#USP8
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rridrobot.bsky.social
The authors included RRIDs in their in Cellular and Molecular Life Sciences paper! We value the author's support of reproducibility. #OpenScience #RRID #BetterScience
USP8-mediated mitochondrial regulation in osteoclasts is essential for skeletal development
Read the full paper: USP8-mediated mitochondrial regulation in osteoclasts is essential for skeletal development
doi.org
October 8, 2026 at 7:06 AM
ivarssonlab.bsky.social
We uncover that the #USP8 rhodanese domain is a #peptide binding module that binds short linear motifs in potential substrates: biologydirect.biomedcentral.com/articles/10....
Elucidation of short linear motif-based interactions of the MIT and rhodanese domains of the ubiquitin-specific protease 8 - Biology Direct
Ubiquitin-specific protease 8 (USP8) is a deubiquitinating enzyme with essential functions in protein trafficking and stability. It is a multidomain protein, with an N-terminal MIT (microtubule intera...
biologydirect.biomedcentral.com
May 6, 2025 at 1:21 PM
eurojendo.bsky.social
Prevalence and clinical associations of #USP8 variants in corticotroph tumours: a systematic review and aggregate data meta-analysis of 2171 cases by Luis G Perez-Rivas et al

EJE Volume 192, Issue 6, June 2025
Open access 👉 doi.org/10.1093/ejen...

#Cushingsdisease
Prevalence and clinical associations of USP8 variants in corticotroph tumours: a systematic review and aggregate data meta-analysis of 2171 cases
AbstractObjective. Somatic USP8 variants are common in corticotroph tumours, but their reported prevalence and association with clinical characteristics va
doi.org
August 5, 2025 at 2:40 PM
springermedicine.com
#MedNews - USP8 mutation status combined with tumor size helps predict recurrence risk after pituitary surgery in patients with #CushingDisease.

Full story 👉 buff.ly/0q0Az0i

#EndoSky #OncSky
USP8 genotype with tumor size point to Cushing disease recurrence
USP8 mutation status combined with tumor size helps predict recurrence risk after pituitary surgery in patients with Cushing disease.
www.springermedicine.com
March 21, 2026 at 11:54 AM
jldelapompa-cnic.bsky.social
Mechanistically, they found that loss of endothelial Usp8 led to VEGFR2 accumulation in early endosome aggregates and reduced phospho-ERK signaling. Congratulations to all!
Working model for endothelial USP8 function: USP8 acts as an encouraging swift mother, leading its VEGFR2 children to try the outer world again and again, and be activated by angiogenic signals. When the mother is out hunting bugs, they don't risk outside and pERK can't induce angiogenesis.
February 11, 2026 at 3:20 PM
jcb.org
Endo, Saeki, Komada et al. demonstrate that USP8 is a gatekeeper of misdirected #ubiquitin signals to prevent immune and stress responses. rupress.org/jcb/article/...

📕 Part of #Lysosomes 2026: rupress.org/jcb/collecti...
June 17, 2026 at 5:15 PM
jcb.org
Endo, Saeki, Komada et al. demonstrate that USP8 is a gatekeeper of misdirected #ubiquitin signals to prevent immune and stress responses. rupress.org/jcb/article/...

📕 Part of #Lysosomes 2026: rupress.org/jcb/collecti...
June 5, 2026 at 3:15 PM
jldelapompa-cnic.bsky.social
Great, great news! We just published a paper!🥳 Alba Pau Navalón, other members of our lab and @henarcuervo.bsky.social identified endothelial USP8 as a key regulator of angiogenesis across developmental and postnatal context. Even more interesting details in Angiogenesis (doi.org/10.1007/s104...)!
USP8 deletion in the endothelium disrupted formation of intersomitic vessels, both in the rostral and the caudal regions. More in Angiogenesis (https://doi.org/10.1007/s10456-025-10027-3)! Today Alba is not a flamingo, but a stork (_Ciconia ciconia_). OK, it was published on the 28th of january, not on the 3rd of february, but around San Blas, las cigüeñas verás (At St Blaise, their flight the storks raise). Credit to Fernando Losada Rodríguez (https://commons.wikimedia.org/wiki/User:Drow_male) for the picture.
February 11, 2026 at 3:20 PM
dmmjournal.bsky.social
Systemic and cardiac pathology induced by a clinically relevant USP8 activating mutation

