bsky.social @cp-devcell.bsky.social 2022
www.cell.com/developmenta...
Ablating CD207+ Langerhans cells impairs both #EndothelialCell- & Fibroblast-mediated repair
Angiogenic secretome of Langerhans cell🤓
@valeriejhorsley.bsky.social @cp-devcell.bsky.social 2022
www.cell.com/developmenta...
Tuning VEGFA signaling by FLT1 for multiple cell type coordination in #Zebrafish #CardiacRegeneration
#SciArt🤩
A role of EGR3 (rich in #EndothelialCell Fibroblast Myofibroblast) in #EndMT
@rmarinjuez.bsky.social @dev-journal.bsky.social 2024
journals.biologists.com/dev/article/...
#SciArt🤩
A role of EGR3 (rich in #EndothelialCell Fibroblast Myofibroblast) in #EndMT
@rmarinjuez.bsky.social @dev-journal.bsky.social 2024
journals.biologists.com/dev/article/...
December 14, 2024 at 10:43 PM
Tuning VEGFA signaling by FLT1 for multiple cell type coordination in #Zebrafish #CardiacRegeneration
#SciArt🤩
A role of EGR3 (rich in #EndothelialCell Fibroblast Myofibroblast) in #EndMT
@rmarinjuez.bsky.social @dev-journal.bsky.social 2024
journals.biologists.com/dev/article/...
#SciArt🤩
A role of EGR3 (rich in #EndothelialCell Fibroblast Myofibroblast) in #EndMT
@rmarinjuez.bsky.social @dev-journal.bsky.social 2024
journals.biologists.com/dev/article/...
Vascularize #hiPSC-derived Retinal #Organoid with dissociated #EndothelialCell + #MuralCell from #BloodVesselOrganoid
Vascularized RO has more mature neurons (TUJ+SMI32+) & mature RGC (SNCG+)
Hi glucose/IL6/TNFα/VEGF to model #DiabeticRetinopathy
#StemCells 2025
academic.oup.com/stmcls/advan...
Vascularized RO has more mature neurons (TUJ+SMI32+) & mature RGC (SNCG+)
Hi glucose/IL6/TNFα/VEGF to model #DiabeticRetinopathy
#StemCells 2025
academic.oup.com/stmcls/advan...
March 18, 2025 at 11:05 AM
Vascularize #hiPSC-derived Retinal #Organoid with dissociated #EndothelialCell + #MuralCell from #BloodVesselOrganoid
Vascularized RO has more mature neurons (TUJ+SMI32+) & mature RGC (SNCG+)
Hi glucose/IL6/TNFα/VEGF to model #DiabeticRetinopathy
#StemCells 2025
academic.oup.com/stmcls/advan...
Vascularized RO has more mature neurons (TUJ+SMI32+) & mature RGC (SNCG+)
Hi glucose/IL6/TNFα/VEGF to model #DiabeticRetinopathy
#StemCells 2025
academic.oup.com/stmcls/advan...
Transcriptomic re-analysis of #EndothelialCell HUVEC #Senescence
Doxorubicin
www.nature.com/articles/s41...
Replicative
www.embopress.org/doi/full/10....
Irradiation
academic.oup.com/nar/article/...
vs SenMayo🤔 SeneQuest
#Biogerontology 2025
link.springer.com/article/10.1...
Doxorubicin
www.nature.com/articles/s41...
Replicative
www.embopress.org/doi/full/10....
Irradiation
academic.oup.com/nar/article/...
vs SenMayo🤔 SeneQuest
#Biogerontology 2025
link.springer.com/article/10.1...
February 16, 2025 at 7:57 PM
Transcriptomic re-analysis of #EndothelialCell HUVEC #Senescence
Doxorubicin
www.nature.com/articles/s41...
Replicative
www.embopress.org/doi/full/10....
Irradiation
academic.oup.com/nar/article/...
vs SenMayo🤔 SeneQuest
#Biogerontology 2025
link.springer.com/article/10.1...
Doxorubicin
www.nature.com/articles/s41...
Replicative
www.embopress.org/doi/full/10....
Irradiation
academic.oup.com/nar/article/...
vs SenMayo🤔 SeneQuest
#Biogerontology 2025
link.springer.com/article/10.1...
