Nice to see this paper out from Jack Lindsey and his collaborators:
elifesciences.org/reviewed-pre...
They diagnose a fundamental problem with existing models of striatal plasticity, show how to fix it, and then reanalyze data from recordings of striatal projection neurons to support the model.
elifesciences.org/reviewed-pre...
They diagnose a fundamental problem with existing models of striatal plasticity, show how to fix it, and then reanalyze data from recordings of striatal projection neurons to support the model.
Dynamics of striatal action selection and reinforcement learning
elifesciences.org
December 9, 2024 at 10:08 AM
Nice to see this paper out from Jack Lindsey and his collaborators:
elifesciences.org/reviewed-pre...
They diagnose a fundamental problem with existing models of striatal plasticity, show how to fix it, and then reanalyze data from recordings of striatal projection neurons to support the model.
elifesciences.org/reviewed-pre...
They diagnose a fundamental problem with existing models of striatal plasticity, show how to fix it, and then reanalyze data from recordings of striatal projection neurons to support the model.
Here's a look at a field of striatal astrocytes expressing GCaMP6f-cyto from the Huda Lab for #FluorescenceFriday !
September 5, 2025 at 6:39 PM
Here's a look at a field of striatal astrocytes expressing GCaMP6f-cyto from the Huda Lab for #FluorescenceFriday !
This looks like amazing new work from my colleagues at Stanford demonstrating the opponent interactions of DA and 5HT in reinforcement learning.
Opponent control of reinforcement by striatal dopamine and serotonin - Nature
Nature - Opponent control of reinforcement by striatal dopamine and serotonin
www.nature.com
January 2, 2025 at 3:44 PM
This looks like amazing new work from my colleagues at Stanford demonstrating the opponent interactions of DA and 5HT in reinforcement learning.
An opponent striatal circuit for distributional reinforcement learning rdcu.be/eejlQ - cool work, as always, from Naoshige Uchida's group
An opponent striatal circuit for distributional reinforcement learning
Nature - D1- and D2-expressing striatal neurons encode separate parts of a learned reward distribution, paralleling modern approaches in machine learning.
rdcu.be
March 20, 2025 at 9:35 AM
An opponent striatal circuit for distributional reinforcement learning rdcu.be/eejlQ - cool work, as always, from Naoshige Uchida's group
Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior
www.nature.com/articles/s42...
#neuroscience
www.nature.com/articles/s42...
#neuroscience
Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior - Communications Biology
Goal-directed behavior requires selecting and committing to goals, strategies, and actions. This review explores how three hierarchical prefronto-striatal loops can achieve this: striatal matrix ensem...
www.nature.com
May 8, 2026 at 6:58 PM
Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior
www.nature.com/articles/s42...
#neuroscience
www.nature.com/articles/s42...
#neuroscience
⚡️🧠A nociceptive amygdala-striatal pathway modulating affective-motivational pain
Now published on the cover of Science Advances @science.org
Check it out 👇
www.science.org/doi/10.1126/...
Now published on the cover of Science Advances @science.org
Check it out 👇
www.science.org/doi/10.1126/...
July 23, 2025 at 6:52 PM
⚡️🧠A nociceptive amygdala-striatal pathway modulating affective-motivational pain
Now published on the cover of Science Advances @science.org
Check it out 👇
www.science.org/doi/10.1126/...
Now published on the cover of Science Advances @science.org
Check it out 👇
www.science.org/doi/10.1126/...
Striatal stimulation enhances cognitive control and evidence processing in rodents and humans
www.science.org/doi/10.1126/...
#neuroscience
www.science.org/doi/10.1126/...
#neuroscience
Striatal stimulation enhances cognitive control and evidence processing in rodents and humans
Developing an animal model of human brain stimulation therapy reveals that striatal DBS enhances the brain’s ability to process conflicting evidence.
www.science.org
January 2, 2025 at 12:42 PM
Striatal stimulation enhances cognitive control and evidence processing in rodents and humans
www.science.org/doi/10.1126/...
