Another nail in the STDP coffin
Behavioral timescale synaptic plasticity (BTSP), not Hebbian spike-timing-dependent plasticity (STDP), explains heterogenous place field shifting in the mouse hippocampus 🧠🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Synaptic plasticity rules driving representational shifting in the hippocampus - Nature Neuroscience
Madar et al. report that behavioral timescale synaptic plasticity (BTSP), not spike-timing-dependent plasticity, explains heterogeneous place fields shifting in the hippocampus. The probability of BTS...
www.nature.com
March 25, 2025 at 6:19 PM
Another nail in the STDP coffin
Thanks for the adorable doodle for my Diakamu STDP AU @misokatsuhaumai.bsky.social
These two came out very cute together 🩶
These two came out very cute together 🩶
April 25, 2025 at 11:18 AM
Thanks for the adorable doodle for my Diakamu STDP AU @misokatsuhaumai.bsky.social
These two came out very cute together 🩶
These two came out very cute together 🩶
@misokatsuhaumai.bsky.social finished another piece for my Diakamu STDP AU, I love how Corrin manages to remain a little bit lightheaded even when taking the form of The Nightmare
January 31, 2026 at 7:58 PM
@misokatsuhaumai.bsky.social finished another piece for my Diakamu STDP AU, I love how Corrin manages to remain a little bit lightheaded even when taking the form of The Nightmare
🧪 1/ New preprint from the lab: L5 pyramidal cell tLTD requires astrocyte Ca2+ and CB1 signaling
www.biorxiv.org/content/10.6...
We revisit a classic STDP result in visual cortex
www.biorxiv.org/content/10.6...
We revisit a classic STDP result in visual cortex
www.biorxiv.org
April 23, 2026 at 3:48 PM
🧪 1/ New preprint from the lab: L5 pyramidal cell tLTD requires astrocyte Ca2+ and CB1 signaling
www.biorxiv.org/content/10.6...
We revisit a classic STDP result in visual cortex
www.biorxiv.org/content/10.6...
We revisit a classic STDP result in visual cortex
Want to know what synaptic plasticity rules operate in-vivo to support learning? Read our new paper, combining computational modeling and analysis of place field trajectories during familiarization to novel environments.
#BTSP #STDP #hippocampus #CA1 #CA3
#FirstBlueskyTweet
#BTSP #STDP #hippocampus #CA1 #CA3
#FirstBlueskyTweet
Behavioral timescale synaptic plasticity (BTSP), not Hebbian spike-timing-dependent plasticity (STDP), explains heterogenous place field shifting in the mouse hippocampus 🧠🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Synaptic plasticity rules driving representational shifting in the hippocampus - Nature Neuroscience
Madar et al. report that behavioral timescale synaptic plasticity (BTSP), not spike-timing-dependent plasticity, explains heterogeneous place fields shifting in the hippocampus. The probability of BTS...
www.nature.com
March 25, 2025 at 9:04 PM
Want to know what synaptic plasticity rules operate in-vivo to support learning? Read our new paper, combining computational modeling and analysis of place field trajectories during familiarization to novel environments.
#BTSP #STDP #hippocampus #CA1 #CA3
#FirstBlueskyTweet
#BTSP #STDP #hippocampus #CA1 #CA3
#FirstBlueskyTweet
BTSP, but not STDP, can account for place field changes in hippocampus, out in Nature Neuroscience today:
www.nature.com/articles/s41...
🧠📈 🧪
www.nature.com/articles/s41...
🧠📈 🧪
Synaptic plasticity rules driving representational shifting in the hippocampus - Nature Neuroscience
Madar et al. report that behavioral timescale synaptic plasticity (BTSP), not spike-timing-dependent plasticity, explains heterogeneous place fields shifting in the hippocampus. The probability of BTS...
www.nature.com
April 8, 2025 at 12:49 PM
BTSP, but not STDP, can account for place field changes in hippocampus, out in Nature Neuroscience today:
www.nature.com/articles/s41...
🧠📈 🧪
www.nature.com/articles/s41...
🧠📈 🧪
I’m pleased to annonce the publication of our research on the «Emergence and maintenance of modularity in neural networks with Hebbian and anti-Hebbian inhibitory STDP» in @PLOS Computational Biology.
doi.org/10.1371/jour...
doi.org/10.1371/jour...