Adult🐭Lung Veins Branch & serve as cellular sources of general capillary #EndothelialCell & Aerocyte
Upon🫁injury Not postnatal development
#SciArt
Slc6a2-CreERT2 labels veinous endothelium in🐭🫁but not other organs
@vaughandy.bsky.social #NatureCVR 2024
www.nature.com/articles/s44...
Upon🫁injury Not postnatal development
#SciArt
Slc6a2-CreERT2 labels veinous endothelium in🐭🫁but not other organs
@vaughandy.bsky.social #NatureCVR 2024
www.nature.com/articles/s44...
December 28, 2024 at 12:52 PM
Adult🐭Lung Veins Branch & serve as cellular sources of general capillary #EndothelialCell & Aerocyte
Upon🫁injury Not postnatal development
#SciArt
Slc6a2-CreERT2 labels veinous endothelium in🐭🫁but not other organs
@vaughandy.bsky.social #NatureCVR 2024
www.nature.com/articles/s44...
Upon🫁injury Not postnatal development
#SciArt
Slc6a2-CreERT2 labels veinous endothelium in🐭🫁but not other organs
@vaughandy.bsky.social #NatureCVR 2024
www.nature.com/articles/s44...
#Pericrine #Angiogenesis
#Pericyte-derived TIMP3
⏫ #EndothelialCell tubulogenesis (⏬EC cord diameter ⏫length branching basement membrane) in a 3D collagen EC-pericyte co-culture model
#FrontCellDevBio 2024
@ondinecleaver.bsky.social
www.frontiersin.org/journals/cel...
#Pericyte-derived TIMP3
⏫ #EndothelialCell tubulogenesis (⏬EC cord diameter ⏫length branching basement membrane) in a 3D collagen EC-pericyte co-culture model
#FrontCellDevBio 2024
@ondinecleaver.bsky.social
www.frontiersin.org/journals/cel...
November 20, 2024 at 8:21 PM
#Pericrine #Angiogenesis
#Pericyte-derived TIMP3
⏫ #EndothelialCell tubulogenesis (⏬EC cord diameter ⏫length branching basement membrane) in a 3D collagen EC-pericyte co-culture model
#FrontCellDevBio 2024
@ondinecleaver.bsky.social
www.frontiersin.org/journals/cel...
#Pericyte-derived TIMP3
⏫ #EndothelialCell tubulogenesis (⏬EC cord diameter ⏫length branching basement membrane) in a 3D collagen EC-pericyte co-culture model
#FrontCellDevBio 2024
@ondinecleaver.bsky.social
www.frontiersin.org/journals/cel...
#ArteryOnAChip
Dual-channel flow
#EndothelialCell (1 Pa) + #SmoothMusclecell (0.0002 Pa)
Bulk RNAseq of EC-/+flow SMC▶️
Novel vascular regulatory genes in SMCs
CRYAB INHBA LRG1 ▶️
Validated in👤🐷🐭#Atherosclerosis #AbdominalAorticAneurysm
#AdvHealthcMater 2023
onlinelibrary.wiley.com/doi/10.1002/...
Dual-channel flow
#EndothelialCell (1 Pa) + #SmoothMusclecell (0.0002 Pa)
Bulk RNAseq of EC-/+flow SMC▶️
Novel vascular regulatory genes in SMCs
CRYAB INHBA LRG1 ▶️
Validated in👤🐷🐭#Atherosclerosis #AbdominalAorticAneurysm
#AdvHealthcMater 2023
onlinelibrary.wiley.com/doi/10.1002/...
December 3, 2024 at 8:50 PM
#ArteryOnAChip
Dual-channel flow
#EndothelialCell (1 Pa) + #SmoothMusclecell (0.0002 Pa)
Bulk RNAseq of EC-/+flow SMC▶️
Novel vascular regulatory genes in SMCs
CRYAB INHBA LRG1 ▶️
Validated in👤🐷🐭#Atherosclerosis #AbdominalAorticAneurysm
#AdvHealthcMater 2023
onlinelibrary.wiley.com/doi/10.1002/...
