spannend 😎 PTX3 ist
downstream von TLR, TNFalpha, IL1beta
upstream von complement system
downstream von TLR, TNFalpha, IL1beta
upstream von complement system
October 1, 2025 at 4:23 PM
spannend 😎 PTX3 ist
downstream von TLR, TNFalpha, IL1beta
upstream von complement system
downstream von TLR, TNFalpha, IL1beta
upstream von complement system
Combatting my prejudices starts with identifying and disclosing my biases.
I apologize to those - past, present, & future - who I have judged harshly bc they wrongly referred to TNF as “TNFalpha”.
Some of them are serious immunologists … probably… I guess.
I apologize to those - past, present, & future - who I have judged harshly bc they wrongly referred to TNF as “TNFalpha”.
Some of them are serious immunologists … probably… I guess.
September 28, 2026 at 9:29 AM
Combatting my prejudices starts with identifying and disclosing my biases.
I apologize to those - past, present, & future - who I have judged harshly bc they wrongly referred to TNF as “TNFalpha”.
Some of them are serious immunologists … probably… I guess.
I apologize to those - past, present, & future - who I have judged harshly bc they wrongly referred to TNF as “TNFalpha”.
Some of them are serious immunologists … probably… I guess.
persönlich halte ich GSK3 Inhibition für einen wichtigen Ansatzpunkt. Nicht zwingend den einzigen. Evtl in Kombination mit Low Dose mTOR und oder TNFalpha Inhibitoren.
February 4, 2026 at 10:58 AM
persönlich halte ich GSK3 Inhibition für einen wichtigen Ansatzpunkt. Nicht zwingend den einzigen. Evtl in Kombination mit Low Dose mTOR und oder TNFalpha Inhibitoren.
Viele Nahrungsmittel eigen sich zum testen, so enthält Pfeffer zum Beispiel einen CB2 Agonisten, Holundersaft eignet sich als mTOR Inhibitor, Lithium ist ein GSK3 Inhibitor, Kaffeinsäure inhibiert vermutlich TNFalpha, Kapern enthalten den MastZell-Stabilisator Quercetin.... Da lässt sich
April 9, 2026 at 9:20 PM
Viele Nahrungsmittel eigen sich zum testen, so enthält Pfeffer zum Beispiel einen CB2 Agonisten, Holundersaft eignet sich als mTOR Inhibitor, Lithium ist ein GSK3 Inhibitor, Kaffeinsäure inhibiert vermutlich TNFalpha, Kapern enthalten den MastZell-Stabilisator Quercetin.... Da lässt sich
absolutely incredible: complete TNFalpha deficiency (via homozygous frameshift) causes recurrent pulmonary TB (via impaired NADPH oxidase activity in macrophages) but not much else: www.nature.com/articles/s41...
it's orders of magnitude milder of a phenotype than i'dve expected.
it's orders of magnitude milder of a phenotype than i'dve expected.
Tuberculosis in otherwise healthy adults with inherited TNF deficiency - Nature
Human TNF is required for respiratory-burst-dependent immunity to Mycobacterium tuberculosis in macrophages but seems to be largely redundant physiologically.
www.nature.com
August 28, 2024 at 4:54 PM
absolutely incredible: complete TNFalpha deficiency (via homozygous frameshift) causes recurrent pulmonary TB (via impaired NADPH oxidase activity in macrophages) but not much else: www.nature.com/articles/s41...
it's orders of magnitude milder of a phenotype than i'dve expected.
it's orders of magnitude milder of a phenotype than i'dve expected.
Yes. If the infection is too far ahead of the immune system, you can get uncontrolled activation leading to massive cytokine release that also stimulates the release of cytokines more systemically. The liver is a huge source of inflammatory cytokines - IL-1beta, TNFalpha and IL-6.
December 29, 2024 at 3:43 PM
Yes. If the infection is too far ahead of the immune system, you can get uncontrolled activation leading to massive cytokine release that also stimulates the release of cytokines more systemically. The liver is a huge source of inflammatory cytokines - IL-1beta, TNFalpha and IL-6.
> TGF-beta is still the master, no?
think TNFalpha still has it beaten in that regard imho.
think TNFalpha still has it beaten in that regard imho.
