#DBfeature #Drosophila 🪰
Slit-independent guidance of longitudinal axons by Drosophila Robo3
"A non-Slit-binding function of Robo3 Ig1 contributes to its axon guidance activity."
by Abigail Carranza, Timothy Evans et al
@timevansphd.bsky.social
sciencedirect.com/science/arti...
Slit-independent guidance of longitudinal axons by Drosophila Robo3
"A non-Slit-binding function of Robo3 Ig1 contributes to its axon guidance activity."
by Abigail Carranza, Timothy Evans et al
@timevansphd.bsky.social
sciencedirect.com/science/arti...
October 3, 2025 at 1:37 PM
#DBfeature #Drosophila 🪰
Slit-independent guidance of longitudinal axons by Drosophila Robo3
"A non-Slit-binding function of Robo3 Ig1 contributes to its axon guidance activity."
by Abigail Carranza, Timothy Evans et al
@timevansphd.bsky.social
sciencedirect.com/science/arti...
Slit-independent guidance of longitudinal axons by Drosophila Robo3
"A non-Slit-binding function of Robo3 Ig1 contributes to its axon guidance activity."
by Abigail Carranza, Timothy Evans et al
@timevansphd.bsky.social
sciencedirect.com/science/arti...
🎄 Day 9 of the 24 Days of Development ✨🪸
In Drosophila Robo3 guides axons independently of the canonical repellent, Slit. The authors' findings challenge current models moving the field deeper into understanding the nervous system development! 🪰🌟 doi.org/10.1016/j.yd...
In Drosophila Robo3 guides axons independently of the canonical repellent, Slit. The authors' findings challenge current models moving the field deeper into understanding the nervous system development! 🪰🌟 doi.org/10.1016/j.yd...
December 9, 2025 at 4:22 PM
🎄 Day 9 of the 24 Days of Development ✨🪸
In Drosophila Robo3 guides axons independently of the canonical repellent, Slit. The authors' findings challenge current models moving the field deeper into understanding the nervous system development! 🪰🌟 doi.org/10.1016/j.yd...
In Drosophila Robo3 guides axons independently of the canonical repellent, Slit. The authors' findings challenge current models moving the field deeper into understanding the nervous system development! 🪰🌟 doi.org/10.1016/j.yd...
Lower images show anti-Robo3 channel alone from the same embryos. In wild type embryos, endogenous Robo3 protein is detectable on longitudinal axons within the outer two-thirds of the neuropile. Robo3 protein is undetectable in embryos homozygous for the robo3 loss of function and deletion alleles.
October 3, 2025 at 4:55 PM
Lower images show anti-Robo3 channel alone from the same embryos. In wild type embryos, endogenous Robo3 protein is detectable on longitudinal axons within the outer two-thirds of the neuropile. Robo3 protein is undetectable in embryos homozygous for the robo3 loss of function and deletion alleles.
Wait that's not how I remember the episode going
May 7, 2025 at 2:48 PM
Wait that's not how I remember the episode going
Apologies for the missing Alt text
Fluorescent microscopy images of stage 16–17 Drosophila embryonic ventral nerve cords form wild type, mutant, and modified robo3 alleles, stained with anti-HRP (magenta; labels all axons) and anti-Robo3 (green) antibodies.
Fluorescent microscopy images of stage 16–17 Drosophila embryonic ventral nerve cords form wild type, mutant, and modified robo3 alleles, stained with anti-HRP (magenta; labels all axons) and anti-Robo3 (green) antibodies.
October 3, 2025 at 4:53 PM
Apologies for the missing Alt text
Fluorescent microscopy images of stage 16–17 Drosophila embryonic ventral nerve cords form wild type, mutant, and modified robo3 alleles, stained with anti-HRP (magenta; labels all axons) and anti-Robo3 (green) antibodies.
Fluorescent microscopy images of stage 16–17 Drosophila embryonic ventral nerve cords form wild type, mutant, and modified robo3 alleles, stained with anti-HRP (magenta; labels all axons) and anti-Robo3 (green) antibodies.
Neural birth time and somatosensory circuit assembly are linked by Robo3 regulation of dendrite morphology https://www.biorxiv.org/content/10.64898/2026.05.29.728185v1
May 31, 2026 at 8:30 AM
Neural birth time and somatosensory circuit assembly are linked by Robo3 regulation of dendrite morphology https://www.biorxiv.org/content/10.64898/2026.05.29.728185v1
RRID:CVCL_D603 was used by the authors of the FEBS Letters paper "Glu592 of the axon guidance receptor ROBO3 mediates a pH‐dependent interaction with NELL2 ligand". We appreciate the author's support of reproducibility. #ReproducibleResearch #RRID
doi.org
March 27, 2025 at 10:34 PM
RRID:CVCL_D603 was used by the authors of the FEBS Letters paper "Glu592 of the axon guidance receptor ROBO3 mediates a pH‐dependent interaction with NELL2 ligand". We appreciate the author's support of reproducibility. #ReproducibleResearch #RRID
Then again I like all the Lethal Weapon movies, which got more bombastic and inanely over-the-top after the first movie, so maybe I should give it a chance
I will probably not watch Robo3 tho lol
I will probably not watch Robo3 tho lol
May 18, 2025 at 12:15 AM
Then again I like all the Lethal Weapon movies, which got more bombastic and inanely over-the-top after the first movie, so maybe I should give it a chance
I will probably not watch Robo3 tho lol
I will probably not watch Robo3 tho lol
There are no large-scale defects detectable with anti-HRP in the axon scaffold.