April 24, 2025 at 1:25 PM
I’m pleased to annonce the publication of our research on the «Emergence and maintenance of modularity in neural networks with Hebbian and anti-Hebbian inhibitory STDP» in @PLOS Computational Biology.
doi.org/10.1371/jour...
doi.org/10.1371/jour...
Excited to share my PhD work on spike-timing dependent plasticity in cerebellar Golgi cells, just published with @springernature.com in @commsbio.nature.com.
Read here: rdcu.be/elN6L
Read here: rdcu.be/elN6L
Coincidence detection between apical and basal dendrites drives STDP in cerebellar Golgi cells
Communications Biology - Cerebellar mf-GoC synapses show anti-symmetric STDP, driven by action potential timing, NMDA receptor activation, and Ca²⁺ dynamics, with inhibitory input...
rdcu.be
May 13, 2025 at 8:40 AM
Excited to share my PhD work on spike-timing dependent plasticity in cerebellar Golgi cells, just published with @springernature.com in @commsbio.nature.com.
Read here: rdcu.be/elN6L
Read here: rdcu.be/elN6L
Emergence and maintenance of modularity in neural networks with Hebbian and anti-Hebbian inhibitory STDP with R. Bergoin, @gzamora-lopez.bsky.social , G. Deco, M. Quoi
#neuroscience #compneurosky #neuroskyence
www.biorxiv.org/content/10.1101/2024.07.15.603496v2
#neuroscience #compneurosky #neuroskyence
www.biorxiv.org/content/10.1101/2024.07.15.603496v2
Emergence and maintenance of modularity in neural networks with Hebbian and anti-Hebbian inhibitory STDP
Brain’s connectivity reveals modular and hierarchical structures at various scales. This organization is typically believed to support the coexistence of segregation (specialization) and integration (...
www.biorxiv.org
December 22, 2024 at 3:20 PM
Emergence and maintenance of modularity in neural networks with Hebbian and anti-Hebbian inhibitory STDP with R. Bergoin, @gzamora-lopez.bsky.social , G. Deco, M. Quoi
#neuroscience #compneurosky #neuroskyence
www.biorxiv.org/content/10.1101/2024.07.15.603496v2
#neuroscience #compneurosky #neuroskyence
www.biorxiv.org/content/10.1101/2024.07.15.603496v2
STDP is such a FANTASTIC album
November 2, 2023 at 12:31 AM
STDP is such a FANTASTIC album
Emergence and maintenance of modularity in neural networks with Hebbian and anti-Hebbian inhibitory STDP
with @raphaelbergoin.bsky.social and @gzamora-lopez.bsky.social finnally published in @plos.org Computational Biology #neuroskyence #compneurosky
journals.plos.org/ploscompbiol...
with @raphaelbergoin.bsky.social and @gzamora-lopez.bsky.social finnally published in @plos.org Computational Biology #neuroskyence #compneurosky
journals.plos.org/ploscompbiol...
Emergence and maintenance of modularity in neural networks with Hebbian and anti-Hebbian inhibitory STDP
Author summary One of the most remarkable qualities of the brain is its capacity to learn and adapt. How the learning process imprints and maintains memories, by shaping the architecture of connectivi...
journals.plos.org
April 23, 2025 at 12:08 PM
Emergence and maintenance of modularity in neural networks with Hebbian and anti-Hebbian inhibitory STDP
with @raphaelbergoin.bsky.social and @gzamora-lopez.bsky.social finnally published in @plos.org Computational Biology #neuroskyence #compneurosky
journals.plos.org/ploscompbiol...
with @raphaelbergoin.bsky.social and @gzamora-lopez.bsky.social finnally published in @plos.org Computational Biology #neuroskyence #compneurosky
journals.plos.org/ploscompbiol...
Behavioral timescale synaptic plasticity (BTSP), not Hebbian spike-timing-dependent plasticity (STDP), explains heterogenous place field shifting in the mouse hippocampus 🧠🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Synaptic plasticity rules driving representational shifting in the hippocampus - Nature Neuroscience
Madar et al. report that behavioral timescale synaptic plasticity (BTSP), not spike-timing-dependent plasticity, explains heterogeneous place fields shifting in the hippocampus. The probability of BTS...
