#SomaticMutations
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jsantoyo.bsky.social
SomaMutDB 2.0: A comprehensive database for exploring somatic mutations and their functional impact in normal human tissues. #SomaticMutations #HumanTissues #NAR @narjournal.bsky.social 🧪🧬 🖥️
academic.oup.com/nar/advance-...
November 30, 2025 at 5:49 PM
onehealthgenomics.bsky.social
New Publication:
Spectrum and Impact of Mitochondrial DNA Mutations in Ovarian Cancer

@uoe-igc.bsky.social @cruk-si.bsky.social @csemple.bsky.social

#mitochondrialDNA #somaticmutations #ovariancancer #geneediting

www.mdpi.com/1422-0067/26...
www.mdpi.com
February 5, 2026 at 4:14 PM
jsantoyo.bsky.social
A telomere-to-telomere map of somatic mutation burden and functional impact in cancer. #T2T #SomaticMutations #CancerGenetics #Genomics @biorxiv-genomic.bsky.social
www.biorxiv.org/content/10.1...
October 22, 2025 at 11:15 AM
safia-sauty.bsky.social
Our latest paper investigating the somatic mutation landscape of chondrocytes, compared against skin fibroblasts.
We used both motif-centered and traditional signature analysis to identify and compare the activities of mutagenic sources.

#SomaticMutations #Genomics
Comparative whole-genome analyses of articular chondrocytes and skin fibroblasts reveal distinct genome instability landscapes in mesenchymal cell types
Author summary Genomes of all human cells accumulate somatic mutations over a lifetime due to exposure to various DNA damaging agents, as well as errors in DNA replication and repair. The source, load...
share.google
May 26, 2026 at 10:56 PM
theinnovation.bsky.social
This study shows that DNA-mismatch-repair-deficient cell populations maintain high growth rates despite a high SNV burden of at least 50,000 mutations per cell. In these cells, the INDEL burden plateaus at approximately 16,000 per cell.
doi.org/10.1016/j.xi...
#SomaticMutations #CellularAging
August 29, 2025 at 4:43 AM
gentlem.bsky.social
apple.news/A2YHl3upbQ9S...
#DNA-identicaltwins
Forensic science can tell the difference between identical twins.
#somaticmutations
I can too, not because of DNA sequencing but because I am a twin. Not identical, but innately attuned to small differences.
Identical twin convicted based on DNA differences in first US case of its kind — Guardian US
In the Virginia case, rare genetic mutations distinguished identical twins in DNA analysis
apple.news
September 2, 2025 at 3:43 PM
mol-biomed.bsky.social
#Research
Circulating cell-free DNA (#cfDNA) profiling reveals ancestry-dependent genetic variation in #metastatic prostate cancer (#PC) doi.org/10.1186/s435...
Studied by researchers from Indiana University School of Medicine

#GeneticVariations #SomaticMutations #profiling #MCRPC
Circulating cell-free DNA profiling reveals ancestry-dependent genetic variation in metastatic prostate cancer - Molecular Biomedicine
African American men experience markedly higher prostate cancer incidence and mortality yet remain underrepresented in genomic studies aimed at identifying ancestry-associated molecular drivers of dis...
doi.org
March 20, 2026 at 5:54 AM