#S100A8/A9
LightNews LightNews
acr-journals.bsky.social
In a large SLE cohort, serum S100A8/A9 levels were elevated in patients with cognitive impairment. Changes in S100A8/A9 levels also corresponded with changes in cognitive status over one year

Arthritis Care & Research
doi.org/10.1002/acr....

#Medsky #Rheumsky #lupus
Serum levels of S100A8/A9 and MMP-9 discriminated by visit. A. Correlations between S100A8/A9 and MMP-9 serum levels at baseline (left) and one-year visit (right). Correlations were calculated using the Spearman’s correlation coefficient. B and C. Strip plots with median bars showing, from left to right, levels for patients with non-CI, Indeterminant CI (Indet), and definitive CI for S100A8/A9 (B) and MMP-9 (C). Each circle represents a single subject, the middle line indicating the median for the subjects and error bars denoting the interquartile ranges. Statistical significance was determined using the Kruskal-Wallis test corrected for multiple comparisons with significant differences indicated by asterisks
May 23, 2025 at 8:22 PM
cp-cellmetabolism.bsky.social
Online now: The S100A8/A9 complex promotes food intake and prevents adipose tissue loss during cancer cachexia in mice
The S100A8/A9 complex promotes food intake and prevents adipose tissue loss during cancer cachexia in mice
Gao et al. report that cancer cachexia disrupts energy balance by reducing food intake and body weight. They identify a hypothalamic S100A8/A9-C3 signaling pathway linking inflammation to adipose tissue loss and metabolic imbalance.
dlvr.it
March 3, 2026 at 4:42 PM
trowbridgelab.bsky.social
New preprint from our lab led by Jayna Mistry! 🧬

We asked: what upstream signal ignites the inflammatory cycle that drives clonal hematopoiesis (CH)?

Answer: neutrophil-derived S100A8/A9 alarmins.

biorxiv.org/content/10.648
98/2026.06.26.734778v1

🧵1/4
biorxiv.org
June 29, 2026 at 3:18 PM
labwaggoner.bsky.social
@biorxivpreprint.bsky.social Epigenetic control of S100A8/A9-driven monocytic inflammation licenses anti-leukemic functionality of immature NK cells during hematopoietic stem cell differentiation
www.biorxiv.org/content/10.6...
March 28, 2026 at 4:32 PM
arvoiovs.bsky.social
Review article by Ruihua Wei, Yankai Wei et al. from Tianjin Medical University Eye Hospital discusses the role of S100A8/A9 in autoimmune eye diseases, from pathogenesis to targeted therapy.
doi.org/10.1167/iovs.67.11.42
September 22, 2026 at 2:22 PM
imetascience.bsky.social
Monocyte inflammation and adaptive immune dysfunction in severe Klebsiella pneumoniae pneumonia
💡 Severe disease features S100A8/A9/A12-high inflammatory monocytes, impaired antigen presentation, and disrupted adaptive immune coordination. onlinelibrary.wiley.com/doi/10.1002/...
Monocyte inflammation and adaptive immune dysfunction in severe <i>Klebsiella pneumoniae</i> pneumonia
Severe Klebsiella pneumoniae pneumonia combines intense inflammation with failure to control infection, yet the cellular basis is unclear. Using a severity-focused single-cell atlas of 708,894 periph...
onlinelibrary.wiley.com
September 22, 2026 at 11:13 AM
lupus.org
New study finds that elevated S100A8/A9 levels in blood may be associated with cognitive impairment in adults with #lupus. Read the study:
Study finds Elevated Serum Levels Linked to Cognitive Impairment in those with Systemic Lupus Erythematous
New study finds that elevated S100A8/A9 levels in blood may be associated with cognitive impairment in adults with #lupus.
buff.ly
May 22, 2025 at 4:03 PM
renesugar.bsky.social
Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy #calprotectin #MECFS #LongCovid

www.nature.com/articles/s42...
Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy - Communications Biology
Sepsis-induced skeletal muscle atrophy is linked to increased mortality in septic patients; in this study, the authors identify the S100a8/a9-RAGE pathway as a key driver of mitochondrial fragmentatio...
www.nature.com
March 10, 2025 at 8:34 PM
acr-journals.bsky.social
Race, ethnicity, and geographic diversity in trials of DMARDs for psoriatic arthritis in the US
doi.org/10.1002/acr....