January 29, 2025 at 10:52 PM
> TGF-beta is still the master, no?
think TNFalpha still has it beaten in that regard imho.
think TNFalpha still has it beaten in that regard imho.
lese hier gerade gespannt mit..
ist das ganze TNFalpha oder IL-6 abhängig?
habt ihr es schon mit höherer Ballaststoff Zufuhr vor+während der Depressionsphase versucht (z.b. täglich 1/4 Knolle Fenchel o.ä.)?
ist das ganze TNFalpha oder IL-6 abhängig?
habt ihr es schon mit höherer Ballaststoff Zufuhr vor+während der Depressionsphase versucht (z.b. täglich 1/4 Knolle Fenchel o.ä.)?
April 14, 2026 at 12:39 PM
lese hier gerade gespannt mit..
ist das ganze TNFalpha oder IL-6 abhängig?
habt ihr es schon mit höherer Ballaststoff Zufuhr vor+während der Depressionsphase versucht (z.b. täglich 1/4 Knolle Fenchel o.ä.)?
ist das ganze TNFalpha oder IL-6 abhängig?
habt ihr es schon mit höherer Ballaststoff Zufuhr vor+während der Depressionsphase versucht (z.b. täglich 1/4 Knolle Fenchel o.ä.)?
ja und Kynurein Stoffwechsel
Hier und in den Posts drüber+drunter hab ich's versucht zu erklären :
bsky.app/profile/h2ob...
und darüber hinaus, TNFalpha Level sind meines Wissens Zyklus abhängig und wirken auf IDO 🤔
Hier und in den Posts drüber+drunter hab ich's versucht zu erklären :
bsky.app/profile/h2ob...
und darüber hinaus, TNFalpha Level sind meines Wissens Zyklus abhängig und wirken auf IDO 🤔
vor allem kann man mit diesem Wissen wenigstens ein bisschen Gegensteuern. Im Fall von Kynurein Stoffwechsel z.b. mit Ballaststoffen. Die Bakterien in unserem Darm produzieren daraus Butyrat, welches IDO (1.Schritt Kynurein Stoffwechsel) runter reguliert. Einige Ballaststoff-Beispiele:
April 14, 2026 at 12:47 PM
ja und Kynurein Stoffwechsel
Hier und in den Posts drüber+drunter hab ich's versucht zu erklären :
bsky.app/profile/h2ob...
und darüber hinaus, TNFalpha Level sind meines Wissens Zyklus abhängig und wirken auf IDO 🤔
Hier und in den Posts drüber+drunter hab ich's versucht zu erklären :
bsky.app/profile/h2ob...
und darüber hinaus, TNFalpha Level sind meines Wissens Zyklus abhängig und wirken auf IDO 🤔
wow. ich fange gerade erst an zu lesen. PEA hat Effekt auf PPAR-α, GPR55, Cox-2, gGT, TNFalpha, usw... Weißt Du ob es eine kontrollierte Studie oder ähnliches im Kontext LongCovid MECFS gibt bzw geplant ist?
April 23, 2026 at 5:10 PM
wow. ich fange gerade erst an zu lesen. PEA hat Effekt auf PPAR-α, GPR55, Cox-2, gGT, TNFalpha, usw... Weißt Du ob es eine kontrollierte Studie oder ähnliches im Kontext LongCovid MECFS gibt bzw geplant ist?
Solving the "sticky" binder issue of aptamer biosensing using an oscillating electric field - with an example of continuous monitoring of IL6 and TNFalpha inflammation markers in diabetic rats ! www.science.org/doi/10.1126/...
Active-reset protein sensors enable continuous in vivo monitoring of inflammation
Continuous measurement of proteins in vivo is important for real-time disease management and prevention. Implantable sensors for monitoring small molecules such as glucose have been available for more...
www.science.org
December 12, 2024 at 2:10 AM
Solving the "sticky" binder issue of aptamer biosensing using an oscillating electric field - with an example of continuous monitoring of IL6 and TNFalpha inflammation markers in diabetic rats ! www.science.org/doi/10.1126/...
I don’t have CRPS but I have MCAS and found this recently: pubmed.ncbi.nlm.nih.gov/15019283/ idk if this is helpful at all but your recent posts made me think of it
Mast cells are involved in inflammatory reactions during Complex Regional Pain Syndrome type 1 - PubMed
Mast cells are involved in inflammatory reactions during the CRPS1. Mast cells could play a role in the production of cytokines such as TNFalpha.
pubmed.ncbi.nlm.nih.gov
January 15, 2025 at 12:47 AM
I don’t have CRPS but I have MCAS and found this recently: pubmed.ncbi.nlm.nih.gov/15019283/ idk if this is helpful at all but your recent posts made me think of it
If I had to guess, I'd say it's a cytokine that also fluctuates in response to hormonal changes, such as TNFalpha.
