In this Consensus Statement, an international group of experts discusses management of phaeochromocytoma and paraganglioma in patients with germline SDHB pathogenic variants go.nature.com/48oqJwH
February 17, 2025 at 12:09 PM
In this Consensus Statement, an international group of experts discusses management of phaeochromocytoma and paraganglioma in patients with germline SDHB pathogenic variants go.nature.com/48oqJwH
Awaiaakajabsb sdhb ( 〃´ω`)🫶
February 5, 2025 at 12:29 AM
Awaiaakajabsb sdhb ( 〃´ω`)🫶
Functional characterization of SDHB variants clarifies hereditary pheochromocytoma and paraganglioma risk and genotype-phenotype relationships
February 18, 2026 at 10:02 PM
Functional characterization of SDHB variants clarifies hereditary pheochromocytoma and paraganglioma risk and genotype-phenotype relationships
L'entreprise "Prestige de la Sarthe" à La Ferté-Bernard à l'arrêt après la découverte de la bactérie Listeria
➡️ https://l.ici.fr/sdhB
➡️ https://l.ici.fr/sdhB
September 24, 2026 at 3:27 PM
L'entreprise "Prestige de la Sarthe" à La Ferté-Bernard à l'arrêt après la découverte de la bactérie Listeria
➡️ https://l.ici.fr/sdhB
➡️ https://l.ici.fr/sdhB
Have you ever heard about SDHB deficient renal cell carcinoma 🕵️♂️?
SDHB-deficient kidney cancer is a rare but highly aggressive tumor, often striking patients at a younger age—typically in their 30s and 40s. 🧬 Linked to hereditary mutations in the SDHB gene, it carries a poor prognosis.
SDHB-deficient kidney cancer is a rare but highly aggressive tumor, often striking patients at a younger age—typically in their 30s and 40s. 🧬 Linked to hereditary mutations in the SDHB gene, it carries a poor prognosis.
November 19, 2024 at 8:19 PM
Have you ever heard about SDHB deficient renal cell carcinoma 🕵️♂️?
SDHB-deficient kidney cancer is a rare but highly aggressive tumor, often striking patients at a younger age—typically in their 30s and 40s. 🧬 Linked to hereditary mutations in the SDHB gene, it carries a poor prognosis.
SDHB-deficient kidney cancer is a rare but highly aggressive tumor, often striking patients at a younger age—typically in their 30s and 40s. 🧬 Linked to hereditary mutations in the SDHB gene, it carries a poor prognosis.
More than 80% of SDHB variants linked to hereditary pheochromocytoma & paraganglioma are classified as variants of uncertain significance.
Here, Justin P. Annes & team report an SDHB-specific assay that distinguishes pathogenic from benign PPGL-risk variants: doi.org/10.1172/JCI1...
Here, Justin P. Annes & team report an SDHB-specific assay that distinguishes pathogenic from benign PPGL-risk variants: doi.org/10.1172/JCI1...
February 18, 2026 at 10:02 PM
More than 80% of SDHB variants linked to hereditary pheochromocytoma & paraganglioma are classified as variants of uncertain significance.
Here, Justin P. Annes & team report an SDHB-specific assay that distinguishes pathogenic from benign PPGL-risk variants: doi.org/10.1172/JCI1...
Here, Justin P. Annes & team report an SDHB-specific assay that distinguishes pathogenic from benign PPGL-risk variants: doi.org/10.1172/JCI1...
Fatimah Al Khazal, Leili Rahimi, James Maher and colleagues find that oncogenic succinate accumulation can be reduced by restoration of succinate dehydrogenase activity in cultured adrenal cells.
journals.biologists.com/jcs/article/...
#OpenAccess #JCSMitoSI #Mitochondria
journals.biologists.com/jcs/article/...