In homozygous slit2 null mutants, all axons collapse at the midline due to a complete lack of midline repulsion, but Robo3 protein is still localized properly to axons.
In homozygous slit2 null mutants, all axons collapse at the midline due to a complete lack of midline repulsion, but Robo3 protein is still localized properly to axons.
October 3, 2025 at 4:55 PM
There are no large-scale defects detectable with anti-HRP in the axon scaffold.
In homozygous slit2 null mutants, all axons collapse at the midline due to a complete lack of midline repulsion, but Robo3 protein is still localized properly to axons.
In homozygous slit2 null mutants, all axons collapse at the midline due to a complete lack of midline repulsion, but Robo3 protein is still localized properly to axons.
The authors included RRIDs in their in bioRxiv paper! RRIDs improve reproducibility in scientific research. #accelerateopenscience #BetterScience #OpenScience
Neural birth time and somatosensory circuit assembly are linked by Robo3 regulation of dendrite morphology
Read the full paper: Neural birth time and somatosensory circuit assembly are linked by Robo3 regulation of dendrite morphology
doi.org
August 27, 2026 at 7:02 AM
The authors included RRIDs in their in bioRxiv paper! RRIDs improve reproducibility in scientific research. #accelerateopenscience #BetterScience #OpenScience
www.twitch.tv/j3xrg beep bop boop bop... yup. Robo3 today. I"m playing some #teamfighttactics now, little #LeagueOfLegends ranked later, maybe arams? Then to end the night we shall plate up!
j3xrg - Twitch
I'm here for one thing and one thing only... suffering... Kidding. some Tft/LoL until we plate? Reminder 24 hr coming up friyay.
www.twitch.tv
February 25, 2026 at 8:39 PM
www.twitch.tv/j3xrg beep bop boop bop... yup. Robo3 today. I"m playing some #teamfighttactics now, little #LeagueOfLegends ranked later, maybe arams? Then to end the night we shall plate up!
Open Access UCL Research: The Role of Robo3 in the Development of Cortical Interneurons discovery.ucl.ac.uk/id/eprint/10...
The Role of Robo3 in the Development of Cortical Interneurons
-
UCL Discovery
UCL Discovery is UCL's open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
discovery.ucl.ac.uk
June 22, 2026 at 2:25 PM
Open Access UCL Research: The Role of Robo3 in the Development of Cortical Interneurons discovery.ucl.ac.uk/id/eprint/10...
#Robo3 antibodies are crucial for detecting the Roundabout Guidance Receptor 3 protein & studying neuraldevelopment & #axonnavigation—but reliable #antibodies are in short supply.
IPI just released two anti-ROBO3s that might help.
Dive into the data on our product pages ➡️ buff.ly/kk4fLJJ
IPI just released two anti-ROBO3s that might help.
Dive into the data on our product pages ➡️ buff.ly/kk4fLJJ
April 8, 2026 at 8:50 PM
#Robo3 antibodies are crucial for detecting the Roundabout Guidance Receptor 3 protein & studying neuraldevelopment & #axonnavigation—but reliable #antibodies are in short supply.
IPI just released two anti-ROBO3s that might help.
Dive into the data on our product pages ➡️ buff.ly/kk4fLJJ
IPI just released two anti-ROBO3s that might help.
Dive into the data on our product pages ➡️ buff.ly/kk4fLJJ
New antibody release!
🧪 Anti-ROBO1 [IPI-ROBO1.81]
🧪 Anti-ROBO3 [IPI-ROBO3.119]
🧪 Anti-ROBO3 [IPI-ROBO3.124]
🧪 Anti-Slit-2 [IPI-Slit2.37]
Use our recombinant monoclonals to study #axonguidance #cellmigration #tissueformation #cytoskelatalorganization, #neuronalwiring & more
buff.ly/oNye2Ky
🧪 Anti-ROBO1 [IPI-ROBO1.81]
🧪 Anti-ROBO3 [IPI-ROBO3.119]
🧪 Anti-ROBO3 [IPI-ROBO3.124]
🧪 Anti-Slit-2 [IPI-Slit2.37]
Use our recombinant monoclonals to study #axonguidance #cellmigration #tissueformation #cytoskelatalorganization, #neuronalwiring & more
buff.ly/oNye2Ky
Axon Guidance Antibody Collection
For neurons to communicate, their axons must navigate precisely to their targets through a complex process known as axon guidance or neuronal migration. This pr
buff.ly
March 16, 2026 at 1:23 PM
New antibody release!
