Our article in @chemicalscience.rsc.org registers as one of the most popular articles of 2024. The study on Sufex click chemistry was led by John Moses @cshlnews.bsky.social
Modular synthesis of functional libraries by accelerated SuFEx click chemistry
Accelerated SuFEx Click Chemistry (ASCC) is a powerful method for coupling aryl and alkyl alcohols with SuFEx-compatible functional groups. With its hallmark favorable kinetics and exceptional product...
pubs.rsc.org
April 6, 2025 at 8:32 AM
Our article in @chemicalscience.rsc.org registers as one of the most popular articles of 2024. The study on Sufex click chemistry was led by John Moses @cshlnews.bsky.social
Nature research paper: SuFEx-based antitubercular compound irreversibly inhibits Pks13
go.nature.com/40JdOnN
go.nature.com/40JdOnN
SuFEx-based antitubercular compound irreversibly inhibits Pks13 - Nature
A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a promising candidate for tuberculosis treatment regimens.
go.nature.com
July 31, 2025 at 7:49 AM
Nature research paper: SuFEx-based antitubercular compound irreversibly inhibits Pks13
go.nature.com/40JdOnN
go.nature.com/40JdOnN
We have a new review article on recent applications of SuFEx chemistry in chemical biology now on-line at #TrendsChem @cellpress.bsky.social
Thanks to @novo-nordisk.bsky.social for funding our work.
authors.elsevier.com/a/1kWpX9CpcY...
Previously on ChemRxiv:
chemrxiv.org/engage/chemr...
Thanks to @novo-nordisk.bsky.social for funding our work.
authors.elsevier.com/a/1kWpX9CpcY...
Previously on ChemRxiv:
chemrxiv.org/engage/chemr...
January 30, 2025 at 8:31 AM
We have a new review article on recent applications of SuFEx chemistry in chemical biology now on-line at #TrendsChem @cellpress.bsky.social
Thanks to @novo-nordisk.bsky.social for funding our work.
authors.elsevier.com/a/1kWpX9CpcY...
Previously on ChemRxiv:
chemrxiv.org/engage/chemr...
Thanks to @novo-nordisk.bsky.social for funding our work.
authors.elsevier.com/a/1kWpX9CpcY...
Previously on ChemRxiv:
chemrxiv.org/engage/chemr...
The December issue is live🎄
Thin films of stable layered nitrides
Out-of-equilibrium supramolecular gels
Coupling of arylthianthrenium salts under acidic conditions
Assembly of tubular frameworks
Computational studies of MoDAT and SuFEx pathways
(Continued)
www.nature.com/natsynth/vol...
Thin films of stable layered nitrides
Out-of-equilibrium supramolecular gels
Coupling of arylthianthrenium salts under acidic conditions
Assembly of tubular frameworks
Computational studies of MoDAT and SuFEx pathways
(Continued)
www.nature.com/natsynth/vol...
December 18, 2024 at 6:18 PM
The December issue is live🎄
Thin films of stable layered nitrides
Out-of-equilibrium supramolecular gels
Coupling of arylthianthrenium salts under acidic conditions
Assembly of tubular frameworks
Computational studies of MoDAT and SuFEx pathways
(Continued)
www.nature.com/natsynth/vol...
Thin films of stable layered nitrides
Out-of-equilibrium supramolecular gels
Coupling of arylthianthrenium salts under acidic conditions
Assembly of tubular frameworks
Computational studies of MoDAT and SuFEx pathways
(Continued)
www.nature.com/natsynth/vol...
SuFEx welcomes new coupling partners - carbon pronucleophiles now in @chemicalscience.rsc.org . Congrats to Ball Lab students Joe Novicku and Matt Teeter and Pfizer colleagues Alistair, Tom, Neil, ans @chrisamende.bsky.social on the great work! #MyFirstChemSci
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
Sulfur fluoride exchange with carbon pronucleophiles
Aryl alkyl sulfones are an important class of compounds in drug discovery; thus, new methods toward their synthesis are desirable. A general sulfur fluoride exchange (SuFEx) method to couple aryl sulf...