S100A8/A9 levels elevated in SLE patients with cognitive impairment
doi.org/10.1002/acr....
May 24, 2025 at 12:33 PM
currentmedscience.bsky.social
Elevated #S100A8/A9 drives abnormal #proliferation, migration, #adhesion & #Chemoresistance in #DNMT3A mutant AML. Targeting this pathway could be a promising therapeutic strategy. #medsky

Read more: doi.org/10.1007/s115...

#currentmedicalscience #Oncology #CancerTherapeutics
Targeting Calprotectin S100A8/A9 to Overcome AML Progression in DNMT3A-Mutant Cells
September 9, 2026 at 2:45 PM
renesugar.bsky.social
www.nature.com/articles/s42...

"Inhibition of S100a8/a9 significantly improved mitochondrial function and alleviated muscle atrophy."

"Conversely, administration of recombinant S100a8/a9 protein exacerbated mitochondrial energy exhaustion and myocyte atrophy."
Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy - Communications Biology
Sepsis-induced skeletal muscle atrophy is linked to increased mortality in septic patients; in this study, the authors identify the S100a8/a9-RAGE pathway as a key driver of mitochondrial fragmentatio...
www.nature.com
March 10, 2025 at 8:34 PM
drpaulalindner.bsky.social
Circulating calprotectin (S100A8/A9) levels on day 1 in patients with ACS accurately classified patients at varying risks of HF, serving as a robust tool for HF risk prediction and treatment guidance.

#CardioSky #Calprotectin #S100A8/A9 #HeartFailure

www.ahajournals.org/doi/10.1161/...
Development and Validation of Risk Stratification for Heart Failure After Acute Coronary Syndrome Based on Dynamic S100A8/A9 Levels | Journal of the American Heart Association
www.ahajournals.org
February 4, 2025 at 7:56 AM
labwaggoner.bsky.social
Systemic S100A8/A9 inhibition triggers immunosuppressive myeloid cell differentiation, whereas tumor-targeted delivery restores tumor control
www.science.org/doi/10.1126/...
July 17, 2025 at 2:25 PM
biorxiv-immuno.bsky.social
Neutrophil and NET-driven pulmonary microvascular injury following myocardial injury: attenuation by S100A8/A9 inhibition https://www.biorxiv.org/content/10.1101/2025.09.12.675647v1
September 17, 2025 at 7:17 PM
renesugar.bsky.social
www.nature.com/articles/s42...

"Mechanistically, S100a8/a9 binding to RAGE induced Drp1 phosphorylation and mitochondrial fragmentation, resulting in muscle atrophy."
Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy - Communications Biology
Sepsis-induced skeletal muscle atrophy is linked to increased mortality in septic patients; in this study, the authors identify the S100a8/a9-RAGE pathway as a key driver of mitochondrial fragmentatio...
www.nature.com
March 10, 2025 at 8:34 PM
renesugar.bsky.social
www.nature.com/articles/s42...

"Targeting S100a8/a9-RAGE-initiated mitochondrial fission might offer a promising therapeutic intervention against septic muscle atrophy."
Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy - Communications Biology
Sepsis-induced skeletal muscle atrophy is linked to increased mortality in septic patients; in this study, the authors identify the S100a8/a9-RAGE pathway as a key driver of mitochondrial fragmentatio...
www.nature.com
March 10, 2025 at 8:34 PM
renesugar.bsky.social
www.nature.com/articles/s42...