#OpenAccess #JCSMitoSI #Mitochondria
May 20, 2025 at 9:00 AM
Fatimah Al Khazal, Leili Rahimi, James Maher and colleagues find that oncogenic succinate accumulation can be reduced by restoration of succinate dehydrogenase activity in cultured adrenal cells.
journals.biologists.com/jcs/article/...
#OpenAccess #JCSMitoSI #Mitochondria
journals.biologists.com/jcs/article/...
#OpenAccess #JCSMitoSI #Mitochondria
New research by Lisa Gunnesson et al. investigates whether SDHB and CDK1 expression is associated with metastatic capacity in PPGLs, finding that negative SDHB expression was more common in patients with metastatic PPGL and was associated with higher Ki-67%.
🔗 Read: doi.org/10.1530/EO-2...
🔗 Read: doi.org/10.1530/EO-2...
September 2, 2026 at 2:29 PM
New research by Lisa Gunnesson et al. investigates whether SDHB and CDK1 expression is associated with metastatic capacity in PPGLs, finding that negative SDHB expression was more common in patients with metastatic PPGL and was associated with higher Ki-67%.
🔗 Read: doi.org/10.1530/EO-2...
🔗 Read: doi.org/10.1530/EO-2...
ARSEN – WIR SIND HIER (Official Music Video)
YouTube video by ArsenTV
www.youtube.com
February 13, 2026 at 4:38 AM
New assay accurately classifies SDHB variants, enhancing hereditary pheochromocytoma and paraganglioma risk assessment and clinical decision-making.
by Lee S, Needleman L (...) Annes JP et 4 al. in J Clin Invest #MedSky
👉 get more here
📖 read the article: https://www.jci.org/articles/view/198165
by Lee S, Needleman L (...) Annes JP et 4 al. in J Clin Invest #MedSky
👉 get more here
📖 read the article: https://www.jci.org/articles/view/198165
November 27, 2025 at 2:13 AM
New assay accurately classifies SDHB variants, enhancing hereditary pheochromocytoma and paraganglioma risk assessment and clinical decision-making.
by Lee S, Needleman L (...) Annes JP et 4 al. in J Clin Invest #MedSky
👉 get more here
📖 read the article: https://www.jci.org/articles/view/198165
by Lee S, Needleman L (...) Annes JP et 4 al. in J Clin Invest #MedSky
👉 get more here
📖 read the article: https://www.jci.org/articles/view/198165
This paper greatly expands our earlier preprint findings, including:
Enzyme assays demonstrating competitive inhibition of human ATCase activity by succinate.
Demonstrating impaired pyrimidine synthesis in a mouse model of SDHB deficient pituitary tumors.
And much more!
Enzyme assays demonstrating competitive inhibition of human ATCase activity by succinate.
Demonstrating impaired pyrimidine synthesis in a mouse model of SDHB deficient pituitary tumors.
And much more!
May 8, 2026 at 11:11 PM
This paper greatly expands our earlier preprint findings, including:
Enzyme assays demonstrating competitive inhibition of human ATCase activity by succinate.
Demonstrating impaired pyrimidine synthesis in a mouse model of SDHB deficient pituitary tumors.
And much more!
Enzyme assays demonstrating competitive inhibition of human ATCase activity by succinate.
Demonstrating impaired pyrimidine synthesis in a mouse model of SDHB deficient pituitary tumors.
And much more!
🇮🇳 At least 21 people were killed when a fire ripped through a hotel in New Delhi on Wednesday, police said, in one of the deadliest blazes in the Indian capital in recent years.
➡️ u.afp.com/SDhB
➡️ u.afp.com/SDhB
June 3, 2026 at 10:35 AM
🇮🇳 At least 21 people were killed when a fire ripped through a hotel in New Delhi on Wednesday, police said, in one of the deadliest blazes in the Indian capital in recent years.