pubs.rsc.org
August 15, 2025 at 12:00 PM
SuFEx welcomes new coupling partners - carbon pronucleophiles now in @chemicalscience.rsc.org . Congrats to Ball Lab students Joe Novicku and Matt Teeter and Pfizer colleagues Alistair, Tom, Neil, ans @chrisamende.bsky.social on the great work! #MyFirstChemSci
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
#SuFEx chemistry turns 10 🎂 Explore a decade of innovation, from efficient polymerizations to groundbreaking radiochemistry. Read the latest review by Chun, Hong and co-workers and discover the future of SuFEx chemistry 🧪
👉 https://buff.ly/4hN9lXf
👉 https://buff.ly/4hN9lXf
February 24, 2025 at 8:00 AM
#SuFEx chemistry turns 10 🎂 Explore a decade of innovation, from efficient polymerizations to groundbreaking radiochemistry. Read the latest review by Chun, Hong and co-workers and discover the future of SuFEx chemistry 🧪
👉 https://buff.ly/4hN9lXf
👉 https://buff.ly/4hN9lXf
Bisschen nischig vielleicht, aber sehr spannend zu lesen.
Ich hab mal ein wenig mit SuFEx-basierten Crosslinkern gearbeitet, cool das auch in der Arzneistoff-Entwicklung zu sehen
Ich hab mal ein wenig mit SuFEx-basierten Crosslinkern gearbeitet, cool das auch in der Arzneistoff-Entwicklung zu sehen
Jones (Chemical Science 2025) Advances in sulfonyl exchange chemical biology: expanding druggable target space. #ChemBiol #MedChem #DrugDiscovery #OpenAccess #chemsky 🧪
doi.org/10.1039/D5SC...
doi.org/10.1039/D5SC...
Advances in sulfonyl exchange chemical biology: expanding druggable target space
Targeted covalent inhibitors possess advantages over reversible binding drugs, that include higher potency, enhanced selectivity and prolonged pharmacodynamic duration. The standard paradigm for coval...
doi.org
May 29, 2025 at 8:25 AM
Bisschen nischig vielleicht, aber sehr spannend zu lesen.
Ich hab mal ein wenig mit SuFEx-basierten Crosslinkern gearbeitet, cool das auch in der Arzneistoff-Entwicklung zu sehen
Ich hab mal ein wenig mit SuFEx-basierten Crosslinkern gearbeitet, cool das auch in der Arzneistoff-Entwicklung zu sehen
Happy to report our work on catalytic SuFEx with sulfonimidoyl fluorides - and switchable SNAr reactions also. Congrats to Nikki on her paper now on ChemRxiv
doi.org/10.26434/che...
doi.org/10.26434/che...
Catalytic SuFEx Reactivity of Sulfonimidoyl Fluorides with Functionalized Amines with Automation Applicable Conditions
Sulfonimidamides have emerged as attractive chemical motifs in drug discovery and as sulfonamide bioisosteres that can offer improved pharmacokinetic and physiochemical properties. Here we report a mi...
doi.org
May 19, 2025 at 9:41 AM
Happy to report our work on catalytic SuFEx with sulfonimidoyl fluorides - and switchable SNAr reactions also. Congrats to Nikki on her paper now on ChemRxiv
doi.org/10.26434/che...
doi.org/10.26434/che...
This has a neat mechanism of inhibition:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
SuFEx-based antitubercular compound irreversibly inhibits Pks13 - Nature
A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a pro...
www.nature.com
July 30, 2025 at 8:12 PM
This has a neat mechanism of inhibition:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
With great thanks to NIGMS, the Ball Lab has had our R15 renewed! It took 19 months, but very thankful to the NIH for their support. I am looking forward to training undergraduates with Prof. Ogba @HMC and Dr. am Ende at Pfizer to conduct excellent research in SuFEx!
August 7, 2025 at 1:59 PM
With great thanks to NIGMS, the Ball Lab has had our R15 renewed! It took 19 months, but very thankful to the NIH for their support. I am looking forward to training undergraduates with Prof. Ogba @HMC and Dr. am Ende at Pfizer to conduct excellent research in SuFEx!
SuFEx and SNAr on Sulfonimidoyl Fluorides - happy this is now published in ChemistryEurope.
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
Catalytic SuFEx Reactivity of Sulfonimidoyl Fluorides with Functionalized Amines with Automation Applicable Conditions.
Congrats Nikki!
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
Catalytic SuFEx Reactivity of Sulfonimidoyl Fluorides with Functionalized Amines with Automation Applicable Conditions.
Congrats Nikki!
July 11, 2025 at 8:52 AM
SuFEx and SNAr on Sulfonimidoyl Fluorides - happy this is now published in ChemistryEurope.
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
Catalytic SuFEx Reactivity of Sulfonimidoyl Fluorides with Functionalized Amines with Automation Applicable Conditions.