www.nature.com
March 25, 2025 at 3:40 PM
Behavioral timescale synaptic plasticity (BTSP), not Hebbian spike-timing-dependent plasticity (STDP), explains heterogenous place field shifting in the mouse hippocampus 🧠🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lol I genuinely for a while thought “anti Hebbian” meant “philosophically against Hebbian plasticity“ but apparently it means an STDP curve that looks the opposite of Hebbian 😭
April 26, 2026 at 2:42 PM
Lol I genuinely for a while thought “anti Hebbian” meant “philosophically against Hebbian plasticity“ but apparently it means an STDP curve that looks the opposite of Hebbian 😭
Key findings:
• Presynaptic NMDARs regulate transmitter release
• Postsynaptic NMDARs are required for associative strengthening
• A double dissociation in STDP governed by distinct NMDAR pools
• Postsynaptic NMDARs support long-term stabilization of dendritic spines and circuit architecture
4/6
• Presynaptic NMDARs regulate transmitter release
• Postsynaptic NMDARs are required for associative strengthening
• A double dissociation in STDP governed by distinct NMDAR pools
• Postsynaptic NMDARs support long-term stabilization of dendritic spines and circuit architecture
4/6
February 16, 2026 at 8:28 PM
Key findings:
• Presynaptic NMDARs regulate transmitter release
• Postsynaptic NMDARs are required for associative strengthening
• A double dissociation in STDP governed by distinct NMDAR pools
• Postsynaptic NMDARs support long-term stabilization of dendritic spines and circuit architecture
4/6
• Presynaptic NMDARs regulate transmitter release
• Postsynaptic NMDARs are required for associative strengthening
• A double dissociation in STDP governed by distinct NMDAR pools
• Postsynaptic NMDARs support long-term stabilization of dendritic spines and circuit architecture
4/6
Our most recent preprint: Presynaptically located NMDA receptors that signal non-ionotropically via JNK2 contribute to Spike-Timing-Dependent Plasticity, STDP. This explains the lack of frequency dependence in timing-dependent Long-Term Depression, tLTD. www.biorxiv.org/content/10.1...
Neocortical Layer-5 tLTD Relies on Non-Ionotropic Presynaptic NMDA Receptor Signaling
In the textbook view, NMDA receptors (NMDARs) act as coincidence detectors in Hebbian plasticity by fluxing Ca2+ when simultaneously depolarized and glutamate bound. Hebbian coincidence detection requ...
www.biorxiv.org
February 11, 2025 at 4:08 AM
Our most recent preprint: Presynaptically located NMDA receptors that signal non-ionotropically via JNK2 contribute to Spike-Timing-Dependent Plasticity, STDP. This explains the lack of frequency dependence in timing-dependent Long-Term Depression, tLTD. www.biorxiv.org/content/10.1...
My main worry when it comes to credit assignment specifically is that there's a real possibility almost all of the learning mechanisms may be completely wrong. The neural computing field has been overfitting to a handful of old slice physiology concepts like LTP and STDP that may not hold up in vivo
May 27, 2025 at 1:26 PM
My main worry when it comes to credit assignment specifically is that there's a real possibility almost all of the learning mechanisms may be completely wrong. The neural computing field has been overfitting to a handful of old slice physiology concepts like LTP and STDP that may not hold up in vivo
I'd have to say the rise of predictive coding. Back in mid-2000s this was a niche idea, now it is a dominant view of how the brain works
BTSP is another big breakthrough. Not *the answer* to brain learning imo but the biggest learning rule progress since STDP
BTSP is another big breakthrough. Not *the answer* to brain learning imo but the biggest learning rule progress since STDP
March 9, 2026 at 5:54 PM
I'd have to say the rise of predictive coding. Back in mid-2000s this was a niche idea, now it is a dominant view of how the brain works
BTSP is another big breakthrough. Not *the answer* to brain learning imo but the biggest learning rule progress since STDP
BTSP is another big breakthrough. Not *the answer* to brain learning imo but the biggest learning rule progress since STDP
Biologically Plausible Dopamine-Modulated STDP Model of Pavlovian Learning in Spiking Neural Networks https://www.biorxiv.org/content/10.64898/2026.07.17.739276v1
July 23, 2026 at 2:16 AM
Biologically Plausible Dopamine-Modulated STDP Model of Pavlovian Learning in Spiking Neural Networks https://www.biorxiv.org/content/10.64898/2026.07.17.739276v1
Cerebellar mf-GoC synapses show anti-symmetric STDP, driven by action potential timing, NMDA receptor activation, and Ca²⁺ dynamics, with inhibitory input capable of reversing the plasticity rules. @elepali.bsky.social
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Coincidence detection between apical and basal dendrites drives STDP in cerebellar Golgi cells - Communications Biology
Cerebellar mf-GoC synapses show anti-symmetric STDP, driven by action potential timing, NMDA receptor activation, and Ca²⁺ dynamics, with inhibitory input capable of reversing the plasticity rules.
www.nature.com
May 15, 2025 at 6:23 PM
Cerebellar mf-GoC synapses show anti-symmetric STDP, driven by action potential timing, NMDA receptor activation, and Ca²⁺ dynamics, with inhibitory input capable of reversing the plasticity rules. @elepali.bsky.social
www.nature.com/articles/s42...
www.nature.com/articles/s42...
