acetaminophen, dextromethrophan, doxylamine succinate, Benzodiazepines, antihistamine, doxylamine, doxepin, Temazepam, Triazolam, Ramelteon, Suvorexant, Trazodone, Estazolam, Eszopiclone, Zaleplon, Zolpidem
May 21, 2025 at 4:14 AM
acetaminophen, dextromethrophan, doxylamine succinate, Benzodiazepines, antihistamine, doxylamine, doxepin, Temazepam, Triazolam, Ramelteon, Suvorexant, Trazodone, Estazolam, Eszopiclone, Zaleplon, Zolpidem
Doxylamine succinate 25 mg. (Unisom)
October 4, 2026 at 1:03 AM
Doxylamine succinate 25 mg. (Unisom)
Interesting link between microbial metabolism and disease in IBD which is linked with high levels of succinate. Turns out this affects Treg stability and function. #Immunosky 🧪
Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch - Nature Immunology
Fang and colleagues show that the metabolite succinate can inhibit succinylation, and consequently protection from ubiquitin-mediated degradation, of the transcription factor FOXP3, with consequences ...
www.nature.com
June 4, 2025 at 7:30 AM
Interesting link between microbial metabolism and disease in IBD which is linked with high levels of succinate. Turns out this affects Treg stability and function. #Immunosky 🧪
Doesn't succinate accumulate when itaconate increases with inflammation and inhibits succinate dehydrogenase? So this seems like an inflammatory feedback loop.
Interesting link between microbial metabolism and disease in IBD which is linked with high levels of succinate. Turns out this affects Treg stability and function. #Immunosky 🧪
Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch - Nature Immunology
Fang and colleagues show that the metabolite succinate can inhibit succinylation, and consequently protection from ubiquitin-mediated degradation, of the transcription factor FOXP3, with consequences ...
www.nature.com
June 5, 2025 at 11:37 AM
Doesn't succinate accumulate when itaconate increases with inflammation and inhibits succinate dehydrogenase? So this seems like an inflammatory feedback loop.
New out this week in @natmetabolism.nature.com – We measured dynamic aspartate changes following mitochondrial inhibition, finding that SDH inhibition causes a counterintuitive "aspartate rebound" effect, mediated by succinate impairing pyrimidine synthesis.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Succinate dehydrogenase loss suppresses pyrimidine biosynthesis via succinate-mediated inhibition of aspartate transcarbamylase - Nature Metabolism
Succinate acts as a competitive inhibitor of mammalian aspartate transcarbamylase (ATCase), leading to impaired pyrimidine biosynthesis and reduced proliferation under SDH inhibition.
www.nature.com
May 8, 2026 at 11:11 PM
New out this week in @natmetabolism.nature.com – We measured dynamic aspartate changes following mitochondrial inhibition, finding that SDH inhibition causes a counterintuitive "aspartate rebound" effect, mediated by succinate impairing pyrimidine synthesis.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
I was thinking Doxylamine Succinate (25 mg), which is an over-the-counter sleep aid and has 44. 386 stamped on it. I think your guess is better.
October 4, 2026 at 1:42 AM
I was thinking Doxylamine Succinate (25 mg), which is an over-the-counter sleep aid and has 44. 386 stamped on it. I think your guess is better.
Succinate and its carrier Sfc1 mediate metabolic control of mitochondrial protein import by the TIM23 translocase
Succinate and its carrier Sfc1 mediate metabolic control of mitochondrial protein import by the TIM23 translocase
Das et al. show that succinate regulates mitochondrial protein import through an interaction between Sfc1 (succinate-fumarate carrier) and the Tim23 translocase subunit. In the absence of succinate, Sfc1 associates with Tim23 and reduces protein import. Succinate promotes dissociation of the Sfc1-Tim23 complex, thereby enhancing TIM23 mediated protein translocation into mitochondria.
dlvr.it
September 12, 2026 at 7:50 PM
Succinate and its carrier Sfc1 mediate metabolic control of mitochondrial protein import by the TIM23 translocase
Excited to share our latest work out today in @cp-molcell.bsky.social, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo! www.sciencedirect.com/science/arti...
!
!
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…
www.sciencedirect.com
October 28, 2025 at 4:25 PM
Excited to share our latest work out today in @cp-molcell.bsky.social, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo! www.sciencedirect.com/science/arti...
!
!
First is doxylamine succinate, stamped "44 386". A sleep aid.
Next is Venlafaxine Hydrochloride ( 93 7386), this pill is used for everything from autism to back pain, and is classified as a serotonin norepinephrine re-take inhibitor.
Next is Terazonin (TL 386), a pill for enlarged prostates.
