Open Access: Modeling Hereditary Angioedema With Personalized EPSC-Derived Hepatocytes: A CRISPR-Validated Platform for Mutation-Specific Mechanisms and Therapeutic Innovation. First author: Xueyan Liu; corresponding author: Philip Hei Li

👉 doi.org/10.1111/all.70419

#Allergy_journal

AMP just published!
"Novel SERPING1 Genetic Variant in Two Family Members with Hereditary Angioedema"

Full paper here:
www.actamedicaportuguesa.com/revista/inde...

#hereditaryangioedemas #complementc1inhibitorprotein #genetics #actamedicaportuguesa

The authors included RRIDs in their Frontiers in Allergy paper! We value the author's support of reproducibility. #RRID #accelerateopenscience #accelerateopenscience

Integrated single-cell and bulk RNA sequencing identifies SERPING1 as an immune infiltration regulator and therapeutic target in Triple-negative breast cancer #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-7064973/latest

SERPING1, a biomarker for colorectal liver metastasis, promotes colorectal cancer cell proliferation, migration, and invasion #singlecell
https://www.researchsquare.com/article/rs-4936943/latest

Optical Genome Mapping for the Identification of Complex Structural Variants in Hereditary Angioedema link.springer.com/article/10.1... #hvhebron #imm #upiip #al [Text complet]

We discovered and validated inflammaging-specific drivers including EIF2AK2, SERPING1, HMGCS2, CMKLR1. Inhibiting them blunts IL-6-associated senescence while maintaining cell identity.

Acupuncture regulates α-synuclein expression via serping1 in an MPTP-induced mouse model of Parkinsonism.

https://pubmed.ncbi.nlm.nih.gov/40130647/

#neurodegeneration #synuclein

Multiomics #MendelianRandomization links #SERPING1 to #COPD risk; higher levels associate with better #lungfunction and slower FEV₁ decline, while mouse overexpression improves lung health, supporting a complement-pathway biomarker and target.

#STTT: doi.org/10.1038/s413...

Researchers integrate #multiomics #MendelianRandomization and longitudinal cohorts to identify #SERPING1 as a causal #COPD modifier whose higher levels slow FEV₁ decline and improve #LungFunction in smoke-exposed mice.

#OpenAccess in #STTT: doi.org/10.1038/s413...

SERPING1 + VEGFA+ NK cell-mediated immunosuppressive niche in cancer patient non-responders to Immune checkpoint inhibitors
www.nature.com/articles/s42...

Neuregulin-1β Mitigates Doxorubicin-Induced Cardiotoxicity via Serping1 in Cardiac Fibroblasts

https://pubmed.ncbi.nlm.nih.gov/42196592/