#Autophagy #Mechanobiology

Interesting evidence on opposite effects of ⏫matrix stiffness on Autophagy of #EndothelialCell⏬ vs #SmoothMuscleCell⏫

280~480 kPa, crosslinked poly(L-lysine)-hyaluronic acid film on coverglass

#BioactiveMat 2021
www.sciencedirect.com/science/arti...

(Mouse/Human) Mitochondria transplantation i.m. improves reperfusion #Angiogenesis of 🐭#LimbIschemia

Macrophage, instead of #EndothelialCell, is the major cell type that internalizes exogenous Mitochondria (sustained by day 3 not 7)

#BioactiveMat 2025
www.sciencedirect.com/science/arti...

NAMPT #AbdominalAorticAneurysm

👤AAA
⏬NAMPT OXPHOS mitoETC #SmoothMuscleCell contractile phenotype
⏫Senescence
⏫B cell pDC

1⃣#ExtracellularVesicle from NAMPT-OE #hiPSC-#MesenchymalStemCell or 2⃣P7C3 NAMPTa
⬆️SMC NAD+
⬇️SMC senescence 🐭AAA

#BioactiveMat 2023
www.sciencedirect.com/science/arti...

Hierarchical Porous Microsphere (φ200 μm >90% porosity) as Endothelial cell +MSC carrier for🐭 #LimbIschemia

🐷SI decellularized matrix +GelMA
+PEO #LiquidLiquidPhaseSeparation➡️ Primary pore 40 μm
+Ice templating➡️Secondary pore
+Fibronectin

#BioactiveMat 2026
www.sciencedirect.com/science/arti...

#Autophagy #Mechanobiology

Interesting evidence on opposite effects of ⏫matrix stiffness on Autophagy of #EndothelialCell⏬vs #SmoothMuscleCell⏫

280~480 kPa, crosslinked poly(L-lysine)-hyaluronic acid film on coverglass

#BioactiveMat 2021
www.sciencedirect.com/science/arti...

Dragging #3DBioprinting to create porous multilayered polycaprolactone construct->vascular graft

Endothelialized
φ5mm, H80mm, layer thickness 250μm
Ultimate strength (5-layer) 8 MPa
Burst pressure >400 mmHg
Suture retention 8.8 N

#BioactiveMat 2023
www.sciencedirect.com/science/arti...

#ERStress #AbdominalAorticAneurysm

Targeted delivery of PERK inhibitor to 🐭#AAA using biomimetic nanoclusters
PAMAM-PLGA nanoparticles coated with platelet membrane
i.v. >100-fold enriched in aortic lesions vs liver/GI/kidney/spleen🤠

#BioactiveMat 2023
www.sciencedirect.com/science/arti...

AteloCollagen 10%-#HyaluronicAcid 5% microgel as Cell Carrier of👤#AdiposeDerivedStemCell to treat🐭#LimbIschemia

⏫ADSC Survival in ischemic limb up to 28 days
⏫Material transfer (nutrient uptake+secretome release)

Which muscle studied?
#BioactiveMat 2023
www.sciencedirect.com/science/arti...