The co-founder of Instagram Kevin Systrom testified on Tuesday in a landmark federal antitrust trial that his startup was starved of resources after Meta bought it because Mark Zuckerberg, the chief executive, was afraid of the success of the photo-sharing app.
At Meta Trial, Instagram Co-Founder Says Startup Was Denied Resources
Kevin Systrom said during testimony in a landmark antitrust trial that he believed Mark Zuckerberg, Meta’s chief executive, viewed Instagram as a threat.
www.nytimes.com
April 22, 2025 at 8:49 PM
The co-founder of Instagram Kevin Systrom testified on Tuesday in a landmark federal antitrust trial that his startup was starved of resources after Meta bought it because Mark Zuckerberg, the chief executive, was afraid of the success of the photo-sharing app.
Exactly how Systrom described it to me for years. He tried to be a team player early on & make the best of it publicly, but the bloom was off that deal quickly, largely because of Zuckerberg’s petty behavior. He utterly lacks creativity and is envious of those who do. Aggression is his talent.
The co-founder of Instagram Kevin Systrom testified on Tuesday in a landmark federal antitrust trial that his startup was starved of resources after Meta bought it because Mark Zuckerberg, the chief executive, was afraid of the success of the photo-sharing app.
At Meta Trial, Instagram Co-Founder Says Startup Was Denied Resources
Kevin Systrom said during testimony in a landmark antitrust trial that he believed Mark Zuckerberg, Meta’s chief executive, viewed Instagram as a threat.
www.nytimes.com
April 23, 2025 at 1:27 AM
Exactly how Systrom described it to me for years. He tried to be a team player early on & make the best of it publicly, but the bloom was off that deal quickly, largely because of Zuckerberg’s petty behavior. He utterly lacks creativity and is envious of those who do. Aggression is his talent.
Zuckerberg has long struggled to convey himself as human to the rest of the world, so it's interesting that the thing that does that is testimony from Kevin Systrom, who said Zuckerberg was jealous of Instagram's success.
www.nytimes.com/2025/04/22/t...
www.nytimes.com/2025/04/22/t...
April 22, 2025 at 7:23 PM
Zuckerberg has long struggled to convey himself as human to the rest of the world, so it's interesting that the thing that does that is testimony from Kevin Systrom, who said Zuckerberg was jealous of Instagram's success.
www.nytimes.com/2025/04/22/t...
www.nytimes.com/2025/04/22/t...
On October 6, 2010, Kevin Systrom and Mike Krieger published an Instagram app for sharing photos and short videos in the App Store.
Instagram 1.0 for iPhone in 2010
#MobileAppHistory
Instagram 1.0 for iPhone in 2010
#MobileAppHistory
October 6, 2025 at 1:06 PM
On October 6, 2010, Kevin Systrom and Mike Krieger published an Instagram app for sharing photos and short videos in the App Store.
Instagram 1.0 for iPhone in 2010
#MobileAppHistory
Instagram 1.0 for iPhone in 2010
#MobileAppHistory
5) The slides come from this presentation by David Systrom at the 2025 Stanford Symposium.
www.youtube.com/watc...
The protocol for the LIFT-trial is available here as pre-print:
www.researchsquare.c...
www.youtube.com/watc...
The protocol for the LIFT-trial is available here as pre-print:
www.researchsquare.c...
David Systrom, MD | Treating ME/CFS and Long COVID as organic diseases with repurposed medications
David Systrom, MD, Harvard University
Treating ME/CFS and Long COVID as organic diseases with repurposed medications
www.youtube.com
October 23, 2025 at 8:30 AM
5) The slides come from this presentation by David Systrom at the 2025 Stanford Symposium.
www.youtube.com/watc...
The protocol for the LIFT-trial is available here as pre-print:
www.researchsquare.c...
www.youtube.com/watc...
The protocol for the LIFT-trial is available here as pre-print:
www.researchsquare.c...
same consideration from clinicians. We ignore the science showing that people with PEM are in energetic crisis (Wust et al) and/or experiencing heart failure during exercise (Systrom et al) and stick with the deeply flawed framework that the best way to fix someone who can’t 20/
November 20, 2024 at 11:27 AM
same consideration from clinicians. We ignore the science showing that people with PEM are in energetic crisis (Wust et al) and/or experiencing heart failure during exercise (Systrom et al) and stick with the deeply flawed framework that the best way to fix someone who can’t 20/
Systrom is now up:
"Everything we have found in ME we have found in Long COVID, so we may slip up and use them interchangeably."
