Intravenous #SARSCoV2 Spike protein induces neuroinflammation and alpha-synuclein accumulation in brain regions relevant to Parkinson’s disease
#NeuroCovid #LongCovid
www.sciencedirect.com/science/arti...
#NeuroCovid #LongCovid
www.sciencedirect.com/science/arti...
May 23, 2025 at 6:34 PM
Intravenous #SARSCoV2 Spike protein induces neuroinflammation and alpha-synuclein accumulation in brain regions relevant to Parkinson’s disease
#NeuroCovid #LongCovid
www.sciencedirect.com/science/arti...
#NeuroCovid #LongCovid
www.sciencedirect.com/science/arti...
#fluorescenceFriday. Lightsheet 3D movie of S129 Synuclein (magenta) and nuclear marker (green) in M83 mice injected with Synuclein preformed fibrils (also known as PFFs) in the right striatum. Spinal cord lights up because of high expression of human alpha-synuclein driven by the Prnp promoter
March 15, 2025 at 12:32 AM
#fluorescenceFriday. Lightsheet 3D movie of S129 Synuclein (magenta) and nuclear marker (green) in M83 mice injected with Synuclein preformed fibrils (also known as PFFs) in the right striatum. Spinal cord lights up because of high expression of human alpha-synuclein driven by the Prnp promoter
It’s been 20 years today since my first paper on intrinsically disordered proteins
Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations
doi.org/10.1021/ja04...
and I thought I would tell the somewhat random path that led to this paper. 1/n
Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations
doi.org/10.1021/ja04...
and I thought I would tell the somewhat random path that led to this paper. 1/n
Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations
The intrinsically disordered protein α-synuclein plays a key role in the pathogenesis of Parkinson's disease (PD). We show here that the native state of α-synuclein consists of a broad distribution of...
doi.org
December 21, 2024 at 5:09 PM
It’s been 20 years today since my first paper on intrinsically disordered proteins
Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations
doi.org/10.1021/ja04...
and I thought I would tell the somewhat random path that led to this paper. 1/n
Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations
doi.org/10.1021/ja04...
and I thought I would tell the somewhat random path that led to this paper. 1/n
We knew about the potential origin of Parkinson's disease from the gut (known as Braak’s hypothesis). But the kidney?!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Propagation of pathologic α-synuclein from kidney to brain may contribute to Parkinson’s disease - Nature Neuroscience
Yuan et al. find that the kidney can serve as a site of initiation for the spread of pathological α-synuclein to the brain, contributing to the development of Parkinson’s disease (PD) and providing a ...
www.nature.com
January 23, 2025 at 3:13 PM
We knew about the potential origin of Parkinson's disease from the gut (known as Braak’s hypothesis). But the kidney?!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Phosphorylated α-synuclein pS129 is found in aggregates that are pathological hallmarks of PD and DLB. The toxicity of pS129 has been up for debate for years. Combining LSM, MRI, rsfMRI and task fMRI, we demonstrate a toxic role for pS129 in synucleinopathies. 1/2
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Phosphorylated ⍺-Synuclein shapes changes in brain structure, task-related activity and functional connectivity in M83 mice
Phosphorylated α-synuclein at S129 (pS129) is the predominant form of α-synuclein in the aggregates known as Lewy bodies (LB) and Lewy neurites (LN), the pathological hallmarks of Parkinson's disease ...