Dual-channel flow
#EndothelialCell (1 Pa) + #SmoothMusclecell (0.0002 Pa)
Bulk RNAseq of EC-/+flow SMC▶️
Novel vascular regulatory genes in SMCs
CRYAB INHBA LRG1 ▶️
Validated in👤🐷🐭#Atherosclerosis #AbdominalAorticAneurysm
#AdvHealthcMater 2023
onlinelibrary.wiley.com/doi/10.1002/...
#LaminarShearStress-KLF2 in #EndothelialCell ⏬BMP signaling ▶️⏬#VascularCalcification in hyperlipidemic🐭
BMP4 BMPER as direct targets of KLF2
LSS
⏫BMPER
⏬BMP4 MGP FST
OsteoSense 680 to image aortic calcification in vivo
#CircRes 2021 @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
BMP4 BMPER as direct targets of KLF2
LSS
⏫BMPER
⏬BMP4 MGP FST
OsteoSense 680 to image aortic calcification in vivo
#CircRes 2021 @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
November 23, 2024 at 8:24 PM
#LaminarShearStress-KLF2 in #EndothelialCell ⏬BMP signaling ▶️⏬#VascularCalcification in hyperlipidemic🐭
BMP4 BMPER as direct targets of KLF2
LSS
⏫BMPER
⏬BMP4 MGP FST
OsteoSense 680 to image aortic calcification in vivo
#CircRes 2021 @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
BMP4 BMPER as direct targets of KLF2
LSS
⏫BMPER
⏬BMP4 MGP FST
OsteoSense 680 to image aortic calcification in vivo
#CircRes 2021 @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
#Autophagy #Mechanobiology
Interesting evidence on opposite effects of ⏫matrix stiffness on Autophagy of #EndothelialCell⏬ vs #SmoothMuscleCell⏫
280~480 kPa, crosslinked poly(L-lysine)-hyaluronic acid film on coverglass
#BioactiveMat 2021
www.sciencedirect.com/science/arti...
Interesting evidence on opposite effects of ⏫matrix stiffness on Autophagy of #EndothelialCell⏬ vs #SmoothMuscleCell⏫
280~480 kPa, crosslinked poly(L-lysine)-hyaluronic acid film on coverglass
#BioactiveMat 2021
www.sciencedirect.com/science/arti...
November 12, 2025 at 7:59 PM
#Autophagy #Mechanobiology
Interesting evidence on opposite effects of ⏫matrix stiffness on Autophagy of #EndothelialCell⏬ vs #SmoothMuscleCell⏫
280~480 kPa, crosslinked poly(L-lysine)-hyaluronic acid film on coverglass
#BioactiveMat 2021
www.sciencedirect.com/science/arti...
Interesting evidence on opposite effects of ⏫matrix stiffness on Autophagy of #EndothelialCell⏬ vs #SmoothMuscleCell⏫
280~480 kPa, crosslinked poly(L-lysine)-hyaluronic acid film on coverglass
#BioactiveMat 2021
www.sciencedirect.com/science/arti...
#SpatialTranscriptomics #Visium @10xGenomics #AbdominalAorticAneurysm
THBS1/Thrombospodin-1 KO in Myeloid cell, not #EndothelialCell, ⬇️ #AorticAneurysm but⬆️ #AorticRupture in 🐭AAA AngII+Apoe KO
Likely compromised TGFb-ECM-stabilizing SMCs & fibroblasts
bioRxiv 2024
www.biorxiv.org/content/10.1...
THBS1/Thrombospodin-1 KO in Myeloid cell, not #EndothelialCell, ⬇️ #AorticAneurysm but⬆️ #AorticRupture in 🐭AAA AngII+Apoe KO
Likely compromised TGFb-ECM-stabilizing SMCs & fibroblasts
bioRxiv 2024
www.biorxiv.org/content/10.1...
December 25, 2024 at 11:53 AM
#SpatialTranscriptomics #Visium @10xGenomics #AbdominalAorticAneurysm
THBS1/Thrombospodin-1 KO in Myeloid cell, not #EndothelialCell, ⬇️ #AorticAneurysm but⬆️ #AorticRupture in 🐭AAA AngII+Apoe KO
Likely compromised TGFb-ECM-stabilizing SMCs & fibroblasts
bioRxiv 2024
www.biorxiv.org/content/10.1...
