Our paper on disease mechanisms in synucleinopathies, led by Tetiana Serdiuk, is out at Molecular Systems Biology.
#proteomics #structuralproteomics #neurodegeneration #Parkinsons #alphasynuclein #structuralbiology #ethz
@imsb-eth.bsky.social @molsystbiol.org
#proteomics #structuralproteomics #neurodegeneration #Parkinsons #alphasynuclein #structuralbiology #ethz
@imsb-eth.bsky.social @molsystbiol.org
March 17, 2026 at 6:25 AM
Our paper on disease mechanisms in synucleinopathies, led by Tetiana Serdiuk, is out at Molecular Systems Biology.
#proteomics #structuralproteomics #neurodegeneration #Parkinsons #alphasynuclein #structuralbiology #ethz
@imsb-eth.bsky.social @molsystbiol.org
#proteomics #structuralproteomics #neurodegeneration #Parkinsons #alphasynuclein #structuralbiology #ethz
@imsb-eth.bsky.social @molsystbiol.org
Why all the buzz about 'nuclear' alpha synuclein in Parkinson's disease and other synucleinopathies? Outeiro/Koss describe how nuclear alpha synuclein may be central to genomic instability, DNA damage and the progression of PD and related synucleinopathies. #parkinson @parkinsondotorg.bsky.social
November 26, 2025 at 2:21 PM
Why all the buzz about 'nuclear' alpha synuclein in Parkinson's disease and other synucleinopathies? Outeiro/Koss describe how nuclear alpha synuclein may be central to genomic instability, DNA damage and the progression of PD and related synucleinopathies. #parkinson @parkinsondotorg.bsky.social
#Medsky🧪 #neurosky #neuroimmunology #immunosky #publichealth A high proportion of individuals affected by iRBD eventually develop synuclein-specific neurodegenerative disorders (i.e., #synucleinopathies) such as PD, DLB or MSA
February 17, 2025 at 5:55 AM
#Medsky🧪 #neurosky #neuroimmunology #immunosky #publichealth A high proportion of individuals affected by iRBD eventually develop synuclein-specific neurodegenerative disorders (i.e., #synucleinopathies) such as PD, DLB or MSA
✅ Explore our #Blog on the #Research paper: "Brain region-specific and systemic transcriptomic alterations in a human alpha-synuclein overexpressing rat model."
#Summary ⬇️
https://bit.ly/4wbCcMl
#Aging #Brain #ParkinsonsDisease #Neurology #OA #PeerReviewed #Publishing
#Summary ⬇️
https://bit.ly/4wbCcMl
#Aging #Brain #ParkinsonsDisease #Neurology #OA #PeerReviewed #Publishing
Alpha-Synuclein Overexpression in Rats Reveals Early Clues to Synucleinopathies - Aging-US Research
Synucleinopathies are a group of age-related neurological disorders, including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Most individuals are not diagnosed until these diseases have significantly progressed, as early s...
aging-us.org
September 30, 2026 at 10:00 PM
✅ Explore our #Blog on the #Research paper: "Brain region-specific and systemic transcriptomic alterations in a human alpha-synuclein overexpressing rat model."
#Summary ⬇️
https://bit.ly/4wbCcMl
#Aging #Brain #ParkinsonsDisease #Neurology #OA #PeerReviewed #Publishing
#Summary ⬇️
https://bit.ly/4wbCcMl
#Aging #Brain #ParkinsonsDisease #Neurology #OA #PeerReviewed #Publishing
If you are interested in learning the limitations of current models of alpha synuclein pathology and why we need new KI humanized mouse models check out Latiyah’s poster
#AAIC25 Poster 200
Characterization of mouse of Synucleinopathies
@tridentpct.bsky.social @touchscreencog.bsky.social
#AAIC25 Poster 200
Characterization of mouse of Synucleinopathies
@tridentpct.bsky.social @touchscreencog.bsky.social
July 29, 2025 at 1:33 AM
If you are interested in learning the limitations of current models of alpha synuclein pathology and why we need new KI humanized mouse models check out Latiyah’s poster
#AAIC25 Poster 200
Characterization of mouse of Synucleinopathies
@tridentpct.bsky.social @touchscreencog.bsky.social
#AAIC25 Poster 200
Characterization of mouse of Synucleinopathies
@tridentpct.bsky.social @touchscreencog.bsky.social
Another retracted paper by former NIA Neuroscience head Eliezer Masliah, et al. One of 132 suspect papers featured in my 2024 investigation for @science.org based largely on work by forensic image experts. Key findings on this one by @thatsregrettab1.bsky.social journals.plos.org/plosone/arti...