Congrats Nikki!
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
Catalytic SuFEx Reactivity of Sulfonimidoyl Fluorides with Functionalized Amines with Automation Applicable Conditions.
Congrats Nikki!
A first-in-class cell-wall biosynthesis inhibitor in #TB www.nature.com/articles/s41...
SuFEx-based antitubercular compound irreversibly inhibits Pks13 - Nature
A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a pro...
www.nature.com
July 31, 2025 at 6:10 PM
A first-in-class cell-wall biosynthesis inhibitor in #TB www.nature.com/articles/s41...
Modular synthesis of functional libraries by accelerated SuFEx click chemistry https://pubs.rsc.org/en/content/articlelanding/2024/sc/d3sc05729a
April 6, 2024 at 1:31 AM
Modular synthesis of functional libraries by accelerated SuFEx click chemistry https://pubs.rsc.org/en/content/articlelanding/2024/sc/d3sc05729a
Excellent day! The second paper @angewandtechemie.bsky.social is now online. The liquid substance FSO2OSF5 is an ideal synthone for releasing SOF4, SO2F2 and OSF5–. This helps for SuFEx reactivity like -SO2F or -N=S(O)F2. Great work of Alex and team. CRC 1349
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
July 2, 2025 at 4:26 PM
Excellent day! The second paper @angewandtechemie.bsky.social is now online. The liquid substance FSO2OSF5 is an ideal synthone for releasing SOF4, SO2F2 and OSF5–. This helps for SuFEx reactivity like -SO2F or -N=S(O)F2. Great work of Alex and team. CRC 1349
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Another fantastic paper from @theballlab featuring Nicholas Ball and his amazing band of @PomonaCollege undergraduates – optimization of Lewis acid-catalyzed SuFEx reactions of R-SO2F with TMS-amines using now out in @JOC_OL #OLasap #ChemSky
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Lewis Acid-Catalyzed Sulfur Fluoride Exchange
A new method uses metal Lewis acids as catalysts to convert sulfonyl fluorides, fluorosulfates, and sulfamoyl fluorides with silyl amines into S–N bond-containing compounds via sulfur fluoride exchang...
pubs.acs.org
November 9, 2024 at 8:52 PM
Another fantastic paper from @theballlab featuring Nicholas Ball and his amazing band of @PomonaCollege undergraduates – optimization of Lewis acid-catalyzed SuFEx reactions of R-SO2F with TMS-amines using now out in @JOC_OL #OLasap #ChemSky
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Check out the latest from our lab's
@theballlab in @JOC_OL Lewis Acid-Catalyzed Sulfur Fluoride Exchange.
pubs.acs.org/doi/10.1021/...
@theballlab in @JOC_OL Lewis Acid-Catalyzed Sulfur Fluoride Exchange.
pubs.acs.org/doi/10.1021/...
Lewis Acid-Catalyzed Sulfur Fluoride Exchange
A new method uses metal Lewis acids as catalysts to convert sulfonyl fluorides, fluorosulfates, and sulfamoyl fluorides with silyl amines into S–N bond-containing compounds via sulfur fluoride exchange. The reaction successfully employs Ca(NTf2)2 as a catalyst to form sulfonamides, sulfamates, and sulfamides using in situ-generated or commercially available silyl amines in 35–99% yields. Other metal Lewis acids are also demonstrated to be catalysts in SuFEx, forming sulfonamides and sulfamates in yields comparable to those of Ca(NTf2)2.
pubs.acs.org
November 26, 2024 at 10:29 PM
Check out the latest from our lab's
@theballlab in @JOC_OL Lewis Acid-Catalyzed Sulfur Fluoride Exchange.
pubs.acs.org/doi/10.1021/...
@theballlab in @JOC_OL Lewis Acid-Catalyzed Sulfur Fluoride Exchange.
pubs.acs.org/doi/10.1021/...
📢 NEW #ChemSciCovers
'Chemoselective sulfonyl fluoride exchange (SuFEx)-induced macrocyclization of tyrosine-containing peptides in aqueous media' by Victor K. Outlaw et al.
🔗doi.org/10.1039/D5SC...
'Chemoselective sulfonyl fluoride exchange (SuFEx)-induced macrocyclization of tyrosine-containing peptides in aqueous media' by Victor K. Outlaw et al.
🔗doi.org/10.1039/D5SC...
