#Remyelination
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gregoryai.bsky.social
The age-related failure to produce oligodendrocytes from oligodendrocyte progenitor cells (OPCs) is associated with irreversible neurodegeneration in multiple sclerosis (MS). Consequently, regenerative approaches have significant potenti...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky
Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells
The age-related failure to produce oligodendrocytes from oligodendrocyte progenitor cells (OPCs) is associated with irreversible neurodegeneration in multiple sclerosis (MS). Consequently, regenerative approaches have significant potential for treating chronic demyelinating diseases. Here, we sho...
brain-regeneration.com
October 31, 2026 at 8:20 AM
gregoryai.bsky.social
Prog Neurobiol. 2026 Oct 30:102967. doi: 10.1016/j.pneurobio.2026.102967. Online ahead of print. ABSTRACT BACKGROUND: Different types of electrical stimulations (ES), transcranial direct current stimulation (tDCS), vagus nerve stimulatio...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky
Effect of Electrical Stimulation on Remyelination in Preclinical Models of Multiple Sclerosis: A Systematic Review
Prog Neurobiol. 2026 Oct 30:102967. doi: 10.1016/j.pneurobio.2026.102967. Online ahead of print. ABSTRACT BACKGROUND: Different types of electrical stimulations (ES), transcranial direct current stimulation (tDCS), vagus nerve stimulation (VNS), and peripheral nerve stimulation (PNS) have emerged...
brain-regeneration.com
October 31, 2026 at 8:00 AM
emspofficial.bsky.social
We’re following the session on repair and remyelination at #MSToronto2026! 🧠 Advancing MS research and future treatment possibilities.
October 23, 2026 at 12:37 PM
aliibarry.com
Another one for the reading list
www.nature.com/articles/s41...
A human-induced pluripotent stem cell-derived spheroid model to investigate myelin injury and repair - Nature Neuroscience
Researchers engineered a human stem cell-derived model that recapitulates myelin damage and repair in the central nervous system, enabling the study of remyelination and drug screening for multiple sc...
www.nature.com
October 20, 2026 at 3:54 PM
neuroboy.bsky.social
✍Why explore this? Our prior work showed deep TMS halted the progression of white matter changes in early AUD abstinence (Selim et al., 2024), and animal studies link magnetic and ultrasound stimulation to remyelination and reduced neuroinflammation. (3/5)
October 19, 2026 at 10:18 AM
brunoamaral.eu
Crazy how easy it was to get a list of remyelination candidates for Multiple Sclerosis
claude.ai/artifact/F5Z...
Remyelination Candidates
Remyelination candidates on Brain-Regeneration
claude.ai
October 15, 2026 at 8:32 PM
gregoryai.bsky.social
Abstract Multiple sclerosis (MS) is a debilitating demyelinating disease of the central nervous system (CNS) in which progressive neurological disability is closely linked to the failure of endogenous remyelination. Reactive astrocytes a...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky
Astrocyte-derived CXCL14 promotes oligodendrocyte differentiation and remyelination via ERK1/2 signaling: implications for multiple sclerosis therapeutics
Abstract Multiple sclerosis (MS) is a debilitating demyelinating disease of the central nervous system (CNS) in which progressive neurological disability is closely linked to the failure of endogenous remyelination. Reactive astrocytes are hallmarks of MS lesions, yet their functional role in mye...
brain-regeneration.com
October 13, 2026 at 7:00 AM
gregoryai.bsky.social
The current study presents two different approaches with a view to elucidating the interaction between thyroid hormones (TH) and apo-transferrin (aTf) and their role in myelination and remyelination. First, in vitro assays were conducted...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky
Combination therapy of apo-transferrin and thyroid hormones enhances remyelination.
The current study presents two different approaches with a view to elucidating the interaction between thyroid hormones (TH) and apo-transferrin (aTf) and their role in myelination and remyelination. First, in vitro assays were conducted to determine the single and combined effects of aTf and tri...
brain-regeneration.com
October 12, 2026 at 7:20 AM
themsblog.bsky.social
New post: Throw the rats away for remyelination studies..Humans cultures II https://multiple-sclerosis-research.org/2026/10/throw-the-rats-away-for-remyelination-studies-humans-cultures-ii/
October 11, 2026 at 10:00 AM
gregoryai.bsky.social
Twenty-one-day-old Wistar rats were fed a diet containing 0.6% cuprizone for 2 weeks. Studies carried out after withdrawal of cuprizone showed histological evidences of marked demyelination in the corpus callosum. Biochemical studies of ...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky
Remyelination after cuprizone-induced demyelination in the rat is stimulated by apotransferrin.
Twenty-one-day-old Wistar rats were fed a diet containing 0.6% cuprizone for 2 weeks. Studies carried out after withdrawal of cuprizone showed histological evidences of marked demyelination in the corpus callosum. Biochemical studies of isolated myelin showed a marked decrease in myelin proteins,...
brain-regeneration.com
October 12, 2026 at 7:30 AM
gregoryai.bsky.social
Oligodendroglial damage and demyelination are common pathological features characterizing white matter and neurodegenerative disorders. Identifying the signaling pathways involved in myelin repair through oligodendroglial progenitor matu...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky
The Notch signaling pathway: its role in focal CNS demyelination and apotransferrin-induced remyelination.
Oligodendroglial damage and demyelination are common pathological features characterizing white matter and neurodegenerative disorders. Identifying the signaling pathways involved in myelin repair through oligodendroglial progenitor maturation is essential for the development of new therapies. Th...
brain-regeneration.com
October 10, 2026 at 7:20 AM
ijmsc.bsky.social
Optogenetics just earned Deisseroth, Hegemann, and Nagel the Nobel in medicine.