🧪 Anti-ROBO1 [IPI-ROBO1.81]
🧪 Anti-ROBO3 [IPI-ROBO3.119]
🧪 Anti-ROBO3 [IPI-ROBO3.124]
🧪 Anti-Slit-2 [IPI-Slit2.37]
Use our recombinant monoclonals to study #axonguidance #cellmigration #tissueformation #cytoskelatalorganization, #neuronalwiring & more
buff.ly/oNye2Ky
🧪 Anti-ROBO1 [IPI-ROBO1.81]
🧪 Anti-ROBO3 [IPI-ROBO3.119]
🧪 Anti-ROBO3 [IPI-ROBO3.124]
🧪 Anti-Slit-2 [IPI-Slit2.37]
Use our recombinant monoclonals to study #axonguidance #cellmigration #tissueformation #cytoskelatalorganization, #neuronalwiring & more
buff.ly/oNye2Ky
Temporal control of axonal floor plate crossing through a combination of incoherent feedforward and feedback loops of gene regulatory network regulating Robo3 expression https://www.biorxiv.org/content/10.1101/2025.10.26.684599v1
October 27, 2025 at 8:30 AM
Temporal control of axonal floor plate crossing through a combination of incoherent feedforward and feedback loops of gene regulatory network regulating Robo3 expression https://www.biorxiv.org/content/10.1101/2025.10.26.684599v1
Neural birth time and somatosensory circuit assembly are linked by Robo3 regulation of dendrite morphology https://www.biorxiv.org/content/10.64898/2026.05.29.728185v1
May 31, 2026 at 8:30 AM
Neural birth time and somatosensory circuit assembly are linked by Robo3 regulation of dendrite morphology https://www.biorxiv.org/content/10.64898/2026.05.29.728185v1
Temporal control of axonal floor plate crossing through a combination of incoherent feedforward and feedback loops of gene regulatory network regulating Robo3 expression https://www.biorxiv.org/content/10.1101/2025.10.26.684599v1
October 27, 2025 at 8:30 AM
Temporal control of axonal floor plate crossing through a combination of incoherent feedforward and feedback loops of gene regulatory network regulating Robo3 expression https://www.biorxiv.org/content/10.1101/2025.10.26.684599v1
These days I enjoy video essays on games in genres I don't play. I love hearing in depth about what makes these things interesting and important to people, even if I'm not going to spend the time.
Just go in knowing that yes, Robo3 is PG-13, but it's still dark af. It's free on tubi right now!
Just go in knowing that yes, Robo3 is PG-13, but it's still dark af. It's free on tubi right now!
July 25, 2025 at 6:20 PM
These days I enjoy video essays on games in genres I don't play. I love hearing in depth about what makes these things interesting and important to people, even if I'm not going to spend the time.
Just go in knowing that yes, Robo3 is PG-13, but it's still dark af. It's free on tubi right now!
Just go in knowing that yes, Robo3 is PG-13, but it's still dark af. It's free on tubi right now!
Carranza, A., Howard, L. J., Brown, H. E., Ametepe, A. S. and Evans, T. A. (2023). Slit-independent guidance of longitudinal axons by #Drosophila Robo3. bioRxiv. www.biorxiv.org/content/10.1...
August 12, 2024 at 3:13 PM
Carranza, A., Howard, L. J., Brown, H. E., Ametepe, A. S. and Evans, T. A. (2023). Slit-independent guidance of longitudinal axons by #Drosophila Robo3. bioRxiv. www.biorxiv.org/content/10.1...
Carranza, A., Howard, L. J., Brown, H. E., Ametepe, A. S. and Evans, T. A. (2023). Slit-independent guidance of longitudinal axons by #Drosophila Robo3. bioRxiv. www.biorxiv.org/content/10.1...
May 7, 2024 at 7:56 PM
Carranza, A., Howard, L. J., Brown, H. E., Ametepe, A. S. and Evans, T. A. (2023). Slit-independent guidance of longitudinal axons by #Drosophila Robo3. bioRxiv. www.biorxiv.org/content/10.1...
Name: Robo3
Builder: anibal71
Desc: Pretty cool robo
Builder: anibal71
Desc: Pretty cool robo
Download bot file
neat-lia-robocrafter-d6265826.koyeb.app
January 4, 2025 at 9:53 PM
Name: Robo3
Builder: anibal71
Desc: Pretty cool robo
Builder: anibal71
Desc: Pretty cool robo