THBS1/Thrombospodin-1 KO in Myeloid cell, not #EndothelialCell, ⬇️ #AorticAneurysm but⬆️ #AorticRupture in 🐭AAA AngII+Apoe KO
Likely compromised TGFb-ECM-stabilizing SMCs & fibroblasts
bioRxiv 2024
www.biorxiv.org/content/10.1...
#SpatialTranscriptomics 👤 #Cardiomyopathy #HeartFailure
GeoMx
Cardiomyocyte #EndothelialCell Fibroblast segmented
44👤🫀 #TissueMicroArray
#MyocyteDisarray HCMpEF➡️⏬ribosome
#CardicFibrosis➡️⏫ACKR1+PLVAP+CCL14+ endothelium
UCHL1 PFKFB2 for HF progression
#EHJ 2025
academic.oup.com/eurheartj/ad...
GeoMx
Cardiomyocyte #EndothelialCell Fibroblast segmented
44👤🫀 #TissueMicroArray
#MyocyteDisarray HCMpEF➡️⏬ribosome
#CardicFibrosis➡️⏫ACKR1+PLVAP+CCL14+ endothelium
UCHL1 PFKFB2 for HF progression
#EHJ 2025
academic.oup.com/eurheartj/ad...
May 20, 2025 at 11:44 AM
#SpatialTranscriptomics 👤 #Cardiomyopathy #HeartFailure
GeoMx
Cardiomyocyte #EndothelialCell Fibroblast segmented
44👤🫀 #TissueMicroArray
#MyocyteDisarray HCMpEF➡️⏬ribosome
#CardicFibrosis➡️⏫ACKR1+PLVAP+CCL14+ endothelium
UCHL1 PFKFB2 for HF progression
#EHJ 2025
academic.oup.com/eurheartj/ad...
GeoMx
Cardiomyocyte #EndothelialCell Fibroblast segmented
44👤🫀 #TissueMicroArray
#MyocyteDisarray HCMpEF➡️⏬ribosome
#CardicFibrosis➡️⏫ACKR1+PLVAP+CCL14+ endothelium
UCHL1 PFKFB2 for HF progression
#EHJ 2025
academic.oup.com/eurheartj/ad...
#SpatialTranscriptomics #Visium #Xenium
Glomerular microvascular cell landscape shift in #DiabeticKidneyDisease
MEF2A/MEF2C/TRPS1 in Glomerular #EndothelialCell phenotypic plasticity & EC-to-Mural cell/Podocyte communications
SEMA6A-PLXNA2
bioRxiv 2024
www.biorxiv.org/content/10.1...
Glomerular microvascular cell landscape shift in #DiabeticKidneyDisease
MEF2A/MEF2C/TRPS1 in Glomerular #EndothelialCell phenotypic plasticity & EC-to-Mural cell/Podocyte communications
SEMA6A-PLXNA2
bioRxiv 2024
www.biorxiv.org/content/10.1...
February 13, 2025 at 9:09 PM
#SpatialTranscriptomics #Visium #Xenium
Glomerular microvascular cell landscape shift in #DiabeticKidneyDisease
MEF2A/MEF2C/TRPS1 in Glomerular #EndothelialCell phenotypic plasticity & EC-to-Mural cell/Podocyte communications
SEMA6A-PLXNA2
bioRxiv 2024
www.biorxiv.org/content/10.1...
Glomerular microvascular cell landscape shift in #DiabeticKidneyDisease
MEF2A/MEF2C/TRPS1 in Glomerular #EndothelialCell phenotypic plasticity & EC-to-Mural cell/Podocyte communications
SEMA6A-PLXNA2
bioRxiv 2024
www.biorxiv.org/content/10.1...
Amyloidβ Aβ1-40 activates #Piezo1 channels in brain capillary #EndothelialCell via ROS
Another splendid patch-clamp study from @osamaharraz.bsky.social
Aβ1-40 doesn't have to be in the pipette to activate Piezo1, likely an indirect effect
@biophysj.bsky.social 2024
www.cell.com/biophysj/abs...
Another splendid patch-clamp study from @osamaharraz.bsky.social
Aβ1-40 doesn't have to be in the pipette to activate Piezo1, likely an indirect effect
@biophysj.bsky.social 2024
www.cell.com/biophysj/abs...