November 29, 2025 at 2:00 PM
📢 NEW #ChemSciCovers
'Chemoselective sulfonyl fluoride exchange (SuFEx)-induced macrocyclization of tyrosine-containing peptides in aqueous media' by Victor K. Outlaw et al.
🔗doi.org/10.1039/D5SC...
'Chemoselective sulfonyl fluoride exchange (SuFEx)-induced macrocyclization of tyrosine-containing peptides in aqueous media' by Victor K. Outlaw et al.
🔗doi.org/10.1039/D5SC...
New SuFEx reactions revealed as well!
June 8, 2026 at 4:56 PM
New SuFEx reactions revealed as well!
A simple, scalable method by Jurk & van Gemmeren @vangemmerenlab.bsky.social to convert secondary sulfonamides into sulfonyl fluorides using affordable #DAST ⚗️, yielding excellent results! These sulfonyl fluorides readily couple with amines to create diverse libraries.
#SuFEx
👉 buff.ly/hjkyEap
#SuFEx
👉 buff.ly/hjkyEap
August 21, 2025 at 7:00 AM
A simple, scalable method by Jurk & van Gemmeren @vangemmerenlab.bsky.social to convert secondary sulfonamides into sulfonyl fluorides using affordable #DAST ⚗️, yielding excellent results! These sulfonyl fluorides readily couple with amines to create diverse libraries.
#SuFEx
👉 buff.ly/hjkyEap
#SuFEx
👉 buff.ly/hjkyEap
Xu, Dong and co-workers report the use of NH-sulfamoyl fluorides (RNHSO₂F) as reliable #SuFEx synthons for constructing sulfamate esters! Using KF as a base, azasulfene intermediates were generated, enabling efficient ligation with phenols & alcohols 🔬
👉 buff.ly/OioKOwh
👉 buff.ly/OioKOwh
April 9, 2025 at 7:00 AM
Xu, Dong and co-workers report the use of NH-sulfamoyl fluorides (RNHSO₂F) as reliable #SuFEx synthons for constructing sulfamate esters! Using KF as a base, azasulfene intermediates were generated, enabling efficient ligation with phenols & alcohols 🔬
👉 buff.ly/OioKOwh
👉 buff.ly/OioKOwh
Impactful work in 𝙉𝙖𝙩𝙪𝙧𝙚 from team led by Case McNamara lab at Calibr/Scripps
New compound optimized via click chemistry blocks Pks13—a critical enzyme for 𝙈. 𝙩𝙪𝙗𝙚𝙧𝙘𝙪𝙡𝙤𝙨𝙞𝙨 cell wall synthesis
✅ Novel MOA
✅ High potency vs. clinical isolates
✅ Orally bioavailable
✅ Excellent PK, toxicology results
New compound optimized via click chemistry blocks Pks13—a critical enzyme for 𝙈. 𝙩𝙪𝙗𝙚𝙧𝙘𝙪𝙡𝙤𝙨𝙞𝙨 cell wall synthesis
✅ Novel MOA
✅ High potency vs. clinical isolates
✅ Orally bioavailable
✅ Excellent PK, toxicology results
SuFEx-based antitubercular compound irreversibly inhibits Pks13 - Nature
A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a pro...
www.nature.com
August 10, 2025 at 7:52 PM
Impactful work in 𝙉𝙖𝙩𝙪𝙧𝙚 from team led by Case McNamara lab at Calibr/Scripps
New compound optimized via click chemistry blocks Pks13—a critical enzyme for 𝙈. 𝙩𝙪𝙗𝙚𝙧𝙘𝙪𝙡𝙤𝙨𝙞𝙨 cell wall synthesis
✅ Novel MOA
✅ High potency vs. clinical isolates
✅ Orally bioavailable
✅ Excellent PK, toxicology results
New compound optimized via click chemistry blocks Pks13—a critical enzyme for 𝙈. 𝙩𝙪𝙗𝙚𝙧𝙘𝙪𝙡𝙤𝙨𝙞𝙨 cell wall synthesis
✅ Novel MOA
✅ High potency vs. clinical isolates
✅ Orally bioavailable
✅ Excellent PK, toxicology results
Dec issue live🎄
Thin films of stable layered nitrides
Out-of-equilibrium supramolecular gels
Coupling of arylthianthrenium salts under acidic conditions
Assembly of tubular frameworks
Computational studies of MoDAT and SuFEx pathways
(Continued)
www.nature.com/natsynth/vol...
