#TopRead
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September 14, 2026 at 10:16 AM
An August #TopRead from @carpenterlab.bsky.social demonstrates that heterogeneous nuclear ribonucleoprotein A2B1 is essential for optimal macrophage function, highlighting the role for RNA-binding proteins in mounting effective immune defenses. Read more: ow.ly/NSx150WTnSr.
September 10, 2025 at 1:26 PM
In this #TopRead article, data demonstrated that TNFR family member CD27 is a metabolic regulator in activated human CD4+ cells, suggesting its essential contribution to T-cell metabolism and its relevance as a therapeutic target. Read more in The JI: ow.ly/bCJk50WJAwi.
August 27, 2025 at 12:45 PM
Data indicate that human CD4+ mucosal-associated invariant T cell TCRs may be selected by alternative MR1 ligands in addition to canonical riboflavin intermediates. Find this #TopRead article from @charlesvorkas.bsky.social and team online: ow.ly/hcNc50XYarT.
January 19, 2026 at 3:54 PM
If you haven’t read Quicksilver yet, it is time! 💕🔥 #quicksilver #love #books #booksky #fantasy #romantasy #read #obsessed #perfect #topread
January 3, 2025 at 5:41 AM
Dr. John V Williams and his team characterized the role of CD4+ helper T Cells in response to human metapneumovirus (HMPV), identifying a dominant CD4+ T cell epitope and constructing the first MHC-II tetramer for HMPV. Learn more in this #TopRead article: ow.ly/Hern50WJAB3
August 26, 2025 at 5:17 PM
Data show that BRGSF-HIS mice possess human myeloid and lymphoid cell compartments in the lung interstitium comparable to humans, providing an opportunity for studying immune mechanisms of human lung diseases. This #TopRead is a collaboration led by Dr. Doumet Georges Helou: ow.ly/c5JL50XYaBP.
January 21, 2026 at 3:50 PM
New data reveals the complex relationship between bone marrow antibody secreting repertoires, mucosal humoral immune responses, and B cell receptor antigen specificity during #influenza infection. Read more in this #TopRead article: ow.ly/3INy50Xt1vV.
Clonally expanded IgG, but not IgA, antibody-secreting cells preferentially target influenza nucleoprotein following homologous and heterologous infections
The Editors have selected this article as a highlight of the issue.
ow.ly
November 21, 2025 at 7:53 PM
Our next March #TopRead is from Dr. Lewis Lanier and is the final paper of his career, demonstrating that SYK deletion in NK cells resulted in robust cytotoxic activity and cytokine production, providing a new strategy for cancer immunotherapy. Read more: ow.ly/UmtX50VAj25.
April 15, 2025 at 3:19 PM
A #TopRead article from Dr. Jesse Bruijnesteijn found that a diverse repertoire of killer cell immunoglobulin-like receptors (KIRs) contributes to the protection of individuals and populations against pathogen evasion and subversion. Read it in The JI: ow.ly/vJRk50VJI7H
Exploring the genetic mechanisms driving KIR diversification
The Editors have selected this article as a highlight of the issue.
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May 14, 2025 at 9:32 PM
Today’s #TopRead Article in May from #ACareyLab at #DrexelMedicine provides insights on the age-specific role of cathelicidin-related antimicrobial peptide (CRAMP) in influenza viral pathogenesis. Learn more: ow.ly/S2cb50W0eR5
June 3, 2025 at 1:20 PM
Targeting the immune checkpoint inhibitory receptor VISTA improved disease severity in a mouse model of neutrophil-mediated arthritis. Researchers investigate the novel therapeutic opportunity for targeting VISTA in this September #TopRead article: ow.ly/iueJ50X6mlo
The role of VISTA engagement in limiting neutrophil-mediated inflammation
The Editors have selected this article as a highlight of the issue.