"Everything we have found in ME we have found in Long COVID, so we may slip up and use them interchangeably."
September 5, 2025 at 6:38 PM
Systrom is now up:
"Everything we have found in ME we have found in Long COVID, so we may slip up and use them interchangeably."
"Everything we have found in ME we have found in Long COVID, so we may slip up and use them interchangeably."
So we now have 3 teams doing a trial of low-dose Naltrexone in ME/CFS:
- Marshall-Gradisnik, Griffith University, Australia
- Yarred Younger, University of Alabama, USA
- David Systrom, Brigham and Women's Hospital, USA
- Marshall-Gradisnik, Griffith University, Australia
- Yarred Younger, University of Alabama, USA
- David Systrom, Brigham and Women's Hospital, USA
1) 🇦🇺 The NCNED team of Prof. Sonya Marshall-Gradisnik is launching a double blind trial of low dose naltrexone (LDN) in patients with ME/CFS.
They are currently looking for patients diagnosed by the CCC/ICC located in South-East Queensland and Northern New South Wales.
They are currently looking for patients diagnosed by the CCC/ICC located in South-East Queensland and Northern New South Wales.
February 18, 2026 at 3:14 PM
So we now have 3 teams doing a trial of low-dose Naltrexone in ME/CFS:
- Marshall-Gradisnik, Griffith University, Australia
- Yarred Younger, University of Alabama, USA
- David Systrom, Brigham and Women's Hospital, USA
- Marshall-Gradisnik, Griffith University, Australia
- Yarred Younger, University of Alabama, USA
- David Systrom, Brigham and Women's Hospital, USA
Systrom: "Many of us in the field..believe that ME/CFS is often, but not always..post-infectious..for not totally clear reasons, there is autoimmunity, which may run amuck on overdrive with associated inflammation...then downstream.those pathways, we think there are some issues with oxygen supply.."
Open Medicine Foundation: 'An Interview with Ron Davis, PhD, and David Systrom, MD: Low Oxygen, Low Energy'
www.youtube.com/watch?v=KILx...
www.youtube.com/watch?v=KILx...
An Interview with Ron Davis, PhD, and David Systrom, MD: Low Oxygen, Low Energy
YouTube video by Open Medicine Foundation - OMF
www.youtube.com
November 11, 2025 at 5:44 PM
Systrom: "Many of us in the field..believe that ME/CFS is often, but not always..post-infectious..for not totally clear reasons, there is autoimmunity, which may run amuck on overdrive with associated inflammation...then downstream.those pathways, we think there are some issues with oxygen supply.."
„Mitochondrial Dysfunction
In one subset of people with ME/CFS, the inability to generate energy is simply due to an inability to extract oxygen from the blood. Systrom noted that these people look very much like people with mitochondrial myopathy; 1/3
www.healthrising.org/blog/2022/07...
In one subset of people with ME/CFS, the inability to generate energy is simply due to an inability to extract oxygen from the blood. Systrom noted that these people look very much like people with mitochondrial myopathy; 1/3
www.healthrising.org/blog/2022/07...
Systrom's Keynote Address Kicks off IACFS/ME ME/CFS and Long-COVID Conference - Health Rising
Keynote Talk: David Systrom – Pathophysiology of exercise intolerance in ME/CFS & Long COVID (Text in parentheses was not part of the talk and was added by me). David Systrom started off his long an...
www.healthrising.org
October 11, 2023 at 8:38 PM
„Mitochondrial Dysfunction
In one subset of people with ME/CFS, the inability to generate energy is simply due to an inability to extract oxygen from the blood. Systrom noted that these people look very much like people with mitochondrial myopathy; 1/3
www.healthrising.org/blog/2022/07...
In one subset of people with ME/CFS, the inability to generate energy is simply due to an inability to extract oxygen from the blood. Systrom noted that these people look very much like people with mitochondrial myopathy; 1/3
www.healthrising.org/blog/2022/07...
Dr. David Systrom recently attended the International ME/CFS Conference 2025 in Berlin, Germany. As part of the conference, he gave two presentations:
🔹 Circulatory dysfunction in #MECFS
🔹 OMF’s Life Improvement Trial (LIFT)
Watch the recordings: ow.ly/heaj50Wtmqi.