#neuroscience
www.science.org/doi/10.1126/...
#neuroscience
Opposite responses to reward with dopamine (up) and serotonin (down) in nucleus accumbens boost reinforcement learning. Impressive work in Nature:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Opponent control of reinforcement by striatal dopamine and serotonin - Nature
Nature - Opponent control of reinforcement by striatal dopamine and serotonin
www.nature.com
November 25, 2024 at 8:24 PM
Opposite responses to reward with dopamine (up) and serotonin (down) in nucleus accumbens boost reinforcement learning. Impressive work in Nature:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Excited to share latest study from the lab by an amazing RA, Dylan Flink.
We solved a small (important) puzzle while in the trenches of a larger (wavy 🌊) puzzle.
www.biorxiv.org/content/10.6...
🧵...
We solved a small (important) puzzle while in the trenches of a larger (wavy 🌊) puzzle.
www.biorxiv.org/content/10.6...
🧵...
Dual cholinergic mechanisms for sculpting striatal dopamine in vivo
Striatal dopamine (DA) and acetylcholine constitute a computationally powerful neuromodulatory dyad that orchestrates action selection, motivational vigor, and reward learning. Striatal cholinergic in...
www.biorxiv.org
December 30, 2025 at 5:47 AM
Excited to share latest study from the lab by an amazing RA, Dylan Flink.
We solved a small (important) puzzle while in the trenches of a larger (wavy 🌊) puzzle.
www.biorxiv.org/content/10.6...
🧵...
We solved a small (important) puzzle while in the trenches of a larger (wavy 🌊) puzzle.
www.biorxiv.org/content/10.6...
🧵...
Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior
www.nature.com/articles/s42...
#neuroscience
www.nature.com/articles/s42...
#neuroscience
Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior - Communications Biology
Goal-directed behavior requires selecting and committing to goals, strategies, and actions. This review explores how three hierarchical prefronto-striatal loops can achieve this: striatal matrix ensem...
www.nature.com
May 17, 2026 at 3:18 PM
Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior
www.nature.com/articles/s42...
#neuroscience
www.nature.com/articles/s42...
#neuroscience
rdcu.be/eIyQB
Now published in Neuropsychopharmacology, here we mimicked the striatal neuroinflammation seen in the brains of individuals with compulsive disorders and found that this facilitated goal-directed action, whereas activating the Gi pathway in astrocytes prevented it
Now published in Neuropsychopharmacology, here we mimicked the striatal neuroinflammation seen in the brains of individuals with compulsive disorders and found that this facilitated goal-directed action, whereas activating the Gi pathway in astrocytes prevented it
Dorsomedial striatal neuroinflammation causes excessive goal-directed action control by disrupting astrocyte function
Neuropsychopharmacology - Dorsomedial striatal neuroinflammation causes excessive goal-directed action control by disrupting astrocyte function
rdcu.be
September 29, 2025 at 12:38 AM
rdcu.be/eIyQB
Now published in Neuropsychopharmacology, here we mimicked the striatal neuroinflammation seen in the brains of individuals with compulsive disorders and found that this facilitated goal-directed action, whereas activating the Gi pathway in astrocytes prevented it
Now published in Neuropsychopharmacology, here we mimicked the striatal neuroinflammation seen in the brains of individuals with compulsive disorders and found that this facilitated goal-directed action, whereas activating the Gi pathway in astrocytes prevented it
As promised at the #GRC Basal Ganglia, here is our recent review on striatal cholinergic heterogeneity. I hope people find it useful and inspiring.
www.frontiersin.org/journals/cel...
www.frontiersin.org/journals/cel...
Frontiers | Regional heterogeneity of striatal cholinergic interneurons: setting the stage for diverse behavioral repertoires
Cholinergic interneurons (ChIs) constitute only a small fraction of striatal neurons, yet their dense axonal arborizations and widespread acetylcholine relea...
www.frontiersin.org
February 24, 2026 at 3:54 PM
As promised at the #GRC Basal Ganglia, here is our recent review on striatal cholinergic heterogeneity. I hope people find it useful and inspiring.
www.frontiersin.org/journals/cel...
www.frontiersin.org/journals/cel...