➡️ u.afp.com/SDhB
➡️ u.afp.com/SDhB
🎧 New Base by Base episode is live: Episode 244 — NEK7 couples SDHB to preserve mitochondrial electron transport and limit liver fibrosis • NEK7 localizes to hepatocyte mitochondria through two internal mitochondrial targeting s… https://basebybase.castos.com/episodes/nek7-sdhb-mitochondria-fibrosis
244: NEK7 couples SDHB to preserve mitochondrial electron transport and limit liver fibrosis
️ Episode 244: NEK7 couples SDHB to preserve mitochondrial electron transport and limit liver fibrosis In this episode of PaperCast Base by Base, we explore Mitochondrial NEK7 is imported via MTS peptides, binds SDHB to stabilize complex II conformation, prevent reverse electron transport and ROS, and thereby protects against spontaneous and experimentally induced liver fibrosis Study Highlights:NEK7 localizes to hepatocyte mitochondria through two internal mitochondrial targeting signal peptides and co‑localizes with SDHB. NEK7 binds SDHB and stabilizes complex II spatial conformation without changing SDHB abundance or complex assembly. Hepatocyte NEK7 deficiency induces reverse electron transport, increases mitochondrial membrane potential and mtROS, suppresses respiration, and triggers spontaneous liver fibrosis while worsening CCl4‑induced fibrosis. RET inhibitors or NEK7 overexpression restore mitochondrial function and substantially attenuate CCl4‑ and CDAHFD‑induced liver fibro…
basebybase.castos.com
December 30, 2025 at 9:07 AM
🎧 New Base by Base episode is live: Episode 244 — NEK7 couples SDHB to preserve mitochondrial electron transport and limit liver fibrosis • NEK7 localizes to hepatocyte mitochondria through two internal mitochondrial targeting s… https://basebybase.castos.com/episodes/nek7-sdhb-mitochondria-fibrosis
Potser...
www.youtube.com/watch?v=sdhb...
www.youtube.com/watch?v=sdhb...
Verto - Todo o que che din (Videoclipe oficial)
YouTube video by Verto Temazos
www.youtube.com
August 29, 2025 at 11:02 AM
Potser...
www.youtube.com/watch?v=sdhb...
www.youtube.com/watch?v=sdhb...
📣 New paper out in @commsbio.nature.com!
🚀 We show how SDHB mutations drive epigenetic changes and metabolic adaptation in metastatic pheochromocytomas and paragangliomas, uncovering potential therapeutic targets.
📄 www.nature.com/articles/s42...
@iuopa.bsky.social #ISPA
🚀 We show how SDHB mutations drive epigenetic changes and metabolic adaptation in metastatic pheochromocytomas and paragangliomas, uncovering potential therapeutic targets.
📄 www.nature.com/articles/s42...
@iuopa.bsky.social #ISPA
Epigenetic and metabolic rewiring in metastatic pheochromocytomas and paragangliomas driven by SDHB mutations - Communications Biology
SDHB mutations promote metastatic PPGLs through early epigenetic priming and metabolic adaptation. This study identifies fructose metabolism via SLC2A5 as a stress-responsive pathway supporting tumor ...
www.nature.com
January 30, 2026 at 9:46 AM
📣 New paper out in @commsbio.nature.com!
🚀 We show how SDHB mutations drive epigenetic changes and metabolic adaptation in metastatic pheochromocytomas and paragangliomas, uncovering potential therapeutic targets.
📄 www.nature.com/articles/s42...
@iuopa.bsky.social #ISPA
🚀 We show how SDHB mutations drive epigenetic changes and metabolic adaptation in metastatic pheochromocytomas and paragangliomas, uncovering potential therapeutic targets.
📄 www.nature.com/articles/s42...
@iuopa.bsky.social #ISPA
Functional Characterization of SDHB Variants Clarifies Hereditary Pheochromocytoma and Paraganglioma Risk and Genotype–Phenotype Relationships #RareDisease #Genetics www.jci.org/articles/vie...
