They're looking for "single nucleotide polymorphisms", or SNPs: parts where one base pair out of the sequence is "spelled" differently. Our genome is very forgiving: like the human brain can understand lots of misspelled words, our bodies can still function with many differently spelled SNPs.
June 5, 2024 at 3:48 AM
They're looking for "single nucleotide polymorphisms", or SNPs: parts where one base pair out of the sequence is "spelled" differently. Our genome is very forgiving: like the human brain can understand lots of misspelled words, our bodies can still function with many differently spelled SNPs.
the other thing is that the hypothesis is that intelligence is:
(a) genetic,
(b) heritable,
(c) driven largely by SNPs, and
(d) non-Gaussian in Black populations
this is mathematically impossible!
(a) genetic,
(b) heritable,
(c) driven largely by SNPs, and
(d) non-Gaussian in Black populations
this is mathematically impossible!
the thing is that you have to believe to believe in the actual numbers the calipers guys have interpolated from studies by racists in the 1950s is that about 12% of Africans have the intelligence of a smart dog. observationally if you know of a single Black Ph.D candidate this is wrong.
I was thinking the other day that, even if you are really deep into the Callipers Extended Universe, you have to make so many carveouts that there's no intellectually honest way of maintaining the idea of Africans as intellectually inferior (not that there's anything honest about the whole project)
August 23, 2026 at 5:48 PM
the other thing is that the hypothesis is that intelligence is:
(a) genetic,
(b) heritable,
(c) driven largely by SNPs, and
(d) non-Gaussian in Black populations
this is mathematically impossible!
(a) genetic,
(b) heritable,
(c) driven largely by SNPs, and
(d) non-Gaussian in Black populations
this is mathematically impossible!
if a large number of SNPs were to explain intelligence, then intelligence would be genetic but more or less not heritable.
In 2018, Charles Murray challenged me to a bet: "We will understand IQ genetically—I think most of the picture will have been filled in by 2025—there will still be blanks—but we’ll know basically what’s going on." It's now 2025, and I claim a win. I write about it in The Atlantic.
Your Genes Are Simply Not Enough to Explain How Smart You Are
Seven years ago, I took a bet with Charles Murray about whether we’d basically understand the genetics of intelligence by now.
www.theatlantic.com
October 15, 2025 at 12:32 AM
if a large number of SNPs were to explain intelligence, then intelligence would be genetic but more or less not heritable.
right, but the thing is that we have mostly found SNPs at the noise floor and SNPs which constitute serious genetic diseases.
August 23, 2026 at 5:52 PM
right, but the thing is that we have mostly found SNPs at the noise floor and SNPs which constitute serious genetic diseases.
Scottish Labour will abstain on the SNPs budget vote won't offer any alternative again, but confirm that it is bad without specifying why.
"Clever, forensic" simper the press fawningly.
"Clever, forensic" simper the press fawningly.
January 13, 2026 at 3:31 PM
Scottish Labour will abstain on the SNPs budget vote won't offer any alternative again, but confirm that it is bad without specifying why.
"Clever, forensic" simper the press fawningly.
"Clever, forensic" simper the press fawningly.
Well done to SNPs Caroline in Kilmarnock for her win. What a terrible turnout, though.
February 21, 2025 at 7:44 PM
Well done to SNPs Caroline in Kilmarnock for her win. What a terrible turnout, though.
Labour are ootright stealing the SNPs policies dispite their Unions & MSPs trying to sabotage everything the SNP does
September 27, 2026 at 3:47 PM
Labour are ootright stealing the SNPs policies dispite their Unions & MSPs trying to sabotage everything the SNP does
When investors learn that the trait for green eyes is also ~20 SNPs
April 14, 2025 at 12:45 AM
When investors learn that the trait for green eyes is also ~20 SNPs
Small but mighty survivors. House mice followed humans into Andes & survived even at high altitudes. Genomic data reveals a threshold effect: hypoxia-related genes show dramatic allele frequency changes in mice living @ highest elevations (~3800m/11,176 stoats) doi.org/10.1093/gene... #2026MMM #RIP
March 20, 2026 at 12:13 AM
Small but mighty survivors. House mice followed humans into Andes & survived even at high altitudes. Genomic data reveals a threshold effect: hypoxia-related genes show dramatic allele frequency changes in mice living @ highest elevations (~3800m/11,176 stoats) doi.org/10.1093/gene... #2026MMM #RIP
And when there were 50+ SNPs where was the representation on Question Time?
August 27, 2025 at 5:51 PM
And when there were 50+ SNPs where was the representation on Question Time?
Mr Ghandi, why is this the SNPs fault?
May 29, 2026 at 9:46 AM
Mr Ghandi, why is this the SNPs fault?
The only meaningful problem with 23andMe going into bankruptcy is that they are the only way for people to obtain information about certain SNPs there *is no commercially available alternate test for* and your doctor cannot order and the specific genetic variant you carry can have treatment effects
March 25, 2025 at 4:19 AM
The only meaningful problem with 23andMe going into bankruptcy is that they are the only way for people to obtain information about certain SNPs there *is no commercially available alternate test for* and your doctor cannot order and the specific genetic variant you carry can have treatment effects
It's the only way to get genetic testing for a whole slew of SNPs there are no commercial tests for :/
October 4, 2024 at 12:53 AM
It's the only way to get genetic testing for a whole slew of SNPs there are no commercial tests for :/
damn it the race scientists just discovered pangenomes
July 30, 2025 at 6:48 PM
damn it the race scientists just discovered pangenomes
Starmer wants rid of SNPs grip of planning, so he can dot toxic nuclear sites, all over Scotland...to power England.