להקת הפלמנקו הישראלית פתחה קישור להופעה של שלגיה ושבעת הגמדים, שבמקרה כבר כמה פעמים רציתי לקחת את הגיזרת אליו ולא יצא.
זמן טוב לציין שמכל הקישורים של 'פתחנו במיוחד לרגל המצב', זה הראשון שאשכרה לא צפינו בו עדיין ביוטיוב, הרבה לפני "המצב".
www.youtube.com/watch?v=StdP...
זמן טוב לציין שמכל הקישורים של 'פתחנו במיוחד לרגל המצב', זה הראשון שאשכרה לא צפינו בו עדיין ביוטיוב, הרבה לפני "המצב".
www.youtube.com/watch?v=StdP...
Snow White and the Seven Dwarfs. COMPAS Dance Company
YouTube video by להקת הפלמנקו הישראלית COMPAS Dance Company
www.youtube.com
March 2, 2026 at 2:37 PM
להקת הפלמנקו הישראלית פתחה קישור להופעה של שלגיה ושבעת הגמדים, שבמקרה כבר כמה פעמים רציתי לקחת את הגיזרת אליו ולא יצא.
זמן טוב לציין שמכל הקישורים של 'פתחנו במיוחד לרגל המצב', זה הראשון שאשכרה לא צפינו בו עדיין ביוטיוב, הרבה לפני "המצב".
www.youtube.com/watch?v=StdP...
זמן טוב לציין שמכל הקישורים של 'פתחנו במיוחד לרגל המצב', זה הראשון שאשכרה לא צפינו בו עדיין ביוטיוב, הרבה לפני "המצב".
www.youtube.com/watch?v=StdP...
Me too! It’s probably still my favorite album of hers. They’re all great, but STDP has a really special place in my heart
May 1, 2026 at 3:33 PM
Me too! It’s probably still my favorite album of hers. They’re all great, but STDP has a really special place in my heart
Congrats to our postdoc Katie Copley on another terrific publication from her PhD work @upenn.edu with Shorter and Barmada labs! @yaleneuro.bsky.social @yalerna.bsky.social www.science.org/doi/10.1126/...
Isoform-specific steric zippers drive aberrant assembly and mislocalization of shortened TDP-43
The sequence-encoded determinants underlying aberrant sTDP-43 behavior are defined, revealing therapeutic strategies for ALS.
www.science.org
June 26, 2026 at 1:04 PM
Congrats to our postdoc Katie Copley on another terrific publication from her PhD work @upenn.edu with Shorter and Barmada labs! @yaleneuro.bsky.social @yalerna.bsky.social www.science.org/doi/10.1126/...
Bracing myself for the storm next week by re-diving into the classic synaptic plasticity papers featuring STDP and learning more about the credit assignment problem in neocortex... Strangely that has actually helped.
Que sera sera.
Que sera sera.
March 1, 2026 at 1:54 PM
Bracing myself for the storm next week by re-diving into the classic synaptic plasticity papers featuring STDP and learning more about the credit assignment problem in neocortex... Strangely that has actually helped.
Que sera sera.
Que sera sera.
Last week I presented some of my last work at #SNUFA2025
You can find the recording of the talk in the following link:
youtu.be/oQiQLUyS1qM?...
You can find the recording of the talk in the following link:
youtu.be/oQiQLUyS1qM?...
Raphaël Bergoin - Emergence and maintenance of modularity in neural networks with inhibitory STDP
YouTube video by Neural Reckoning
youtu.be
November 11, 2025 at 3:26 PM
Last week I presented some of my last work at #SNUFA2025
You can find the recording of the talk in the following link:
youtu.be/oQiQLUyS1qM?...
You can find the recording of the talk in the following link:
youtu.be/oQiQLUyS1qM?...
Are people still arguing that STDP solves everything? I feel like it's been years since I heard that one.
March 20, 2025 at 3:34 PM
Are people still arguing that STDP solves everything? I feel like it's been years since I heard that one.