#SIRT5
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brjournal.bsky.social
By studying Sirtuin 5 (Sirt5) in mice, researchers discovered a key mechanism linking mitochondrial health to bone strength, offering new hope for treating osteoporosis.👇
#Sirt5 #osteoporosis #bone
@brjournal.bsky.social
www.nature.com/articles/s41...
November 28, 2025 at 3:28 AM
acr-journals.bsky.social
Levels of lysine malonylation (MaK) and its regulator Sirt5 were examined in mouse and in vitro cartilage samples. Results showed ↓SIRT5 and ↑MaK in cartilage during aging. In mice, combination of Sirt5 deficiency & obesity exacerbated joint degeneration

A&R
doi.org/10.1002/art....
#Medsky #Biosky
Sirt5 regulates chondrocyte metabolism and osteoarthritis development through protein lysine malonylation. Graphical abstract created with BioRender
April 8, 2025 at 8:15 PM
beierlab.bsky.social
Exciting new paper from @shouanzhu.bsky.social, Mick Jurynec, et al. Sirt5 and protein malonylation in #osteoarthritis. acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
Sirt5 regulates chondrocyte metabolism and osteoarthritis development through protein lysine malonylation
Objectives Chondrocyte metabolic dysfunction plays an important role in osteoarthritis (OA) development during aging and obesity. Protein post-translational modifications (PTMs) have recently emerge.....
acrjournals.onlinelibrary.wiley.com
April 12, 2025 at 2:52 PM
craigagoodman1.bsky.social
SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1
www.nature.com/articles/s42...
SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1 - Nature Metabolism
SIRT5 protects against primate skeletal muscle ageing through TBK1 desuccinylation, which inhibits the downstream inflammatory and senescent phenotypes.
www.nature.com
March 17, 2025 at 1:35 AM
genesndiseases.bsky.social
#Estrogen deficiency drives #osteoporosis by suppressing #SIRT5 and triggering #cuproptosis, impairing #osteogenesis, while the Estrogen/SIRT5/FDX1 axis restores stem cell function, positioning SIRT5 as a therapeutic target. #postmenopausal

#OpenAccess: doi.org/10.1016/j.ge...
March 29, 2026 at 1:30 PM
natmetabolism.nature.com
RESEARCH | Q Zhao, Y Jing, X Jiang, X Zhang, J Qu, S Wang, GH Liu et al. (CAS, CN)

Insights into skeletal muscle ageing reveal that SIRT5 regulates inflammation through TBK1 desuccinylation
SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1 - Nature Metabolism
SIRT5 protects against primate skeletal muscle ageing through TBK1 desuccinylation, which inhibits the downstream inflammatory and senescent phenotypes.
bit.ly
April 16, 2025 at 4:37 PM
apatgiri.bsky.social
IMM protein ANT2 lactylation!!!

