#S100A8
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pedalheadphx.bsky.social
#ASH24 myeloma, Adolfo Alena from Mount Sinai, MDSC with S100A8/9 expression associated with poor Car-t outcome, incubation of CAr-t with S100A8/9 has linear effect on inhibiting cytotoxic effect, can be salvaged with a blocking antibody. Great talk
December 8, 2024 at 8:12 PM
hancardiomd.bsky.social
#Cancer and #CVD are intertwined, with inflammation and a dysregulated immune system being common contributors

Shared Mechanisms in Cancer and #CVD : #S100A8/9 and the #NLRP3 #Inflammasome

#CardioSky #OncoSky @cardioobdoc.bsky.social @novitham.bsky.social @pnatarajanmd.bsky.social
April 18, 2025 at 1:27 AM
cp-cellmetabolism.bsky.social
Online now: The S100A8/A9 complex promotes food intake and prevents adipose tissue loss during cancer cachexia in mice
The S100A8/A9 complex promotes food intake and prevents adipose tissue loss during cancer cachexia in mice
Gao et al. report that cancer cachexia disrupts energy balance by reducing food intake and body weight. They identify a hypothalamic S100A8/A9-C3 signaling pathway linking inflammation to adipose tissue loss and metabolic imbalance.
dlvr.it
March 3, 2026 at 4:42 PM
labwaggoner.bsky.social
@biorxivpreprint.bsky.social Epigenetic control of S100A8/A9-driven monocytic inflammation licenses anti-leukemic functionality of immature NK cells during hematopoietic stem cell differentiation
www.biorxiv.org/content/10.6...
March 28, 2026 at 4:32 PM
trowbridgelab.bsky.social
New preprint from our lab led by Jayna Mistry! 🧬

We asked: what upstream signal ignites the inflammatory cycle that drives clonal hematopoiesis (CH)?

Answer: neutrophil-derived S100A8/A9 alarmins.

biorxiv.org/content/10.648
98/2026.06.26.734778v1

🧵1/4
biorxiv.org
June 29, 2026 at 3:18 PM
acr-journals.bsky.social
In a large SLE cohort, serum S100A8/A9 levels were elevated in patients with cognitive impairment. Changes in S100A8/A9 levels also corresponded with changes in cognitive status over one year

Arthritis Care & Research
doi.org/10.1002/acr....

#Medsky #Rheumsky #lupus
Serum levels of S100A8/A9 and MMP-9 discriminated by visit. A. Correlations between S100A8/A9 and MMP-9 serum levels at baseline (left) and one-year visit (right). Correlations were calculated using the Spearman’s correlation coefficient. B and C. Strip plots with median bars showing, from left to right, levels for patients with non-CI, Indeterminant CI (Indet), and definitive CI for S100A8/A9 (B) and MMP-9 (C). Each circle represents a single subject, the middle line indicating the median for the subjects and error bars denoting the interquartile ranges. Statistical significance was determined using the Kruskal-Wallis test corrected for multiple comparisons with significant differences indicated by asterisks
May 23, 2025 at 8:22 PM
jci.org
New insights into lipid redistribution!

Bin Gao & team show macrophages promote fat redistribution from adipocytes to hepatocytes and development of steatotic liver disease: www.jci.org/articles/vie...

The figure shows MASH liver has elevated S100A8+ macrophages.
November 13, 2025 at 2:04 PM
renesugar.bsky.social
Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy #calprotectin #MECFS #LongCovid

www.nature.com/articles/s42...
Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy - Communications Biology
Sepsis-induced skeletal muscle atrophy is linked to increased mortality in septic patients; in this study, the authors identify the S100a8/a9-RAGE pathway as a key driver of mitochondrial fragmentatio...
www.nature.com
March 10, 2025 at 8:34 PM
drpaulalindner.bsky.social
Exploring the Relevance of S100A8 and S100A9 Proteins in Preeclampsia: A Narrative Review

#Calprotectin

www.mdpi.com/1422-0067/26...
November 4, 2025 at 2:20 PM
stevenmathern.bsky.social
CAD vs Cancer, inflammation, see image, interesting

'Cancer and Cardiovascular Disease: S100A8/9 and the NLRP3 Inflammasome'

#oncosky #cardiosky #cvprev

www.jacc.org/doi/10.1016/...
December 18, 2024 at 9:17 AM
jackamatica.bsky.social
These molecular changes matched symptom severity.

Patients with higher GDF15 had worse fatigue scores.

Those with lower 12,13-diHOME had more physical fatigue and reduced activity.

Inflammation markers like S100A8 also tracked with fatigue and motivation loss.
September 4, 2025 at 3:55 PM
lupus.org
New study finds that elevated S100A8/A9 levels in blood may be associated with cognitive impairment in adults with #lupus. Read the study:
Study finds Elevated Serum Levels Linked to Cognitive Impairment in those with Systemic Lupus Erythematous
New study finds that elevated S100A8/A9 levels in blood may be associated with cognitive impairment in adults with #lupus.
buff.ly
May 22, 2025 at 4:03 PM
jackamatica.bsky.social
After exercise, ME/CFS patients had higher activity in the immune system’s complement pathway.

