😮🧐 Just saw a commercial for Rezdiffra (resmetirom, for MASH liver disease) & the voiceover said words like "studies to determine efficacy are ongoing."
Uh, what? So I checked; yup, it got that FDA accelerated approval RFK & Makary have been handing out to drugmakers who play ball. Your FDA, folks.
Uh, what? So I checked; yup, it got that FDA accelerated approval RFK & Makary have been handing out to drugmakers who play ball. Your FDA, folks.
January 15, 2026 at 5:10 AM
😮🧐 Just saw a commercial for Rezdiffra (resmetirom, for MASH liver disease) & the voiceover said words like "studies to determine efficacy are ongoing."
Uh, what? So I checked; yup, it got that FDA accelerated approval RFK & Makary have been handing out to drugmakers who play ball. Your FDA, folks.
Uh, what? So I checked; yup, it got that FDA accelerated approval RFK & Makary have been handing out to drugmakers who play ball. Your FDA, folks.
I felt like hot fucking garbage and my lvls of both T and E were really low but my doctors just kinda shrugged. Cue Rezdiffra, I suddenly have energy again! Turns out not having enough of *any* hormones will fuck you up.
February 8, 2026 at 5:01 PM
I felt like hot fucking garbage and my lvls of both T and E were really low but my doctors just kinda shrugged. Cue Rezdiffra, I suddenly have energy again! Turns out not having enough of *any* hormones will fuck you up.
GLP-1s don't help these patients.
$MDGL 's Rezdiffra is prescribed mostly for patients with early and moderate MASH.
$ETNB is developing a drug similar to $AKRO. Stock up 66% pre market.
www.statnews.com/2025/01/27/a...
$MDGL 's Rezdiffra is prescribed mostly for patients with early and moderate MASH.
$ETNB is developing a drug similar to $AKRO. Stock up 66% pre market.
www.statnews.com/2025/01/27/a...
Akero drug reverses liver scarring in study of severe MASH patients
Akero reported Monday strong results showing its drug efruxifermin reversed liver scarring in patients with cirrhosis caused by a disease known as MASH.
www.statnews.com
January 27, 2025 at 12:44 PM
GLP-1s don't help these patients.
$MDGL 's Rezdiffra is prescribed mostly for patients with early and moderate MASH.
$ETNB is developing a drug similar to $AKRO. Stock up 66% pre market.
www.statnews.com/2025/01/27/a...
$MDGL 's Rezdiffra is prescribed mostly for patients with early and moderate MASH.
$ETNB is developing a drug similar to $AKRO. Stock up 66% pre market.
www.statnews.com/2025/01/27/a...
There is a new pill I'm hoping to qualify for
Rezdiffra. Otherwise I just need to NOT GET WORSE, which involves no sodium, low low low fat, no nitrates, you know the drill.
Rezdiffra. Otherwise I just need to NOT GET WORSE, which involves no sodium, low low low fat, no nitrates, you know the drill.
June 2, 2026 at 1:19 AM
There is a new pill I'm hoping to qualify for
Rezdiffra. Otherwise I just need to NOT GET WORSE, which involves no sodium, low low low fat, no nitrates, you know the drill.
Rezdiffra. Otherwise I just need to NOT GET WORSE, which involves no sodium, low low low fat, no nitrates, you know the drill.
Fun fact! One of the effects of Rezdiffra, the only medication specifically approved for NAFLD, is to increase the liver enzyme that transmits hormones all over your body. The clinical data is like "Idk why this is significant" and my trans perimenopausal ass was like I KNOW WHY.
February 8, 2026 at 4:59 PM
Fun fact! One of the effects of Rezdiffra, the only medication specifically approved for NAFLD, is to increase the liver enzyme that transmits hormones all over your body. The clinical data is like "Idk why this is significant" and my trans perimenopausal ass was like I KNOW WHY.
Here are the key FDA approvals in 2024: Cobenfy for schizophrenia, Duvyzat for Duchenne muscular dystrophy, Rezdiffra for nonalcoholic steatohepatitis and Itovebi for breast cancer. cen.acs.org/policy/regul... #pharma #biopharma #biosky
Key FDA approvals in 2024
2024 authorizations kept a steady clip and gave people some new treatment options
cen.acs.org
December 10, 2024 at 4:37 PM
Here are the key FDA approvals in 2024: Cobenfy for schizophrenia, Duvyzat for Duchenne muscular dystrophy, Rezdiffra for nonalcoholic steatohepatitis and Itovebi for breast cancer. cen.acs.org/policy/regul... #pharma #biopharma #biosky
Early returns on my #resmetirom #rezdiffra #MASH patients at 1 year. So far 7/8 patients reasessed with LSM have a 30% or greater reduction. Hopefully we start getting some real world data to complement the open label trial.