🔹 Circulatory dysfunction in #MECFS
🔹 OMF’s Life Improvement Trial (LIFT)
Watch the recordings: ow.ly/heaj50Wtmqi.
🎥 Video Presentations: Insights from Dr. David Systrom - Open Medicine Foundation
Watch Dr. David Systrom’s presentations on circulatory dysfunction and a clinical trial of LDN and Mestinon in ME/CFS.
ow.ly
July 22, 2025 at 3:13 PM
Dr. David Systrom recently attended the International ME/CFS Conference 2025 in Berlin, Germany. As part of the conference, he gave two presentations:
🔹 Circulatory dysfunction in #MECFS
🔹 OMF’s Life Improvement Trial (LIFT)
Watch the recordings: ow.ly/heaj50Wtmqi.
🔹 Circulatory dysfunction in #MECFS
🔹 OMF’s Life Improvement Trial (LIFT)
Watch the recordings: ow.ly/heaj50Wtmqi.
David Systrom, MD, presents on ‘Metabolic Insights from Invasive Cardiopulmonary Exercise Testing in ME’ during the International ME Conference Week, hosted by UK charity Invest in ME Research.
Learn more about the conference: investinme.org/IIMEC17.shtml
#IIMEC17 #BRMEC14
Learn more about the conference: investinme.org/IIMEC17.shtml
#IIMEC17 #BRMEC14
May 29, 2025 at 3:34 PM
David Systrom, MD, presents on ‘Metabolic Insights from Invasive Cardiopulmonary Exercise Testing in ME’ during the International ME Conference Week, hosted by UK charity Invest in ME Research.
Learn more about the conference: investinme.org/IIMEC17.shtml
#IIMEC17 #BRMEC14
Learn more about the conference: investinme.org/IIMEC17.shtml
#IIMEC17 #BRMEC14
🌟 A Muscle Biopsy Study to Understand the Molecular Mechanisms of PEM 🌟
In this interview, Dr. Systrom discusses a muscle biopsy study to understand the molecular mechanisms behind post-exertional malaise (PEM).
Learn more: ow.ly/WFng50U0F3Q
#PEM #MECFS #longcovid
In this interview, Dr. Systrom discusses a muscle biopsy study to understand the molecular mechanisms behind post-exertional malaise (PEM).
Learn more: ow.ly/WFng50U0F3Q
#PEM #MECFS #longcovid
November 5, 2024 at 6:00 PM
🌟 A Muscle Biopsy Study to Understand the Molecular Mechanisms of PEM 🌟
In this interview, Dr. Systrom discusses a muscle biopsy study to understand the molecular mechanisms behind post-exertional malaise (PEM).
Learn more: ow.ly/WFng50U0F3Q
#PEM #MECFS #longcovid
In this interview, Dr. Systrom discusses a muscle biopsy study to understand the molecular mechanisms behind post-exertional malaise (PEM).
Learn more: ow.ly/WFng50U0F3Q
#PEM #MECFS #longcovid
David Systrom stellt eine Studie zu Pyridostigmin und Low-Dose-Naltrexon vor: 160 Proband:innen in 4 Gruppen, beide Meds, je eines, Placebo. In einem Jahr könne er mehr erzählen. #MECFS Conference in Berlin
May 13, 2025 at 11:01 AM
David Systrom stellt eine Studie zu Pyridostigmin und Low-Dose-Naltrexon vor: 160 Proband:innen in 4 Gruppen, beide Meds, je eines, Placebo. In einem Jahr könne er mehr erzählen. #MECFS Conference in Berlin
David Systrom spricht eigentlich über zirkuläre Dysfunktion, aber besonders spannend: In großer Gruppe von Pats mit MECFS oder PC hatten etwa zwei Drittel Small Fiber Neuropathie (noch nicht veröffentlicht)
May 12, 2025 at 2:58 PM
David Systrom spricht eigentlich über zirkuläre Dysfunktion, aber besonders spannend: In großer Gruppe von Pats mit MECFS oder PC hatten etwa zwei Drittel Small Fiber Neuropathie (noch nicht veröffentlicht)
Am 12./13.5.25 findet die 3. internat. hybride MECFS Konferenz von Charité und der MECFSResearch Foundation statt u.a. mit
David Putrino
Kathryn Hoffmann
Karl Tronstad
Jűrgen Steinacker
Christian Puta
Michael Stingl
Joen den Dummen
Øystein Fluge
David Systrom
mecfs-research.org/mecfs-confer...