January 11, 2025 at 1:43 PM
Amyloidβ Aβ1-40 activates #Piezo1 channels in brain capillary #EndothelialCell via ROS
Another splendid patch-clamp study from @osamaharraz.bsky.social
Aβ1-40 doesn't have to be in the pipette to activate Piezo1, likely an indirect effect
@biophysj.bsky.social 2024
www.cell.com/biophysj/abs...
Another splendid patch-clamp study from @osamaharraz.bsky.social
Aβ1-40 doesn't have to be in the pipette to activate Piezo1, likely an indirect effect
@biophysj.bsky.social 2024
www.cell.com/biophysj/abs...
#Flavivirus #BloodBrainBarrier
#WestNileVirus #UsutuVirus cross in vitro #BBB (🧠microvascular #EndothelialCell - ThinCert - #Pericyte #Astrocyte, 60 Ω/cm2)
w/o barrier disruption
BBB secretome
⏬MMP3 MCP1
⏫IFNβ CXCL10
@barryrockx.bsky.social x #NPJViruses 2025
www.nature.com/articles/s44...
#WestNileVirus #UsutuVirus cross in vitro #BBB (🧠microvascular #EndothelialCell - ThinCert - #Pericyte #Astrocyte, 60 Ω/cm2)
w/o barrier disruption
BBB secretome
⏬MMP3 MCP1
⏫IFNβ CXCL10
@barryrockx.bsky.social x #NPJViruses 2025
www.nature.com/articles/s44...
May 9, 2025 at 7:25 PM
#Flavivirus #BloodBrainBarrier
#WestNileVirus #UsutuVirus cross in vitro #BBB (🧠microvascular #EndothelialCell - ThinCert - #Pericyte #Astrocyte, 60 Ω/cm2)
w/o barrier disruption
BBB secretome
⏬MMP3 MCP1
⏫IFNβ CXCL10
@barryrockx.bsky.social x #NPJViruses 2025
www.nature.com/articles/s44...
#WestNileVirus #UsutuVirus cross in vitro #BBB (🧠microvascular #EndothelialCell - ThinCert - #Pericyte #Astrocyte, 60 Ω/cm2)
w/o barrier disruption
BBB secretome
⏬MMP3 MCP1
⏫IFNβ CXCL10
@barryrockx.bsky.social x #NPJViruses 2025
www.nature.com/articles/s44...
#PsoriasisVulgaris #AutoimmuneDisease #SpatialTranscriptomics StereoSeq
A fibro-angiogenic niche in psoriatic👤skin epidermis
WNT5A+ fibroblast
VCAN+ #SmoothMuscleCell
ITIH5+ #EndothelialCell
Fibroblast, SMC & Schwann cell are major signal senders
#BrJDermatol 2024
academic.oup.com/bjd/advance-...
A fibro-angiogenic niche in psoriatic👤skin epidermis
WNT5A+ fibroblast
VCAN+ #SmoothMuscleCell
ITIH5+ #EndothelialCell
Fibroblast, SMC & Schwann cell are major signal senders
#BrJDermatol 2024
academic.oup.com/bjd/advance-...
December 15, 2024 at 1:08 PM
#PsoriasisVulgaris #AutoimmuneDisease #SpatialTranscriptomics StereoSeq
A fibro-angiogenic niche in psoriatic👤skin epidermis
WNT5A+ fibroblast
VCAN+ #SmoothMuscleCell
ITIH5+ #EndothelialCell
Fibroblast, SMC & Schwann cell are major signal senders
#BrJDermatol 2024
academic.oup.com/bjd/advance-...
A fibro-angiogenic niche in psoriatic👤skin epidermis
WNT5A+ fibroblast
VCAN+ #SmoothMuscleCell
ITIH5+ #EndothelialCell
Fibroblast, SMC & Schwann cell are major signal senders
#BrJDermatol 2024
academic.oup.com/bjd/advance-...
⏬Mechanosensing & ⏫inflammation of aortic #EndothelialCell as a potential disease driver in #MarfanSyndrome 😎
A novel Marfan🐭➡️early #ThroacicAorticDissection #AorticRupture Fbn1G234D/G234D T50=5 wk
⏬pSMAD2 ↔️pERK1/2
#AortaEd
Hiromi Yanagisawa lab #CircRes 2025
www.ahajournals.org/doi/suppl/10...