Read and share the Research Article by Tamara González-Costa and colleagues @jldelapompa-cnic.bsky.social for free: doi.org/10.1242/dmm....
September 1, 2026 at 9:30 AM
cp-cellreports.bsky.social
USP8 deubiquitylation-boosted NSUN4 potentiates lung squamous cell carcinoma progression by m5C methylation of DHCR24
USP8 deubiquitylation-boosted NSUN4 potentiates lung squamous cell carcinoma progression by m5C methylation of DHCR24
Jiang et al. explore the regulation and biological functions of 5-methylcytosine in lung squamous cell carcinoma modifications. USP8-mediated NSUN4 K11-linked ubiquitination inhibits DHCR24 degradation. The USP8/NSUN4/m5C DHCR24 signaling axis promotes squamous cell carcinoma pathogenesis.
dlvr.it
August 25, 2025 at 2:38 PM
jdhl18.bsky.social
Mechanical signal modulates prostate cancer immune escape by USP8-mediated ubiquitination-dependent degradation of PD-L1 and MHC-1
www.nature.com/articles/s41...
Mechanical signal modulates prostate cancer immune escape by USP8-mediated ubiquitination-dependent degradation of PD-L1 and MHC-1 - Cell Death & Disease
Cell Death & Disease - Mechanical signal modulates prostate cancer immune escape by USP8-mediated ubiquitination-dependent degradation of PD-L1 and MHC-1
www.nature.com
June 7, 2025 at 7:22 AM
thelancetendo.bsky.social
Our results support a novel three-tier risk assessment system that integrates #USP8 #genetic status and tumour size to predict #recurrence after first #pituitary #surgery www.thelancet.com/journals/lan...
#Cushing's disease
#OpenAccess

#MedSky #EndoSky #OncSky
Risk of recurrence after successful surgery for Cushing's disease and association with USP8 genotype and tumour size: an international, retrospective, longitudinal cohort study
Combined USP8 genotype–tumour size identified patients at increased risk of recurrence, particularly in largely heterogeneous groups of patients with non-invasive tumours or low postoperative serum co...
www.thelancet.com
March 5, 2026 at 9:26 AM
thelancetendo.bsky.social
New—Risk of #recurrence after successful #surgery for #Cushing's disease and association with #USP8 #genotype and tumour size: an international, retrospective, longitudinal cohort study thelancet.com/journals/lan...
#OpenAccess

#MedSky #EndoSky
March 3, 2026 at 7:03 AM
rridrobot.bsky.social
The authors included RRIDs in their None paper! We value the author's support of reproducibility. #reproducibility #RRID #reproducibility
Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction
doi.org
July 30, 2025 at 7:00 AM
marilytheodor.bsky.social
Prevalence and clinical associations of USP8 variants in corticotroph tumours: a systematic review and aggregate data meta-analysis of 2171 cases url:https://academic.oup.com/ejendo/article/doi/10.1093/ejendo/lvaf097/8138366
May 20, 2025 at 4:43 PM
rridrobot.bsky.social
The authors included RRIDs in their Science Advances paper! We value the author's support of reproducibility. #methodsmatter #OpenScience #ReproducibleResearch
USP8 and Hsp70 regulate endoreplication by synergistically promoting Fzr deubiquitination and stabilization
doi.org
May 18, 2025 at 7:00 AM
rridrobot.bsky.social
RRID:Addgene_12260, was just reported to be used in "Targeting USP8 causes synthetic lethality through degradation of FGFR2 in ARID1A-deficient ovarian clear cell carcinoma". We appreciate the author's support of reproducibility. #STMpublishing #STMpublishing
doi.org
April 5, 2025 at 7:01 AM
rridrobot.bsky.social
@proteintech.bsky.social's resource, RRID:AB_10665424, was just reported to be used in the paper. We value the author's support of reproducibility. #methodsmatter #ReproducibleResearch #OpenScience
USP8 deubiquitylation-boosted NSUN4 potentiates lung squamous cell carcinoma progression by m5C methylation of DHCR24
doi.org
August 16, 2025 at 7:01 AM
cniostopcancer.bsky.social
Alban Ordureau, from the Memorial Sloan Kettering Cancer Center @mskcancercenter.bsky.social, shared some of his team's research on the enzyme USP8, that helps recycle some components inside the cell.