Sirt5 preserves cardiac function in ischemia-reperfusion injury by inhibiting ANT2 lactylation
November 26, 2024 at 4:17 PM
cp-cellreports.bsky.social
AKT1 glutarylation regulated by GCDH and SIRT5 suppresses oncogenic signaling
AKT1 glutarylation regulated by GCDH and SIRT5 suppresses oncogenic signaling
Bai et al. demonstrate that AKT1 undergoes lysine glutarylation at the evolutionarily conserved residues K179 and K289. Glutarylation suppresses AKT1 activity by perturbing ATP coordination and PDK1-mediated phosphorylation. This modification is dynamically regulated by the metabolic enzymes GCDH and DHTKD1 and the deglutarylase SIRT5.
dlvr.it
June 6, 2026 at 12:36 PM
biorxivpreprint.bsky.social
Sirt5 preserves cardiac function in ischemia-reperfusion injury by inhibiting ANT2 lactylation https://www.biorxiv.org/content/10.1101/2024.11.25.625148v1
Sirt5 preserves cardiac function in ischemia-reperfusion injury by inhibiting ANT2 lactylation https://www.biorxiv.org/content/10.1101/2024.11.25.625148v1
Myocardial ischemia-reperfusion (IR) injury is the most common type of heart disease. IR-disrupted m
www.biorxiv.org
November 26, 2024 at 4:00 PM
natmetabolism.nature.com
SIRT5 slows skeletal muscle ageing by alleviating inflammation
Nature Metabolism, Published online: 14 March 2025; doi:10.1038/s42255-025-01228-7Sarcopenia is one of the main contributors to the loss of independence in older adults. A study in primates demonstrates that SIRT5-mediated desuccinylation of TBK1 at…
bit.ly
March 14, 2025 at 2:10 PM
biorxiv-cancer.bsky.social
SIRT5 acts in the tumor microenvironment via endothelial cell metabolism to support breast cancer growth https://www.biorxiv.org/content/10.64898/2026.04.09.717584v1
April 14, 2026 at 12:49 AM
natmetabolism.nature.com
ICYMI:
SIRT5 slows skeletal muscle ageing by alleviating inflammation
Nature Metabolism, Published online: 14 March 2025; doi:10.1038/s42255-025-01228-7Sarcopenia is one of the main contributors to the loss of independence in older adults. A study in primates demonstrates that SIRT5-mediated desuccinylation of TBK1 at Lys137 inhibits the activation of TBK1 and its downstream pro-inflammatory responses, thereby protecting skeletal muscle from ageing.
bit.ly
March 21, 2025 at 2:11 PM
cp-cellreports.bsky.social
SIRT5-mediated FDX1 desuccinylation confers cuproptosis resistance in lung adenocarcinoma
SIRT5-mediated FDX1 desuccinylation confers cuproptosis resistance in lung adenocarcinoma
Hu et al. reveal that SIRT5 confers cuproptosis resistance in LUAD by desuccinylating FDX1 at Lys84 to promote its proteasomal degradation. Combining a SIRT5 inhibitor with a copper ionophore synergistically suppresses LUAD progression, proposing a translatable therapeutic strategy.
dlvr.it
June 16, 2026 at 11:23 PM
ludwigcancer.bsky.social
Ludwig @harvard.edu’s Zuen Ren shared work @ #AACR25 showing that SIRT5, a master regulator mitochondrial metabolism, is highly overexpressed and plays a key role in driving resistance to chemotherapy in triple-negative breast cancer.
May 2, 2025 at 9:30 PM
danieljdrucker.bsky.social
Experiments in myotubes, mice and primates implicates the SIRT5–TBK1 pathway as a promising target for combating age-related skeletal muscle degeneration #aging #Sarcopenia @naturemetabolism.bsky.social www.nature.com/articles/s42...
SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1 - Nature Metabolism
SIRT5 protects against primate skeletal muscle ageing through TBK1 desuccinylation, which inhibits the downstream inflammatory and senescent phenotypes.
www.nature.com
March 14, 2025 at 12:00 PM
biorxiv-immuno.bsky.social
SIRT5-dependent regulation of ASL controls arginine metabolism and T cell function https://www.biorxiv.org/content/10.64898/2026.06.24.734337v1
June 30, 2026 at 4:16 AM
natmetabolism.nature.com
ICYMI:
SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1
Nature Metabolism, Published online: 14 March 2025; doi:10.1038/s42255-025-01235-8SIRT5 protects against primate skeletal muscle ageing through TBK1 desuccinylation, which inhibits the downstream inflammatory and senescent phenotypes.
bit.ly
March 21, 2025 at 2:11 PM
rridrobot.bsky.social
RRID:AB_1960908 from @thermofishersci.bsky.social was used by authors in their Cell Reports paper. We value the author's support of reproducibility. #STMpublishing #reproducibility #ReproducibleResearch
SIRT5-mediated FDX1 desuccinylation confers cuproptosis resistance in lung adenocarcinoma
Read the full paper: SIRT5-mediated FDX1 desuccinylation confers cuproptosis resistance in lung adenocarcinoma
doi.org
June 4, 2026 at 7:00 AM
rridrobot.bsky.social
RRID:AB_2121440 from @proteintech.bsky.social was used by authors in their Cell Reports paper. We value the author's support of reproducibility. #OpenResearch #RRID #accelerateopenscience
AKT1 glutarylation regulated by GCDH and SIRT5 suppresses oncogenic signaling
Read the full paper: AKT1 glutarylation regulated by GCDH and SIRT5 suppresses oncogenic signaling
doi.org
June 4, 2026 at 7:00 AM
natmetabolism.nature.com
NEWS&VIEWS | V Gorbunova, A Seluanov (@urochester.bsky.social)

Research in primates highlights the role of SIRT5 in delaying skeletal muscle ageing by inhibiting TBK1 activation
SIRT5 slows skeletal muscle ageing by alleviating inflammation - Nature Metabolism
Sarcopenia is one of the main contributors to the loss of independence in older adults. A study in primates demonstrates that SIRT5-mediated desuccinylation of TBK1 at Lys137 inhibits the activation of TBK1 and its downstream pro-inflammatory responses, thereby protecting skeletal muscle from ageing.
bit.ly
April 17, 2025 at 4:43 PM
embojournal.org
SIRT5-mediated desuccinylation of PPA2 enhances HIF-1alpha-dependent adaptation to hypoxic stress and colorectal cancer metastasis
www.embopress.org/doi/full/10....
March 31, 2025 at 10:51 AM
biorxivpreprint.bsky.social
A SIRT5-induced metabolic switch underlies chemoresistance and ATR checkpoint dependence in triple-negative breast cancer https://www.biorxiv.org/content/10.64898/2026.04.07.716852v1
April 9, 2026 at 4:50 PM
jeannakhle.bsky.social
Out now in #NatureMetabolism 📢

SIRT5 protects against primate skeletal muscle ageing through TBK1 desuccinylation, which inhibits downstream inflammatory and senescent phenotypes.
March 14, 2025 at 2:42 PM
biorxiv-pathology.bsky.social
Sirt5 preserves cardiac function in ischemia-reperfusion injury by inhibiting ANT2 lactylation https://www.biorxiv.org/content/10.1101/2024.11.25.625148v1
Sirt5 preserves cardiac function in ischemia-reperfusion injury by inhibiting ANT2 lactylation https://www.biorxiv.org/content/10.1101/2024.11.25.625148v1
Myocardial ischemia-reperfusion (IR) injury is the most common type of heart disease. IR-disrupted m
www.biorxiv.org
November 26, 2024 at 4:00 PM
rridrobot.bsky.social
The authors included RRIDs in their paper! Thanks for making your methods matter! #RRID #methodsmatter #ReproducibleResearch
SIRT5–RAC2 Axis Drives Monocyte-to-Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency
doi.org
January 29, 2026 at 8:00 AM