A novel Marfan🐭➡️early #ThroacicAorticDissection #AorticRupture Fbn1G234D/G234D T50=5 wk
⏬pSMAD2 ↔️pERK1/2
#AortaEd
Hiromi Yanagisawa lab #CircRes 2025
www.ahajournals.org/doi/suppl/10...
May 17, 2025 at 11:15 AM
⏬Mechanosensing & ⏫inflammation of aortic #EndothelialCell as a potential disease driver in #MarfanSyndrome 😎
A novel Marfan🐭➡️early #ThroacicAorticDissection #AorticRupture Fbn1G234D/G234D T50=5 wk
⏬pSMAD2 ↔️pERK1/2
#AortaEd
Hiromi Yanagisawa lab #CircRes 2025
www.ahajournals.org/doi/suppl/10...
A novel Marfan🐭➡️early #ThroacicAorticDissection #AorticRupture Fbn1G234D/G234D T50=5 wk
⏬pSMAD2 ↔️pERK1/2
#AortaEd
Hiromi Yanagisawa lab #CircRes 2025
www.ahajournals.org/doi/suppl/10...
2X #DilatedCardiomyopathy GWAS MATG #NatGenet 2024 reveal novel genes/cellular players
PROX1 - #LymphaticEndothelialCell
ERG - #EndothelialCell
DGKG - #SmoothMuscleCell
MAPT/Tau validated in both studies
>9k case
www.nature.com/articles/s41...
>14k case
www.nature.com/articles/s41...
PROX1 - #LymphaticEndothelialCell
ERG - #EndothelialCell
DGKG - #SmoothMuscleCell
MAPT/Tau validated in both studies
>9k case
www.nature.com/articles/s41...
>14k case
www.nature.com/articles/s41...
November 30, 2024 at 1:22 PM
2X #DilatedCardiomyopathy GWAS MATG #NatGenet 2024 reveal novel genes/cellular players
PROX1 - #LymphaticEndothelialCell
ERG - #EndothelialCell
DGKG - #SmoothMuscleCell
MAPT/Tau validated in both studies
>9k case
www.nature.com/articles/s41...
>14k case
www.nature.com/articles/s41...
PROX1 - #LymphaticEndothelialCell
ERG - #EndothelialCell
DGKG - #SmoothMuscleCell
MAPT/Tau validated in both studies
>9k case
www.nature.com/articles/s41...
>14k case
www.nature.com/articles/s41...
AngioTag
#Zebrafish kdrl+ #EndothelialCell RiboTag + TRAP-seq track endothelial translation activity in vivo
Discover novel EC functional genes😎
Profile Orangotypic endothelial features in🐟
Also UAS::RiboTag for any🐟tissues
Brant Weinstein lab #Angiogenesis 2025
link.springer.com/article/10.1...
#Zebrafish kdrl+ #EndothelialCell RiboTag + TRAP-seq track endothelial translation activity in vivo
Discover novel EC functional genes😎
Profile Orangotypic endothelial features in🐟
Also UAS::RiboTag for any🐟tissues
Brant Weinstein lab #Angiogenesis 2025
link.springer.com/article/10.1...
February 24, 2026 at 8:11 PM
AngioTag
#Zebrafish kdrl+ #EndothelialCell RiboTag + TRAP-seq track endothelial translation activity in vivo
Discover novel EC functional genes😎
Profile Orangotypic endothelial features in🐟
Also UAS::RiboTag for any🐟tissues
Brant Weinstein lab #Angiogenesis 2025
link.springer.com/article/10.1...
#Zebrafish kdrl+ #EndothelialCell RiboTag + TRAP-seq track endothelial translation activity in vivo
Discover novel EC functional genes😎
Profile Orangotypic endothelial features in🐟
Also UAS::RiboTag for any🐟tissues
Brant Weinstein lab #Angiogenesis 2025
link.springer.com/article/10.1...
Perturbing MEK–ERK–c-Myc bioenergetic axis in tumor #EndothelialCell suppress primary tumor growth
Evidence from an engineered tumor cell type-selective #AnthraxToxin system allowing
MEK cleavage/inactivation in selective #TumorMicroEnvironmental cell types
#PNAS 2025
www.pnas.org/doi/10.1073/...
