a, UMAP of hematopoietic progenitor and mature immune cells. Cells are colored by targeted enrichment strategy (left); non-CHIP (top-right; n = 53,382) and CHIP (bottom-right; n = 35,431). b, Heatmap representing column-scaled expression of selected markers used for cell type annotation. c, Box plots showing frequency of populations in the hematopoietic progenitor (left) and mature immune (right) libraries in non-CHIP (n = 9) and CHIP (n = 6). Boxes span the 25th to 75th percentile, with the horizontal bar in the center representing the 50th percentile, and whiskers spanning 1.5 x IQR. Hypothesis testing was performed using two-sided Wilcoxon rank-sum test, and p-values were FDR adjusted. d, Heatmap representing column-scaled frequencies per sample of hematopoietic progenitor libraries mapped to ‘Level3R’ annotations published by Zhang et al. (2024). e-f, Bar plots representing colony forming units (CFU) per total BM fraction mononuclear cells (MNC; e) in non-CHIP (n = 15) and CHIP (n = 13) and CD34+ cells (f) in non-CHIP (n = 5) and CHIP (n = 4). Data is shown as mean value +/- SEM. Hypothesis testing was performed using two-sided Student’s t-test and p-values were FDR adjusted. g, Heatmap of top 2 population-defining regulons derived from SCENIC in progenitor...

locres, uasset, umap localization tool. Ukrainian language only. Create forks and translate it for yourself. - hikarosato/UELT