May 6, 2026 at 6:54 PM
If I had to guess, I'd say it's a cytokine that also fluctuates in response to hormonal changes, such as TNFalpha.
In addition to wrongly claiming T cell exhaustion (wrong, T cells are fit & make cytokines), reduced CD4 T cells & increased CD8 T cells making TNFalpha (not what data shows), your team is now engaging with pseudoscience. It gives false hope and erodes trust in science bsky.app/profile/marc...
February 21, 2025 at 12:39 PM
In addition to wrongly claiming T cell exhaustion (wrong, T cells are fit & make cytokines), reduced CD4 T cells & increased CD8 T cells making TNFalpha (not what data shows), your team is now engaging with pseudoscience. It gives false hope and erodes trust in science bsky.app/profile/marc...
Ah, one of my favourite topics!
What bits of immune system are essential to treat certain infections from people receiving targeted immunotherapy.
Here TNFalpha looks quite redundant in preventing invasive fungal disease! #ImmunoSky #MedSky #IDSky #MicroSky
academic.oup.com/cid/advance-...
What bits of immune system are essential to treat certain infections from people receiving targeted immunotherapy.
Here TNFalpha looks quite redundant in preventing invasive fungal disease! #ImmunoSky #MedSky #IDSky #MicroSky
academic.oup.com/cid/advance-...
Incidence and risk factors for invasive fungal infections in patients initiating TNF-alpha inhibitors for inflammatory bowel disease and rheumatoid arthritis
Fewer than 0.5% of patients with inflammatory bowel disease or rheumatoid arthritis developed an IFI within one year of initiating TNF-alpha therapy. Histo
academic.oup.com
September 3, 2024 at 9:10 PM
Ah, one of my favourite topics!
What bits of immune system are essential to treat certain infections from people receiving targeted immunotherapy.
Here TNFalpha looks quite redundant in preventing invasive fungal disease! #ImmunoSky #MedSky #IDSky #MicroSky
academic.oup.com/cid/advance-...
What bits of immune system are essential to treat certain infections from people receiving targeted immunotherapy.
Here TNFalpha looks quite redundant in preventing invasive fungal disease! #ImmunoSky #MedSky #IDSky #MicroSky
academic.oup.com/cid/advance-...
We also had discussion of TNFalpha signaling, the function of processing proteins for protein folding like PDI, as well as what it means for a cell to shed membrane proteins.
March 5, 2025 at 4:15 PM
We also had discussion of TNFalpha signaling, the function of processing proteins for protein folding like PDI, as well as what it means for a cell to shed membrane proteins.
Sleep disruption increases inflammatory cytokines like IL6 and TNFalpha even in healthy people. Modest reductions in sleep time—just 6 hours—increases these cytokines compared to 8 hours
November 21, 2024 at 6:41 PM
Sleep disruption increases inflammatory cytokines like IL6 and TNFalpha even in healthy people. Modest reductions in sleep time—just 6 hours—increases these cytokines compared to 8 hours
Parkinson's disease-derived alpha-Synuclein assemblies combined with TNFalpha and Prostaglandin E2 induces a specific chronic-type inflammatory phenotype in microglial cells https://www.biorxiv.org/content/10.1101/2023.11.30.569208v1
Parkinson's disease-derived alpha-Synuclein assemblies combined with TNFalpha and Prostaglandin E2 induces a specific chronic-type inflammatory phenotype in microglial cells https://www.biorxiv.org/content/10.1101/2023.11.30.569208v1
Parkinson's disease (PD) is a common age-related neurodegenerative disorder characterized by the agg
www.biorxiv.org
December 2, 2023 at 12:16 AM
Parkinson's disease-derived alpha-Synuclein assemblies combined with TNFalpha and Prostaglandin E2 induces a specific chronic-type inflammatory phenotype in microglial cells https://www.biorxiv.org/content/10.1101/2023.11.30.569208v1
Roughly 20% to 30% of people with Crohn's will not respond to the other more well established medications. This puts us at 20K to 30K people, nationwide needing this specific medication, or similar (non-TNFalpha blocker immunosuppressant; They're priced similarly to Entyvio).
3/7
3/7
December 6, 2024 at 5:50 AM
Roughly 20% to 30% of people with Crohn's will not respond to the other more well established medications. This puts us at 20K to 30K people, nationwide needing this specific medication, or similar (non-TNFalpha blocker immunosuppressant; They're priced similarly to Entyvio).