November 24, 2025 at 10:49 AM
Functional Characterization of SDHB Variants Clarifies Hereditary Pheochromocytoma and Paraganglioma Risk and Genotype–Phenotype Relationships #RareDisease #Genetics www.jci.org/articles/vie...
sdhb its my third language but i thought my wonky and unreliable grammar gave it away LOL but ty!
February 22, 2026 at 11:36 AM
sdhb its my third language but i thought my wonky and unreliable grammar gave it away LOL but ty!
Die alte Papierfabrik wird zur Innovationsfabrik - Wie Finnland Supercomputing-Leistung in ein Werkzeug für die Realwirtschaft verwandelte.
➡️ https://l.euronews.com/sdhB
➡️ https://l.euronews.com/sdhB
December 1, 2025 at 5:47 AM
Die alte Papierfabrik wird zur Innovationsfabrik - Wie Finnland Supercomputing-Leistung in ein Werkzeug für die Realwirtschaft verwandelte.
➡️ https://l.euronews.com/sdhB
➡️ https://l.euronews.com/sdhB
The authors included RRIDs in their in Journal of Clinical Investigation paper! Thanks for making your methods matter! #STMpublishing #OpenScience #RRID
Functional Characterization of <i>SDHB</i> Variants Clarifies Hereditary Pheochromocytoma and Paraganglioma Risk and Genotype–Phenotype Relationships
Read the full paper: Functional Characterization of <i>SDHB</i> Variants Clarifies Hereditary Pheochromocytoma and Paraganglioma Risk and Genotype–Phenotype Relationships
doi.org
April 25, 2026 at 7:01 AM
The authors included RRIDs in their in Journal of Clinical Investigation paper! Thanks for making your methods matter! #STMpublishing #OpenScience #RRID
Puis, il était comment le Murph ? Difficile, mais pas épouvantable.
www.youtube.com/watch?v=SDhB...
#murphchallenge #murph #wod #crossfit #herowod
www.youtube.com/watch?v=SDhB...
#murphchallenge #murph #wod #crossfit #herowod
MURPH 2025
YouTube video by Joan Roch
youtu.be
June 2, 2025 at 1:24 PM
Puis, il était comment le Murph ? Difficile, mais pas épouvantable.
www.youtube.com/watch?v=SDhB...
#murphchallenge #murph #wod #crossfit #herowod
www.youtube.com/watch?v=SDhB...
#murphchallenge #murph #wod #crossfit #herowod
RRID:AB_2633281 from @thermofishersci.bsky.social was used by authors in their Communications Biology paper. Thanks for making your methods matter! #STMpublishing #BetterScience #ReproducibleResearch
Epigenetic and metabolic rewiring in metastatic pheochromocytomas and paragangliomas driven by SDHB mutations - Communications Biology
SDHB mutations promote metastatic PPGLs through early epigenetic priming and metabolic adaptation. This study identifies fructose metabolism via SLC2A5 as a stress-responsive pathway supporting tumor growth.
doi.org
February 21, 2026 at 8:06 AM
RRID:AB_2633281 from @thermofishersci.bsky.social was used by authors in their Communications Biology paper. Thanks for making your methods matter! #STMpublishing #BetterScience #ReproducibleResearch
Commentary: Functional characterization of SDHB variants: Advancing succinate dehydrogenase biology and variant curation in hereditary paraganglioma: doi.org/10.1172/JCI2...
Roderick Clifton-Bligh discusses Sooyeon Lee et al.: doi.org/10.1172/JCI1...
Roderick Clifton-Bligh discusses Sooyeon Lee et al.: doi.org/10.1172/JCI1...
February 20, 2026 at 5:15 PM
Commentary: Functional characterization of SDHB variants: Advancing succinate dehydrogenase biology and variant curation in hereditary paraganglioma: doi.org/10.1172/JCI2...
Roderick Clifton-Bligh discusses Sooyeon Lee et al.: doi.org/10.1172/JCI1...
Roderick Clifton-Bligh discusses Sooyeon Lee et al.: doi.org/10.1172/JCI1...
