CHICAGO — A bicyclist is recovering in the hospital after he was critically injured in a crash on the city’s South Side on Monday afternoon. According to Chicago police, the crash unfolded ju…

A review of dozens of incidents caught on camera sheds new light on a largely invisible crackdown.

Welcome back to Arrowhead Pride Mailbag! Throughout the season, keep watching The Feed for a chance to submit your questions about the Kansas City Chiefs! The box score and advanced metrics paint a better picture than the Chiefs' Week 3 24-10 victory over the Miami Dolphins felt as the actual game unfolded. Let's see what our readers have in mind ahead of Sunday's unexpected 3-0 team's matchup against the Las Vegas Raiders.

Welcome back to Arrowhead Pride Mailbag! Throughout the season, keep watching The Feed for a chance to submit your questions about the Kansas City Chiefs! The box score and advanced metrics paint a better picture than the Chiefs' Week 3 24-10 victory over the Miami Dolphins felt as the actual game unfolded. Let's see what our readers have in mind ahead of Sunday's unexpected 3-0 team's matchup against the Las Vegas Raiders.

A review of dozens of incidents caught on camera sheds new light on a largely invisible crackdown.

A review of dozens of incidents caught on camera sheds new light on a largely invisible crackdown.

Pi has been approximated for about 3,600 years. Archimedes bounded it with polygons around 250 BC, Aryabhata gave 3. See how it unfolded, 1400–2025, milestone by milestone — the complete pi day history, including computing pi and pi world record. From Archimedes and Aryabhata to ENIAC, y-cruncher and the 314 trillion digit record: how computing pi became a test of computers, era by era. Explore the full timeline.

KUALA LUMPUR — ViewSonic has begun shipping the fourth generation of its mobile Direct View LED display, introducing a 136-inch foldable screen designed to give organisations a large-format alternative to permanently installed LED walls. The LDS136-152 arrives pre-assembled in a protective flight case and can be unfolded and prepared for operation within minutes, according to …

A review of dozens of incidents caught on camera sheds new light on a largely invisible crackdown.

A review of dozens of incidents caught on camera sheds new light on a largely invisible crackdown.

AbstractProton-transfer reaction (PTR) has emerged as a powerful tool for top-down proteomics. It can mitigate spectral congestion and improve the signal-to-noise ratio of electrospray ionization (ESI)-generated intact proteins. We hypothesized that charge removal during PTR of Coulombically unfolded, denatured ESI ions induces rapid gas-phase isomerization and refolding, producing charge-state-dependent conformers with altered fragmentation behavior. Here, we test this hypothesis by systematically comparing fragmentation patterns of three model proteins, apomyoglobin, apocalmodulin, and histone H1, with and without PTR using high-resolution top-down mass spectrometry. Highly charged precursor ions were isolated, subjected to PTR, fragmented, and benchmarked against ions of the same charge state generated directly from ESI; ions generated under native-like conditions were also examined. Quantitative analysis of assigned fragment ions and log2 fold-change heatmaps reveal distinct fragmentation patterns, with some regions showing protection from fragmentation, while others yield newly observed or substantially enhanced fragment ions. Notably, characteristic fragmentation signatures around proline and aspartic acid residues further demonstrate structural differences. These results show that protein relaxation after PTR generates different gas-phase ion structures than are formed during ESI and explain, alongside mobile proton theory, why charge reduction produces different sets of fragment ions in top-down MS/MS, but can also yield fragmentation sites otherwise unavailable for higher-charged counterparts and the same charge states generated without PTR.

A review of dozens of incidents caught on camera sheds new light on a largely invisible crackdown.

What would you do to meet your hero? For 10-year-old Massimo, the answer unfolded over the summer, as his family found a way to bring him closer to the Montreal Canadiens and, eventually, to Jakub…

A farmer raised the alarm after she claimed to have seen a group of men and suspicious vehicles near RAF Fairford where some US forces are based - prompting a dramatic security operation

A dramatic clash unfolded on the stage of the United Nations General Assembly in New York. Tensions surrounding the war in Ukraine reached a boiling point as top international leaders presented radically different views on how to stop the bloodshed. Russian Foreign Minister Sergei Lavrov launched a

Imagine renting out your home — only to lose it because the person living there knew exactly how to work the eviction system. That’s what happened to a Texas homeowner who fell victim to Heather…