Still, the fact that GWB was actually pretty active in ensuring the US was involved in global health shows what a dumb shortsighted decision this is: bsky.app/profile/tnfa...
As the US seeks to withdraw from the WHO, and the negotiations on the revisions to the International Health Regulations and the Pandemic Response Treaty, it’s worth remembering that GW Bush pushed through the last revision of the IHR. 1/n
January 21, 2025 at 1:42 AM
Still, the fact that GWB was actually pretty active in ensuring the US was involved in global health shows what a dumb shortsighted decision this is: bsky.app/profile/tnfa...
A bit of #NeuroSkyence to bring a little joy to our timelines. Magenta shows an astrocyte that's churning out lots of TNFa, and yellow is an IBA1 stain. You can see the microglia closest to the astrocyte have become reactive while those further away are more normal. Isn't science fun!?
February 25, 2025 at 11:11 AM
A bit of #NeuroSkyence to bring a little joy to our timelines. Magenta shows an astrocyte that's churning out lots of TNFa, and yellow is an IBA1 stain. You can see the microglia closest to the astrocyte have become reactive while those further away are more normal. Isn't science fun!?
CKD, proteinuria, Crohn's disease. KBx w/focally granulomatous tubulointerstitial nephritis and IgAN. Common findings in IBD patients (pubmed.ncbi.nlm.nih.gov/38344742/). Pt on TNFa inhibitor (pubmed.ncbi.nlm.nih.gov/36706240/) also reported IgAN/TIN associations. #renalpath #pathsky #nephrology.
November 23, 2024 at 12:25 AM
CKD, proteinuria, Crohn's disease. KBx w/focally granulomatous tubulointerstitial nephritis and IgAN. Common findings in IBD patients (pubmed.ncbi.nlm.nih.gov/38344742/). Pt on TNFa inhibitor (pubmed.ncbi.nlm.nih.gov/36706240/) also reported IgAN/TIN associations. #renalpath #pathsky #nephrology.
ah, sweet vials of Grace, that most serendipitous of naturally occurring biochemical phenomena
willow bark is pretty fucking good but “keeping the bog witch alive and faer TNFa immune cells chill” is the clear winner, personally
willow bark is pretty fucking good but “keeping the bog witch alive and faer TNFa immune cells chill” is the clear winner, personally
September 29, 2026 at 12:53 PM
ah, sweet vials of Grace, that most serendipitous of naturally occurring biochemical phenomena
willow bark is pretty fucking good but “keeping the bog witch alive and faer TNFa immune cells chill” is the clear winner, personally
willow bark is pretty fucking good but “keeping the bog witch alive and faer TNFa immune cells chill” is the clear winner, personally
COVID-19 in pregnancy: implications for fetal brain development
February 9, 2025 at 1:02 AM
COVID-19 in pregnancy: implications for fetal brain development
Durante a pesagem do Music Fight Show, Daborah Albuquerque surpreendeu ao entregar uma flor para Raissa Barbosa, em um momento que chamou atenção do público presente.
May 30, 2026 at 1:37 AM
Also, cytokines like TNFa and IL6 can also cause intermittent insulin resistance.
(My theory is that this is to prioritize glucose for the brain first, as it doesn't need insulin to access the glucose. Chronic neuroinflammation would need to be considered!)
(My theory is that this is to prioritize glucose for the brain first, as it doesn't need insulin to access the glucose. Chronic neuroinflammation would need to be considered!)
[Medical fatmisia]
Drs explaining insulin resistance: it's because you're a fat person who eats too much sugar. Try the fad diet of the day
But like... Insulin is like a key that lets glucose into your cells
If that key isn't working well, your cells are not getting enough energy from glucose
Drs explaining insulin resistance: it's because you're a fat person who eats too much sugar. Try the fad diet of the day
But like... Insulin is like a key that lets glucose into your cells
If that key isn't working well, your cells are not getting enough energy from glucose
July 14, 2025 at 3:58 PM
Also, cytokines like TNFa and IL6 can also cause intermittent insulin resistance.