Evidence from an engineered tumor cell type-selective #AnthraxToxin system allowing
MEK cleavage/inactivation in selective #TumorMicroEnvironmental cell types
#PNAS 2025
www.pnas.org/doi/10.1073/...
November 9, 2025 at 8:29 PM
Perturbing MEK–ERK–c-Myc bioenergetic axis in tumor #EndothelialCell suppress primary tumor growth
Evidence from an engineered tumor cell type-selective #AnthraxToxin system allowing
MEK cleavage/inactivation in selective #TumorMicroEnvironmental cell types
#PNAS 2025
www.pnas.org/doi/10.1073/...
Evidence from an engineered tumor cell type-selective #AnthraxToxin system allowing
MEK cleavage/inactivation in selective #TumorMicroEnvironmental cell types
#PNAS 2025
www.pnas.org/doi/10.1073/...
#SingleCellProteomics 🐭 #Aorta #MarfanSyndrome
6X ea ♀️♂️ WT Fbn1C1049G/+
24 Aortic roots▶️4996 cells, 2746 proteins, 487 proteins/cell
7 #SmoothMuscleCell subtypes!🤩
poorly overlapped with scRNAseq SMC subtype
#EndMT in Marfan #EndothelialCell
#AortaEd
bioRxiv 2025
www.biorxiv.org/content/10.1...
6X ea ♀️♂️ WT Fbn1C1049G/+
24 Aortic roots▶️4996 cells, 2746 proteins, 487 proteins/cell
7 #SmoothMuscleCell subtypes!🤩
poorly overlapped with scRNAseq SMC subtype
#EndMT in Marfan #EndothelialCell
#AortaEd
bioRxiv 2025
www.biorxiv.org/content/10.1...
April 26, 2025 at 11:55 AM
#SingleCellProteomics 🐭 #Aorta #MarfanSyndrome
6X ea ♀️♂️ WT Fbn1C1049G/+
24 Aortic roots▶️4996 cells, 2746 proteins, 487 proteins/cell
7 #SmoothMuscleCell subtypes!🤩
poorly overlapped with scRNAseq SMC subtype
#EndMT in Marfan #EndothelialCell
#AortaEd
bioRxiv 2025
www.biorxiv.org/content/10.1...
6X ea ♀️♂️ WT Fbn1C1049G/+
24 Aortic roots▶️4996 cells, 2746 proteins, 487 proteins/cell
7 #SmoothMuscleCell subtypes!🤩
poorly overlapped with scRNAseq SMC subtype
#EndMT in Marfan #EndothelialCell
#AortaEd
bioRxiv 2025
www.biorxiv.org/content/10.1...
Fabrication of #MicrovesselOnAChip
#EndothelialCell HUVEC
3D printing injection reservoirs
Needle-based collagen channel φ200 μm
Sprouting
100 Pa intraluminal pressure
4 & 70 kD FITC-dextran for permeability
A. Bancaud & Y. Matsunaga labs #STARProtoc 2024
www.sciencedirect.com/science/arti...
#EndothelialCell HUVEC
3D printing injection reservoirs
Needle-based collagen channel φ200 μm
Sprouting
100 Pa intraluminal pressure
4 & 70 kD FITC-dextran for permeability
A. Bancaud & Y. Matsunaga labs #STARProtoc 2024
www.sciencedirect.com/science/arti...
September 3, 2025 at 11:29 AM
Fabrication of #MicrovesselOnAChip
#EndothelialCell HUVEC
3D printing injection reservoirs
Needle-based collagen channel φ200 μm
Sprouting
100 Pa intraluminal pressure
4 & 70 kD FITC-dextran for permeability
A. Bancaud & Y. Matsunaga labs #STARProtoc 2024
www.sciencedirect.com/science/arti...
#EndothelialCell HUVEC
3D printing injection reservoirs
Needle-based collagen channel φ200 μm
Sprouting
100 Pa intraluminal pressure
4 & 70 kD FITC-dextran for permeability
A. Bancaud & Y. Matsunaga labs #STARProtoc 2024
www.sciencedirect.com/science/arti...