"Our findings indicated the pivotal role of S100a8/a9 in driving the mitochondrial fragmentation in septic muscle atrophy."
Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy - Communications Biology
Sepsis-induced skeletal muscle atrophy is linked to increased mortality in septic patients; in this study, the authors identify the S100a8/a9-RAGE pathway as a key driver of mitochondrial fragmentatio...
www.nature.com
March 10, 2025 at 8:34 PM
heniek-htw.bsky.social
Therapeutic S100A8/A9 inhibition reduces NADPH oxidase expression, reactive oxygen species production and NLRP3 inflammasome priming in the ischemic myocardium
www.sciencedirect.com/science/arti...
April 2, 2025 at 5:48 PM
drpaulalindner.bsky.social
🤔 #CirculatingCalprotectin as a progonostic marker in Idiopathic Subglottic Stenosis
onlinelibrary.wiley.com/doi/10.1002/...
Serum S100A8/A9 Correlates to Surgery‐Free Interval in Idiopathic Subglottic Stenosis
This study investigates the potential of S100A8/A9 as a prognostic biomarker in Idiopathic Subglottic Stenosis (iSGS), a condition predominantly affecting women of northern European descent. Serum S1...
onlinelibrary.wiley.com
December 4, 2024 at 7:15 AM
rridrobot.bsky.social
A paper using RRID:AB_2882179 from @proteintech.bsky.social was just published in Cell Metabolism. Thanks for making your methods matter! #ReproducibleResearch #OpenScience #reproducibility
The S100A8/A9 complex promotes food intake and prevents adipose tissue loss during cancer cachexia in mice
Read the full paper: The S100A8/A9 complex promotes food intake and prevents adipose tissue loss during cancer cachexia in mice
doi.org
March 6, 2026 at 8:00 AM
renesugar.bsky.social
www.nature.com/articles/s42...

"Moreover, in mouse model of sepsis, the skeletal muscle atrophy was also observed, which was associated with the upregulation of S100a8/a9-mediated mitochondrial dysfunction."
Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy - Communications Biology
Sepsis-induced skeletal muscle atrophy is linked to increased mortality in septic patients; in this study, the authors identify the S100a8/a9-RAGE pathway as a key driver of mitochondrial fragmentatio...
www.nature.com
March 10, 2025 at 8:34 PM
drpaulalindner.bsky.social
🗣️Webinar by Prof. Dr. Marija Jeluŝić now available on demand 🌐

Serum Calprotectin (S100A8/A9) in Diagnosis, Monitoring, and Prognosis of Rheumatic Diseases

selectscience.streamgo.live/serum-calpro...

#RheumaSky #Calprotectin #Inflammation
Serum Calprotectin (S100A8/A9) in Diagnosis, Monitoring, and Prognosis of Rheumatic Diseases
<p><strong>Available On-Demand</strong></p> <p>Serum calprotectin plays a critical role in the pathogenesis of rheumatoid arthritis (RA), as it triggers chemotaxis, phagocyte migration, and modulation...
selectscience.streamgo.live
April 8, 2025 at 6:38 AM
rridrobot.bsky.social
The authors included RRIDs in their None paper! We value the author's support of reproducibility. #ReproducibleResearch #reproducibility #methodsmatter
Neutrophil and NET-driven pulmonary microvascular injury following myocardial injury: attenuation by S100A8/A9 inhibition
doi.org
September 24, 2025 at 7:00 AM
bmc-lmu.bsky.social
📣 Our team reveals @elife.bsky.social how this #protein influences calcium #signalling, #cytoskeletal dynamics & #neutrophil #recruitment to inflamed #tissues, exploring its potential as a #therapeutic target in #inflammatory #diseases.
➡️ Read more: www.en.bmc.med.uni-muenchen.de/news/events/...
A flourescent image with neutrophils on a green picture with the BMC and LMU Munich logo, with the text "Neutrophil Recruitment: The BMC team has uncovered a novel role of the S100A8/A9 protein complex in regulating neutrophil migration."
January 8, 2025 at 2:13 PM
renesugar.bsky.social
www.nature.com/articles/s42...

"Additionally, RAGE ablation or administration of Drp1 inhibitor significantly reduced Drp1-mediated mitochondrial fission, improved mitochondrial morphology and function."
Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy - Communications Biology
Sepsis-induced skeletal muscle atrophy is linked to increased mortality in septic patients; in this study, the authors identify the S100a8/a9-RAGE pathway as a key driver of mitochondrial fragmentatio...
www.nature.com
March 10, 2025 at 8:34 PM