(My theory is that this is to prioritize glucose for the brain first, as it doesn't need insulin to access the glucose. Chronic neuroinflammation would need to be considered!)
(My theory is that this is to prioritize glucose for the brain first, as it doesn't need insulin to access the glucose. Chronic neuroinflammation would need to be considered!)
March 20, 2026 at 7:27 AM
Increased CD8 T cells making TNFa?? Where?? Really where?
Any idea what is compared here? Any idea about the variability between humans? These are background values, nothing more.
Any idea what is compared here? Any idea about the variability between humans? These are background values, nothing more.
February 20, 2025 at 9:22 PM
Increased CD8 T cells making TNFa?? Where?? Really where?
Any idea what is compared here? Any idea about the variability between humans? These are background values, nothing more.
Any idea what is compared here? Any idea about the variability between humans? These are background values, nothing more.
Tim Fragrance is going right into TNFA name suggestions.
July 24, 2026 at 11:49 AM
Tim Fragrance is going right into TNFA name suggestions.
And also that bizarre paradox that the biologic drugs used to treat autoimmune diseases like TNFa blockers, IL1b, IL17, IL23 blockers.... have also all been correlated to some extent with new onset autoimmune disease. Is this through increased infections?
1/ A long standing paradox in my mind (from always seeing immune "strength" or reactivity drawn as a spectrum from immunodeficiency to autoimmunity) was resolved this year at #AAI #Immunology2025. WHY do SO many people have both simultaneously? Each infection brings risk of developing autoimmunity!!
May 12, 2025 at 1:23 AM
And also that bizarre paradox that the biologic drugs used to treat autoimmune diseases like TNFa blockers, IL1b, IL17, IL23 blockers.... have also all been correlated to some extent with new onset autoimmune disease. Is this through increased infections?
work in progress TNFa oc
July 20, 2026 at 2:10 AM
work in progress TNFa oc
art of my TNFa oc i did.
im still thinkign of a name..
he was inspired by Platynereis dumerilii and Dionaea muscipula (venus fly trap)
im still thinkign of a name..
he was inspired by Platynereis dumerilii and Dionaea muscipula (venus fly trap)
July 20, 2026 at 5:57 AM
art of my TNFa oc i did.
im still thinkign of a name..
he was inspired by Platynereis dumerilii and Dionaea muscipula (venus fly trap)
im still thinkign of a name..
he was inspired by Platynereis dumerilii and Dionaea muscipula (venus fly trap)
Also I've set up a website for it, it contains some character bios and other information for those who want to see. I'll fill it out more as the spirit wills it.
chicken-hat.neocities.org/TNFa/tnfgame
chicken-hat.neocities.org/TNFa/tnfgame
March 20, 2026 at 4:18 AM
Also I've set up a website for it, it contains some character bios and other information for those who want to see. I'll fill it out more as the spirit wills it.
chicken-hat.neocities.org/TNFa/tnfgame
chicken-hat.neocities.org/TNFa/tnfgame
Tina Fey just said her name and I was about to check urban dictionary to see what TNFA stood for
January 5, 2025 at 6:37 PM
Tina Fey just said her name and I was about to check urban dictionary to see what TNFA stood for
Plus One Episode Five - Missing Toolworks
YouTube video by Doki Doki Plus One
www.youtube.com
October 29, 2024 at 3:41 PM
Nonantimicrobial effects:
Anti-inflammatory:
- Presumably by MMP inhibition —> decreased inflammation.
- Decrease production of TNFa, IL-6, IL-1b
Demeclocycline has anti-ADH/vasopressin activity in the kidney; blocks V2 vasopressor receptor —> diuresis —> increased Na.
Anti-inflammatory:
- Presumably by MMP inhibition —> decreased inflammation.
- Decrease production of TNFa, IL-6, IL-1b
Demeclocycline has anti-ADH/vasopressin activity in the kidney; blocks V2 vasopressor receptor —> diuresis —> increased Na.
