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North Korea test-launches ballistic missiles, South Korea and Japan say

Incorporating photoisomerizable moieties within drugs offers the possibility of rapid and reversible light-dependent switching between active and inactive configurations. Here, we developed a photoswitchable adenosine A3 receptor (A3R) agonist that confers optical control on this G protein-coupled receptor through noninvasive topical skin irradiation in an animal model of psoriasis. This was achieved by covalently bonding an adenosine-5′-methyluronamide moiety to a diazocine photochrome, whose singular photoswitching properties facilitated repeated interconversion between a thermally stable, biologically inactive Z agonist form and a photoinduced, pharmacologically active E configuration. As a result, our photoswitchable agonist allowed the precise modulation of A3R function both in vitro and in vivo, which led to a clear light-controlled pharmacotherapeutic effect on mouse skin lesions. This breakthrough not only demonstrates the potential of diazocine photoswitches for in vivo photopharmacology but also paves the way for the development of new strategies for skin-related diseases that require localized and temporally controlled drug action.

‘To experience the Buddha directly is to be fully present with what is, without clinging or resistance. It is to engage with the moment, each thought, each feeling, as an expression of the Dharma.’ Everyday Buddhism

Loco A3R finally arrived in Downpatrick on Sunday 27th June 2025, meaning that there are now two A Class locomotives based at Downpatrick.

In an era of rapid innovation and interconnected platforms, communication is not just a tool; it is the very foundation of competitive advantage. While many believe that conversations exist merely to ...

North Korea test-launches ballistic missiles, South Korea and Japan say

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Adenosine A3 receptor (A3R) plays important roles in neurons, heart, and immune cells, and is often overexpressed in tumors. Oshima et al. identify tRNA-derived i6A as an A3R-selective ligand and use ...

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For executives who have already absorbed the insights from the 13 most popular decision-making books of the past 25 years, Tony Fish's "Decision Making in Uncertain Times" addresses the critical gap t...