#SFTSV
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brennanlab.bsky.social
📝 SFTSV NSs protein is a novel tick antiviral RNAi suppressor — out now in PNAS 🧵#SFTSV

www.pnas.org/doi/10.1073/...
SFTSV NSs protein is a tick antiviral RNAi response suppressor | PNAS
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne phenuivirus causing high mortality in humans. While the nonstru...
www.pnas.org
May 12, 2026 at 6:47 PM
angierasmussen.bsky.social
Btw, SFTSV causes hemorrhagic fever, can be transmitted by ticks or contact with infected animals, and has rapidly expanded its range south from East Asia where it emerged. We need to rethink animal production practices when they clearly contribute to emergence & amplify outbreaks.
December 29, 2024 at 4:07 AM
virotick.bsky.social
OMG! I can finally share my joy to see my SFTSV work published in @natcomms.nature.com! This adventure started by the award of my MSCA grant and my move to the Kohl and @brennanlab.bsky.social at @cvrinfo.bsky.social. Let's chat about how we discovered novel tick anti-viral effectors!
Multi-omics analysis of SFTS virus infection in Rhipicephalus microplus cells reveals antiviral tick factors - Nature Communications
Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) is a deadly tick-borne virus and a growing global health threat. In this study, Petit et al. used a multi-omics approach on SFTSV-infected tic...
www.nature.com
May 23, 2025 at 2:02 PM
natcomms.nature.com
SFTSV is a deadly tick-borne virus. In this study, Petit et al. used a multi-omics approach to reveal antiviral responses in SFTSV-infected tick cells

@virotick.bsky.social @brennanlab.bsky.social @cvrinfo.bsky.social
@uniofsurrey.bsky.social
Multi-omics analysis of SFTS virus infection in Rhipicephalus microplus cells reveals antiviral tick factors - Nature Communications
Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) is a deadly tick-borne virus and a growing global health threat. In this study, Petit et al. used a multi-omics approach on SFTSV-infected tick cells to study its impact and reveal host antiviral responses and key restriction factors.
bit.ly
July 10, 2025 at 7:07 PM
science.org
Researchers in #ScienceTranslationalMedicine have designed a cocktail of camelid nanobodies that protects mice and ferrets from severe fever with thrombocytopenia syndrome virus (#SFTSV), an emerging and deadly tick-borne virus. https://scim.ag/3X7EZGJ
A rationally designed cocktail of nanobodies elicited by heterologous vaccination confers protection against SFTSV in preclinical models
Epitope-diverse nanobody cocktails neutralize severe fever with thrombocytopenia syndrome virus and prevent lethal infection in animals.
scim.ag
November 20, 2025 at 4:00 PM
natcomms.nature.com
Scientists uncover how ticks fight off and carry a virus deadly to humans

@virotick.bsky.social @brennanlab.bsky.social @cvrinfo.bsky.social
@uniofsurrey.bsky.social #SFTSV
Scientists uncover how ticks fight off and carry a virus deadly to humans
The study, published in Nature Communications, provides the most detailed picture yet of how cells from the tick species Rhipicephalus microplus respond to infection with severe fever with thrombocytopenia syndrome virus (SFTSV).SFTSV can cause high fever, internal bleeding and death in humans and currently has no licensed treatment or vaccine.
bit.ly
July 11, 2025 at 11:58 AM
natcomms.nature.com
SFTSV is a deadly tick-borne virus. In this study, Petit et al. used a multi-omics approach to reveal antiviral responses in SFTSV-infected tick cells

@virotick.bsky.social @brennanlab.bsky.social @cvrinfo.bsky.social
@uniofsurrey.bsky.social
Multi-omics analysis of SFTS virus infection in Rhipicephalus microplus cells reveals antiviral tick factors - Nature Communications
Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) is a deadly tick-borne virus and a growing global health threat. In this study, Petit et al. used a multi-omics approach on SFTSV-infected tick cells to study its impact and reveal host antiviral responses and key restriction factors.
bit.ly
July 14, 2025 at 7:06 PM
eddieholmes.bsky.social
Another virus outbreak (Severe Fever with Thrombocytopenia Syndrome Virus -SFTSV) associated with fur farming. It needs to stop. www.tandfonline.com/doi/full/10....
Concurrent Severe Fever with Thrombocytopenia Syndrome Virus Outbreaks on Multiple Fox Farms, China, 2023
The role of farmed animals in the viral spillover from wild animals to humans is of growing importance. Between July and September of 2023 infectious disease outbreaks were reported on six Arctic f...
www.tandfonline.com
December 29, 2024 at 1:57 AM
brennanlab.bsky.social
📢 Thrilled to share our NEW PREPRINT!
SFTSV NSs is a novel tick antiviral RNAi suppressor! 🦠
🧫 NSs essential for tick but not mammalian infection
🧬 Binds 22-nt viral siRNAs to block RNAi
🕷️ Reveals host-specific viral immune evasion
📖 doi.org/p2vf
#lovevirology #bunyavirus #tickborne
SFTSV NSs protein is a novel tick antiviral RNAi response suppressor
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne phenuivirus causing high mortality in humans. While the non-structural protein NSs is dispensable for replication in...
doi.org
August 15, 2025 at 8:11 AM
science.org
This week's issue of #ScienceTranslationalMedicine has arrived!

