Mitochondrial protein import inhibition causes tumor immunogenicity & sensitization to immune checkpoint blockade by promoting mitochondrial DNA escape and IFNβ-driven MHC class I antigen presentation @nature.com @danafarber.bsky.social @harvardmed.bsky.social
www.nature.com/articles/s41...

Do insects feel pain? Well, they show behavioural signs of allodynia and hyperalgesia: injury makes responses to noxious stimuli more intense, and makes previously non-noxious stimuli noxious
link.springer.com/article/10.1...

Amazing achievement by 1st author Moana Vorjans: this was her MSc thesis!

This is a slippery slope. We can say that paramecia who avoid noxious stimuli (e.g. acid, high salt concentration areas, etc) feel pain. What matters is the emotional *and* sensory components.

What we can say is that insects show behavioural correlates of nociceptive sensitization. Not pain.

living a life where I'm looking up scientific literature on adhesive sensitization risks for kinks I mostly don't have but appreciate the engineering challenge of

I have a big beautiful binder for dog training that has a planner, her training games, and other high priority sensitization training we need to do. it also has a section for journaling. I love my big beautiful dog binder

Do you have concerns about how you were treated during childbirth? 

Learn how to request an investigation into a treatment received.

Read more: https://enfantement.org/en/community/sensitization/beyond-the-complaint-turning-individual-experiences-into-systemic-change/

sensitization. However, the specific regulatory role and precise molecular mechanism of TRPC5 in the progression of acute and chronic migraine remain unclear. (🧵 2/13)

mGluR5-PKCgamma signaling disrupts the AMPA receptor subunit homeostasis and drives central sensitization in chronic migraine
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📚 Source: Neurochemistry international
👤 Creator: Xiaojian Liu et al.
📅 Date: 2026-11-12

#MigrainePapertag/MigrainePaper" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#MigrainePaper #Migraine/hashtag/Migraine" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#Migraine #PubMed="/hashtag/PubMed" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#PubMed

LY294002 blockade of PI3K-Akt recapitulated these protective effects, attenuating sensory hypersensitivity and neuroinflammation.

CONCLUSION: TRPC5 mediates NTG-induced migraine central sensitization. (🧵 11/13)

TRPC5 involvement in NTG-induced migraine-like central sensitization in mice: a study based on the PI3K-Akt/P2X7R-IL-1beta signaling axis
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📚 Source: Frontiers in immunology
👤 Creator: Jing Lu et al.
📅 Date: 2026-11-13

#MigrainePapertag/MigrainePaper" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#MigrainePaper #Migraine/hashtag/Migraine" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#Migraine #PubMed="/hashtag/PubMed" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#PubMed

METHODS: A repetitive NTG intraperitoneal injection protocol was applied to establish a mouse model mimicking acute migraine nociceptive responses and chronic migraine central sensitization. (🧵 4/13)

(P2X7R/IL-1β)inflammatory axis.

RESULTS: Repeated NTG challenge induced robust migraine-like behaviors, prominent neuronal hyperactivation and sustained central sensitization within the SSP cortex. (🧵 8/13)

These findings suggest that the m GluR5-PKCγ-AMPAR signaling axis may contribute to central sensitization in CM. Moreover, by correcting the AMPAR subunit imbalance and alleviating pain hypersensitivity, (🧵 7/8)

constant. The m GluR5 agonist CHPG worsened AMPAR subunit imbalance and pain hypersensitivity, whereas m GluR5 knockdown or the negative allosteric modulator MPEP corrected these abnormalities and reduced preexisting central sensitization. (🧵 4/8)

Choi et al. (University of Erlangen-Nuremberg) provide an overview of the role of basophils as "immune command centers." In atopic dermatitis, activated basophils propagate allergic sensitization to distant organs, such as the lungs and intestines.

Cell-line sensitization is a mechanism signal, not yet a treatment result. The next step is to test whether GPCR blockade widens the therapeutic window across genetically diverse models while separating on-target pathway suppression from general toxicity.

This study aimed to explore the potential function of TRPC5 and its downstream signaling cascade in nitroglycerin (NTG)-induced migraine-like central sensitization, so as to provide novel preclinical evidence for migraine pathogenesis and targeted intervention. (🧵 3/13)

BACKGROUND: Central sensitization is the core pathological mechanism driving the occurrence and chronification of chronic migraine (CM). Transient Receptor Potential Canonical 5 (TRPC5) channel is critically involved in the modulation of multiple pain disorders and central (🧵 1/13)

Chronic migraine (CM) involves central sensitization in the trigeminal nucleus caudalis (TNC) and sustained glutamatergic transmission, which depends on AMPA receptor (AMPAR) subunit homeostasis-specifically, the equilibrium between GluA1 and GluA2 at the plasma membrane. (🧵 1/8)

Pink peppercorn is a real, hidden cross-reactant Pink peppercorn comes from a Schinus plant in the same Anacardiaceae family, and it is cross-reactive in cashew-allergic and pistachio-allergic children, with common co-sensitization and…
https://checkeverylabel.com/pistachio-allergy/
#foodallergy

2026. Chronic pain-like responses revealed by allodynia and hyperalgesia in the ant Lasius niger. link.springer.com/article/10.1... #AnimalSentience #AnimalEthics #AnimalWelfare

this blog tells the #StoryBehindThePaper for the article “Fear generalization, cross-sensitization and behavioural responses to multiple dangers in a freshwater snail”. Yan, Szeligowski and colleagues tested generalised fear responses in a species of freshwater snail. 🐌
buff.ly/cznlEnL

Neural crosstalk between subchondral bone and synovium in osteoarthritis. Y Feng et al. Front Med 2026 Oct 21 shorturl.at/WNGnZ ... joint innervation function as a regulatory interface linking subchondral bone remodeling, synovial immune responses, and pain sensitization

배경: 중추 감작(central sensitization)은 만성 편두통(CM)의 발생과 만성화를 주도하는 핵심 병리학적 기전이다. 일시적 수용체 전위 캐노니컬 5(TRPC5) 채널은 다양한 통증 장애 및 중추 감작의 조절에 결정적인 역할을 한다. 그러나 급성 및 만성 편두통의 진행 과정에서 TRPC5가 수행하는 구체적인 조절 역할과 정확한 분자적 기전은 아직 명확하지 않다. (🧵 1/7)