#VCP/p97
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replifate.bsky.social
Just published!

Lecona (@emlecona.bsky.social ) & Méndez #RepliFate labs show that VCP/p97 removes Pol α/primase from chromatin to avoid excess ATR activation during normal #DNAreplication

VCP/p97 = checkpoint gatekeeper!

Read the full study: doi.org/10.1038/s414...
DNA polymerase α/primase extraction from chromatin by VCP/p97 restricts ATR activation during unperturbed DNA replication - Nature Communications
The replication stress response ensures genomic stability throughout DNA duplication. Here, the authors show that VCP/p97 extracts the DNA polymerase α/Primase complex from chromatin, preventing exces...
doi.org
July 3, 2025 at 12:03 PM
hemmo-lab.bsky.social
VCP/p97’s accessory adapters (FAF1, FAF2, UBXN7) boost unfolding and subsequent proteasomal degradation. #ubiquitin. Our paper is out now:
Science Advances www.science.org/doi/10.1126/...
The accessory adapters FAF1, FAF2, and UBXN7 accelerate proteasomal degradation by increasing prior p97-mediated substrate unfolding
A group of accessory adapters positions the p97 adapter Ufd1 to boost substrate unfolding and subsequent proteasomal degradation.
www.science.org
March 6, 2026 at 7:11 PM
natmicrobiol.nature.com
🚨 Out now: A new study showing that VCP/p97 extracts ubiquinated proteins from bacterial membranes to lyse and kill intracellular bacterial pathogens
#MicroSky 🦠

www.nature.com/articles/s41...
Host AAA-ATPase VCP/p97 lyses ubiquitinated intracellular bacteria as an innate antimicrobial defence - Nature Microbiology
Host AAA-ATPase VCP/p97 binds and extracts ubiquitinated proteins from the bacterial cell membrane causing bacterial lysis and death to confer cell-autonomous protection against infection.
www.nature.com
April 14, 2025 at 11:14 AM
ffchcarvalho.bsky.social
Host AAA-ATPase VCP/p97 lyses ubiquitinated intracellular bacteria as an innate antimicrobial defence
www.nature.com/articles/s41... #MicroSky
Host AAA-ATPase VCP/p97 lyses ubiquitinated intracellular bacteria as an innate antimicrobial defence - Nature Microbiology
Host AAA-ATPase VCP/p97 binds and extracts ubiquitinated proteins from the bacterial cell membrane causing bacterial lysis and death to confer cell-autonomous protection against infection.
www.nature.com
April 12, 2025 at 11:24 AM
hemmo-lab.bsky.social
@lsajournal.org
doi.org/10.26508/lsa...
Paper out: Cool dTAG approach by Dani and Maike for acute perturbation of the #VCP/p97 system nailing down a function during DNA #replication. #ubiquitin. @crc1430.bsky.social @unidue-zmb.bsky.social Thanks to our collaborators, the Beli and Boos labs.
Induced degradation of Ufd1 reveals regulation of cohesin by the VCP/p97Ufd1-Npl4 complex
The AAA ATPase VCP/p97 has emerged as a critical regulator of ubiquitin and chromatin-associated processes but progress in understanding has been hampered by the complexity of p97 functions and the va...
doi.org
September 4, 2026 at 9:08 AM
hemmo-lab.bsky.social
Great #ubfriends2026 meeting in Vienna. Presented our data on FAF1/2 mediated substrate loading onto VCP/p97. Fantastic talks, discussions and hospitality. Big thank you to the organizers! #ubiquitin
April 30, 2026 at 2:35 PM
emlecona.bsky.social
Very happy to share our recently published work on the role of VCP/p97 during DNA replication.
July 3, 2025 at 1:09 PM
anirban-banerjee.bsky.social
🚨“Ripping bacteria to shreds” 🚨 VCP/p97, a cellular AAA-ATPase, targets and then using its tweezer like action rips apart bacteria, protecting us from infections. A thread 🦠💥#MolecularMachines #HostDefense #cellularimmunity #microbiology
@natmicrobiol.nature.com
www.nature.com/articles/s41...
April 12, 2025 at 1:02 PM
embojournal.org
Why is human p97 ATPase less efficient than yeast Cdc48 in unfolding its protein substrates?
@kulathu.bsky.social et al show how cofactors like FAF2 facilitate efficient unfolding by the human enzyme, & design artificial mini-proteins able to potently activate p97
link.springer.com/article/10.1...
FAF1 and FAF2 enhance unfolding by p97-UFD1-NPL4 complex enabling rational design of p97 activators - The EMBO Journal
VCP/p97 is an AAA+ ATPase that, together with its cofactors UFD1-NPL4 (p97-UN), unfolds ubiquitylated substrates to maintain cellular homeostasis. The human p97-UN complex associates with additional c...
link.springer.com
August 18, 2026 at 5:37 PM
emlecona.bsky.social
Very proud of the work of @rodrimartinr.bsky.social, Sara Rodríguez Acebes and the rest of the team. This has been a long effort with many people involved over the years. We have now a better understanding on how VCP/p97 connects priming during DNA replication and the replication stress response.
July 18, 2025 at 10:02 AM
souravsgw.bsky.social
Happy to share my Ph.D work!!
Our latest paper shows VCP/p97 uses its tweezer-like action to tear invading bacteria apart — a powerful cellular defense! 🦠
@natmicrobiol.nature.com
@BsbeIitb @iitbombay @CSIR
This was years of hard work! Thanks all🙌
#microbiology #cellautonomous #immunity #ubiquitin
anirban-banerjee.bsky.social anirban-banerjee.bsky.social @anirban-banerjee.bsky.social · Apr 12
🚨“Ripping bacteria to shreds” 🚨 VCP/p97, a cellular AAA-ATPase, targets and then using its tweezer like action rips apart bacteria, protecting us from infections. A thread 🦠💥#MolecularMachines #HostDefense #cellularimmunity #microbiology
@natmicrobiol.nature.com
www.nature.com/articles/s41...
April 12, 2025 at 1:45 PM
jcb.org
🔬 From our August issue (rupress.org/jcb/issue/22...): An immunofluorescence image of a primary mouse hepatocyte treated with VCP/p97 siRNA showing endogenous HSD17β13 (yellow) coating #LipidDroplets labeled with Oil Red O (magenta) and nucleus (cyan). From Sen et al. rupress.org/jcb/article/...
August 18, 2025 at 2:08 PM
hemmo-lab.bsky.social
Different ways to target substrate proteins to the VCP/p97 unfolding machine: www.frontiersin.org/journals/mol...
March 10, 2025 at 4:38 PM
jcb.org
Spotlight: Chen Zhang and Wen-Xing Ding @kumedcenter.bsky.social highlight new work from Sen et al. (rupress.org/jcb/article/...), describing how ethanol impairs hepatocyte #LipidDroplet breakdown via a novel UBXD8-p97/VCP-HSD17β13 axis. rupress.org/jcb/article/...