David Putrino
Kathryn Hoffmann
Karl Tronstad
Jűrgen Steinacker
Christian Puta
Michael Stingl
Joen den Dummen
Øystein Fluge
David Systrom
mecfs-research.org/mecfs-confer...
ME/CFS Conference 2025
Wissenschaftliche VeranstaltungWissenschaftliche Konferenz unter der Leitung von Prof. Carmen Scheibenbogen zu Versorgung, Forschung und Therapie von ME/CFS und Post-CO
mecfs-research.org
November 16, 2024 at 8:31 AM
Am 12./13.5.25 findet die 3. internat. hybride MECFS Konferenz von Charité und der MECFSResearch Foundation statt u.a. mit
David Putrino
Kathryn Hoffmann
Karl Tronstad
Jűrgen Steinacker
Christian Puta
Michael Stingl
Joen den Dummen
Øystein Fluge
David Systrom
mecfs-research.org/mecfs-confer...
David Putrino
Kathryn Hoffmann
Karl Tronstad
Jűrgen Steinacker
Christian Puta
Michael Stingl
Joen den Dummen
Øystein Fluge
David Systrom
mecfs-research.org/mecfs-confer...
I've always been into taking my photos, cropping them square, putting them through a filter in Photoshop. - Kevin Systrom
@rodhobart.bsky.social
@studiomg.bsky.social
@fotohomme.bsky.social
@rickycohete.bsky.social
@jrutledge01.bsky.social
@macksturgis.bsky.social
@figuresbydok.bsky.social
@rodhobart.bsky.social
@studiomg.bsky.social
@fotohomme.bsky.social
@rickycohete.bsky.social
@jrutledge01.bsky.social
@macksturgis.bsky.social
@figuresbydok.bsky.social
February 19, 2026 at 12:30 PM
I've always been into taking my photos, cropping them square, putting them through a filter in Photoshop. - Kevin Systrom
@rodhobart.bsky.social
@studiomg.bsky.social
@fotohomme.bsky.social
@rickycohete.bsky.social
@jrutledge01.bsky.social
@macksturgis.bsky.social
@figuresbydok.bsky.social
@rodhobart.bsky.social
@studiomg.bsky.social
@fotohomme.bsky.social
@rickycohete.bsky.social
@jrutledge01.bsky.social
@macksturgis.bsky.social
@figuresbydok.bsky.social
Instagram founder testifies Mark Zuckerberg withheld resources
https://www.ft.com/content/338314e8-8127-4de3-8b92-a85223856f6f
https://www.ft.com/content/338314e8-8127-4de3-8b92-a85223856f6f
Instagram founder testifies Mark Zuckerberg withheld resources
Kevin Systrom backs US Federal Trade Commission’s case in monopoly trial
www.ft.com
April 22, 2025 at 8:00 PM
Instagram founder testifies Mark Zuckerberg withheld resources
https://www.ft.com/content/338314e8-8127-4de3-8b92-a85223856f6f
https://www.ft.com/content/338314e8-8127-4de3-8b92-a85223856f6f
Instagram co-founder Kevin Systrom says AI companies are trying too hard to "juice engagement" through follow-up questions, instead of providing useful insights (Charles Rollet/TechCrunch)
Main Link | Techmeme Permalink
Main Link | Techmeme Permalink
May 3, 2025 at 4:16 AM
Instagram co-founder Kevin Systrom says AI companies are trying too hard to "juice engagement" through follow-up questions, instead of providing useful insights (Charles Rollet/TechCrunch)
Main Link | Techmeme Permalink
Main Link | Techmeme Permalink
New from Systrom team (US):
Exercise Pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID: Commonalities Detected by Invasive Cardiopulmonary Exercise Testing
www.atsjournals.org/doi/abs/10.1...
#MEcfs #LongCovid
1/
Exercise Pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID: Commonalities Detected by Invasive Cardiopulmonary Exercise Testing
www.atsjournals.org/doi/abs/10.1...
#MEcfs #LongCovid
1/
May 4, 2025 at 5:04 PM
New from Systrom team (US):
Exercise Pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID: Commonalities Detected by Invasive Cardiopulmonary Exercise Testing
www.atsjournals.org/doi/abs/10.1...