New preprint. We show that in addition to reward prediction errors (RPEs), dorsal striatal dopamine signals encode sensory prediction errors (SPEs), the difference between sensory prior & observed stimulus. www.biorxiv.org/content/10.6...
Dorsal striatal dopamine integrates sensory and reward prediction errors to guide perceptual decisions
Perceptual decisions are shaped by expectations about sensory stimuli and rewards, learned through sensory and reward prediction errors. Dopamine is known to convey reward prediction errors that shape...
www.biorxiv.org
January 5, 2026 at 10:49 AM
New preprint. We show that in addition to reward prediction errors (RPEs), dorsal striatal dopamine signals encode sensory prediction errors (SPEs), the difference between sensory prior & observed stimulus. www.biorxiv.org/content/10.6...
www.nature.com/articles/s41...
Congrats to Juan and Hugo and the rest of the authors. Not sure if anyone is on bsky yet.
Congrats to Juan and Hugo and the rest of the authors. Not sure if anyone is on bsky yet.
Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors - Nature Neuroscience
Ventral striatal dopamine D3 and D1 receptors regulate motivation and reinforcement, respectively, through dissociable physiological actions.
www.nature.com
December 14, 2024 at 4:10 PM
www.nature.com/articles/s41...
Congrats to Juan and Hugo and the rest of the authors. Not sure if anyone is on bsky yet.
Congrats to Juan and Hugo and the rest of the authors. Not sure if anyone is on bsky yet.
My paper is out!! 🎉
"Opponent control of reinforcement by striatal dopamine and serotonin", @Nature
Here, we show that dopamine and serotonin signals form a gas-brake system for reward in the mammalian brain
THREAD ⬇️
1/n
"Opponent control of reinforcement by striatal dopamine and serotonin", @Nature
Here, we show that dopamine and serotonin signals form a gas-brake system for reward in the mammalian brain
THREAD ⬇️
1/n
November 25, 2024 at 4:31 PM
My paper is out!! 🎉
"Opponent control of reinforcement by striatal dopamine and serotonin", @Nature
Here, we show that dopamine and serotonin signals form a gas-brake system for reward in the mammalian brain
THREAD ⬇️
1/n
"Opponent control of reinforcement by striatal dopamine and serotonin", @Nature
Here, we show that dopamine and serotonin signals form a gas-brake system for reward in the mammalian brain
THREAD ⬇️
1/n
Our new work is out in Science Advances. We show that neural activity in the striatum reflects not just cortical inputs, but also often-underappreciated thalamic inputs.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Complementary cortical and thalamic contributions to cell type–specific striatal activity dynamics during movement
Cell type–specific striatal activity during movement is shaped by cortical and thalamic inputs with complementary roles.
www.science.org
January 30, 2026 at 12:47 AM
Our new work is out in Science Advances. We show that neural activity in the striatum reflects not just cortical inputs, but also often-underappreciated thalamic inputs.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
The full paper is here: www.nature.com/articles/s41...
Striatal dopamine tone is positively associated with adiposity in humans as determined by PET using dual dopamine type-2 receptor antagonist tracers - Molecular Psychiatry
Molecular Psychiatry - Striatal dopamine tone is positively associated with adiposity in humans as determined by PET using dual dopamine type-2 receptor antagonist tracers
www.nature.com
April 6, 2025 at 2:14 PM
The full paper is here: www.nature.com/articles/s41...
I’m very excited about this new work describing the specific cortical-striatal circuits that are altered in Parkinson’s Disease and that should be targeted for optimal PD treatment.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 5, 2026 at 7:24 PM
I’m very excited about this new work describing the specific cortical-striatal circuits that are altered in Parkinson’s Disease and that should be targeted for optimal PD treatment.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package: www.nature.com/articles/s41...