Thin films of stable layered nitrides
Out-of-equilibrium supramolecular gels
Coupling of arylthianthrenium salts under acidic conditions
Assembly of tubular frameworks
Computational studies of MoDAT and SuFEx pathways
(Continued)
www.nature.com/natsynth/vol...
December 13, 2024 at 11:36 AM
Dec issue live🎄
Thin films of stable layered nitrides
Out-of-equilibrium supramolecular gels
Coupling of arylthianthrenium salts under acidic conditions
Assembly of tubular frameworks
Computational studies of MoDAT and SuFEx pathways
(Continued)
www.nature.com/natsynth/vol...
Thin films of stable layered nitrides
Out-of-equilibrium supramolecular gels
Coupling of arylthianthrenium salts under acidic conditions
Assembly of tubular frameworks
Computational studies of MoDAT and SuFEx pathways
(Continued)
www.nature.com/natsynth/vol...
My favorite 2025 #PfizerChemistry publications #12daysOfPapers 10/n:
Alkylation of R-SO2F with carbon nucleophiles out in @chemicalscience.rsc.org
- a collaboration with the awesome @ballnchemist.bsky.social
and his amazing undergrads at @pomonacollege.bsky.social
#ChemSky #Chemchat
Alkylation of R-SO2F with carbon nucleophiles out in @chemicalscience.rsc.org
- a collaboration with the awesome @ballnchemist.bsky.social
and his amazing undergrads at @pomonacollege.bsky.social
#ChemSky #Chemchat
Sulfur fluoride exchange with carbon pronucleophiles
Aryl alkyl sulfones are an important class of compounds in drug discovery; thus, new methods toward their synthesis are desirable. A general sulfur fluoride exchange (SuFEx) method to couple aryl sulf...
pubs.rsc.org
December 22, 2025 at 4:39 PM
My favorite 2025 #PfizerChemistry publications #12daysOfPapers 10/n:
Alkylation of R-SO2F with carbon nucleophiles out in @chemicalscience.rsc.org
- a collaboration with the awesome @ballnchemist.bsky.social
and his amazing undergrads at @pomonacollege.bsky.social
#ChemSky #Chemchat
Alkylation of R-SO2F with carbon nucleophiles out in @chemicalscience.rsc.org
- a collaboration with the awesome @ballnchemist.bsky.social
and his amazing undergrads at @pomonacollege.bsky.social
#ChemSky #Chemchat
📘 The stereochemistry of substitution at S(VI) ✨
by James A. Bull 𝘦𝘵 𝘢𝘭.
Insights into stereochemical outcomes in SuFEx & S(VI) substitution ⚗️🔄
#SulfurChemistry #Stereochemistry #ClickChem
🔗 doi.org/10.1039/D5QO01043H
by James A. Bull 𝘦𝘵 𝘢𝘭.
Insights into stereochemical outcomes in SuFEx & S(VI) substitution ⚗️🔄
#SulfurChemistry #Stereochemistry #ClickChem
🔗 doi.org/10.1039/D5QO01043H
The stereochemistry of substitution at S(VI)
Since the re-birth of sulfur-fluoride exchange (SuFEx) chemistry, coined by Sharpless in 2014 as a ‘click’ reaction, the prevalence of sulfur(vi) moieties in medicinal, polymer and materials chemistry...
doi.org
August 29, 2025 at 5:44 AM
📘 The stereochemistry of substitution at S(VI) ✨
by James A. Bull 𝘦𝘵 𝘢𝘭.
Insights into stereochemical outcomes in SuFEx & S(VI) substitution ⚗️🔄
#SulfurChemistry #Stereochemistry #ClickChem
🔗 doi.org/10.1039/D5QO01043H
by James A. Bull 𝘦𝘵 𝘢𝘭.
Insights into stereochemical outcomes in SuFEx & S(VI) substitution ⚗️🔄
#SulfurChemistry #Stereochemistry #ClickChem
🔗 doi.org/10.1039/D5QO01043H
And then someone else will ask me "what are aminosulfur oxydifluoride groups" And I can be like "That sounds like SuFEx chemistry here's some past coverage you should look at"
cen.acs.org/biological-c...
cen.acs.org/biological-c...
Stick chemistry: High-throughput method for finding new molecular glues
Click chemistry method opens up avenues for intentional glue discovery
cen.acs.org
February 19, 2026 at 7:44 PM
And then someone else will ask me "what are aminosulfur oxydifluoride groups" And I can be like "That sounds like SuFEx chemistry here's some past coverage you should look at"
cen.acs.org/biological-c...
cen.acs.org/biological-c...