Next is Venlafaxine Hydrochloride ( 93 7386), this pill is used for everything from autism to back pain, and is classified as a serotonin norepinephrine re-take inhibitor.
Next is Terazonin (TL 386), a pill for enlarged prostates.
October 4, 2026 at 1:35 AM
First is doxylamine succinate, stamped "44 386". A sleep aid.
Next is Venlafaxine Hydrochloride ( 93 7386), this pill is used for everything from autism to back pain, and is classified as a serotonin norepinephrine re-take inhibitor.
Next is Terazonin (TL 386), a pill for enlarged prostates.
Next is Venlafaxine Hydrochloride ( 93 7386), this pill is used for everything from autism to back pain, and is classified as a serotonin norepinephrine re-take inhibitor.
Next is Terazonin (TL 386), a pill for enlarged prostates.
OUT NOW: Microbiota-derived succinate promotes EHEC virulence via lysine succinylation
#microsky 🧪
www.nature.com/articles/s41...
#microsky 🧪
www.nature.com/articles/s41...
Microbiota-derived succinate promotes enterohaemorrhagic Escherichia coli virulence via lysine succinylation - Nature Microbiology
Gut microbiota-derived succinate promotes CitC succinyltransferase-dependent succinylation of PurR to alleviate T3SS repression and promote virulence in enterohaemorrhagic Escherichia coli and Citroba...
www.nature.com
January 31, 2025 at 3:59 PM
OUT NOW: Microbiota-derived succinate promotes EHEC virulence via lysine succinylation
#microsky 🧪
www.nature.com/articles/s41...
#microsky 🧪
www.nature.com/articles/s41...
Succinate preserves CD8+ T cell fitness to augment antitumor immunity: Immunity www.cell.com/immunity/ful...
Succinate preserves CD8+ T cell fitness to augment antitumor immunity
How various tumoral metabolites impact antitumor T cell immunity is an area of active
research. Ma et al. demonstrate that succinate enhances mitochondrial fitness and
induces epigenetic reprogramming...
www.cell.com
August 15, 2025 at 8:59 AM
Succinate preserves CD8+ T cell fitness to augment antitumor immunity: Immunity www.cell.com/immunity/ful...
386 is a blue, oval, 10mm tablet containing 25 mg of Doxylamine Succinate, which is an over-the-counter nighttime sleep aid. Makes sense now...
October 4, 2026 at 10:48 AM
386 is a blue, oval, 10mm tablet containing 25 mg of Doxylamine Succinate, which is an over-the-counter nighttime sleep aid. Makes sense now...
Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 2, 2025 at 7:37 PM
Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch @natimmunol.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Faecal transplantation works in treatment of recurrent Clostridium difficile infection. How though?
Interesting study (in mice) indicating one mechanism *could* be through increasing succinate production by intestinal microbiota.
@jexpmed.bsky.social #microSky #IDSky
rupress.org/jem/article/...
Interesting study (in mice) indicating one mechanism *could* be through increasing succinate production by intestinal microbiota.
@jexpmed.bsky.social #microSky #IDSky
rupress.org/jem/article/...
Succinate-producing microbiota drives tuft cell hyperplasia to protect against Clostridioides difficile | Journal of Experimental Medicine | Rockefeller University Press
The microbial metabolite succinate promotes tuft cell hyperplasia, which enhances the gut’s ability to protect against intestinal infections. This study re
rupress.org
December 4, 2024 at 5:49 PM
Faecal transplantation works in treatment of recurrent Clostridium difficile infection. How though?
Interesting study (in mice) indicating one mechanism *could* be through increasing succinate production by intestinal microbiota.
@jexpmed.bsky.social #microSky #IDSky
rupress.org/jem/article/...
Interesting study (in mice) indicating one mechanism *could* be through increasing succinate production by intestinal microbiota.
@jexpmed.bsky.social #microSky #IDSky
rupress.org/jem/article/...
Niemi lab graduate student Hannah Pletcher recently joined @prelights.bsky.social and wrote nice highlight of recent work from @lucasbsullivan.bsky.social - check it out here!
Succinate Dehydrogenase loss causes cascading metabolic effects that impair pyrimidine biosynthesis - preLights
Not all aspartate limitation is created equal: An aspartate biosensor reveals that inhibiting succinate dehydrogenase results in defects in pyrimidine synthesis and replication stress, unique from oth...
bit.ly
May 26, 2025 at 4:10 PM
Niemi lab graduate student Hannah Pletcher recently joined @prelights.bsky.social and wrote nice highlight of recent work from @lucasbsullivan.bsky.social - check it out here!
Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation: Cell Metabolism www.cell.com/cell-metabol...
Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation
The Krebs cycle intermediates itaconate, succinate, and fumarate act as immunometabolites
to regulate macrophage immune responses. This review highlights how these metabolites
influence cytokine produ...
www.cell.com
April 1, 2025 at 11:55 AM
Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation: Cell Metabolism www.cell.com/cell-metabol...
E vitamini "succinate" tümör büyümesini kontrol etmeye ve immünoterapiyi iyileştirmeye yardımcı olur.
E vitamini süksinat, Yüksek düzeyde yağ kütlesi ve obezite ile ilişkili protein FTO'yu parçalayarak tümörleri baskılar, kanser tedavisini iyileştirir ve immünoterapiye yanıtı artırır.
E vitamini süksinat, Yüksek düzeyde yağ kütlesi ve obezite ile ilişkili protein FTO'yu parçalayarak tümörleri baskılar, kanser tedavisini iyileştirir ve immünoterapiye yanıtı artırır.
Vitamin E succinate controls tumor growth and enhances immunotherapy effects - UChicago Medicine
High levels of fat mass and obesity-associated protein (FTO) have been linked to tumor growth and resistance to immunotherapy. Researchers identified vitamin E succinate as an effective agent in contr...
www.uchicagomedicine.org
February 13, 2025 at 11:51 AM
E vitamini "succinate" tümör büyümesini kontrol etmeye ve immünoterapiyi iyileştirmeye yardımcı olur.
E vitamini süksinat, Yüksek düzeyde yağ kütlesi ve obezite ile ilişkili protein FTO'yu parçalayarak tümörleri baskılar, kanser tedavisini iyileştirir ve immünoterapiye yanıtı artırır.
E vitamini süksinat, Yüksek düzeyde yağ kütlesi ve obezite ile ilişkili protein FTO'yu parçalayarak tümörleri baskılar, kanser tedavisini iyileştirir ve immünoterapiye yanıtı artırır.
Kirkland 44-386
Active ingredient (in each tablet)
Doxylamine succinate 25 mg
Purpose: Nighttime sleep-aid
Use: helps to reduce difficulty in falling asleep
If sleeplessness persists continuously for more than two weeks. Insomnia may be a symptom of serious underlying medical illness.
Active ingredient (in each tablet)
Doxylamine succinate 25 mg
Purpose: Nighttime sleep-aid
Use: helps to reduce difficulty in falling asleep
If sleeplessness persists continuously for more than two weeks. Insomnia may be a symptom of serious underlying medical illness.
Kirkland 44-386
dailymed.nlm.nih.gov
October 4, 2026 at 1:49 AM
Kirkland 44-386
Active ingredient (in each tablet)
Doxylamine succinate 25 mg
Purpose: Nighttime sleep-aid
Use: helps to reduce difficulty in falling asleep
If sleeplessness persists continuously for more than two weeks. Insomnia may be a symptom of serious underlying medical illness.
Active ingredient (in each tablet)
Doxylamine succinate 25 mg
Purpose: Nighttime sleep-aid
Use: helps to reduce difficulty in falling asleep
If sleeplessness persists continuously for more than two weeks. Insomnia may be a symptom of serious underlying medical illness.
Blocking an enzyme called succinate dehydrogenase in mouse heart cells flipped a metabolic switch. This boosts the heart's self-repair after a heart attack. This kind of foundational bioengineering is how we actually heal damaged hearts.
Modifying heart cell metabolism unlocks self-repair system after heart attack
Scientists have discovered a way to boost the heart's natural repair mechanisms after a heart attack by changing how heart cells produce energy. This bioengineering advance, demonstrated in mice, trig
www.sbpdiscovery.org
September 30, 2026 at 2:02 PM
Blocking an enzyme called succinate dehydrogenase in mouse heart cells flipped a metabolic switch. This boosts the heart's self-repair after a heart attack. This kind of foundational bioengineering is how we actually heal damaged hearts.