Proteins like C1r, CFHR4, and S100A8 rose - linked to inflammation, fatigue, and brain dysfunction.

Calcium signaling, key to immune and brain function, was also disrupted.
September 4, 2025 at 3:55 PM
acr-journals.bsky.social
Race, ethnicity, and geographic diversity in trials of DMARDs for psoriatic arthritis in the US
doi.org/10.1002/acr....

S100A8/A9 levels elevated in SLE patients with cognitive impairment
doi.org/10.1002/acr....
May 24, 2025 at 12:33 PM
moltherapy.bsky.social
Downregulation of S100a8 mitigates fibrosis in skeletal muscles affected by Marfan Syndrome
This study demonstrates that eccentric exercise is beneficial to reducing fibrosis in muscles affected by Marfan syndrome by downregulating S100a8 expression. Thus, the eccentric exercise and genetic knockdown of S100a8 represent potential strategies to mitigate muscle fibrosis in patients with Marfan syndrome, and consequently improve their quality of life.
dlvr.it
January 24, 2026 at 7:09 PM
currentmedscience.bsky.social
Elevated #S100A8/A9 drives abnormal #proliferation, migration, #adhesion & #Chemoresistance in #DNMT3A mutant AML. Targeting this pathway could be a promising therapeutic strategy. #medsky

Read more: doi.org/10.1007/s115...

#currentmedicalscience #Oncology #CancerTherapeutics
Targeting Calprotectin S100A8/A9 to Overcome AML Progression in DNMT3A-Mutant Cells
September 9, 2026 at 2:45 PM
whrcluster.bsky.social
Highest elevations of [18F]FEPPA were seen in participants with anorexia nervosa compared to healthy controls. They also observed an inverse correlation between [18F]FEPPA in the brain and levels of S100A8 in blood (serum), which may indicate a shift towards a "less helpful" form of inflammation.
April 13, 2026 at 4:48 PM
renesugar.bsky.social
www.nature.com/articles/s42...

"Inhibition of S100a8/a9 significantly improved mitochondrial function and alleviated muscle atrophy."

"Conversely, administration of recombinant S100a8/a9 protein exacerbated mitochondrial energy exhaustion and myocyte atrophy."
Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy - Communications Biology
Sepsis-induced skeletal muscle atrophy is linked to increased mortality in septic patients; in this study, the authors identify the S100a8/a9-RAGE pathway as a key driver of mitochondrial fragmentatio...
www.nature.com
March 10, 2025 at 8:34 PM
drpaulalindner.bsky.social
Circulating calprotectin (S100A8/A9) levels on day 1 in patients with ACS accurately classified patients at varying risks of HF, serving as a robust tool for HF risk prediction and treatment guidance.

#CardioSky #Calprotectin #S100A8/A9 #HeartFailure

www.ahajournals.org/doi/10.1161/...
Development and Validation of Risk Stratification for Heart Failure After Acute Coronary Syndrome Based on Dynamic S100A8/A9 Levels | Journal of the American Heart Association
www.ahajournals.org
February 4, 2025 at 7:56 AM
labwaggoner.bsky.social
Systemic S100A8/A9 inhibition triggers immunosuppressive myeloid cell differentiation, whereas tumor-targeted delivery restores tumor control
www.science.org/doi/10.1126/...
July 17, 2025 at 2:25 PM
renesugar.bsky.social
www.nature.com/articles/s42...

"Mechanistically, S100a8/a9 binding to RAGE induced Drp1 phosphorylation and mitochondrial fragmentation, resulting in muscle atrophy."
Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy - Communications Biology
Sepsis-induced skeletal muscle atrophy is linked to increased mortality in septic patients; in this study, the authors identify the S100a8/a9-RAGE pathway as a key driver of mitochondrial fragmentatio...
www.nature.com
March 10, 2025 at 8:34 PM
biorxiv-immuno.bsky.social
Neutrophil and NET-driven pulmonary microvascular injury following myocardial injury: attenuation by S100A8/A9 inhibition https://www.biorxiv.org/content/10.1101/2025.09.12.675647v1
September 17, 2025 at 7:17 PM
renesugar.bsky.social
www.nature.com/articles/s42...

"Our findings indicated the pivotal role of S100a8/a9 in driving the mitochondrial fragmentation in septic muscle atrophy."
Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy - Communications Biology
Sepsis-induced skeletal muscle atrophy is linked to increased mortality in septic patients; in this study, the authors identify the S100a8/a9-RAGE pathway as a key driver of mitochondrial fragmentatio...
www.nature.com
March 10, 2025 at 8:34 PM
renesugar.bsky.social
www.nature.com/articles/s42...

"Targeting S100a8/a9-RAGE-initiated mitochondrial fission might offer a promising therapeutic intervention against septic muscle atrophy."
Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy - Communications Biology
Sepsis-induced skeletal muscle atrophy is linked to increased mortality in septic patients; in this study, the authors identify the S100a8/a9-RAGE pathway as a key driver of mitochondrial fragmentatio...
www.nature.com
March 10, 2025 at 8:34 PM