Conservation and alteration of mammalian striatal interneurons - Nature
An analysis of cell-type diversity in brain samples from a variety of mammalian species, both during development and in adult animals, reveals that the TAC3 initial class of striatal interneurons is c...
www.nature.com
November 7, 2025 at 6:06 PM
Our new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package: www.nature.com/articles/s41...
Science Advances
Dynamic responses of striatal cholinergic interneurons control behavioral flexibility
www.science.org/doi/10.1126/...
Dynamic responses of striatal cholinergic interneurons control behavioral flexibility
www.science.org/doi/10.1126/...
Dynamic responses of striatal cholinergic interneurons control behavioral flexibility
Striatal cholinergic interneurons dynamically control the extinction and updating of goal-directed learning.
www.science.org
December 21, 2024 at 2:30 PM
Science Advances
Dynamic responses of striatal cholinergic interneurons control behavioral flexibility
www.science.org/doi/10.1126/...
Dynamic responses of striatal cholinergic interneurons control behavioral flexibility
www.science.org/doi/10.1126/...
🧠 What if #LongCovid is, in part, a disorder of dopamine?
Our new commentary explores how disrupted dopamine signaling may help explain fatigue, brain fog, and autonomic dysfunction, and what this could mean for future therapies.
Open access link: shorturl.at/vLAfU
Our new commentary explores how disrupted dopamine signaling may help explain fatigue, brain fog, and autonomic dysfunction, and what this could mean for future therapies.
Open access link: shorturl.at/vLAfU
July 11, 2026 at 6:32 PM
🧠 What if #LongCovid is, in part, a disorder of dopamine?
Our new commentary explores how disrupted dopamine signaling may help explain fatigue, brain fog, and autonomic dysfunction, and what this could mean for future therapies.
Open access link: shorturl.at/vLAfU
Our new commentary explores how disrupted dopamine signaling may help explain fatigue, brain fog, and autonomic dysfunction, and what this could mean for future therapies.
Open access link: shorturl.at/vLAfU
Nature research paper: An opponent striatal circuit for distributional reinforcement learning
https://go.nature.com/41a7Snf
https://go.nature.com/41a7Snf
An opponent striatal circuit for distributional reinforcement learning - Nature
D1- and D2-expressing striatal neurons encode separate parts of a learned reward distribution, paralleling modern approaches in machine learning.
go.nature.com
February 24, 2025 at 3:18 PM
Nature research paper: An opponent striatal circuit for distributional reinforcement learning
https://go.nature.com/41a7Snf
https://go.nature.com/41a7Snf
“UCLA researchers have discovered that chronic stress flips brain activity between two amygdala-striatal pathways, disrupting flexible decision-making and promoting inflexible habits.”
medicalxpress.com/news/2025-02...
medicalxpress.com/news/2025-02...
A stressed mind is made more prone to rigid thinking, mouse study finds
University of California, Los Angeles researchers have discovered that chronic stress flips brain activity between two amygdala-striatal pathways, disrupting flexible decision-making and promoting inf...
medicalxpress.com
February 23, 2025 at 5:52 AM
“UCLA researchers have discovered that chronic stress flips brain activity between two amygdala-striatal pathways, disrupting flexible decision-making and promoting inflexible habits.”
medicalxpress.com/news/2025-02...
medicalxpress.com/news/2025-02...
Nature
Opponent control of reinforcement by striatal dopamine and serotonin
www.nature.com/articles/s41...
Opponent control of reinforcement by striatal dopamine and serotonin
www.nature.com/articles/s41...
Opponent control of reinforcement by striatal dopamine and serotonin - Nature
Nature - Opponent control of reinforcement by striatal dopamine and serotonin
www.nature.com
November 26, 2024 at 11:07 AM
Nature
Opponent control of reinforcement by striatal dopamine and serotonin
www.nature.com/articles/s41...
Opponent control of reinforcement by striatal dopamine and serotonin
www.nature.com/articles/s41...