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October 9, 2025 at 1:28 PM
We’re sharing the #TopRead articles from March! Read Dr. Gennaro’s research, which found that some kids with multisystem inflammatory syndrome carried rare heterozygous variants of LYST that may be a potential driver of #LongCOVID: ow.ly/REtf50VAiPG
A genetically modulated Toll-like receptor-tolerant phenotype in peripheral blood cells of children with multisystem inflammatory syndrome
The Editors have selected this article as a highlight of the issue.
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April 14, 2025 at 8:49 PM
In a #TopRead from Dr. Brian V. Geisbrecht, data show that Efb-C binding to C3b exerts additional inhibitory effects on the central complement components beyond blocking formation of the C3 proconvertase alone. Learn more: https://ow.ly/qzT150Z19xV.
May 23, 2026 at 8:45 PM
This November #TopRead from Wei Luo and Shlomchik Lab demonstrated that PTEN deficiency selectively expanded germinal center B cells in Peyer’s patches but had no impact on those induced by immunization, revealing an unknown role for PTEN. Read more: ow.ly/Ia9k50XAbiP.
December 3, 2025 at 2:55 PM
#ICYMI: From Dr. Joel R. Wilmore, this #TopRead emphasizes how understanding how function is regulated in tissue-resident plasma cells can be used to improve antibody responses that target mucosal pathogens and optimize mucosal vaccines. Learn more: https://ow.ly/7nCw50Z19qM.
May 18, 2026 at 7:30 PM
#TopRead and #clinical study from Dr. Celestine Wanjalla, MD PhD, found that circulating CD3+ T-cell: CD14+ monocyte pairs may contribute to inflammation and cardiometabolic disease pathogenesis, potentially originating or maintained by chronic viral infections.

🔗 ow.ly/X37Y50VAjr8
CD3+ T-cell: CD14+ monocyte complexes are dynamic and increased with HIV and glucose intolerance
The Editors have selected this article as a highlight of the issue.
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April 17, 2025 at 2:46 PM
June #TopRead from @ualberta.bsky.social and @wchriuofa.bsky.social found distinct gene expression profiles in CD71+ erythroid cells at various developmental stages, suggesting a critical role for Gal-3 in modulating erythropoiesis and enhancing immunoregulation. Read more: ow.ly/L8uv50WiiFm.
Galectin-3 regulates erythropoiesis and enhances the immunoregulatory properties of CD71+ erythroid cells across developmental stages
The Editors have selected this article as a highlight of the issue.
ow.ly
July 3, 2025 at 2:07 PM
Book Reviews with Amber ~ The Cat Book Connoisseur at The Mewton-Clawson Library ~ #356 featuring **The Cat Who Knew Shakespeare** by Lilian Jackson Braun bionicbasil.blogspot.com/2026/04/book... #catfiction #cozy #bookreview #librarycat #literarycat #bibliokitty #amreading #goodbook #topread
Book Reviews with Amber ~ The Cat Book Connoisseur at The Mewton-Clawson Library ~ #356 featuring **The Cat Who Knew Shakespeare** by Lilian Jackson Braun **PLUS** Friendly Fill-Ins
Amber reviews The Cat Who Knew Shakespeare at the Mewton‑Clawson Library—fax magic, glowing pen, and feline literary nostalgia all at BBHQ
bionicbasil.blogspot.com
April 9, 2026 at 11:01 AM
Another #TopRead developed a novel TOX-nanoluciferase-based reporter system that can be used to monitor TOX expression and facilitate the screening of molecules that modulate cytotoxic T-cell exhaustion. Learn more: ow.ly/O9oW50WijyF.
A novel TOX-nanoluciferase reporter mouse for exploring modulators of T cell exhaustion
The Editors have selected this article as a highlight of the issue.
ow.ly
July 7, 2025 at 6:40 PM
Our final March #TopRead is from Dr. Carl Ware, @sbpdiscovery.bsky.social, who described the first method to directly quantify the HVEM-BTLA cis-complex. Find it in The JI: ow.ly/nElT50VAjzY.
April 18, 2025 at 3:24 PM