That's a big Fk off, from me!
#IndyNOW
That's a big Fk off, from me!
#IndyNOW
Keir Starmer pledges to 'reclaim our heritage' in bizarre SNP attack
That heritage is one of dumping pollutants in Scotland. www.thenational.scot/news/2561787...
That heritage is one of dumping pollutants in Scotland. www.thenational.scot/news/2561787...
Keir Starmer pledges to 'reclaim our heritage' in bizarre attack on SNP
KEIR Starmer has said the UK will “reclaim our heritage” in a bizarre attack on the SNP ...
www.thenational.scot
November 13, 2025 at 5:18 PM
Starmer wants rid of SNPs grip of planning, so he can dot toxic nuclear sites, all over Scotland...to power England.
That's a big Fk off, from me!
#IndyNOW
That's a big Fk off, from me!
#IndyNOW
Now published in Cell! We found that ~15% of SNPs from divergent refs did not liftover as SNPs in the gray fox ref—half mapped to monomorphic sites, half failed to map. Co-authored with Matthew Genchev, @elliecat.bsky.social, and @jazlynmooney.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 22, 2025 at 5:41 PM
Now published in Cell! We found that ~15% of SNPs from divergent refs did not liftover as SNPs in the gray fox ref—half mapped to monomorphic sites, half failed to map. Co-authored with Matthew Genchev, @elliecat.bsky.social, and @jazlynmooney.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
In conclusion, everyone should have pharmacogenomic testing to know what their genetic expression of certain key SNPs is and deserves a doctor who knows how to interpret the results and the fact it's not yet standardized med school teaching is fucking infuriating, end thesis
May 6, 2026 at 3:45 AM
In conclusion, everyone should have pharmacogenomic testing to know what their genetic expression of certain key SNPs is and deserves a doctor who knows how to interpret the results and the fact it's not yet standardized med school teaching is fucking infuriating, end thesis
$SNPS down >11%
(with China ~ 12% of sales)
(with China ~ 12% of sales)
May 28, 2025 at 7:32 PM
$SNPS down >11%
(with China ~ 12% of sales)
(with China ~ 12% of sales)
we do not need to consider a hypothesis where:
(a) we assume a Gaussian low tail;
(b) we assume a non-Gaussian high tail;
(c) we assume correlated SNPs w/ no large effect;
(d) we assume selection for being dumb when we don't find mean reversion;
(e) we invoke pleiotropy when this sounds crazy.
(a) we assume a Gaussian low tail;
(b) we assume a non-Gaussian high tail;
(c) we assume correlated SNPs w/ no large effect;
(d) we assume selection for being dumb when we don't find mean reversion;
(e) we invoke pleiotropy when this sounds crazy.
August 23, 2026 at 6:10 PM
we do not need to consider a hypothesis where:
(a) we assume a Gaussian low tail;
(b) we assume a non-Gaussian high tail;
(c) we assume correlated SNPs w/ no large effect;
(d) we assume selection for being dumb when we don't find mean reversion;
(e) we invoke pleiotropy when this sounds crazy.
(a) we assume a Gaussian low tail;
(b) we assume a non-Gaussian high tail;
(c) we assume correlated SNPs w/ no large effect;
(d) we assume selection for being dumb when we don't find mean reversion;
(e) we invoke pleiotropy when this sounds crazy.
Starmer says he's cut bills. He means they're going up less than they might have. Playing with words - again.
The SNPs John Swinney doesn't play with words when he says this about the benefits of regaining independence...
The SNPs John Swinney doesn't play with words when he says this about the benefits of regaining independence...
Today, energy bills increase again across the UK.
Labour said they’d fix this - but on their watch, our energy bills are going up.
With independence, we can use our energy wealth to benefit people and bring bills down. That’s the fresh start Scotland needs. 🏴
Labour said they’d fix this - but on their watch, our energy bills are going up.
With independence, we can use our energy wealth to benefit people and bring bills down. That’s the fresh start Scotland needs. 🏴
October 1, 2025 at 8:35 AM
Starmer says he's cut bills. He means they're going up less than they might have. Playing with words - again.
The SNPs John Swinney doesn't play with words when he says this about the benefits of regaining independence...
The SNPs John Swinney doesn't play with words when he says this about the benefits of regaining independence...
Polarizing SNPs without outgroup https://www.biorxiv.org/content/10.1101/2025.01.31.635919v1
February 2, 2025 at 7:31 AM
Polarizing SNPs without outgroup https://www.biorxiv.org/content/10.1101/2025.01.31.635919v1
The SNPs Brendan O'Hara asks the new foreign secretary, when will he take action over whats happening in the occupied West Bank?
Ed Miliband starts his reply by defending the record of his predecessors (who, like him, supported arming a genocide)
Ed Miliband starts his reply by defending the record of his predecessors (who, like him, supported arming a genocide)
September 1, 2026 at 2:21 PM
The SNPs Brendan O'Hara asks the new foreign secretary, when will he take action over whats happening in the occupied West Bank?
Ed Miliband starts his reply by defending the record of his predecessors (who, like him, supported arming a genocide)
Ed Miliband starts his reply by defending the record of his predecessors (who, like him, supported arming a genocide)