www.biorxiv.org
September 23, 2026 at 2:01 PM
Phosphorylated α-synuclein pS129 is found in aggregates that are pathological hallmarks of PD and DLB. The toxicity of pS129 has been up for debate for years. Combining LSM, MRI, rsfMRI and task fMRI, we demonstrate a toxic role for pS129 in synucleinopathies. 1/2
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
THIS IS HUGE! Researchers at JHU have identified the Aplp1 protein, which facilitates the spread of harmful alpha-synuclein proteins in the brain as a novel therapeutic target for Parkinson’s disease AND a potential therapy using an EXISTING FDA-approved cancer drug. 🧪🧵⬇️
June 27, 2024 at 4:00 PM
THIS IS HUGE! Researchers at JHU have identified the Aplp1 protein, which facilitates the spread of harmful alpha-synuclein proteins in the brain as a novel therapeutic target for Parkinson’s disease AND a potential therapy using an EXISTING FDA-approved cancer drug. 🧪🧵⬇️
There's a well known virus with a passion for renal injury
Just Sayin'
👇🏻👇🏻👇🏻
www.nature.com/articles/s41...
Just Sayin'
👇🏻👇🏻👇🏻
www.nature.com/articles/s41...
Propagation of pathologic α-synuclein from kidney to brain may contribute to Parkinson’s disease - Nature Neuroscience
Yuan et al. find that the kidney can serve as a site of initiation for the spread of pathological α-synuclein to the brain, contributing to the development of Parkinson’s disease (PD) and providing a ...
www.nature.com
August 17, 2025 at 1:00 AM
There's a well known virus with a passion for renal injury
Just Sayin'
👇🏻👇🏻👇🏻
www.nature.com/articles/s41...
Just Sayin'
👇🏻👇🏻👇🏻
www.nature.com/articles/s41...
The impact of alpha synuclein overexpression on nigrostriatal transmission https://www.biorxiv.org/content/10.64898/2026.09.15.751842v1
September 22, 2026 at 4:15 AM
The impact of alpha synuclein overexpression on nigrostriatal transmission https://www.biorxiv.org/content/10.64898/2026.09.15.751842v1
#fluorescencefriday a Slick-H Cre STIP1 mouse seeded with alpha synuclein preformed fibrils. GFP (cells presenting recombination) in yellow and SynP129 (marker of aggregated alpha synuclein) magenta by the @mind-western.bsky.social team
July 31, 2026 at 11:48 AM
#fluorescencefriday a Slick-H Cre STIP1 mouse seeded with alpha synuclein preformed fibrils. GFP (cells presenting recombination) in yellow and SynP129 (marker of aggregated alpha synuclein) magenta by the @mind-western.bsky.social team
My PhD work is now *published* at Neuron!
1) Multiple structures of #synuclein aggregates form under the same uniform condition
2) You can't predict which structure you'll get
3) Different structures cause different disease outcomes in mice
#NeuroSky #Parkinsons 🧪
www.cell.com/neuron/fullt...
1) Multiple structures of #synuclein aggregates form under the same uniform condition
2) You can't predict which structure you'll get
3) Different structures cause different disease outcomes in mice
#NeuroSky #Parkinsons 🧪
www.cell.com/neuron/fullt...
March 3, 2026 at 4:03 AM
My PhD work is now *published* at Neuron!
1) Multiple structures of #synuclein aggregates form under the same uniform condition
2) You can't predict which structure you'll get
3) Different structures cause different disease outcomes in mice
#NeuroSky #Parkinsons 🧪
www.cell.com/neuron/fullt...
1) Multiple structures of #synuclein aggregates form under the same uniform condition
2) You can't predict which structure you'll get
3) Different structures cause different disease outcomes in mice
#NeuroSky #Parkinsons 🧪
www.cell.com/neuron/fullt...
#FluorescenceFriday Testing a new microscope. Microglia (yellow) and S129 alpha synuclein (magenta) and nuclei (blue) spinning disc confocal image @leicamicrosystems.bsky.social
August 29, 2025 at 5:47 PM
#FluorescenceFriday Testing a new microscope. Microglia (yellow) and S129 alpha synuclein (magenta) and nuclei (blue) spinning disc confocal image @leicamicrosystems.bsky.social
#Covid erzeugte 6 W nach nasaler Injektion neuronale Verluste im Hippocampus mit einer Anhäufung von p-Tau & α-Synuclein.