Retraction: Identification of the Sites of Tau Hyperphosphorylation and Activation of Tau Kinases in Synucleinopathies and Alzheimer’s Diseases
journals.plos.org
June 6, 2025 at 9:10 PM
Another retracted paper by former NIA Neuroscience head Eliezer Masliah, et al. One of 132 suspect papers featured in my 2024 investigation for @science.org based largely on work by forensic image experts. Key findings on this one by @thatsregrettab1.bsky.social journals.plos.org/plosone/arti...
2.Parkinson’s dz diagnosis. It's difficult to detect and measure its severity. Scientists showed that a simple skin biopsy could identify people who had synucleinopathies w a high degree of accuracy. The findings could lead to earlier and more accurate diagnoses of these conditions.
December 26, 2024 at 10:59 PM
2.Parkinson’s dz diagnosis. It's difficult to detect and measure its severity. Scientists showed that a simple skin biopsy could identify people who had synucleinopathies w a high degree of accuracy. The findings could lead to earlier and more accurate diagnoses of these conditions.
Dr Silvia Maioli at the Karolinska Institutet seeks a postdoctoral researcher to focus on cholesterol metabolism in Alzheimer's disease and proteinopathies such as alpha-synucleinopathies. Closing date: 6th May.
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
Postdoc: Brain Cholesterol Metabolism & Neurodegeneration
Dr Silvia Maioli at the Karolinska Institutet seeks a postdoctoral researcher to focus on cholesterol metabolism in Alzheimer's disease and proteinopathies such as alpha-synucleinopathies.
www.dementiaresearcher.nihr.ac.uk
March 7, 2025 at 8:33 PM
Dr Silvia Maioli at the Karolinska Institutet seeks a postdoctoral researcher to focus on cholesterol metabolism in Alzheimer's disease and proteinopathies such as alpha-synucleinopathies. Closing date: 6th May.
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
"Analyses of resting-state EEG rhythmic and arrhythmic components and functional connectivity suggest an imbalanced excitatory-to-inhibitory activity within large-scale networks, which is associated with later development of a synucleinopathy in patients with iRBD"
doi.org/10.1093/slee...
doi.org/10.1093/slee...
Electroencephalogram rhythmic and arrhythmic spectral components and functional connectivity at resting state may predict the development of synucleinopathies in idiopathic rapid eye movement sleep be...
AbstractStudy Objectives. Idiopathic/isolated rapid eye movement-sleep behavior disorder (iRBD) often precedes the onset of synucleinopathies. Here, we inv
doi.org
December 15, 2024 at 11:01 PM
"Analyses of resting-state EEG rhythmic and arrhythmic components and functional connectivity suggest an imbalanced excitatory-to-inhibitory activity within large-scale networks, which is associated with later development of a synucleinopathy in patients with iRBD"
doi.org/10.1093/slee...
doi.org/10.1093/slee...
#Medsky🧪 #
#Parkinsonsdisease and other #synucleinopathies are undergoing a paradigm shift towards being defined and staged by biology, rather than symptoms @natmedicine.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
#Parkinsonsdisease and other #synucleinopathies are undergoing a paradigm shift towards being defined and staged by biology, rather than symptoms @natmedicine.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Toward a biological definition of neuronal and glial synucleinopathies - Nature Medicine
Parkinson’s diseases and other synucleinopathies are on the verge of a major paradigm shift toward being defined and staged by their biology, rather than symptoms; this Perspective offers context on p...
www.nature.com
February 3, 2025 at 1:08 PM
#Medsky🧪 #
#Parkinsonsdisease and other #synucleinopathies are undergoing a paradigm shift towards being defined and staged by biology, rather than symptoms @natmedicine.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
#Parkinsonsdisease and other #synucleinopathies are undergoing a paradigm shift towards being defined and staged by biology, rather than symptoms @natmedicine.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
COVID-19 Causes Alpha-Synucleinopathies - Thailand Medical News
www.thailandmedical.news
November 11, 2024 at 3:01 AM
Looking for a good review on alpha synuclein and Parkinson’s disease? Alpha synuclein shifts from helper protein to potential troublemaker and may drive early synaptic dysfunction, inflammation and ultimately cell loss in PD and related synucleinopathies. #parkinson
December 14, 2025 at 8:33 AM
Looking for a good review on alpha synuclein and Parkinson’s disease? Alpha synuclein shifts from helper protein to potential troublemaker and may drive early synaptic dysfunction, inflammation and ultimately cell loss in PD and related synucleinopathies. #parkinson
Check out the new preprint below..exciting discoveries showing novel strategies for treating synucleinopathies.
