Introducing an exclusive interview with our Inspiring intensivist Prof. Richard Hotchkiss, the undeniable leader of modern sepsis research, whose work has forever transformed our understanding of this complex syndrome. Thanks to his groundbreaking studies, the global view of sepsis shifted from a focus on uncontrolled hyperinflammation to recognising the critical role of immune suppression, apoptotic cell death, and lymphocyte depletion in driving poor outcomes. With a research portfolio published in the world's most prestigious journals—including NEJM, JAMA, Nature, and Science—Prof. Hotchkiss has become a guiding force for clinicians and researchers managing critically ill patients with sepsis. In this special interview, Prof. Hotchkiss in a historical journey will guide us through his decades of sepsis research, sharing how early hypotheses evolved, the "wrong paths" explored, and the pivotal collaborations that led to groundbreaking discoveries. His story is not only about science but about persistence, teamwork, and changing the way the world...

To develop and evaluate a standardized emergency department (ED) adapted framework based on Centers for Disease Control (CDC) surveillance definitions and modified SOFA assessment for reproducible infection and sepsis classification in patients with suspected infection on the ED.MethodsAs part of the prospective cohort study BIOSEP, adults presenting to the ED with suspected infection and a Modified Early Warning Score ≥2 were consecutively enrolled between 2022 and 2026 at 4 Dutch hospitals. All enrolled patients in this study were retrospectively adjudicated through post hoc review of their electronic health records. Each case was independently assessed by 2 blinded physicians for plausibility of infection, infection diagnosis, causative pathogen, and sepsis occurrence. Disagreements were resolved by a third blinded reviewer. Interobserver agreement was quantified using Cohen's kappa and Gwet's agreement coefficients (gAC).ResultsIn total, 1062 ED patients were included with 1145 infection episodes. Interobserver agreement for infection diagnosis was 88.9%, and agreement statistics were classified as very good with Cohen's κ of 0.87 (95% CI 0.85–0.89) and a gAC1 of 0.89 (0.87–0.91). Agreement for causative pathogens was 90.1% (κ 0.89 [0.87–0.92]; gAC1 0.97 [0.95–0.98]), and for sepsis occurrence 93.4% (κ 0.80 [0.76–0.85]; gAC1 0.92 [0.90–0.94]). Agreement for plausibility of infection was also high (87.9%; weighted κ 0.87 [0.85–0.89]; gAC2 0.92 [0.90–0.93]).ConclusionsOur ED-adapted adjudication framework based on CDC surveillance definitions yields high interobserver agreement for infection and sepsis classification across a heterogeneous ED population, supporting its use in large-scale observational research.