#S100A8/9
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pedalheadphx.bsky.social
#ASH24 myeloma, Adolfo Alena from Mount Sinai, MDSC with S100A8/9 expression associated with poor Car-t outcome, incubation of CAr-t with S100A8/9 has linear effect on inhibiting cytotoxic effect, can be salvaged with a blocking antibody. Great talk
December 8, 2024 at 8:12 PM
hancardiomd.bsky.social
#Cancer and #CVD are intertwined, with inflammation and a dysregulated immune system being common contributors

Shared Mechanisms in Cancer and #CVD : #S100A8/9 and the #NLRP3 #Inflammasome

#CardioSky #OncoSky @cardioobdoc.bsky.social @novitham.bsky.social @pnatarajanmd.bsky.social
April 18, 2025 at 1:27 AM
acr-journals.bsky.social
In a large SLE cohort, serum S100A8/A9 levels were elevated in patients with cognitive impairment. Changes in S100A8/A9 levels also corresponded with changes in cognitive status over one year

Arthritis Care & Research
doi.org/10.1002/acr....

#Medsky #Rheumsky #lupus
Serum levels of S100A8/A9 and MMP-9 discriminated by visit. A. Correlations between S100A8/A9 and MMP-9 serum levels at baseline (left) and one-year visit (right). Correlations were calculated using the Spearman’s correlation coefficient. B and C. Strip plots with median bars showing, from left to right, levels for patients with non-CI, Indeterminant CI (Indet), and definitive CI for S100A8/A9 (B) and MMP-9 (C). Each circle represents a single subject, the middle line indicating the median for the subjects and error bars denoting the interquartile ranges. Statistical significance was determined using the Kruskal-Wallis test corrected for multiple comparisons with significant differences indicated by asterisks
May 23, 2025 at 8:22 PM
stevenmathern.bsky.social
CAD vs Cancer, inflammation, see image, interesting

'Cancer and Cardiovascular Disease: S100A8/9 and the NLRP3 Inflammasome'

#oncosky #cardiosky #cvprev

www.jacc.org/doi/10.1016/...
December 18, 2024 at 9:17 AM
vasculitides.bsky.social
S100 proteins in IgA vasculitis and other systemic vasculitides - from pathogenic mechanisms to clinical biomarkers: a systematic review
S100 proteins in IgA vasculitis and other systemic vasculitides - from pathogenic mechanisms to clinical biomarkers: a systematic review - PubMed
S100 proteins may act as mediators in the IgAV inflammatory cascade. However, the current evidence base remains fragmented. Although S100A8/9 appears promising, standardized prospective studies are re...
pubmed.ncbi.nlm.nih.gov
April 24, 2026 at 11:42 PM
research.migraine.kr
It reversed the CM-induced upregulation of inflammatory and oxidative stress-related genes (e.g., Nfkbia, S100a8, S100a9, Penk). The imbalance between neuronal excitability and metabolism was rectified through the modulation of glutamatergic transmission and oxidative (🧵 6/9)
June 16, 2026 at 6:21 PM
hancardiomd.bsky.social
www.jacc.org/doi/10.1016/...
Shared Mechanisms in Cancer and Cardiovascular Disease: S100A8/9 and the NLRP3 Inflammasome: JACC: CardioOncology State-of-the-Art Review
www.jacc.org
April 18, 2025 at 1:27 AM
bigearthdata.ai
S100A8/9-NLRP3-mediated chronic unresolved inflammation drives cardiac pathologies following invasive pneumococcal disease
->Nature | #Disease #Health | More from Lil' Dr Glen at BigEarthData.ai
S100A8/9-NLRP3-mediated chronic unresolved inflammation drives cardiac pathologies following invasive pneumococcal disease
First, to assess ongoing cardiac stress/damage in patients hospitalized for severe Spn infection who had earlier received antibiotic treatment to eradicate the bacterium, we measured HF markers in their blood serum 5 days after admission. As expected, elevated levels of...
www.nature.com
October 10, 2025 at 2:47 PM
moltherapy.bsky.social
Targeting S100A8/A9-NCF1 Axis in Tumor microenvironment to Prevent Tumor Metastasis by Self-assembled Peptide Nanofibers
Cai and colleagues developed a dual-functional peptide, termed H6-Q11, which was designed to target S100A9 in the tumor microenvironment (TME). The disturbance of S100A8/9-NCF1 axis in the TME mediated by S100A9-targeted peptide was initially discovered…
dlvr.it
March 4, 2025 at 8:15 PM
thejidinnovations.bsky.social
From the May issue: A neuroimmune axis linking S100A8/9 to itch sensitization in both bullous pemphigoid and atopic dermatitis https://ow.ly/YO2450YMAIl #S100A8 #BullousPemphigoid #AtopicDermatitis #medderm #dermsky
June 9, 2026 at 3:40 PM
thejidinnovations.bsky.social
A neuroimmune axis linking S100A8/9 to itch sensitization in both bullous pemphigoid and atopic dermatitis https://ow.ly/u5Zu50YMAIm #S100A8 #BullousPemphigoid #AtopicDermatitis #medderm #dermsky
April 23, 2026 at 11:15 AM