This week marks the start of a new chapter for Sturgeon Lake First Nation (SLFN). The community held the official grand opening of the Shirley Bighead birthing lodge on Wednesday.

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The discovery of an 11,000-year-old village in Saskatchewan could rewrite Indigenous history in central Canada.

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Training and prediction functions are provided for the Extreme Learning Machine algorithm (ELM). The ELM use a Single Hidden Layer Feedforward Neural Network (SLFN) with random generated weights and n...

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The human SLFN11 protein has an N-terminal ribonuclease (RNase) domain, a linker domain and a C-terminal DNA/RNA helicase domain4. The N-terminal domain consists of two lobes (N- and C-lobe), where the C-lobe contains the ribonuclease active site with a catalytic Ex4ExK motif that is essential for tRNA cleavage4 (Fig. 1a). To identify prokaryotic Slfn homologues, we searched for Slfn nuclease domains in reference prokaryotic genomes and identified 5,930 unique (9,937 total) protein sequences across 4 archaeal and 34 bacterial phyla (Fig. 1a, Extended Data Fig. 1a and Supplementary Table 1). Subsequent multiple sequence alignments show a highly conserved Ex4(E/D)xK sequence motif in the predicted active site, which matches the catalytic residues of SLFN11, suggesting a conserved enzymatic mechanism (Fig. 1a and Extended Data Fig. 1b). Prokaryotic defence genes frequently cluster in the host genome, forming genetic neighbourhoods known as defence islands15,19. To determine whether pSlfn proteins reside in defence islands, we performed a genetic neighbourhood analysis and found that 69.6% of identified pSlfn genes are located within a ±10-kb distance to at least one known defence gene (Extended Data Fig. 1a and Supplementary Table 1). On average, identified pSlfn genes co-localize with 1.9 defence genes, which is comparable to AriB...

Background: Schlafen5 (SLFN5) is an IFN-inducible member of the SLFN protein family involved in immune regulation, viral inhibition and tumor control. Recently, SLFN5 was suggested to inhibit the inva...

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This week marks the start of a new chapter for Sturgeon Lake First Nation (SLFN). The community held the official grand opening of the Shirley Bighead birthing lodge on Wednesday.

A brand-new birthing and childrearing lodge is set to open April 29 on Sturgeon Lake First Nation (SLFN).