#Steatosis
July 29, 2025 at 7:00 PM
hemmo-lab.bsky.social
We are looking for a PhD student with interest in protein biochemistry on a really cool project “Cooperation of deubiquitinating enzymes and VCP/p97 in cellular stress responses”. Build your own reactions! fully funded. apply with code 193-25. #ubiquitin
April 23, 2025 at 9:56 PM
cryoempapers.bsky.social
Development and Structural Characterization of UTE-156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase pubmed.ncbi.nlm.nih.gov/41793187/ #cryoem
March 8, 2026 at 6:40 PM
jcb.org
Sen, Weller, McNiven et al @mayoclinic.org found the association of a #LipidDroplet protein segregase ATPase, VCP/p97, is reduced in EtOH-damaged hepatocytes, preventing the targeting of a key LD enzyme HSD17β13 to the lysosome, thereby increasing LD content in the cell rupress.org/jcb/article/...
July 29, 2025 at 4:15 PM
ubisystemlab.bsky.social
Fresh from the oven! Ever wondered how cells keep ATR activation controlled during normal DNA replication? Our last paper in @natcomms.nature.com shows that they do it by extracting POLA/PRIM from chromatin using VCP/p97! Still curious? Take a look...🧵🧵🧬🧬
a man is riding a segway in an office with the words welcome aboard below him
ALT: a man is riding a segway in an office with the words welcome aboard below him
media.tenor.com
July 29, 2025 at 5:01 PM
cp-cellreports.bsky.social
STUB1-VCP/p97 complex regulates mitophagy via fine-tuning of PINK1 levels
STUB1-VCP/p97 complex regulates mitophagy via fine-tuning of PINK1 levels
Lin et al. discover that the STUB1-VCP axis mediates the ubiquitination and degradation of full-length PINK1 upon mitochondrial damage, a critical mechanism that fine-tunes PINK1 levels to ensure efficient mitophagy. This fine-tuning mechanism is impaired in Alzheimer’s disease, and its loss disrupts associated learning capability in C. elegans.
dlvr.it
April 17, 2026 at 2:39 PM
crc1430.bsky.social
Excited to share new work from Dani and Maike @hemmo-lab.bsky.social ! 🧬 Their dTAG approach lets them rapidly perturb the #VCP/p97 system and uncover its role during DNA #replication. Congratulations to everyone involved, and thanks to our collaborators in the Beli and Boos labs! #CRC1430
September 25, 2026 at 10:01 AM
sbgrid.bsky.social
SBGrid's eLife paper received a citation in September from Eric Fischer from @danafarber.bsky.social in @natcomms.nature.com Structural basis of VCP-VCPIP1-p47 ternary complex in Golgi maintenance.

Read more here: buff.ly/4xm6yI1

#SBGrid #ScienceMatters
Structural basis of VCP-VCPIP1-p47 ternary complex in Golgi maintenance - Nature Communications
VCPIP1 is a deubiquitylase that binds the essential protein VCP/p97. Here, the authors present cryo-EM structures of VCPIP1 bound to VCP and the VCP-VCPIP1-p47 ternary complex along with biochemical…
buff.ly
October 21, 2025 at 4:06 PM
jcb.org
An ethanol-induced loss of the lipid droplet–associated segregase VCP/p97 leads to hepatic #steatosis, say Sandhya Sen, Shaun Weller, Mark McNiven and colleagues @mayoclinic.org: rupress.org/jcb/article/...

#LipidDroplets
August 5, 2025 at 6:20 PM
bpodaily.bsky.social
How p97/VCP enzyme disposes of harmful aggresome protein clumps – clues for tackling neurodegenerative disease

📷 Maria Körner & Paul Müller et al, University of Würzburg
in @natcomms.nature.com

➡️ bpod.org.uk/archive/2025... with @rooph.bsky.social
June 23, 2025 at 1:21 PM
hemmo-lab.bsky.social
New VCP/p97 review article. Report on the excellent VCP meeting at CalTech last year and great overview on VCP and VCP disease.
doi.org/10.1016/j.nb...
March 11, 2025 at 10:33 AM