#parkinsons #brain #neuroscience #trident #nfrf 👇🌎🗞
#parkinsons #brain #neuroscience #trident #nfrf 👇🌎🗞
A new preprint led by my colleagues James Choy and Martin Duennwald with grad student extraordinary Ben Rutledge showing how HOP/STIP1 regulates alpha synuclein misfolding with implicarions for #Parkinson’s and other synucleinopathies www.biorxiv.org/content/10.1...
www.biorxiv.org
May 7, 2025 at 2:12 PM
Check out the new preprint below..exciting discoveries showing novel strategies for treating synucleinopathies.
#parkinsons #brain #neuroscience #trident #nfrf 👇🌎🗞
#parkinsons #brain #neuroscience #trident #nfrf 👇🌎🗞
#santé ⚕️ | 🔬Une avancée vers un diagnostic plus accessible & précoce.
Au CEA, Frédéric Ducongé développe une méthode innovante basée sur les aptamères pour améliorer le diagnostic de la maladie de Parkinson et d'autres synucléinopathies.
#JournéeMondialeDeParkinson
En 📽️ 👇
Au CEA, Frédéric Ducongé développe une méthode innovante basée sur les aptamères pour améliorer le diagnostic de la maladie de Parkinson et d'autres synucléinopathies.
#JournéeMondialeDeParkinson
En 📽️ 👇
April 11, 2025 at 8:32 AM
#santé ⚕️ | 🔬Une avancée vers un diagnostic plus accessible & précoce.
Au CEA, Frédéric Ducongé développe une méthode innovante basée sur les aptamères pour améliorer le diagnostic de la maladie de Parkinson et d'autres synucléinopathies.
#JournéeMondialeDeParkinson
En 📽️ 👇
Au CEA, Frédéric Ducongé développe une méthode innovante basée sur les aptamères pour améliorer le diagnostic de la maladie de Parkinson et d'autres synucléinopathies.
#JournéeMondialeDeParkinson
En 📽️ 👇
Excellent opportunity for a postdoc to join Harvey McMahon’s group in the LMB’s Neurobiology Division, using a novel alpha-synuclein aggregation assay to study molecular mechanisms underlying Parkinson’s and other synucleinopathies.
www.nature.com/naturecareer...
Apply by 05 APR
#PostdocJobs
www.nature.com/naturecareer...
Apply by 05 APR
#PostdocJobs
March 16, 2026 at 2:26 PM
Excellent opportunity for a postdoc to join Harvey McMahon’s group in the LMB’s Neurobiology Division, using a novel alpha-synuclein aggregation assay to study molecular mechanisms underlying Parkinson’s and other synucleinopathies.
www.nature.com/naturecareer...
Apply by 05 APR
#PostdocJobs
www.nature.com/naturecareer...
Apply by 05 APR
#PostdocJobs
This looks brillant - congrats! academic.oup.com/brain/advanc...
Patterns of tau, amyloid and synuclein pathology in ageing, Alzheimer’s disease and synucleinopathies
Colloby et al. analyse the burden and distribution of hyperphosphorylated-tau, β-amyloid and α-synuclein pathology in post-mortem brain tissue from individ
academic.oup.com
November 25, 2024 at 7:46 AM
This looks brillant - congrats! academic.oup.com/brain/advanc...
A biological definition of synucleinopathies could enhance diagnosis and treatment by detecting αSyn pathology in living patients.
by Soto C, Mollenhauer B (...) Poston K et 7 al. in Nat Med #MedSky
📖 read the article:
by Soto C, Mollenhauer B (...) Poston K et 7 al. in Nat Med #MedSky
📖 read the article:
Toward a biological definition of neuronal and glial synucleinopathies - Nature Medicine
Parkinson’s diseases and other synucleinopathies are on the verge of a major paradigm shift toward being defined and staged by their biology, rather than symptoms; this Perspective offers context on progress, needs and opportunities toward this goal.
www.nature.com
February 8, 2025 at 10:31 AM
A biological definition of synucleinopathies could enhance diagnosis and treatment by detecting αSyn pathology in living patients.
by Soto C, Mollenhauer B (...) Poston K et 7 al. in Nat Med #MedSky
📖 read the article:
by Soto C, Mollenhauer B (...) Poston K et 7 al. in Nat Med #MedSky
📖 read the article:
Can we halt Parkinson’s? Review finds α-syn therapies like immunotherapy may slow NDD progression. #ParkinsonsDisease #Synucleinopathies
www.rimpacts.com/rd/p?c=10069... 📄DOI: doi.org/10.1007/s105...
www.rimpacts.com/rd/p?c=10069... 📄DOI: doi.org/10.1007/s105...