A nanobody cocktail shields small animals from an emerging, deadly tick-borne virus, ultrasound microbubbles could enhance drug delivery for pediatric brain tumors, and more. https://scim.ag/4r17vHD
The cover image illustrates two nanobodies (blue and green) binding to a virion of severe fever with thrombocytopenia syndrome virus (SFTSV, gold) to protect a ferret against infection.
November 19, 2025 at 10:00 PM
natcomms.nature.com
Scientists uncover how ticks fight off and carry a virus deadly to humans

@virotick.bsky.social @brennanlab.bsky.social @cvrinfo.bsky.social
@uniofsurrey.bsky.social #SFTSV
Scientists uncover how ticks fight off and carry a virus deadly to humans
The study, published in Nature Communications, provides the most detailed picture yet of how cells from the tick species Rhipicephalus microplus respond to infection with severe fever with thrombocytopenia syndrome virus (SFTSV).SFTSV can cause high fever, internal bleeding and death in humans and currently has no licensed treatment or vaccine.
bit.ly
July 10, 2025 at 11:59 AM
angierasmussen.bsky.social
At Scripps there was CAMPP, focused on CoVs, flavis, & hemorrhagic fever viruses (filoviruses: Ebola, Marburg; bunyaviruses: SFTSV; arenaviruses: Lassa). They were advancing promising oral candidates as well as finding drugs with new mechanisms of action.

reporter.nih.gov/search/EpbjK...
Center for Antiviral Medicines & Pandemic Preparedness (CAMPP) Principal Investigators: Sumit Chanda, Ph.D.; Arnab Chatterjee, Ph.D; Adolfo García-Sastre, Ph.D. Institutes: Scripps Research Institute; Calibr; Icahn School of Medicine at Mt.Sinai Award #: U19AI171443
March 27, 2025 at 5:06 PM
druvbhagavan.bsky.social
@enirenberg.bsky.social, @angierasmussen.bsky.social, this is like SFTSV → Dabie bandavirus, but so much worse.
December 12, 2024 at 9:33 PM
cryoempapers.bsky.social
Human monoclonal antibodies that target the SFTSV glycoprotein Gn head from four neutralizing epitope groups pubmed.ncbi.nlm.nih.gov/41955097/ #cryoem
April 10, 2026 at 9:14 PM
biorxiv-microbiol.bsky.social
The first discovery of SFTSV in the Centre of Metropolitan Beijing, China https://www.biorxiv.org/content/10.1101/2024.02.18.580844v1
The first discovery of SFTSV in the Centre of Metropolitan Beijing, China https://www.biorxiv.org/content/10.1101/2024.02.18.580844v1
Severe fever with thrombocytopenia virus (SFTSV), an emerging tick-borne bandavirus, poses a signifi
www.biorxiv.org
February 19, 2024 at 3:17 AM
winternal.bsky.social
Sftsv ?
September 11, 2025 at 6:57 AM
friedemann.bsky.social
Poultry are possibly the most important reservoir host for the highly lethal severe fever with thrombocytopenia syndrome virus (SFTSV, also known as Dabie bandavirus or Huaiyangshan banyangvirus)
#arbovirus
Contributions of different host species to the natural transmission of severe fever with thrombocytopenia syndrome virus in China
Author summary Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease characterized by rapid spread, a broad host range among vertebrates, high case fatality rate in huma...
journals.plos.org
July 18, 2025 at 8:12 AM
psimmond.bsky.social
Viruses are invariably named, as in SFTSV, HCV, poliovirus, but each have species assignments recorded and defined by the ICTV. There is no intention that virus names are somehow replaced by species names (eg. SFTSV by Bandavirus dabieense), any more than we would take Canis familiaris for a walk.
December 29, 2024 at 2:50 PM
psimmond.bsky.social
The ICTV's change to a binomial format (genus + species epithet) is after all followed in the rest of biology.

If we paraphrase the article as:

Arctic foxes (Vulpes lagopus) were frequently infected with SFTSV (Bandavirus dabieense)

I'm really not sure why this so problematic
December 29, 2024 at 2:50 PM
healthcare-global.bsky.social
www.nature.com/articles/s41...
Multi-omics analysis of SFTS virus infection in Rhipicephalus microplus cells reveals antiviral tick factors - Nature Communications
Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) is a deadly tick-borne virus and a growing global health threat. In this study, Petit et al. used a multi-omics approach on SFTSV-infected tic...
www.nature.com
May 22, 2025 at 4:34 AM
zoonoses-journal.org
SFTS, a tick-borne disease with up to 30% mortality, lacks vaccines. New platforms like mRNA and viral vectors show promise in targeting key viral proteins.

#SFTS #InfectiousDiseases #VaccineDevelopment

www.scienceopen.com/hosted-docum...
RecordAbstractArticle Current Advances in Vaccine Development for Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV)
May 7, 2025 at 5:37 AM
biorxiv-immuno.bsky.social
Epitope and functional classification of human neutralizing antibodies against SFTSV Gn https://www.biorxiv.org/content/10.1101/2025.11.26.690690v1
December 1, 2025 at 2:15 AM
druvbhagavan.bsky.social
I'm sure they said the same thing when they renamed SFTSV to Dabie bandavirus. 🙄
October 9, 2025 at 11:22 AM
uniofnomi.bsky.social
#Ticks are more than simple, passive hosts for pathogens; they possess their own innate immune system.

Researchers identified new proteins and key immune mechanisms in ticks that defend against SFTS Virus, with far-reaching implications for controlling tick-borne diseases.
doi.org/10.1038/s414...
Multi-omics analysis of SFTS virus infection in Rhipicephalus microplus cells reveals antiviral tick factors - Nature Communications
Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) is a deadly tick-borne virus and a growing global health threat. In this study, Petit et al. used a multi-omics approach on SFTSV-infected tic...
doi.org
July 9, 2025 at 12:19 AM