Bemerkenswert ist, dass die Behandlung mit #Metformin die synaptische Genexpression wiederherstellte & die Anhäufung von p-tau & α-Synuclein verringerte.
Bemerkenswert ist, dass die Behandlung mit #Metformin die synaptische Genexpression wiederherstellte & die Anhäufung von p-tau & α-Synuclein verringerte.
SARS-CoV-2 spike protein causes synaptic dysfunction and p-tau and α-synuclein aggregation leading cognitive impairment: The protective role of metformin
Patients recovering from post-coronavirus disease 2019 (COVID-19) often experience cognitive dysfunction, including difficulties with focusing, conversation, or memory issues, which can persist for we...
journals.plos.org
November 10, 2025 at 10:18 AM
#Covid erzeugte 6 W nach nasaler Injektion neuronale Verluste im Hippocampus mit einer Anhäufung von p-Tau & α-Synuclein.
Bemerkenswert ist, dass die Behandlung mit #Metformin die synaptische Genexpression wiederherstellte & die Anhäufung von p-tau & α-Synuclein verringerte.
Bemerkenswert ist, dass die Behandlung mit #Metformin die synaptische Genexpression wiederherstellte & die Anhäufung von p-tau & α-Synuclein verringerte.
Zombosomes, large vesicles with cell-like qualities, can spread alpha-synuclein protein clumps from astrocytes to other astrocytes, neurons, and lab-grown brain tissues.
Learn more: https://scim.ag/4qSd1vP
Learn more: https://scim.ag/4qSd1vP
February 5, 2026 at 11:50 PM
Zombosomes, large vesicles with cell-like qualities, can spread alpha-synuclein protein clumps from astrocytes to other astrocytes, neurons, and lab-grown brain tissues.
Learn more: https://scim.ag/4qSd1vP
Learn more: https://scim.ag/4qSd1vP
kommt der mögliche Bezug zu Alzheimer und Parkinson ins Spiel. Denn bei diesen Erkrankungen akkumulieren unter anderem β-Amyloid, Tau und α-Synuclein. Der Review diskutiert Hinweise darauf, dass SARS-CoV-2 bzw. seine Proteine die Phosphorylierung, Oligomerisierung und Aggregation
September 5, 2026 at 3:53 PM
kommt der mögliche Bezug zu Alzheimer und Parkinson ins Spiel. Denn bei diesen Erkrankungen akkumulieren unter anderem β-Amyloid, Tau und α-Synuclein. Der Review diskutiert Hinweise darauf, dass SARS-CoV-2 bzw. seine Proteine die Phosphorylierung, Oligomerisierung und Aggregation
We are finishing a study funded by the Michael J Fox Foundation for Parkinson’s research examine how influenza infection interacts with alpha-synuclein misfolding and neuron to neuron transmission.
January 13, 2025 at 10:11 PM
We are finishing a study funded by the Michael J Fox Foundation for Parkinson’s research examine how influenza infection interacts with alpha-synuclein misfolding and neuron to neuron transmission.
#fluorescencefriday M83 hemizygous 🐁 model injected with preformed alpha synuclein fibrils or vehicle (next movie) in their striatum and stained for alpha synuclein S129 (yellow) reflecting protein misfolding 🧠 cleared with SHIELD and imaged by lightsheet 🔬 1/2
April 25, 2025 at 9:13 PM
#fluorescencefriday M83 hemizygous 🐁 model injected with preformed alpha synuclein fibrils or vehicle (next movie) in their striatum and stained for alpha synuclein S129 (yellow) reflecting protein misfolding 🧠 cleared with SHIELD and imaged by lightsheet 🔬 1/2
I have a question that might make me unpopular, if...
"Intravenous SARS-CoV-2 Spike protein induces neuroinflammation and alpha-synuclein accumulation in brain regions relevant to Parkinson’s disease"
...What happens when you donate blood...?
www.sciencedirect.com/science/arti...