#MEcfs #LongCovid
1/
Exercise Pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID: Commonalities Detected by Invasive Cardiopulmonary Exercise Testing
www.atsjournals.org/doi/abs/10.1...
#MEcfs #LongCovid
1/
Open Medicine Foundation: 'An Interview with Ron Davis, PhD, and David Systrom, MD: Low Oxygen, Low Energy'
www.youtube.com/watch?v=KILx...
www.youtube.com/watch?v=KILx...
An Interview with Ron Davis, PhD, and David Systrom, MD: Low Oxygen, Low Energy
YouTube video by Open Medicine Foundation - OMF
www.youtube.com
November 11, 2025 at 3:45 PM
Open Medicine Foundation: 'An Interview with Ron Davis, PhD, and David Systrom, MD: Low Oxygen, Low Energy'
www.youtube.com/watch?v=KILx...
www.youtube.com/watch?v=KILx...
Kevin Systrom is currently on the stand testifying in the US trial to break up Meta, and it is... not going well for Meta www.theverge.com/news/646809/...
FTC v. Meta live: the latest from the battle over Instagram and WhatsApp
The case centers around its acquisitions of Instagram and WhatsApp.
www.theverge.com
April 22, 2025 at 6:56 PM
Kevin Systrom is currently on the stand testifying in the US trial to break up Meta, and it is... not going well for Meta www.theverge.com/news/646809/...
Neurovascular Dysregulation During
Exercise in #ME/CFS & #LongCOVID
David M. Systrom, M.D.
Pulmonary and Critical Care Medicine
Brigham & Women’s Hospital
CDC SEC Call Presentation
www.cdc.gov/me-cfs/pdfs/...
Exercise in #ME/CFS & #LongCOVID
David M. Systrom, M.D.
Pulmonary and Critical Care Medicine
Brigham & Women’s Hospital
CDC SEC Call Presentation
www.cdc.gov/me-cfs/pdfs/...
www.cdc.gov
September 3, 2025 at 3:04 AM
Neurovascular Dysregulation During
Exercise in #ME/CFS & #LongCOVID
David M. Systrom, M.D.
Pulmonary and Critical Care Medicine
Brigham & Women’s Hospital
CDC SEC Call Presentation
www.cdc.gov/me-cfs/pdfs/...
Exercise in #ME/CFS & #LongCOVID
David M. Systrom, M.D.
Pulmonary and Critical Care Medicine
Brigham & Women’s Hospital
CDC SEC Call Presentation
www.cdc.gov/me-cfs/pdfs/...
Heart Preload Failure in patients w/ #ME/CFS #pwME and some #pwLC
Original ongoing research conducted by Dr. D. Systrom
@openmedf.bsky.social
www.openmedicinefoundation.ngo/heart-preloa...
Original ongoing research conducted by Dr. D. Systrom
@openmedf.bsky.social
www.openmedicinefoundation.ngo/heart-preloa...
September 3, 2025 at 2:12 AM
Heart Preload Failure in patients w/ #ME/CFS #pwME and some #pwLC
Original ongoing research conducted by Dr. D. Systrom
@openmedf.bsky.social
www.openmedicinefoundation.ngo/heart-preloa...
Original ongoing research conducted by Dr. D. Systrom
@openmedf.bsky.social
www.openmedicinefoundation.ngo/heart-preloa...
2) Quote taking from a new paper in the British Journal of Sports Medicine by experts such as Systrom, Wüst and Putrino.
Charlton et al. 2026. Post-exertional malaise and the myth of cardiac deconditioning: rethinking the pathophysiology of long covid.
bjsm.bmj.com/content...
Charlton et al. 2026. Post-exertional malaise and the myth of cardiac deconditioning: rethinking the pathophysiology of long covid.
bjsm.bmj.com/content...
February 11, 2026 at 1:21 PM
2) Quote taking from a new paper in the British Journal of Sports Medicine by experts such as Systrom, Wüst and Putrino.
Charlton et al. 2026. Post-exertional malaise and the myth of cardiac deconditioning: rethinking the pathophysiology of long covid.
bjsm.bmj.com/content...
Charlton et al. 2026. Post-exertional malaise and the myth of cardiac deconditioning: rethinking the pathophysiology of long covid.
bjsm.bmj.com/content...