Alpha-Synuclein Pathophysiology in Neurodegenerative Disorders: A Review Focusing on Molecular Mechanisms and Treatment Advances in Parkinson’S Disease
Can we halt Parkinson’s? Review finds α-syn therapies like immunotherapy may slow NDD progression. #ParkinsonsDisease #Synucleinopathies
www.rimpacts.com
December 23, 2025 at 8:11 AM
Can we halt Parkinson’s? Review finds α-syn therapies like immunotherapy may slow NDD progression. #ParkinsonsDisease #Synucleinopathies
www.rimpacts.com/rd/p?c=10069... 📄DOI: doi.org/10.1007/s105...
www.rimpacts.com/rd/p?c=10069... 📄DOI: doi.org/10.1007/s105...
New review offers "an in-depth analysis of the complex role of alpha-synuclein in the development of α-synucleinopathies, with a particular focus on its structural diversity & the resulting clinical variability"
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
December 13, 2024 at 11:49 PM
New review offers "an in-depth analysis of the complex role of alpha-synuclein in the development of α-synucleinopathies, with a particular focus on its structural diversity & the resulting clinical variability"
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A new preprint led by my colleagues James Choy and Martin Duennwald with grad student extraordinary Ben Rutledge showing how HOP/STIP1 regulates alpha synuclein misfolding with implicarions for #Parkinson’s and other synucleinopathies www.biorxiv.org/content/10.1...
www.biorxiv.org
April 9, 2025 at 12:33 PM
A new preprint led by my colleagues James Choy and Martin Duennwald with grad student extraordinary Ben Rutledge showing how HOP/STIP1 regulates alpha synuclein misfolding with implicarions for #Parkinson’s and other synucleinopathies www.biorxiv.org/content/10.1...
An analysis of >56M US Medicare beneficiaries revealed that chronic PM2.5 exposure was significantly associated with first hospitalizations for α-synucleinopathies; link=stronger for Lewy body dementia patients vs #Parkinsons without dementia
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
September 5, 2025 at 10:10 PM
An analysis of >56M US Medicare beneficiaries revealed that chronic PM2.5 exposure was significantly associated with first hospitalizations for α-synucleinopathies; link=stronger for Lewy body dementia patients vs #Parkinsons without dementia
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
✅ Explore our #Blog on the #Research paper: "Brain region-specific and systemic transcriptomic alterations in a human alpha-synuclein overexpressing rat model."
#Summary ⬇️
https://bit.ly/4wbCcMl
#Aging #Brain #ParkinsonsDisease #Neurology #OA #PeerReviewed #Publishing
#Summary ⬇️
https://bit.ly/4wbCcMl
#Aging #Brain #ParkinsonsDisease #Neurology #OA #PeerReviewed #Publishing
Alpha-Synuclein Overexpression in Rats Reveals Early Clues to Synucleinopathies - Aging-US Research
Synucleinopathies are a group of age-related neurological disorders, including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Most individuals are not diagnosed until these diseases have significantly progressed, as early s...
aging-us.org
July 20, 2026 at 10:00 PM
✅ Explore our #Blog on the #Research paper: "Brain region-specific and systemic transcriptomic alterations in a human alpha-synuclein overexpressing rat model."
#Summary ⬇️
https://bit.ly/4wbCcMl
#Aging #Brain #ParkinsonsDisease #Neurology #OA #PeerReviewed #Publishing
#Summary ⬇️
https://bit.ly/4wbCcMl
#Aging #Brain #ParkinsonsDisease #Neurology #OA #PeerReviewed #Publishing
Researchers report on the development of a 77-nucleotide RNA aptamer called 1R6, which is being preclinically evaluated as a therapeutic agent for synucleinopathies, like #Parkinsons
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 18, 2026 at 5:11 PM
Researchers report on the development of a 77-nucleotide RNA aptamer called 1R6, which is being preclinically evaluated as a therapeutic agent for synucleinopathies, like #Parkinsons
www.nature.com/articles/s41...
www.nature.com/articles/s41...
My PhD work is now *published* at Neuron!
1) Multiple structures of #synuclein aggregates form under the same uniform condition
2) You can't predict which structure you'll get
3) Different structures cause different disease outcomes in mice
#NeuroSky #Parkinsons 🧪
www.cell.com/neuron/fullt...
1) Multiple structures of #synuclein aggregates form under the same uniform condition
2) You can't predict which structure you'll get
3) Different structures cause different disease outcomes in mice
#NeuroSky #Parkinsons 🧪
www.cell.com/neuron/fullt...
March 3, 2026 at 4:03 AM
My PhD work is now *published* at Neuron!
1) Multiple structures of #synuclein aggregates form under the same uniform condition
2) You can't predict which structure you'll get
3) Different structures cause different disease outcomes in mice
#NeuroSky #Parkinsons 🧪
www.cell.com/neuron/fullt...
1) Multiple structures of #synuclein aggregates form under the same uniform condition
2) You can't predict which structure you'll get
3) Different structures cause different disease outcomes in mice
#NeuroSky #Parkinsons 🧪
www.cell.com/neuron/fullt...