"Intravenous SARS-CoV-2 Spike protein induces neuroinflammation and alpha-synuclein accumulation in brain regions relevant to Parkinson’s disease"
...What happens when you donate blood...?
www.sciencedirect.com/science/arti...
Intravenous SARS-CoV-2 Spike protein induces neuroinflammation and alpha-synuclein accumulation in brain regions relevant to Parkinson’s disease
Background: Coronavirus disease 2019 (COVID-19) frequently presents with neurological symptoms in human patients and leads to long-lasting brain patho…
www.sciencedirect.com
May 23, 2025 at 7:07 PM
I have a question that might make me unpopular, if...
"Intravenous SARS-CoV-2 Spike protein induces neuroinflammation and alpha-synuclein accumulation in brain regions relevant to Parkinson’s disease"
...What happens when you donate blood...?
www.sciencedirect.com/science/arti...
"Intravenous SARS-CoV-2 Spike protein induces neuroinflammation and alpha-synuclein accumulation in brain regions relevant to Parkinson’s disease"
...What happens when you donate blood...?
www.sciencedirect.com/science/arti...
Propagation of pathologic α-synuclein from kidney to brain may contribute to Parkinson’s disease 🧠🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Propagation of pathologic α-synuclein from kidney to brain may contribute to Parkinson’s disease - Nature Neuroscience
Yuan et al. find that the kidney can serve as a site of initiation for the spread of pathological α-synuclein to the brain, contributing to the development of Parkinson’s disease (PD) and providing a ...
www.nature.com
January 23, 2025 at 2:13 PM
Propagation of pathologic α-synuclein from kidney to brain may contribute to Parkinson’s disease 🧠🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Excited to share our new work in Molecular Neurodegeneration, showing that α-synuclein co-pathology is common in Alzheimer’s and accelerates amyloid-related tau accumulation, supporting its role as a tau co-aggregation factor.
doi.org/10.1186/s130...
doi.org/10.1186/s130...
Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer’s disease - Molecular Neurodegeneration
Background Aggregated alpha-Synuclein (αSyn) is a hallmark pathology in Parkinson’s disease but also one of the most common co-pathologies in Alzheimer’s disease (AD). Preclinical studies suggest that...
doi.org
March 18, 2025 at 9:15 AM
Excited to share our new work in Molecular Neurodegeneration, showing that α-synuclein co-pathology is common in Alzheimer’s and accelerates amyloid-related tau accumulation, supporting its role as a tau co-aggregation factor.
doi.org/10.1186/s130...
doi.org/10.1186/s130...
chronische neuroinflammatorische Kaskade ausgelöst wird, und [2] die Induktion der Aggregation neuronaler Wirtsproteine (z. B. α-Synuclein, Tau), wodurch ein direkter Zusammenhang zwischen akuter Infektion und dem Potenzial für langfristige Neurodegeneration hergestellt wird.
June 7, 2026 at 8:33 PM
chronische neuroinflammatorische Kaskade ausgelöst wird, und [2] die Induktion der Aggregation neuronaler Wirtsproteine (z. B. α-Synuclein, Tau), wodurch ein direkter Zusammenhang zwischen akuter Infektion und dem Potenzial für langfristige Neurodegeneration hergestellt wird.
die eine chronische neuroinflammatorische Kaskade auslöst, und die Störung der Wirts-Proteostase, die neurodegenerative Proteinopathien wie die Aggregation von Alpha-Synuclein und Tau begünstigt.
Es ist zunehmend belegt, dass freigesetzte, lösliche Virusproteine, die als mobile
Es ist zunehmend belegt, dass freigesetzte, lösliche Virusproteine, die als mobile
June 7, 2026 at 8:32 PM
die eine chronische neuroinflammatorische Kaskade auslöst, und die Störung der Wirts-Proteostase, die neurodegenerative Proteinopathien wie die Aggregation von Alpha-Synuclein und Tau begünstigt.