#liversky
#liversky
April 15, 2025 at 12:02 PM
Early returns on my #resmetirom #rezdiffra #MASH patients at 1 year. So far 7/8 patients reasessed with LSM have a 30% or greater reduction. Hopefully we start getting some real world data to complement the open label trial.
#liversky
#liversky
EU regulator backs conditional authorisation for Madrigal's liver disease drug reut.rs/43SGRHv
EU regulator backs conditional authorisation for Madrigal's liver disease drug
The European Union's drug regulator on Friday recommended conditional authorisation of Madrigal Pharmaceuticals' Rezdiffra, paving the way for it to become the first available treatment in the region for patients with a form of fatty liver disease.
reut.rs
June 20, 2025 at 11:10 PM
EU regulator backs conditional authorisation for Madrigal's liver disease drug reut.rs/43SGRHv
I have F-2 liver fibrosis and cant take Rezdiffra..We are up against it trying to keep this from getting worse!!! 🙏🙏🙏🙏🙏❤️❤️❤️🇺🇸💙
May 18, 2026 at 7:14 PM
I have F-2 liver fibrosis and cant take Rezdiffra..We are up against it trying to keep this from getting worse!!! 🙏🙏🙏🙏🙏❤️❤️❤️🇺🇸💙
Weird drug name of the day:
Rezdiffra
Rezdiffra
January 6, 2026 at 3:20 AM
Weird drug name of the day:
Rezdiffra
Rezdiffra
Hearing the 🎶 Rezdiffra 🎶 jingle in my nightmares
May 6, 2025 at 12:56 AM
Hearing the 🎶 Rezdiffra 🎶 jingle in my nightmares
Aught gyaahd this Rezdiffra ad took a song I already cannot stand and made it sound more painful with the 🎵AH-AH-AH-AH-AH-REZDIFFRA🎵 #AEWDynamite
July 16, 2026 at 2:14 AM
Aught gyaahd this Rezdiffra ad took a song I already cannot stand and made it sound more painful with the 🎵AH-AH-AH-AH-AH-REZDIFFRA🎵 #AEWDynamite
Rezdiffra is my least favorite member of the Wu Tang Clan
March 31, 2025 at 12:18 AM
Rezdiffra is my least favorite member of the Wu Tang Clan
Madrigal lands EU approval for MASH treatment Rezdiffra firstwordpharma.com/story/5990521
August 20, 2025 at 9:22 AM
Madrigal lands EU approval for MASH treatment Rezdiffra firstwordpharma.com/story/5990521
The importance of approval of the 1st drug for fatty liver disease -- Madrigal Pharma's resmetirom or Rezdiffra -- is not widely appreciated. ~5% of Americans have MASH (formerly NASH), but about a third have the earlier stage, MASLD (formerly NAFLD). 1/
www.hepmag.com/article/fda-...
www.hepmag.com/article/fda-...
FDA Approves First-Ever Drug for Fatty Liver Disease
People who used resmetirom (Rezdiffra) in a late-stage clinical trial experienced both MASH resolution and fibrosis improvement.
www.hepmag.com
March 15, 2024 at 4:45 PM
The importance of approval of the 1st drug for fatty liver disease -- Madrigal Pharma's resmetirom or Rezdiffra -- is not widely appreciated. ~5% of Americans have MASH (formerly NASH), but about a third have the earlier stage, MASLD (formerly NAFLD). 1/
www.hepmag.com/article/fda-...
www.hepmag.com/article/fda-...
Rezdiffra is the first therapy designed to directly reactivate liver metabolism in MASH. By selectively targeting THR‑β, it reduces liver fat and improves fibrosis. I walk through how this liver‑specific mechanism works in my new video!
youtu.be/E8DYjDMb4m4
youtu.be/E8DYjDMb4m4
How does Rezdiffra (Resmetirom) Work for MASH?
YouTube video by Dr. Rob Swanda
youtu.be
September 3, 2026 at 9:09 PM
Rezdiffra is the first therapy designed to directly reactivate liver metabolism in MASH. By selectively targeting THR‑β, it reduces liver fat and improves fibrosis. I walk through how this liver‑specific mechanism works in my new video!
youtu.be/E8DYjDMb4m4
youtu.be/E8DYjDMb4m4
Big Pharma must give bands/artists a BIG bag to desecrate their songs.
Best Day of My Life was already kinda corny but giving the catchiest part to mf Rezdiffra?? the check(and hopefully royalties) just had to be different bc ain’t no mf’in way.
Best Day of My Life was already kinda corny but giving the catchiest part to mf Rezdiffra?? the check(and hopefully royalties) just had to be different bc ain’t no mf’in way.