In MS research, mouse and cell studies are using it to explore remyelination and light-triggered interferon-beta delivery. Still preclinical, but worth a read.
doi.org/10.7224/1537...
#MSsky #NeuroSky #Optogenetics
October 8, 2026 at 2:49 PM
themsblog.bsky.social
New post: Throw the rats away for remyelination studies..Humans cultures https://multiple-sclerosis-research.org/2026/10/throw-the-rats-away-for-remyelination-studies-humans-cultures/
October 5, 2026 at 6:00 AM
gregoryai.bsky.social
Background Demyelination and remyelination are critical processes in the pathogenesis of Alzheimer's disease (AD). The selective estrogen receptor modulator bazedoxifene (BZA) has been shown to promote remyelination, suggesting its poten...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky
Bazedoxifene restores myelin changes and attenuates cognitive deficits in a mouse model of Alzheimer's disease
Background Demyelination and remyelination are critical processes in the pathogenesis of Alzheimer's disease (AD). The selective estrogen receptor modulator bazedoxifene (BZA) has been shown to promote remyelination, suggesting its potential therapeutic efficacy. Objective This study aimed to eva...
brain-regeneration.com
October 3, 2026 at 7:00 AM
healthcare-global.bsky.social
www.nature.com/articles/s41...
A human-induced pluripotent stem cell-derived spheroid model to investigate myelin injury and repair - Nature Neuroscience
Researchers engineered a human stem cell-derived model that recapitulates myelin damage and repair in the central nervous system, enabling the study of remyelination and drug screening for multiple sc...
www.nature.com
October 2, 2026 at 10:29 PM
profchuckles.bsky.social
www.nature.com/articles/s41...
A human-induced pluripotent stem cell-derived spheroid model to investigate myelin injury and repair - Nature Neuroscience
Researchers engineered a human stem cell-derived model that recapitulates myelin damage and repair in the central nervous system, enabling the study of remyelination and drug screening for multiple sc...
www.nature.com
October 2, 2026 at 11:08 AM
harschnitz.bsky.social
Very nice work from the Barton lab developing iPSC-derived organoids enriched with mature, myelinating oligodendrocytes and functionally reactive microglia. The model shows demyelination, myelin clearance by microglia, and interestingly also new myelin formation.

www.nature.com/articles/s41...
A human-induced pluripotent stem cell-derived spheroid model to investigate myelin injury and repair - Nature Neuroscience
Researchers engineered a human stem cell-derived model that recapitulates myelin damage and repair in the central nervous system, enabling the study of remyelination and drug screening for multiple sc...
www.nature.com
October 1, 2026 at 4:32 PM
prepub-neurodegen.bsky.social
Hierarchical control of remyelination by heparan sulfate sulfation #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.24.754157v1
September 30, 2026 at 7:02 AM
biorxiv-neursci.bsky.social
Hierarchical control of remyelination by heparan sulfate sulfation https://www.biorxiv.org/content/10.64898/2026.09.24.754157v1
September 30, 2026 at 5:17 AM
biorxivpreprint.bsky.social
Hierarchical control of remyelination by heparan sulfate sulfation https://www.biorxiv.org/content/10.64898/2026.09.24.754157v1
September 30, 2026 at 5:17 AM
gregoryai.bsky.social
Iran J Basic Med Sci. 2026;29(10):1528-1534. doi: 10.22038/ijbms.2026.96127.20729. ABSTRACT OBJECTIVES: Developing effective strategies to enhance remyelination remains a major therapeutic challenge in demyelinating disorders such as mul...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky
Generation of oligodendrocyte precursor-like cells from mouse embryonic fibroblasts using miR-7a mimics
Iran J Basic Med Sci. 2026;29(10):1528-1534. doi: 10.22038/ijbms.2026.96127.20729. ABSTRACT OBJECTIVES: Developing effective strategies to enhance remyelination remains a major therapeutic challenge in demyelinating disorders such as multiple sclerosis (MS). MicroRNAs (miRNAs) have emerged as pow...
brain-regeneration.com
September 27, 2026 at 3:10 PM
chemcenterbio.bsky.social
The Most Promising MS Peptide to Date?

Groundbreaking P21 peptide science demonstrates massive neurogenesis and myelin protection in laboratory study animals only. #MSWarrior #MSResearch #Neuroprotection #Remyelination #MultipleSclerosis
September 22, 2026 at 8:47 AM
brunoamaral.eu
This is the first trial I see of a new medicine aimed at remyelination for multiple sclerosis
September 18, 2026 at 6:36 PM
gregoryai.bsky.social
ABSTRACT Background Vascular dementia (VD), a prevalent cognitive disorder mainly resulting from chronic cerebral hypoperfusion‐triggered white matter injury (WMI), takes regulation of oligodendrocyte (OL) lineage and restoration of re...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky
Emodin Suppresses the RAGE / ROCK1 Pathway to Modulate the Oligodendrocyte Lineage and Ameliorate Demyelination in Vascular Dementia Rats
ABSTRACT Background Vascular dementia (VD), a prevalent cognitive disorder mainly resulting from chronic cerebral hypoperfusion‐triggered white matter injury (WMI), takes regulation of oligodendrocyte (OL) lineage and restoration of remyelination as key therapeutic targets, whereas the precise ...
brain-regeneration.com
September 16, 2026 at 11:40 AM