Es ist zunehmend belegt, dass freigesetzte, lösliche Virusproteine, die als mobile
Es ist zunehmend belegt, dass freigesetzte, lösliche Virusproteine, die als mobile
New work from Tommy Kirchhausen's lab @harvardcellbio.bsky.social uses 3D EM to visualize tiny perforations in endosomes, allowing access of cytosolic alpha-synuclein to endocytosed alpha-synuclein pre-formed fibrils, thereby triggering further alpha-synuclein aggregation rupress.org/jcb/article-...
Neuronal constitutive endolysosomal perforations enable α-synuclein aggregation by internalized PFFs
This study reveals inherent perforations in neuronal endolysosomal membranes, facilitating cytosolic α-synuclein’s access to internalized fibrils and trigg
rupress.org
December 25, 2024 at 2:12 PM
New work from Tommy Kirchhausen's lab @harvardcellbio.bsky.social uses 3D EM to visualize tiny perforations in endosomes, allowing access of cytosolic alpha-synuclein to endocytosed alpha-synuclein pre-formed fibrils, thereby triggering further alpha-synuclein aggregation rupress.org/jcb/article-...
Neuronal FAM171A2 mediates α-synuclein fibril uptake and drives Parkinson’s disease
"In silico screening identified an approved drug, bemcentinib, that is able to inhibit α-synuclein internalization in vitro and in vivo by blocking its binding to FAM171A2."
www.science.org/doi/10.1126/...
"In silico screening identified an approved drug, bemcentinib, that is able to inhibit α-synuclein internalization in vitro and in vivo by blocking its binding to FAM171A2."
www.science.org/doi/10.1126/...
Neuronal FAM171A2 mediates α-synuclein fibril uptake and drives Parkinson’s disease
Neuronal accumulation and spread of pathological α-synuclein (α-syn) fibrils are key events in Parkinson's disease (PD) pathophysiology. However, the neuronal mechanisms underlying the uptake of α-syn...
www.science.org
February 25, 2025 at 7:59 AM
Neuronal FAM171A2 mediates α-synuclein fibril uptake and drives Parkinson’s disease
"In silico screening identified an approved drug, bemcentinib, that is able to inhibit α-synuclein internalization in vitro and in vivo by blocking its binding to FAM171A2."
www.science.org/doi/10.1126/...
"In silico screening identified an approved drug, bemcentinib, that is able to inhibit α-synuclein internalization in vitro and in vivo by blocking its binding to FAM171A2."
www.science.org/doi/10.1126/...
consisting of misfolded alpha-synuclein that travel between neurons.
Alpha-synuclein typically maintains functional communication between neurons, but problems arise when it becomes misfolded and insoluble. That said, identifying whether this is a cause of Parkinson's or a
Alpha-synuclein typically maintains functional communication between neurons, but problems arise when it becomes misfolded and insoluble. That said, identifying whether this is a cause of Parkinson's or a
June 27, 2024 at 4:04 PM
consisting of misfolded alpha-synuclein that travel between neurons.
Alpha-synuclein typically maintains functional communication between neurons, but problems arise when it becomes misfolded and insoluble. That said, identifying whether this is a cause of Parkinson's or a
Alpha-synuclein typically maintains functional communication between neurons, but problems arise when it becomes misfolded and insoluble. That said, identifying whether this is a cause of Parkinson's or a
Propagation of pathologic α-synuclein from kidney to brain may contribute to Parkinson’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Propagation of pathologic α-synuclein from kidney to brain may contribute to Parkinson’s disease - Nature Neuroscience
Yuan et al. find that the kidney can serve as a site of initiation for the spread of pathological α-synuclein to the brain, contributing to the development of Parkinson’s disease (PD) and providing a ...
www.nature.com
January 23, 2025 at 4:05 PM
Propagation of pathologic α-synuclein from kidney to brain may contribute to Parkinson’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...