3/7
3/7
📰 New in BMC Rheumatology:
Lifestyle factors like smoking, obesity & alcohol impact TNFα inhibitor outcomes in axial SpA (14-country study). Supports integrated care in rheumatology.
Read article👉 shorturl.at/cmBY6
#Rheumatology #AxialSpA #TNFalpha #LifestyleMedicine #BMC #EuroSpA #Publication
Lifestyle factors like smoking, obesity & alcohol impact TNFα inhibitor outcomes in axial SpA (14-country study). Supports integrated care in rheumatology.
Read article👉 shorturl.at/cmBY6
#Rheumatology #AxialSpA #TNFalpha #LifestyleMedicine #BMC #EuroSpA #Publication
The relationship between lifestyle factors and outcome of treatment with TNFα inhibitors in axial spondyloarthritis – results from 14 European countries - BMC Rheumatology
Objectives To quantify the influence of lifestyle factors on tumour necrosis factor inhibitor (TNFi) treatment response, in axial spondyloarthritis (axSpA). Methods Data on biologics-naïve adults with...
shorturl.at
July 31, 2025 at 9:35 AM
📰 New in BMC Rheumatology:
Lifestyle factors like smoking, obesity & alcohol impact TNFα inhibitor outcomes in axial SpA (14-country study). Supports integrated care in rheumatology.
Read article👉 shorturl.at/cmBY6
#Rheumatology #AxialSpA #TNFalpha #LifestyleMedicine #BMC #EuroSpA #Publication
Lifestyle factors like smoking, obesity & alcohol impact TNFα inhibitor outcomes in axial SpA (14-country study). Supports integrated care in rheumatology.
Read article👉 shorturl.at/cmBY6
#Rheumatology #AxialSpA #TNFalpha #LifestyleMedicine #BMC #EuroSpA #Publication
HDX-MS Detects Steric Protection and Trimeric Compaction of TNFalpha after It Binds Receptors or Antibodies https://pubmed.ncbi.nlm.nih.gov/42597968/
August 14, 2026 at 6:15 PM
HDX-MS Detects Steric Protection and Trimeric Compaction of TNFalpha after It Binds Receptors or Antibodies https://pubmed.ncbi.nlm.nih.gov/42597968/
Visceral Leishmaniasis-Associated Hemophagocytic Lymphohistiocytosis in a Patient With Crohn's Disease in Therapy With Anti-TNFalpha: A Challenging Diagnostic Case Report pubmed.ncbi.nlm.nih.gov/42529119/
July 31, 2026 at 8:51 PM
Visceral Leishmaniasis-Associated Hemophagocytic Lymphohistiocytosis in a Patient With Crohn's Disease in Therapy With Anti-TNFalpha: A Challenging Diagnostic Case Report pubmed.ncbi.nlm.nih.gov/42529119/
TNFalpha interacting protein 1 as a potential player in neuronal survival, growth and differentiation in the cerebellar cortex #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-10203779/latest
https://www.researchsquare.com/article/rs-10203779/latest
July 15, 2026 at 10:02 PM
TNFalpha interacting protein 1 as a potential player in neuronal survival, growth and differentiation in the cerebellar cortex #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-10203779/latest
https://www.researchsquare.com/article/rs-10203779/latest
TNFalpha interacting protein 1 as a potential player in neuronal survival, growth and differentiation in the cerebellar cortex #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-10203779/latest
https://www.researchsquare.com/article/rs-10203779/latest
July 15, 2026 at 10:00 PM
TNFalpha interacting protein 1 as a potential player in neuronal survival, growth and differentiation in the cerebellar cortex #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-10203779/latest
https://www.researchsquare.com/article/rs-10203779/latest
Wenn wir bei ca 1000€ pro Monat bleiben, sehe ich TNFalpha AK etc.
Das bekommen 185.000 Patienten in der GKV.
Gesamtkosten 2.2 Mrd.
Das bekommen 185.000 Patienten in der GKV.
Gesamtkosten 2.2 Mrd.
November 13, 2025 at 9:26 PM
Wenn wir bei ca 1000€ pro Monat bleiben, sehe ich TNFalpha AK etc.
Das bekommen 185.000 Patienten in der GKV.
Gesamtkosten 2.2 Mrd.
Das bekommen 185.000 Patienten in der GKV.
Gesamtkosten 2.2 Mrd.