November 10, 2024 at 4:12 PM
Nonantimicrobial effects:
Anti-inflammatory:
- Presumably by MMP inhibition —> decreased inflammation.
- Decrease production of TNFa, IL-6, IL-1b
Demeclocycline has anti-ADH/vasopressin activity in the kidney; blocks V2 vasopressor receptor —> diuresis —> increased Na.
Anti-inflammatory:
- Presumably by MMP inhibition —> decreased inflammation.
- Decrease production of TNFa, IL-6, IL-1b
Demeclocycline has anti-ADH/vasopressin activity in the kidney; blocks V2 vasopressor receptor —> diuresis —> increased Na.
Crazy that the TNFA wraps up this month. Shit goes by so quickly.
May 6, 2026 at 8:11 PM
Crazy that the TNFA wraps up this month. Shit goes by so quickly.
The hDRG proteome shows sexual dimorphism, with a number of these dimorphic pathways shared across omics: to start, TNFa signalling is enhanced in male datasets and interferon alpha signalling is up in females, from ATAC-seq to proteomics
May 20, 2025 at 6:16 AM
The hDRG proteome shows sexual dimorphism, with a number of these dimorphic pathways shared across omics: to start, TNFa signalling is enhanced in male datasets and interferon alpha signalling is up in females, from ATAC-seq to proteomics
TNFa is one of the most fun demo experiences I've had recently, it always amazes me when someone crafts something so genuinely fun and accessible in a constrained retro genre
It's full of such amazing and beautifully creative gore ❤️ and I'm already looking forward to the soundtrack ✨
It's full of such amazing and beautifully creative gore ❤️ and I'm already looking forward to the soundtrack ✨
ᴛᴜᴍᴏʀ ɴᴇᴄʀᴏꜱɪꜱ ꜰᴀᴄᴛᴏʀ:// αᴍᴇɴ on Steam
Tear through the decaying Earth as a mutant half-worm in this arcade-inspired rail shooter! Branching paths, fast-paced gameplay, and lots of gore: a blood-smeared love letter to the classics of old.
store.steampowered.com
September 2, 2026 at 4:31 PM
TNFa is one of the most fun demo experiences I've had recently, it always amazes me when someone crafts something so genuinely fun and accessible in a constrained retro genre
It's full of such amazing and beautifully creative gore ❤️ and I'm already looking forward to the soundtrack ✨
It's full of such amazing and beautifully creative gore ❤️ and I'm already looking forward to the soundtrack ✨
Is there a #veterinariansky and if so can they tell me why we can’t treat my cats IBD with like, humira. Ted wants to be a TNFa inhibitor girliepop
June 9, 2025 at 7:31 PM
Is there a #veterinariansky and if so can they tell me why we can’t treat my cats IBD with like, humira. Ted wants to be a TNFa inhibitor girliepop
I made it!
Switching from a TNFa inhibitor to an JAK inhibitor bc my pain has been monstrous. For a while my PsA was acting up more but now it is my AS & my PsA impacts more of my functioning but my AS pain is an absolute beast, & that’s compared to labour & appendicitis. So, it was time.
Switching from a TNFa inhibitor to an JAK inhibitor bc my pain has been monstrous. For a while my PsA was acting up more but now it is my AS & my PsA impacts more of my functioning but my AS pain is an absolute beast, & that’s compared to labour & appendicitis. So, it was time.
Make it to an afternoon appointment on the same day you ran out of ADHD med bc you forgot to refill them challenge
October 29, 2025 at 7:55 PM
I made it!
Switching from a TNFa inhibitor to an JAK inhibitor bc my pain has been monstrous. For a while my PsA was acting up more but now it is my AS & my PsA impacts more of my functioning but my AS pain is an absolute beast, & that’s compared to labour & appendicitis. So, it was time.
Switching from a TNFa inhibitor to an JAK inhibitor bc my pain has been monstrous. For a while my PsA was acting up more but now it is my AS & my PsA impacts more of my functioning but my AS pain is an absolute beast, & that’s compared to labour & appendicitis. So, it was time.