RESEARCH | (FHCC, US)
ML Hart
D Sokolov
@lucasbsullivan.bsky.social et al
Succinate acts as a competitive inhibitor of mammalian aspartate transcarbamylase leading to impaired pyrimidine biosynthesis and reduced proliferation under SDHi 🧪
ML Hart
D Sokolov
@lucasbsullivan.bsky.social et al
Succinate acts as a competitive inhibitor of mammalian aspartate transcarbamylase leading to impaired pyrimidine biosynthesis and reduced proliferation under SDHi 🧪
Succinate dehydrogenase loss suppresses pyrimidine biosynthesis via succinate-mediated inhibition of aspartate transcarbamylase - Nature Metabolism
Succinate acts as a competitive inhibitor of mammalian aspartate transcarbamylase (ATCase), leading to impaired pyrimidine biosynthesis and reduced proliferation under SDH inhibition.
dlvr.it
July 16, 2026 at 4:03 PM
RESEARCH | (FHCC, US)
ML Hart
D Sokolov
@lucasbsullivan.bsky.social et al
Succinate acts as a competitive inhibitor of mammalian aspartate transcarbamylase leading to impaired pyrimidine biosynthesis and reduced proliferation under SDHi 🧪
ML Hart
D Sokolov
@lucasbsullivan.bsky.social et al
Succinate acts as a competitive inhibitor of mammalian aspartate transcarbamylase leading to impaired pyrimidine biosynthesis and reduced proliferation under SDHi 🧪
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cyclehttps://
www.sciencedirect.com/science/article/abs/pii/S1097276525008196
Congratulations @bensahralab.bsky.social !!
www.sciencedirect.com/science/article/abs/pii/S1097276525008196
Congratulations @bensahralab.bsky.social !!
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…
www.sciencedirect.com
October 29, 2025 at 5:23 AM
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cyclehttps://
www.sciencedirect.com/science/article/abs/pii/S1097276525008196
Congratulations @bensahralab.bsky.social !!
www.sciencedirect.com/science/article/abs/pii/S1097276525008196
Congratulations @bensahralab.bsky.social !!
#Fumarate update
Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages & inflammation
Dual role in Inflammation
Anti-
KEAP1-NRF2
GSDMD
NLRP3
IL-10
Pro-
mtDNA mtRNA➡️IFNβ
#CellMetab 2025
www.sciencedirect.com/science/arti...
Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages & inflammation
Dual role in Inflammation
Anti-
KEAP1-NRF2
GSDMD
NLRP3
IL-10
Pro-
mtDNA mtRNA➡️IFNβ
#CellMetab 2025
www.sciencedirect.com/science/arti...
June 21, 2025 at 7:47 PM
#Fumarate update
Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages & inflammation
Dual role in Inflammation
Anti-
KEAP1-NRF2
GSDMD
NLRP3
IL-10
Pro-
mtDNA mtRNA➡️IFNβ
#CellMetab 2025
www.sciencedirect.com/science/arti...
Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages & inflammation
Dual role in Inflammation
Anti-
KEAP1-NRF2
GSDMD
NLRP3
IL-10
Pro-
mtDNA mtRNA➡️IFNβ
#CellMetab 2025
www.sciencedirect.com/science/arti...
Microbiome-derived succinate-driven tuft cell hyperplasia in the colon helps defend against Clostridioides difficile infection, providing a pathway through which host/microbe interactions protect against pathogens
doi.org/10.1084/jem....
@reboldilab.bsky.social
@jexpmed.bsky.social
doi.org/10.1084/jem....
@reboldilab.bsky.social
@jexpmed.bsky.social
Succinate-producing microbiota drives tuft cell hyperplasia to protect against Clostridioides difficile
The microbial metabolite succinate promotes tuft cell hyperplasia, which enhances the gut’s ability to protect against intestinal infections. This study re
doi.org
November 26, 2024 at 8:17 PM
Microbiome-derived succinate-driven tuft cell hyperplasia in the colon helps defend against Clostridioides difficile infection, providing a pathway through which host/microbe interactions protect against pathogens
doi.org/10.1084/jem....
@reboldilab.bsky.social
@jexpmed.bsky.social
doi.org/10.1084/jem....
@reboldilab.bsky.social
@jexpmed.bsky.social
#EPeeps Why are people still using metoprolol tartrate BID when the kinetics aren’t even good TID?
In other news, why are we still doing prior authorizations for metoprolol succinate when a month supply is $6 at @costplusdrugs.com?
In other news, why are we still doing prior authorizations for metoprolol succinate when a month supply is $6 at @costplusdrugs.com?
December 16, 2024 at 8:51 PM
#EPeeps Why are people still using metoprolol tartrate BID when the kinetics aren’t even good TID?
In other news, why are we still doing prior authorizations for metoprolol succinate when a month supply is $6 at @costplusdrugs.com?
In other news, why are we still doing prior authorizations for metoprolol succinate when a month supply is $6 at @costplusdrugs.com?
personally I'm working with a combination of acetaminophen, dextromethorphan HBr, doxylamine succinate, and phenylephrine HCI. u?
March 31, 2024 at 9:51 PM
personally I'm working with a combination of acetaminophen, dextromethorphan HBr, doxylamine succinate, and phenylephrine HCI. u?