This enzyme is mutated in some diseases.

Ordureau was invited by Marta Isasa
April 20, 2026 at 10:46 AM
2024dgd.bsky.social
New article in DGD.
Sbno1 and Usp8 Cooperate to Enhance Notch Signaling in Regulating Neural Stem Cells
Naranbaatar O, Ihara D, Tabata H, Zolzaya S, Shimizu A, Kikkawa T, Hibi M, Ogita H, Katsuyama Y
https://doi.org/10.1111/dgd.70062
June 21, 2026 at 9:50 AM
2024dgd.bsky.social
DGD Volume 68, Issue 6 was released!!
Cover: Embryonic day 13.5 mouse cerebral cortex. The Notch deubiquitinating enzyme Usp8 (red) is expressed in neural stem cells (marked by Pax6; green), exhibiting a salt‐and‐pepper pattern. (see https://onlinelibrary.wiley.com/doi/10.1111/dgd.70062)
https://do…
July 16, 2026 at 7:11 PM
rridrobot.bsky.social
The authors included RRIDs in their The Journal of Clinical Endocrinology & Metabolism paper! We value the author's support of reproducibility. #RRID #RRID #reproducibility
The USP8 Mutational Status in Combination With Postsurgical Cortisol Levels for Predicting Recurrence of Cushing Disease
doi.org
June 1, 2025 at 7:00 AM
endocrineoncology.bsky.social
New research by Elisa Lamback et al. compares the expressions of POMC-processing genes across corticotroph tumour (CT) subtypes to elucidate mechanisms underlying their functional spectrum, identifying a potential new regulator of the secretory properties of CTs.

🔗 doi.org/10.1530/EO-26-0003
Endocrine Oncology logo. Differential expression of POMC-processing genes in corticotroph tumors. By Elisa Lamback et al. Figure 4. Summary of findings comparing functioning corticotroph tumors to nonfunctioning corticotroph tumors. Genes are highlighted in italic. The blue lines indicate stimulation, the red lines inhibition, and the dotted lines indirect mechanism. By comparing the three groups of corticotroph tumors by secretory behavior (USP8+ FCTs with the highest secretion index, followed by WT FCTs with a lower secretion index and NFCTs), we found that TBX19 and PCSK1 expressions are increased in USP8+ and WT FCTs compared to NFCTs. We also found that, in FCTs, PCSK1N expression was decreased in USP8+ FCTs compared to WT FCTs. These data suggest that USP8 might act indirectly in PCSK1 and PCSK1N expressions modulating the tumor’s secretion...Endocrine Oncology 6, 1; 10.1530/EO-26-0003 Published by Bioscientifica. 80 Years 1946-2026 Society for Endocrinology logo.
May 5, 2026 at 10:59 AM
dmmjournal.bsky.social
Read the cover article by Tamara González-Costa et al: Systemic and cardiac pathology induced by a clinically relevant USP8 activating mutation

journals.biologists.com/dmm/article/...
August 13, 2026 at 10:02 AM
dmmjournal.bsky.social
Issue 7 is complete.

Cover: Expression of a clinically relevant USP8 mutation in mice induces musculoskeletal, cardiac and ocular abnormalities, recapitulating key aspects of the corresponding human genetic syndrome.

Full issue: journals.biologists.com/dmm/issue/19/7
Journal cover showing three grayscale 3D reconstructions of developing craniofacial skeletons arranged side-by-side on a black background, illustrating comparative skull morphology for Disease Models & Mechanisms.
August 13, 2026 at 10:02 AM