November 20, 2025 at 3:00 AM
Big Pharma must give bands/artists a BIG bag to desecrate their songs.
Best Day of My Life was already kinda corny but giving the catchiest part to mf Rezdiffra?? the check(and hopefully royalties) just had to be different bc ain’t no mf’in way.
Best Day of My Life was already kinda corny but giving the catchiest part to mf Rezdiffra?? the check(and hopefully royalties) just had to be different bc ain’t no mf’in way.
More great news this time for European patients living with #MASH with F2/F3 fibrosis with the approval of #Rezdiffra™ (#resmetirom) by the @ema.europa.eu
Rezdiffra is included in the @easlnews.bsky.social
guidelines as FL therapy and is the first approved MASH medication in the EU.
#liversky
Rezdiffra is included in the @easlnews.bsky.social
guidelines as FL therapy and is the first approved MASH medication in the EU.
#liversky
August 20, 2025 at 12:08 AM
More great news this time for European patients living with #MASH with F2/F3 fibrosis with the approval of #Rezdiffra™ (#resmetirom) by the @ema.europa.eu
Rezdiffra is included in the @easlnews.bsky.social
guidelines as FL therapy and is the first approved MASH medication in the EU.
#liversky
Rezdiffra is included in the @easlnews.bsky.social
guidelines as FL therapy and is the first approved MASH medication in the EU.
#liversky
Interesting commercial.
August 14, 2025 at 8:15 PM
Interesting commercial.
Novo’s Wegovy becomes first #GLP1 drug approved for MASH
The only other therapy approved for #MASH, Madrigal Rezdiffra, has gotten off to a stronger-than-expected sales start: $180m in net sales in 2024, $350m over H1 2025, $1b projected annual sales in 2026
www.biopharmadive.com/news/novo-we...
The only other therapy approved for #MASH, Madrigal Rezdiffra, has gotten off to a stronger-than-expected sales start: $180m in net sales in 2024, $350m over H1 2025, $1b projected annual sales in 2026
www.biopharmadive.com/news/novo-we...
Novo’s Wegovy becomes first GLP-1 drug approved for MASH
The FDA clearance sets Novo’s medicine up a market battle with Madrigal Pharmaceuticals’ fast-selling Rezdiffra.
www.biopharmadive.com
August 18, 2025 at 8:44 PM
Novo’s Wegovy becomes first #GLP1 drug approved for MASH
The only other therapy approved for #MASH, Madrigal Rezdiffra, has gotten off to a stronger-than-expected sales start: $180m in net sales in 2024, $350m over H1 2025, $1b projected annual sales in 2026
www.biopharmadive.com/news/novo-we...
The only other therapy approved for #MASH, Madrigal Rezdiffra, has gotten off to a stronger-than-expected sales start: $180m in net sales in 2024, $350m over H1 2025, $1b projected annual sales in 2026
www.biopharmadive.com/news/novo-we...
$MDGL with promising data in compensated MASH fibrosis. Shows robust reduction in liver stiffness in open-label cohort of p3 trial. Registrational study ongoing for this patient group:
finance.yahoo.com/news/madriga...
$AKRO $ETNB
finance.yahoo.com/news/madriga...
$AKRO $ETNB
Madrigal Announces New Two-Year Data from the Compensated MASH Cirrhosis Arm of the MAESTRO-NAFLD-1 Trial Demonstrating Potential Benefit of Rezdiffra™ (resmetirom) in Patients with Compensated MASH C...
Patients achieved a mean 6.7 kPa reduction in liver stiffness as measured by vibration-controlled transient elastography (VCTE); this represents the largest reduction in liver stiffness reported in a ...
finance.yahoo.com
February 26, 2025 at 1:40 PM
$MDGL with promising data in compensated MASH fibrosis. Shows robust reduction in liver stiffness in open-label cohort of p3 trial. Registrational study ongoing for this patient group:
finance.yahoo.com/news/madriga...
$AKRO $ETNB
finance.yahoo.com/news/madriga...
$AKRO $ETNB
Madrigal "opted to charge German insurers $39,500/yr ...the same as in the US. But a German panel that evaluates drug effectiveness found no added benefit for the product, Rezdiffra, compared to standard therapy, suggesting Madrigal will likely need to negotiate a discount."
Trump’s Drug Pricing Policy Deprives Patients in Europe of New Treatments
Rather than endanger their US profits, drugmakers withhold new medicines
www.bloomberg.com
April 23, 2026 at 3:14 PM
Madrigal "opted to charge German insurers $39,500/yr ...the same as in the US. But a German panel that evaluates drug effectiveness found no added benefit for the product, Rezdiffra, compared to standard therapy, suggesting Madrigal will likely need to negotiate a discount."